Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(94 produits)
- CDK(500 produits)
- Arrêt du cycle cellulaire(4 produits)
- Chk(42 produits)
- DYRK(48 produits)
- Dynamine(23 produits)
- Ferroptose(215 produits)
- HSP(169 produits)
- Intégrine(224 produits)
- Kinésine(66 produits)
- LIM Kinase(19 produits)
- Microtubules associés(261 produits)
- PKC(102 produits)
- PLK(28 produits)
- ROCK(70 produits)
- Rho(2 produits)
- Wee1(15 produits)
- c-Myc(69 produits)
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3477 produits trouvés pour "Cycle cellulaire/point de contrôle"
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GRGDSP
CAS :<p>Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is used as a soluble integrin-blocking RGD-based peptide.</p>Formule :C22H37N9O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :587.58Chrysomycin A
CAS :<p>Chrysomycin A is an antibiotic that can be derived from Streptomyces.</p>Formule :C28H28O9Couleur et forme :SolidMasse moléculaire :508.52Isocytosine
CAS :<p>Compound PDK0016, with CAS No. 108-53-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0016 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Formule :C4H5N3OCouleur et forme :White To Off-White SolidMasse moléculaire :111.1TLR7 agonist 12
CAS :<p>TLR7 agonist 12, a purine nucleoside analog, inhibits DNA synthesis and induces apoptosis in lymphoid cancers.</p>Formule :C14H19N5O8Couleur et forme :SolidMasse moléculaire :385.33Antibacterial agent 144
<p>Antibacterial Agent 144 (compound 8e) exhibits superior efficacy against multi-resistant Staphylococcus aureus compared to Chloromycin and Amoxicillin.</p>Formule :C26H23N7O3Couleur et forme :SolidMasse moléculaire :481.51Clofarabine-5'-diphosphate trisodium
<p>Clofarabine-5'-diphosphatetrisodium (Clofarabine-DP trisodium) is the sodium salt form of Clofarabine-5'-diphosphate. As a metabolic product of Clofarabine, it results from phosphorylation by deoxycytidine kinase (dCK). Clofarabine-5'-diphosphate trisodium can undergo further phosphorylation to form Clofarabine-5'-triphosphate, demonstrating cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.</p>Formule :C10H10ClFN5Na3O9P2Couleur et forme :SolidMasse moléculaire :529.58CDK7-IN-5
CAS :<p>CDK7-IN-5, a CDK7 inhibitor with an IC 50 value of less than 100 nM, exhibits potent anticancer properties (WO2015154022A1, Compound 104).</p>Formule :C34H45N9O2Couleur et forme :SolidMasse moléculaire :611.7955'-O-DMT-ibu-dC
CAS :<p>5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.</p>Formule :C34H37N3O7Couleur et forme :SolidMasse moléculaire :599.67Catumaxomab
CAS :<p>Catumaxomab is a rat-mouse hybrid lgG2 monoclonal and bispecific antibody that binds to the antigens CD3 and EpCAM for malignant ascites in cancer patients.</p>Degré de pureté :95%Couleur et forme :LiquidAc-dA Phosphoramidite
CAS :<p>Ac-dA Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.</p>Formule :C42H50N7O7PCouleur et forme :SolidMasse moléculaire :795.878PLK1-IN-2
CAS :<p>PLK1-IN-2 is a PLK1 kinase inhibitor with an IC 50 value of 0.384 μM.</p>Formule :C24H27FN8OSCouleur et forme :SolidMasse moléculaire :494.59PROTAC CDK9 degrader-2
CAS :<p>PROTAC CDK9 degrader-2, potent, selective, IC50 17 μM in MCF-7, wogonin-derived, targets CRBN.</p>Formule :C39H36N6O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :748.745-Methylcytidine 5′-triphosphate trisodium
<p>5-Methylcytidine 5′-triphosphate trisodium (5-Methyl-CTP trisodium), a modified nucleoside triphosphate, enhances translational properties and stability, while</p>Formule :C10H15N3Na3O14P3Couleur et forme :SolidMasse moléculaire :563.13IRE1-IN-2
<p>IRE1-IN-2 (compound G15) functions as a potent inhibitor of IRE1. It effectively suppresses lipid accumulation induced by FFA, exhibiting an IC50 value of 2.06 μM.</p>Formule :C16H20O6Couleur et forme :SolidMasse moléculaire :308.12599Ac-MRGDH-NH2
<p>Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.</p>Formule :C25H41N11O8SCouleur et forme :SolidMasse moléculaire :655.727Anti-c-myc Antibody (9E10)
<p>Anti-c-myc Antibody (9E10) is a chimeric mouse IgG1 antibody targeting human c-myc.</p>Couleur et forme :Odour LiquidDSPE-PEG3000-iRGD
<p>DSPE-PEG3000-iRGD is a PEG compound comprising DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrin and undergoes proteolytic cleavage within tumors to produce CRGDK/R, interacting with neuropilin-1. This results in tumor targeting and penetration capabilities. DSPE-PEG3000-iRGD is applicable in drug delivery.</p>Couleur et forme :Odour Solidα-Methyl-DL-aspartic acid
CAS :<p>α-Methyl-DL-aspartic acid specifically inhibits argininosuccinate synthase (ASS), the rate-limiting enzyme in 1-citrulline-to-1-arginine recycling.</p>Formule :C5H9NO4Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :147.13MRK-952
<p>MRK-952 is a NUDIX hydrolase inhibitor. NUDIX enzymes play a role in cellular metabolism, homeostasis, and mRNA processing.</p>Formule :C20H20ClF3N6Couleur et forme :SolidMasse moléculaire :436.861Pseudouridimycin
CAS :<p>Pseudouridimycin: a C-nucleoside antibiotic, inhibits bacterial RNAP, targets Gram-negative and Gram-positive bacteria.</p>Formule :C17H26N8O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :486.44WRN inhibitor 17
CAS :<p>WRN inhibitor 17 (Compound 250) is an orally active inhibitor of Werner syndrome ATP-dependent helicase (WRN), specifically targeting the helicase domain activity of WRN. It holds potential for use in cancer research.</p>Formule :C33H34F4N4O6SCouleur et forme :SolidMasse moléculaire :690.71CD532 hydrochloride
<p>CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.</p>Couleur et forme :SolidClofarabine-5'-triphosphate
CAS :<p>Clofarabine-5'-triphosphate is a metabolite of Clofarabine, produced via phosphorylation by deoxycytidine kinase (dCK). It exhibits cytotoxicity in cancer cells by inhibiting DNA synthesis and DNA repair.</p>Formule :C10H14ClFN5O12P3Couleur et forme :SolidMasse moléculaire :543.62PROTAC MTP3 degrade-1
<p>PROTACMTP3 degrade-1 is a PROTAC degrader for MYC.</p>Formule :C44H38N6O8Couleur et forme :SolidMasse moléculaire :778.27511N3,5-Dimethyl-2'-O-(2-methoxyethyl) uridine
<p>N3,5-Dimethyl-2’-O-(2-methoxyethyl) uridine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.</p>Formule :C14H22N2O7Couleur et forme :SolidMasse moléculaire :330.33CDK5-IN-1
CAS :<p>CDK5-IN-1: Potent CDK5 inhibitor (<10 nM) used in kidney disease research.</p>Formule :C24H25FN6O3SCouleur et forme :SolidMasse moléculaire :496.56Clofarabine-5'-diphosphate
CAS :<p>Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK). It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.</p>Formule :C10H13ClFN5O9P2Couleur et forme :SolidMasse moléculaire :463.64Echistatin
CAS :<p>Potent αVβ3 integrin blocker, stops osteoclast binding & bone loss, hinders platelet aggregation. Ki=0.27 nM, IC50s: 0.1 nM (bone), 30 nM (platelets).</p>Formule :C217H341N71O74S9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5417.1PAT-LM1
<p>PAT-LM1 is a human monoclonal antibody that targets NRB54/NONO. It is applicable in the study of hematological malignancies.</p>Couleur et forme :Odour Liquidα2β1 Integrin Ligand Peptide
CAS :<p>The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular</p>Formule :C14H22N4O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :390.35CTP Synthetase-IN-1 Ammonium salt
<p>CTP Synthetase-IN-1 Ammonium salt is a CTPS inhibitor with potential antibacterial, anti-inflammatory, and antitumor activity for the study of SARS-CoV-2 viral infections</p>Formule :C20H22F3N7O3S2Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :529.56TAS-119
CAS :<p>TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95</p>Formule :C23H22Cl2FN5O3Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :506.36SMS 121
CAS :<p>SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.</p>Formule :C20H21NO5Degré de pureté :98.29%Couleur et forme :SoildMasse moléculaire :355.38Chrexanthomycin C
<p>Chrexanthomycin C, orally active, binds DNA (G4C2)4 G4, Kd 2.8 mM, potential in ALS research.</p>Formule :C31H24O15Couleur et forme :SolidMasse moléculaire :636.515'-O-DMT-N4-Bz-2'-F-dC
CAS :<p>5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.</p>Formule :C37H34FN3O7Couleur et forme :SolidMasse moléculaire :651.68CDK6/9-IN-1
CAS :<p>CDK6/9-IN-1, an oral dual inhibitor of CDK6/9, has IC50s of 40.5nM (CDK6) and 39.5nM (CDK9).</p>Formule :C22H25ClN8OCouleur et forme :SolidMasse moléculaire :452.95JAMM protein inhibitor 2
CAS :<p>JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.</p>Formule :C21H26N2O2Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :338.443'-Deoxyuridine-5'-triphosphate trisodium
<p>3'-dUTP trisodium, a nucleotide analogue, inhibits RNA polymerases I/II and UTP integration into RNA (Ki=2.0 μM).</p>Formule :C9H12N2Na3O14P3Couleur et forme :SoildMasse moléculaire :534.08SNX7
CAS :<p>SNX7 (WAY-323879) inhibits CDKI pathway; useful for studying aging and related diseases.</p>Formule :C15H14N2ODegré de pureté :99.05%Couleur et forme :SolidMasse moléculaire :238.28JB300
CAS :<p>JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.</p>Formule :C43H45ClFN7O10SCouleur et forme :SolidMasse moléculaire :906.3755'-O-DMT-PAC-dA
CAS :<p>5’-O-DMT-PAC-dA can be used in the synthesis of oligoribonucleotides[1].</p>Formule :C39H37N5O7Couleur et forme :SolidMasse moléculaire :687.74UnyLinker 12 TEA
<p>UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.</p>Formule :C39H35NO10C6H15NCouleur et forme :SolidMasse moléculaire :778.34655Gantofiban
CAS :<p>Gantofiban is a glycoprotein IIb/IIIa (GP IIb/IIIa) antagonist used in the treatment of cardiovascular disease and may be used to study thrombosis.</p>Formule :C21H29N5O6Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :447.4811H-Benzo[a]carbazole
CAS :<p>11H-Benzo[a]carbazole is a kinesin-like protein KIF11 inhibitor that can inhibit the viability of HeLa cells.</p>Formule :C16H11NDegré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :217.27KIF2C-IN-1
<p>KIF2C-IN-1 (Compound 7S9) is a selective and potent small molecule inhibitor of KIF2C. It stabilizes the interaction between KIF2C and microtubule proteins, preventing the depolymerization of polyglutamylated microtubules. KIF2C-IN-1 enhances the cytotoxicity of Paclitaxel in Paclitaxel-resistant triple-negative breast cancer (TNBC) cells and, when combined with Paclitaxel, significantly reduces tumor growth in mouse models.</p>Formule :C36H39ClN4O9SCouleur et forme :SolidMasse moléculaire :738.21263GK13S
<p>G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.</p>Formule :C21H22N6O2Couleur et forme :SolidMasse moléculaire :390.44N7-Methyl-2'-O-(2-methoxyethyl) guanosine
<p>N7-Methyl-2’-O-(2-methoxyethyl) guanosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.</p>Formule :C14H21N5O6Couleur et forme :SolidMasse moléculaire :355.35EFdA-TP
CAS :<p>EFdA-TP: potent HIV-1 RT inhibitor; acts via immediate/delayed chain termination (ICT/DCT) and multiple pathways.</p>Formule :C12H15FN5O12P3Couleur et forme :SolidMasse moléculaire :533.195CCT241533 dihydrochloride
CAS :<p>Potent Chk2 inhibitor with 3 nM IC50, 63-fold more selective over Chk1, affects 84 kinases, reduces DNA damage response and apoptosis in cells.</p>Formule :C23H29Cl2FN4O4Couleur et forme :SolidMasse moléculaire :515.415'-DMTr-3'dA(Bz)-methylphosphonami dite
<p>5’-DMTr-3’dA(Bz)-methylphosphonamidite, a purine nucleoside analog, exhibits wide-ranging antitumor activity, specifically targeting indolent lymphoid</p>Formule :C45H51N6O6PCouleur et forme :SolidMasse moléculaire :802.9
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