Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(114 produits)
- CDK(546 produits)
- Arrêt du cycle cellulaire(5 produits)
- Chk(48 produits)
- DYRK(47 produits)
- Dynamine(27 produits)
- Ferroptose(227 produits)
- HSP(180 produits)
- Intégrine(269 produits)
- Kinésine(87 produits)
- LIM Kinase(20 produits)
- Microtubules associés(274 produits)
- PKC(126 produits)
- PLK(25 produits)
- ROCK(62 produits)
- Rho(6 produits)
- Wee1(14 produits)
- c-Myc(76 produits)
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3904 produits trouvés pour "Cycle cellulaire/point de contrôle"
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5'-O-DMT-2'-O-TBDMS-Ac-rC
CAS :5’-O-DMT-2’-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.Formule :C38H47N3O8SiCouleur et forme :SolidMasse moléculaire :701.892Rachelmycin
CAS :Rachelmycin, a potent antibiotic and antitumor agent from Streptomyces zelensis, binds to DNA's minor groove.Formule :C37H33N7O8Couleur et forme :SolidMasse moléculaire :703.712PROTAC CDK9 degrader-7
CAS :PROTAC CDK9 degrader-7 is a proteolysis-targeting chimera (PROTAC) specifically designed to target and mediate the degradation of Cyclin-Dependent Kinase 9 (Formule :C43H50Cl2N8O9Couleur et forme :SoildMasse moléculaire :893.81Fibronectin CS1 Peptide
CAS :Fibronectin CS1 peptide inhibits tumor metastasis, lacking RGD domain; may aid cancer therapy.Formule :C38H64N8O15Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :872.96N6-Methyl-2'-O-(2-methoxyethyl) adenosine
N6-Methyl-2’-O-(2-methoxyethyl) adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Formule :C14H21N5O5Couleur et forme :SolidMasse moléculaire :339.35KIF18A-IN-12
CAS :KIF18A-IN-12 (compound 9), a potent KIF18A inhibitor, exhibits an IC 50 of 45.54 nM and is utilized in cancer research.Formule :C30H39F2N5O4SCouleur et forme :SolidMasse moléculaire :603.72Cotylenin A
CAS :Cotylenin A is a phenanthraquinone compound that synergistically works with vitamin K2 to induce monocyte differentiation and growth arrest. It also inhibits c-Myc expression while inducing cyclin G2 expression in human leukemia HL-60 cells. Cotylenin A is applicable in acute myeloid leukemia research.Formule :C33H50O11Couleur et forme :SolidMasse moléculaire :622.7442'-Fluoro-2'-deoxy-arabinoadenosine 5'-triphosphate triethylamine
2’-Fluoro-2’-deoxy-arabinoadenosine 5’-triphosphate (triethylamine) is a purine nucleoside analog with significant antitumor properties, particularly effectiveFormule :C34H75FN9O12P3Couleur et forme :SolidMasse moléculaire :913.93Emofolin sodium
CAS :Emofolin sodium, a synthetic folate analogue, inhibits DNA/RNA/protein synthesis by blocking dihydrofolate reductase.Formule :C21H25N7Na2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.45MYC-IN-2
CAS :MYC-IN-2 is a protein-protein inhibitor targeting the MYC protein, designed for use in cancer research.Formule :C25H17N3O2SCouleur et forme :SolidMasse moléculaire :423.49Agrocin 84
CAS :Agrocin 84 is a microbial metabolite that inhibits DNA and protein synthesis, as well as amino acid transport, in the susceptible and virulent Agrobacterium strain H-38-9.Formule :C22H36N6O16P2Couleur et forme :SolidMasse moléculaire :702.4992',3'-Dideoxyuridine-5'-O-(1-thiotriphosphate) tetrasodium
2',3'-Dideoxyuridine-5'-O-(1-thiotriphosphate) (ddUTPαS) tetrasodium is a sulfur-containing nucleoside triphosphate derivative.Couleur et forme :Odour Solid[pSer2, pSer5, pSer7]-CTD TFA
Substrate '[pSer2, pSer5, pSer7]-CTD (TFA)' for CDK7 phosphorylates RNA Pol II CTD at ser2, 5, 7.Formule :C98H138F3N21O39Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2291.25Polynucleotide kinase
CAS :Polynucleotide Kinase is a DNA repair enzyme. It exhibits 5'-kinase activity by catalyzing the transfer of phosphate from ATP to the 5'-hydroxyl (OH) end, and also shows 3'-phosphatase activity by converting the 3'-phosphate end into a 3'-OH end.Pyrindamycin A
CAS :Pyrindamycin A is an antibiotic that inhibits DNA synthesis,and shows antitumor activities against murine leukemia.Formule :C26H26ClN3O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :543.95H122
H122 is a TEADPROTAC degrader effective in degrading TEAD1 with a DC50 of 3 nM, and it shows strong affinity for TEAD2, TEAD3, and TEAD4 with Ki values of 2.0, 3.6, and 1.6 nM, respectively. H122 also downregulates Myc expression and inhibits the growth of MSTO-211H and NCI-H226 cells, with IC50 values of 21.3 nM and 0.6 nM, respectively, demonstrating antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)Formule :C45H45ClFN5O8Couleur et forme :SolidMasse moléculaire :838.319SR15006
CAS :SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM).Formule :C16H20ClN3O4SDegré de pureté :99.87%Couleur et forme :SoildMasse moléculaire :385.875'-O-DMT-ibu-dC
CAS :5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.Formule :C34H37N3O7Couleur et forme :SolidMasse moléculaire :599.67FRα-targeting peptide C7 TFA
FRα-targeting peptide C7 TFA is a selective peptide ligand for the folate receptor alpha (FRα) that specifically binds to FRα-expressing cells and has tumor-targeting capabilities in vivo. It is applicable in research related to tumor diagnosis and therapy.Couleur et forme :Odour Solid3'-β-C-Methyl-2-thiouridine
3’-β-C-Methyl-2-thiouridine, a purine nucleoside analog, exhibits extensive antitumor activity, particularly against indolent lymphoid malignancies.Formule :C10H14N2O5SCouleur et forme :SolidMasse moléculaire :274.295-Aza-xylo-cytidine
5-Aza-xylo-cytidine, a purine analog with antitumor effects, inhibits DNA synthesis and induces apoptosis in lymphoid cancers.Formule :C8H12N4O5Couleur et forme :SolidMasse moléculaire :244.2N3-[(Pyrid-4-yl)methyl]uridine
N3-[(Pyrid-4-yl)methyl]uridine, a uridine analog, may have antiepileptic properties and aid in researching anticonvulsants and anxiolytics.Formule :C15H17N3O6Couleur et forme :SolidMasse moléculaire :335.31RNA polymerase II-IN-2
RNA Pol II-IN-2 (20iii) strongly inhibits Pol II (Ki=9.5 nM), is more toxic to CHO/HEK293 than α-amanitin.Formule :C41H58N10O12SCouleur et forme :SolidMasse moléculaire :915.021-(β-D-Xylofuranosyl)-N6-(m-methoxybenzyl)adenine
1-(β-D-Xylofuranosyl)-N6-(m-methoxybenzyl)adenine is an adenosine analog.Formule :C18H21N5O5Couleur et forme :SolidMasse moléculaire :387.39SNX7
CAS :SNX7 (WAY-323879) inhibits CDKI pathway; useful for studying aging and related diseases.Formule :C15H14N2ODegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :238.28LL-K8-22
LL-K8-22: potent CDK8/cyclin C degrader; DC50 ~2.5μM; hinders STAT1 phosphorylation; curbs E2F/MYC cancer pathways; for TNBC study.Formule :C37H43N5OCouleur et forme :SolidMasse moléculaire :573.77ddTTPαS tetrasodium
ddTTPαS tetrasodium is a sulfur-containing nucleotide triphosphate derivative used in chain extension during PCR assays.Couleur et forme :Odour SolidCarbazole
CAS :Carbazole belongs to the class of carbazole-based organic compounds. Carbazole can form novel DNA small groove complexes, inhibiting the synthesis of new DNA or RNA.Formule :C12H9NDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :167.2112'-Amino-2'deoxyadenosine-5'-O-diphosphate sodium
2'-Amino-2'-deoxyadenosine-5'-O-diphosphate (2'-NH2-ADP) sodium is an amine-modified nucleotide, serving as a structural analog of the purine nucleotide ADP.Couleur et forme :Odour SolidBSJ-04-132
Selective Cdk4 degrader. Degrades Cdk4 in Molt-4 cells, with no effect on Cdk6 levels. Displays cereblon-dependent degradation.Couleur et forme :LiquidPurine riboside-5'-O-triphosphate sodium
CAS :Purine riboside-5'-O-triphosphate sodium is an active metabolite of Nebularine and acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 µM and 28 µM, respectively. It also inhibits calmodulin-dependent protein kinase II (CaMKII), with a Ki value of 590 µM.Formule :C10H11N4Na4O13P3Couleur et forme :SolidMasse moléculaire :580.09CDK8/19-IN-3
CDK8/19-IN-3 (compound 3-7) is a potent and selective inhibitor of CDK8 and CDK19. It can increase IL-10 levels and has potential for research in inflammatory bowel disease (IBD).Formule :C20H23FN6O2Couleur et forme :SolidMasse moléculaire :398.434N1-Methylpseudouridine-5′-triphosphate tetralithium
N1-Methylpseudouridine-5′-triphosphate tetralithium, also known as 1-Methylpseudouridine-5′-triphosphate tetralithium, is a nucleobase-modified nucleotide.Formule :C10H13Li4N2O15P3Couleur et forme :SolidMasse moléculaire :521.92'-Chloro-N6-(3-trifluoromethyl)benzyl adenosine
2’-Chloro-N6-(3-trifluoromethyl)benzyl adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoidFormule :C18H17ClF3N5O4Couleur et forme :SolidMasse moléculaire :459.81Py-MAA-Val-Cit-PAB-DX8951
CAS :Py-MAA-Val-Cit-PAB-DX8951, a purine toxin, serves as an intermediate in the synthesis of antibody-drug conjugates [1].Formule :C57H66FN11O13SCouleur et forme :SolidMasse moléculaire :1164.26CPS2
CAS :CPS2: potent, selective PROTAC CDK2 degrader. IC50=24nM, targets acute myeloid leukemia research.Formule :C38H42N12O10S2Couleur et forme :SolidMasse moléculaire :890.946-Methoxypurine-9-β-D-(3-methoxy riboside)
6-Methoxypurine riboside is a purine analog with anti-lymphoma activity via DNA synthesis inhibition and apoptosis induction.Formule :C12H16N4O5Couleur et forme :SolidMasse moléculaire :296.286-Amino-4-hydrozino-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine
6-Amino-4-hydrozino-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a purine nucleoside analogue with broad antitumor activity, particularly againstFormule :C10H15N7O4Couleur et forme :SolidMasse moléculaire :297.27CDP-β-S trisodium salt
CDP-β-S (Cytidine-5'-O-(2-thiodiphosphate)) trisodium salt is a non-hydrolyzable analog of CDP (Cytidine Diphosphate) with antioxidant and free radical scavenging properties.Couleur et forme :Odour SolidZIKV-IN-6
ZIKV-IN-6 (compound 22) acts as a direct inhibitor of the Zika virus (ZIKV) by binding to its RNA-dependent RNA polymerase (RdRp) and obstructing viral RNACouleur et forme :Odour SolidGuanosine 5'-triphosphate trisodium salt hydrate
CAS :5'-GTP trisodium salt hydrate activates G proteins and is a precursor for DNA/RNA synthesis.Formule :C10H18N5NaO15P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :564.185Ascochlorin A
CAS :Ascochlorin A, a compound with a dissociation constant (K D) of 3.29 μM, serves as a novel and potent human dihydroorotate dehydrogenase (hDHODH) inhibitorFormule :C23H31ClO4Couleur et forme :SolidMasse moléculaire :406.95PDI-IN-4
PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb/IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.Formule :C17H12F3NO2Couleur et forme :SolidMasse moléculaire :319.278AAK1-IN-7
AAK1-IN-7 (Compound 16) is a dual inhibitor of AAK1 and GAK with EC50 values of 40 nM and 80 nM, respectively. This compound inhibits the phosphorylation of the AP2-µ2 subunit at the T156 position. However, it demonstrates only weak antiviral activity against RNA viruses.Couleur et forme :Odour SolidEMD527040 hydrochloride
EMD527040 (hydrochloride) is a potent and selective αvβ6 antagonist with antifibrotic properties. It is applicable in research related to liver cancer and hepatic fibrosis.Couleur et forme :Odour SolidXanthosine-5'-Triphosphate
CAS :Xanthosine-5'-Triphosphate (5'-XTP), a nucleotide derived from the deamination of purine bases, plays a crucial role in various biological processes.Formule :C10H15N4O15P3Couleur et forme :SolidMasse moléculaire :524.1645-Methylcytidine 5′-triphosphate
CAS :5-Methylcytidine 5′-triphosphate (5-Methyl-CTP), a modified nucleoside triphosphate, enhances translational properties and stability while reducing innateFormule :C10H18N3O14P3Couleur et forme :SolidMasse moléculaire :497.18LY2812223
CAS :LY2812223: selective mGlu2 agonist; binds mGlu2/mGlu3 (Ki=144/156 nM).Formule :C10H12N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :284.294,6-Dichloroguaiacol
CAS :4,6-Dichloroguaiacol elicits biochemical and morphological alterations in human peripheral blood lymphocytes in vitro.Formule :C7H6Cl2O2Couleur et forme :SolidMasse moléculaire :193.02Rev 2'-O-MOE-C(Bz)-5'-amidite
'Rev 2’-O-MOE-C(Bz)-5’-amidite, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies.Formule :C49H58N5O10PCouleur et forme :SolidMasse moléculaire :907.99
