Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(114 produits)
- CDK(546 produits)
- Arrêt du cycle cellulaire(5 produits)
- Chk(48 produits)
- DYRK(47 produits)
- Dynamine(27 produits)
- Ferroptose(227 produits)
- HSP(180 produits)
- Intégrine(269 produits)
- Kinésine(87 produits)
- LIM Kinase(20 produits)
- Microtubules associés(274 produits)
- PKC(126 produits)
- PLK(25 produits)
- ROCK(62 produits)
- Rho(6 produits)
- Wee1(14 produits)
- c-Myc(76 produits)
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3904 produits trouvés pour "Cycle cellulaire/point de contrôle"
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Ceftriaxone
CAS :Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.Formule :C18H18N8O7S3Degré de pureté :96.08%Couleur et forme :SolidMasse moléculaire :554.586-Amino-4-methoxy-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine
CAS :6-Amino-4-methoxy-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine, a pyrimidine nucleoside analog, exhibits a broad spectrum of biochemical andFormule :C11H15N5O4Couleur et forme :SolidMasse moléculaire :281.276-Thioguanosine
CAS :6-Thioguanosine (6-Mercaptoguanosine) is an active nucleoside and low molecular weight gel.6-Thioguanosine has immunosuppressive properties.Formule :C10H13N5O4SDegré de pureté :97.05%Couleur et forme :Yellow-Green PowderMasse moléculaire :299.31CDK6/9-IN-1
CAS :CDK6/9-IN-1, an oral dual inhibitor of CDK6/9, has IC50s of 40.5nM (CDK6) and 39.5nM (CDK9).Formule :C22H25ClN8OCouleur et forme :SolidMasse moléculaire :452.95Methylcarbamyl PAF C-8
Methylcarbamyl PAF C-8 is resistant to degradation by PAF-AH and has a half-life of over 100 minutes in platelet-poor plasma, exhibiting platelet aggregation activity. In NRK-49 cells overexpressing PAF receptor, it induces the expression of c-myc, c-fos, and activates mitogen-activated protein kinase (MAPK). Furthermore, Methylcarbamyl PAF C-8 can induce G1 phase cell cycle arrest. This compound shows potential for research in cardiovascular and anti-cancer applications.Couleur et forme :Odour SolidRp-dCTPαS tetrasodium
Rp-dCTPαS tetrasodium is a sulfur-containing isomer of dGTP.Couleur et forme :Odour SolidNocarnickelamides B
Nocarnickelamides B (Compound 2) is a linear peptide and an inhibitor of ROCK1/2. It exhibits dual inhibitory activity against ROCK1 and ROCK2, with IC50 values of 14.9 μM and 21.9 μM, respectively. This compound binds to the ATP binding site and inhibits ROCK-mediated cytoskeletal contraction markers, such as myosin light chain activation. Nocarnickelamides B can be utilized in glaucoma research.Formule :C29H42N6O9Couleur et forme :Odour SolidMasse moléculaire :618.68m7GpppUmpG
CAS :m7GpppUmpG, a trinucleotide cap analogue, enables RNA synthesis with cap 0 or 1 structures.Formule :C31H42N12O26P4Couleur et forme :SolidMasse moléculaire :1122.63Antibacterial agent 271
Antibacterialagent 271 is an antimicrobial compound that significantly inhibits Escherichia coli, with a minimum inhibitory concentration (MIC) of 2.2 μM. It disrupts bacterial membrane integrity, reducing metabolic activity. By binding to DNA grooves, it inhibits replication and induces reactive oxygen species (ROS) accumulation, leading to bacterial death. Antibacterialagent 271 shows considerable potential in combating bacterial infections.Couleur et forme :Odour SolidRibonuclease T1
CAS :Rnase T1, an endonuclease, degrades single-stranded RNA to yield 3'-GMP oligonucleotides.
Couleur et forme :SolidDG1
DG1 (Compound 8Nc), a Thymidylate Synthase (TS) inhibitor, impedes angiogenesis and alters metabolic reprogramming in NSCLC cells, while effectively suppressingFormule :C19H17N5O5SCouleur et forme :SolidMasse moléculaire :427.43DSPE-PEG3400-cRGD
DSPE-PEG3400-cRGD is a PEG compound composed of DSPE and the αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to the αvβ3 integrins present on the surface of various cancer cells and neovascularization cells. DSPE-PEG3400-cRGD can be utilized for drug delivery purposes.Couleur et forme :Odour SolidGarenoxacin
CAS :Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.Formule :C23H20F2N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.41αvβ5 integrin-IN-1
CAS :αvβ5 integrin-IN-1, a potent and selective αvβ5 integrin inhibitor, exhibits a high inhibitory potency with a pIC50 value of 8.2.Formule :C25H28F3N3O3Couleur et forme :SolidMasse moléculaire :475.512CDK9 ligand 3
CAS :CDK9ligand 3 is a ligand for CDK9 and can be utilized in the synthesis of PROTAC degraders, specifically PROTAC CDK9degrader-11.Formule :C18H18BrCl2N5O3Couleur et forme :SolidMasse moléculaire :503.177SP-96
CAS :SP-96: Aurora B inhibitor, IC50=0.316 nM, selectively hinders MDA-MD-468 growth, GI50=107 nM, for triple-negative breast cancer research.
Formule :C25H20FN7ODegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :453.47JAMM protein inhibitor 2
CAS :JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.Formule :C21H26N2O2Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :338.44m7GpppCmpG
CAS :m7GpppCmpG, a trinucleotide cap analogue, enables RNA manufacturing with cap 0 or cap 1 structures.Formule :C31H43N13O25P4Couleur et forme :SolidMasse moléculaire :1121.64Adenosine-2-carboxy methyl amide
Adenosine-2-carboxy methyl amide: a purine analog with antitumor effects, inhibits DNA synthesis and induces apoptosis.Formule :C12H16N6O5Couleur et forme :SolidMasse moléculaire :324.29(E/Z)-THZ1 2HCl
CAS :THZ1 2HCl: selective CDK7 allosteric inhibitor, IC50 3.2 nM, hinders cancer cell growth.
Formule :C31H30Cl3N7O2Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :638.98CDK7-IN-7
CAS :CDK7-IN-7: Selective CDK7 inhibitor, IC50 < 50 nM (Patent CN112661745A).Formule :C20H20BrF3N6O2Couleur et forme :SolidMasse moléculaire :513.3195,6-dihydro-5-Fluorouracil
CAS :5,6-dihydro-5-Fluorouracil (5-FUH2) is an inactive metabolite of 5-FU and can be used for the study of organismal metabolism.Formule :C4H5FN2O2Couleur et forme :SolidMasse moléculaire :132.09PROTAC CDK9 degrader-5
CAS :PROTAC CDK9 degrader-5 selectively degrades CDK9 isoforms 42, 55 with DC50 of 0.10μM, 0.14μM via proteasome.Formule :C42H48Cl2N8O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :879.78AV-153
CAS :AV-153, a 1,4-dihydropyridine, reduces DNA damage, stimulates repair, and has anti-cancer properties.Formule :C14H19NNaO6Couleur et forme :SolidMasse moléculaire :320.297CTP Synthetase-IN-1 Ammonium salt
CTP Synthetase-IN-1 Ammonium salt is a CTPS inhibitor with potential antibacterial, anti-inflammatory, and antitumor activity for the study of SARS-CoV-2 viral infectionsFormule :C20H22F3N7O3S2Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :529.56RA-V
RA-V is a natural product that can be used as a reference standard.Formule :C160H202N24O41Couleur et forme :SolidMasse moléculaire :3117.5N3-[(Pyrid-4-yl)methyl]uridine
N3-[(Pyrid-4-yl)methyl]uridine, a uridine analog, may have antiepileptic properties and aid in researching anticonvulsants and anxiolytics.Formule :C15H17N3O6Couleur et forme :SolidMasse moléculaire :335.31LIN28-IN-2
LIN28-IN-2 (Compound Ln268) blocks the interaction between the zinc finger domain (ZKD) of Lin28 and RNA substrates, inhibiting both Lin28a and Lin28b. It also suppresses the proliferation of Lin28-positive cancer cells and the growth of 3D spheroids.Formule :C9H7FN2O2SCouleur et forme :SolidMasse moléculaire :226.227PDI-IN-4
PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb/IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.Formule :C17H12F3NO2Couleur et forme :SolidMasse moléculaire :319.278DNA Gyrase-IN-15
DNA Gyrase-IN-15 (Compound 11) is an antibacterial agent that inhibits both DHPS and DNA gyrase, with IC50 values of 1.73 and 0.07 µM, respectively. It shows antimicrobial activity against Enterococcus faecium (MIC of 15.62 µg/mL), Acinetobacter baumannii, Enterobacter (MIC of 7.81 µg/mL), Pseudomonas aeruginosa, Klebsiella pneumoniae, and Staphylococcus aureus. Additionally, DNA Gyrase-IN-15 exhibits antibiofilm activity against Enterococcus faecium.Formule :C31H26N4O4S2Couleur et forme :SolidMasse moléculaire :582.693SMS 121
CAS :SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.Formule :C20H21NO5Degré de pureté :98.29%Couleur et forme :SoildMasse moléculaire :355.388-NH2-ATP
CAS :8-NH2-ATP is an inactive derivative of adenosine triphosphate (ATP), synthesized from 8-NH2-Ado.Formule :C10H17N6O13P3Couleur et forme :SolidMasse moléculaire :522.20FRα-targeting peptide C7
CAS :FRα-targeting peptide C7 is a selective peptide ligand for folate receptor α (FRα), exhibiting specific binding capabilities to cells expressing FRα and potential for in vivo tumor targeting. This peptide is utilized in research for tumor diagnosis and therapy.Formule :C62H90N18O16SMasse moléculaire :1375.55KIF18A-IN-11
KIF18A-IN-11 (Compound 13) is an effective inhibitor of KIF18A, exhibiting IC50 values below 100 nM in OVCAR3 and MDA-MB-157 cells. It is applicable for cancer research.Formule :C28H38F2N6O4SMasse moléculaire :592.26433TLK1-IN-1
TLK1-IN-1 (Compound 5n) is a TLK1 inhibitor with an IC50 of 7.2 μM for TLK1B and a GI50 of 2.7 μM for LNCaP cells. It induces DNA damage and apoptosis (Apoptosis) in cancer cells and is applicable in prostate cancer research.Formule :C24H23BrClN5O3Couleur et forme :SoildMasse moléculaire :544.83KIF18A-IN-6
CAS :KIF18A-IN-6 (Compound 134) is an orally active KIF18A inhibitor that suppresses KIF18A microtubule-dependent ATPase activity with an IC50 of 0.016 μM.Formule :C28H37N3O5S2Degré de pureté :97.59%Couleur et forme :SolidMasse moléculaire :559.74Ref: TM-T73049
1mg69,00€5mg147,00€10mg231,00€25mg394,00€50mg522,00€100mg728,00€1mL*10mM (DMSO)177,00€2'-Fluoro-2'-deoxy-arabinoadenosine 5'-triphosphate triethylamine
2’-Fluoro-2’-deoxy-arabinoadenosine 5’-triphosphate (triethylamine) is a purine nucleoside analog with significant antitumor properties, particularly effectiveFormule :C34H75FN9O12P3Couleur et forme :SolidMasse moléculaire :913.93ROCK-IN-5
CAS :ROCK-IN-5 (I-B-37) inhibits kinases like ROCK/ERK/GSK; may aid in cardiac and neuro disease studies.Formule :C16H11ClFN3OSDegré de pureté :99.72% - 99.86%Couleur et forme :SolidMasse moléculaire :347.795-O-TBDMS-N4-Benzoyl-2-deoxycytidine
CAS :5-O-TBDMS-N4-Benzoyl-2-deoxycytidine is a modified nucleoside utilized in the synthesis of deoxyribonucleic acid (DNA) or nucleic acid.Formule :C22H31N3O5SiCouleur et forme :SolidMasse moléculaire :445.58pNP-ADPr
CAS :pNP-ADPr: Used in PARG & ARH3 activity assays; aids in PARP enzyme research.Formule :C21H26N6O16P2Couleur et forme :SolidMasse moléculaire :680.41α2β1 Integrin Ligand Peptide
CAS :The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellularFormule :C14H22N4O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :390.35Levomefolate magnesium
CAS :Levomefolate magnesium is the main active folate in food and plasma, essential for DNA synthesis and amino acid regulation, safe for use as a supplement.Formule :C20H23MgN7O6Couleur et forme :SolidMasse moléculaire :481.745'-O-DMT-N4-Bz-2'-F-dC
CAS :5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.Formule :C37H34FN3O7Couleur et forme :SolidMasse moléculaire :651.68TTK/PLK1-IN-1
CAS :TTK/PLK1-IN-1 (Formula I) is a dual inhibitor of TTK (threonine tyrosine kinase) and PLK1 (polo-like kinase 1), with IC₅₀ values of 7 nM and 72 nM respectively.Formule :C30H33N7O2Degré de pureté :97.39%Couleur et forme :SolidMasse moléculaire :523.63Arg-Gly-Glu-Ser TFA
Arg-Gly-Glu-Ser TFA, an RGD-related peptide, serves as a control for evaluating the inhibitory activity of RGDS on fibrinogen binding to activated platelets.Formule :C18H30F3N7O10Couleur et forme :SolidMasse moléculaire :561.47Eg5-IN-3
Eg5-IN-3 (5) is an Eg5 inhibitor targeting a novel allosteric site (α4/α6/L11). It disrupts tubulin assembly, leading to abnormal and irregular formations, which subsequently causes typical mitotic arrest, akin to the effects of Monastrol.Formule :C23H23N7O2Masse moléculaire :429.19132Deoxythymidine-5'-triphosphate
CAS :Deoxythymidine-5'-triphosphate (dTTP) is a nucleoside triphosphate involved in DNA synthesis.Formule :C10H17N2O14P3Couleur et forme :SolidMasse moléculaire :482.1671-(β-D-Xylofuranosyl)-N6-(m-methoxybenzyl)adenine
1-(β-D-Xylofuranosyl)-N6-(m-methoxybenzyl)adenine is an adenosine analog.Formule :C18H21N5O5Couleur et forme :SolidMasse moléculaire :387.39GK13S
G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.Formule :C21H22N6O2Couleur et forme :SolidMasse moléculaire :390.44UnyLinker 12 TEA
UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.Formule :C39H35NO10C6H15NCouleur et forme :SolidMasse moléculaire :778.34655
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