Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(96 produits)
- CDK(505 produits)
- Arrêt du cycle cellulaire(4 produits)
- Chk(42 produits)
- DYRK(48 produits)
- Dynamine(23 produits)
- Ferroptose(215 produits)
- HSP(170 produits)
- Intégrine(227 produits)
- Kinésine(68 produits)
- LIM Kinase(19 produits)
- Microtubules associés(261 produits)
- PKC(102 produits)
- PLK(28 produits)
- ROCK(68 produits)
- Rho(2 produits)
- Wee1(15 produits)
- c-Myc(68 produits)
Affichez 10 plus de sous-catégories
3495 produits trouvés pour "Cycle cellulaire/point de contrôle"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
LN-439A
CAS :<p>LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.</p>Formule :C24H26FN3O4Couleur et forme :SolidMasse moléculaire :439.48KWR095
CAS :<p>KWR095 is an orally active inhibitor of WRN, demonstrating an IC50 of 0.032 μM against WRN ATPase. It disrupts the double-stranded helicase activity of WRN and inhibits tumor cell proliferation, exhibiting antitumor properties.</p>Formule :C33H31ClF3N9O4Couleur et forme :SolidMasse moléculaire :710.105AR-13324 M1 metabolite
CAS :<p>AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate.</p>Formule :C19H19N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :321.37p38α inhibitor 9
CAS :<p>p38α inhibitor9 (Compound 2015) is a p38α inhibitor that effectively blocks the enzyme activity of p38α, with an IC50 of less than 20 nM. It inhibits MK2T334 phosphorylation and activates Cdc25b and Cdc25c while inactivating Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy, and DNA damage. Additionally, p38α inhibitor9 can suppress colorectal cancer (CRC) metastasis.</p>Formule :C27H24FN3O3Couleur et forme :SolidMasse moléculaire :457.496And1 degrader 1
CAS :<p>And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.</p>Formule :C26H27Cl2N3OCouleur et forme :SolidMasse moléculaire :468.42DNA Gyrase-IN-16
CAS :<p>DNA Gyrase-IN-16 (Compound 9) is an inhibitor of DNA gyrase, with an IC50 of 1.609 μM. It exhibits antibacterial properties, effectively inhibiting S. aureus and MRSA, with a MIC of 3.125 μM for both.</p>Formule :C17H15N3O3Couleur et forme :SolidMasse moléculaire :309.319BRD4 Inhibitor-40
CAS :<p>BRD4 Inhibitor-40 (Compound 23) functions as an inhibitor of BRD, effectively targeting BRD4-BD1, BRD4-BD2, BRD2-BD1, and BRD2-BD2, with IC50 values of 16.1, 142.18, 29.35, and 302.35 nM, respectively. It modulates the expression of c-Myc and p21, induces cell cycle arrest in the G1 phase, and inhibits Pkd1-deficient (PN) renal cystic epithelial cells. Additionally, it prevents renal cyst formation in both Madin-Darby canine kidney and embryonic kidney cyst models, and demonstrates renal cyst inhibition activity in mouse models.</p>Formule :C27H32N8OCouleur et forme :SolidMasse moléculaire :484.596CDK2/4-IN-2
CAS :<p>CDK2/4-IN-2 (compound 56) serves as a dual inhibitor for CDK2 and CDK4, exhibiting an IC50 of less than 100 nM. It is applicable in cancer research.</p>Formule :C18H20F3N7O3S2Couleur et forme :SolidMasse moléculaire :503.52BET/Aurora kinase-IN-1
CAS :<p>BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.</p>Formule :C25H30FN7OCouleur et forme :SolidMasse moléculaire :463.55HNC-1664
CAS :<p>HNC-1664 is an orally active inhibitor of RNA-dependent RNA polymerase (RdRP). It exhibits broad-spectrum antiviral activity against coronaviruses, including SARS-CoV-2 wild type and its variants (XBB.1.18, HK.3.1, BF.7.14, BA.1, HCoV-229E, HCoV-OC43), as well as arenaviruses. HNC-1664 also demonstrates anti-infective efficacy in a mouse model infected with the SARS-CoV-2 Delta variant.</p>Formule :C12H13FIN3O3Couleur et forme :SolidMasse moléculaire :393.153IRE1α kinase-IN-5
<p>IRE1α kinase-IN-5 (compound 7) is a potent inhibitor of IRE1α (Ki: 98 nM) and is an ATP-competitive ligand for IRE1α.</p>Formule :C28H30N6O3SCouleur et forme :SolidMasse moléculaire :530.64L-I-OddU
CAS :<p>L-I-OddU: Selective anti-EBV, halts virus DNA/protein synthesis. EC50: 0.03 µM, low toxicity (CC50: 1000 nM).</p>Formule :C8H9IN2O5Couleur et forme :SolidMasse moléculaire :340.072′-O-MOE-CMP
CAS :<p>2′-O-MOE-CMP is a nucleotide analogue utilized in the synthesis of oligonucleotides.</p>Formule :C12H20N3O9PCouleur et forme :SolidMasse moléculaire :381.28(R)-Atuveciclib
CAS :<p>Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].</p>Formule :C18H18FN5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.437-Methylguanosine 5′-monophosphate
CAS :<p>7-Methylguanosine 5′-monophosphate (7-Methylguanylic acid) is a component of nucleic acids.</p>Formule :C11H16N5O8PCouleur et forme :SolidMasse moléculaire :377.25GR 83895
CAS :<p>GR 83895 is an antagonist of prototype fibrinogen receptor.</p>Formule :C29H39N9O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :673.74Rhodblock 1a
CAS :<p>Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway, which disrupts the localization and function of proteins within the Rho pathway. This interference hinders the proper formation of the cleavage furrow during cell division, leading to some cells either failing to form the cleavage furrow or forming a ruptured furrow, resulting in binucleated cells. Rhodblock 1a can be utilized for investigating cell division mechanisms and holds potential for research into cardiovascular diseases and cancer.</p>Formule :C20H16N2O2Couleur et forme :SolidMasse moléculaire :316.353(R)-CSN5i-3
CAS :<p>(R)-CSN5i-3 is CSN5i-3 of the R configuration.</p>Formule :C28H29F2N5O2Degré de pureté :99.76% - 99.97%Couleur et forme :SolidMasse moléculaire :505.56Elacytarabine
CAS :<p>Elacytarabine (M7594 0037), a lipid-conjugated derivative of the nucleoside analog cytarabine, is an antineoplastic drug. It has cytotoxicity in solid tumors.</p>Formule :C27H45N3O6Degré de pureté :97.69%Couleur et forme :SolidMasse moléculaire :507.66CTPS1-IN-1
CAS :<p>CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.</p>Formule :C21H22N6O4S2Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :486.57GFB-12811
CAS :<p>GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.</p>Formule :C22H23F4N5ODegré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :449.44HRO761
CAS :<p>HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.</p>Formule :C31H31ClF3N9O5Degré de pureté :98.74% - 99.62%Couleur et forme :SolidMasse moléculaire :702.08LY3143921 hydrate
CAS :<p>LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].</p>Formule :C16H14FN5O2Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :327.31SR 11302
CAS :<p>SR 11302 is an inhibitor of activator protein-1 (AP-1).</p>Formule :C26H32O2Degré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :376.53INCB086550
CAS :<p>INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.</p>Formule :C41H39N7O4Degré de pureté :98.49%Couleur et forme :SolidMasse moléculaire :693.79Bicyclomycin benzoate
CAS :<p>Bicyclomycin benzoate (BCM benzoate, FR2054) is a broad-spectrum antibiotic and selective Rho protein inhibitor active against Gram-negative bacteria.</p>Formule :C19H22N2O8Couleur et forme :SolidMasse moléculaire :406.39Deoxypseudouridine
CAS :<p>Deoxypseudouridine is a nucleotide analog.</p>Formule :C9H12N2O5Couleur et forme :SolidMasse moléculaire :228.2Troxacitabine
CAS :<p>Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious against Panc-01.</p>Formule :C8H11N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :213.19GSK-3/CDK5/CDK2-IN-1
CAS :<p>GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].</p>Formule :C21H22N4O2Couleur et forme :SolidMasse moléculaire :362.4335'-DMT-3'-TBDMS-ibu-rG
CAS :<p>5'-DMT-3'-TBDMS-ibu-rG is a modified nucleoside employed in deoxyribonucleic acid (DNA) synthesis.</p>Formule :C41H51N5O8SiCouleur et forme :SolidMasse moléculaire :769.96Formycin A
CAS :<p>Formycin A shows antitumor and antiviral activities. Formycin A , a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM.</p>Formule :C10H13N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :267.24Ethynylcytidine
CAS :<p>Ethynylcytidine is a nucleoside antimetabolite.</p>Formule :C11H13N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :267.245'-O-DMT-N6-ibu-dA
CAS :<p>5'-O-DMT-N6-ibu-dA can be utilized in the synthesis of oligodeoxyribonucleotides.</p>Formule :C35H37N5O6Couleur et forme :SolidMasse moléculaire :623.712'-Deoxy-2'-fluoro-5-iodouridine
CAS :<p>2'-Deoxy-2'-fluoro-5-iodouridine is a nucleoside, specifically a fluoro-modified and halo-nucleoside.</p>Formule :C9H10FIN2O5Couleur et forme :SolidMasse moléculaire :372.09PLK1-IN-6
<p>PLK1-IN-6: potent, selective PLK1 inhibitor, IC50 = 0.45 nM, hinders cancer cell growth.</p>Formule :C28H37N9O3Couleur et forme :SolidMasse moléculaire :547.65N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine
CAS :<p>N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine, catalog number T66118 and CAS number 64325-78-6, is a valuable organic compound for life sciences research.</p>Formule :C38H35N5O6Couleur et forme :SolidMasse moléculaire :657.727Tanuxiciclib
CAS :<p>Tanuxiciclib is a cyclin dependent kinase (CDK) inhibitor, specifically designed to interfere with cell cycle progression by inhibiting the activity of CDKs, which are crucial regulators of cell division.</p>Formule :C15H13FN6OCouleur et forme :SolidMasse moléculaire :312.308NSC639828
CAS :<p>NSC639828 is an efficient inhibitor of DNA polymerase α, exhibiting a remarkable IC50 value of 70 μM. Additionally, NSC639828 demonstrates substantial antitumor activity, making it a promising candidate for cancer research.</p>Formule :C18H13BrClN5O3Couleur et forme :SolidMasse moléculaire :462.695'-O-TBDMS-dT
CAS :<p>5’-O-TBDMS-dT is a nucleoside with protective and modification effects.</p>Formule :C16H28N2O5SiCouleur et forme :SolidMasse moléculaire :356.49MitoE10
CAS :<p>MitoE10 is an effective mitochondrial targeting antioxidant.</p>Formule :C42H55O5PSCouleur et forme :SolidMasse moléculaire :702.926-Amino-5-nitropyridin-2-one
CAS :<p>6-Amino-5-nitropyridin-2-one, a pyridine derivative, serves as a nucleobase within hachimoji DNA, where it is specifically paired with 5-aza-7-deazaguanine.</p>Formule :C5H5N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :155.11Ribocil-C
CAS :<p>Ribocil-C is a selective inhibitor of the bacterial riboflavin riboswitch, a synthetic analogue of flavin mononucleotide (FMN), inhibits bacterial cell growth.</p>Formule :C21H21N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :419.5Tibremciclib
CAS :<p>Tibremciclib is a cyclin-dependent kinase 4 (CDK4) inhibitor that exhibits antineoplastic properties [1].</p>Formule :C28H32F2N8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :518.6PHI-101
CAS :<p>PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.</p>Formule :C19H19FN4O2SDegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :386.44YK-2168
CAS :<p>YK-2168 is a differentiated selective inhibitor of CDK9.</p>Formule :C16H18ClN5Couleur et forme :SolidMasse moléculaire :315.80
