Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(114 produits)
- CDK(545 produits)
- Arrêt du cycle cellulaire(5 produits)
- Chk(48 produits)
- DYRK(47 produits)
- Dynamine(27 produits)
- Ferroptose(226 produits)
- HSP(179 produits)
- Intégrine(249 produits)
- Kinésine(87 produits)
- LIM Kinase(20 produits)
- Microtubules associés(274 produits)
- PKC(124 produits)
- PLK(25 produits)
- ROCK(62 produits)
- Rho(6 produits)
- Wee1(14 produits)
- c-Myc(76 produits)
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3859 produits trouvés pour "Cycle cellulaire/point de contrôle"
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5'-ODMT cEt G Phosphoramidite (Amidite)
CAS :5'-ODMT cEt G Amidite is a safe, effective nucleic acid analog with strong antisense activity.Formule :C46H56N7O9PCouleur et forme :SolidMasse moléculaire :881.95FRα-targeting peptide C7 TFA
FRα-targeting peptide C7 TFA is a selective peptide ligand for the folate receptor alpha (FRα) that specifically binds to FRα-expressing cells and has tumor-targeting capabilities in vivo. It is applicable in research related to tumor diagnosis and therapy.Couleur et forme :Odour SolidTAS-119
CAS :TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Formule :C23H22Cl2FN5O3Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :506.36Ref: TM-T34787
1mg97,00€5mg235,00€10mg378,00€25mg748,00€50mg1.169,00€100mg1.644,00€1mL*10mM (DMSO)261,00€Ribonuclease T1
CAS :Rnase T1, an endonuclease, degrades single-stranded RNA to yield 3'-GMP oligonucleotides.
Couleur et forme :SolidDNA Gyrase-IN-12
DNA Gyrase-IN-12 (Compound 6d) is an inhibitor of DNA gyrase. It exhibits antibacterial activity with MIC values ranging from 0.031 to 0.0625 μg/mL against Vancomycin-Intermediate Staphylococcus aureus (VISA) and Enterococcus faecium.Couleur et forme :Odour SolidSMS 121
CAS :SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.Formule :C20H21NO5Degré de pureté :98.29%Couleur et forme :SoildMasse moléculaire :355.38m7GpppUmpG
CAS :m7GpppUmpG, a trinucleotide cap analogue, enables RNA synthesis with cap 0 or 1 structures.Formule :C31H42N12O26P4Couleur et forme :SolidMasse moléculaire :1122.63Garenoxacin
CAS :Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.Formule :C23H20F2N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.41IBU-DC Phosphoramidite
CAS :IBU-DC Phosphoramidite is used for synthesis of oligonucleotides.Formule :C43H54N5O8PCouleur et forme :SolidMasse moléculaire :799.906CTP Synthetase-IN-1 Ammonium salt
CTP Synthetase-IN-1 Ammonium salt is a CTPS inhibitor with potential antibacterial, anti-inflammatory, and antitumor activity for the study of SARS-CoV-2 viral infectionsFormule :C20H22F3N7O3S2Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :529.56JAMM protein inhibitor 2
CAS :JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.Formule :C21H26N2O2Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :338.445-Methylcytidine 5′-triphosphate
CAS :5-Methylcytidine 5′-triphosphate (5-Methyl-CTP), a modified nucleoside triphosphate, enhances translational properties and stability while reducing innateFormule :C10H18N3O14P3Couleur et forme :SolidMasse moléculaire :497.18Ceftriaxone
CAS :Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.Formule :C18H18N8O7S3Degré de pureté :96.08%Couleur et forme :SolidMasse moléculaire :554.58Endo-1,4-β-xylanase
CAS :Endo-1,4-β-xylanase (CtXyn11A) is a type of xylan hydrolase that hydrolyzes the β-1,4-glycosidic bond of the xylan molecule.Couleur et forme :SolidCarbazole
CAS :Carbazole belongs to the class of carbazole-based organic compounds. Carbazole can form novel DNA small groove complexes, inhibiting the synthesis of new DNA or RNA.Formule :C12H9NDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :167.2115-Aza-xylo-cytidine
5-Aza-xylo-cytidine, a purine analog with antitumor effects, inhibits DNA synthesis and induces apoptosis in lymphoid cancers.Formule :C8H12N4O5Couleur et forme :SolidMasse moléculaire :244.2Mps1-IN-6
Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].Formule :C35H39N9O3Couleur et forme :SolidMasse moléculaire :633.74MYC-IN-2
CAS :MYC-IN-2 is a protein-protein inhibitor targeting the MYC protein, designed for use in cancer research.Formule :C25H17N3O2SCouleur et forme :SolidMasse moléculaire :423.49Fibronectin CS1 Peptide
CAS :Fibronectin CS1 peptide inhibits tumor metastasis, lacking RGD domain; may aid cancer therapy.Formule :C38H64N8O15Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :872.96Phen-DC3 Trifluoromethanesulfonate
CAS :Phen-DC3 Trifluoromethanesulfonate targets G-quadruplexes and inhibits FANCJ/DinG helicases; IC50s: 65±6/50±10 nM.Formule :C36H26F6N6O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :848.75Py-MAA-Val-Cit-PAB-DX8951
CAS :Py-MAA-Val-Cit-PAB-DX8951, a purine toxin, serves as an intermediate in the synthesis of antibody-drug conjugates [1].Formule :C57H66FN11O13SCouleur et forme :SolidMasse moléculaire :1164.26Methylcarbamyl PAF C-8
Methylcarbamyl PAF C-8 is resistant to degradation by PAF-AH and has a half-life of over 100 minutes in platelet-poor plasma, exhibiting platelet aggregation activity. In NRK-49 cells overexpressing PAF receptor, it induces the expression of c-myc, c-fos, and activates mitogen-activated protein kinase (MAPK). Furthermore, Methylcarbamyl PAF C-8 can induce G1 phase cell cycle arrest. This compound shows potential for research in cardiovascular and anti-cancer applications.Couleur et forme :Odour SolidCDK7-IN-7
CAS :CDK7-IN-7: Selective CDK7 inhibitor, IC50 < 50 nM (Patent CN112661745A).Formule :C20H20BrF3N6O2Couleur et forme :SolidMasse moléculaire :513.3192'-Fluoro-2'-deoxy-arabinoadenosine 5'-triphosphate triethylamine
2’-Fluoro-2’-deoxy-arabinoadenosine 5’-triphosphate (triethylamine) is a purine nucleoside analog with significant antitumor properties, particularly effectiveFormule :C34H75FN9O12P3Couleur et forme :SolidMasse moléculaire :913.93CDK9-IN-25
CDK9-IN-25 (compound 4a), an imidazopyrazine derivative, functions as a CDK9 inhibitor with an IC50 of 0.24 μM.Formule :C15H16FN5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :285.32Gantofiban
CAS :Gantofiban is a glycoprotein IIb/IIIa (GP IIb/IIIa) antagonist used in the treatment of cardiovascular disease and may be used to study thrombosis.Formule :C21H29N5O6Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :447.48Erythromycin A dihydrate
CAS :Erythromycin dihydrate, a macrolide antibiotic from Streptomyces erythreus, targets 50S ribosomal subunits, blocking protein synthesis.Formule :C37H69NO14Couleur et forme :SolidMasse moléculaire :751.94HDAC-IN-85
HDAC-IN-85 (Compound 1) is an HDAC inhibitor capable of crossing the blood-brain barrier. It exhibits inhibitory effects on brain tumor cell lines and can induce acetylation, resulting in DNA double-strand breaks and promoting RAD51 ubiquitination, which disrupts the DNA repair process. HDAC-IN-85 is applicable in studies of glioblastoma.Formule :C24H27FN4O5Couleur et forme :SolidMasse moléculaire :470.49CDK12/13-IN-2
CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12 and CDK13, exhibiting IC50 values of 15.5 nM and 12.2 nM, respectively. It effectively inhibits the proliferation of breast cancer cells and can be utilized in the research of triple-negative breast cancer.Formule :C24H22FN7O2Couleur et forme :SolidMasse moléculaire :459.48Cytarabine triphosphate
CAS :Ara-CTP, active Cytarabine metabolite, inhibits DNA synthesis, predicts leukemic chemosensitivity.Formule :C9H16N3O14P3Couleur et forme :SolidMasse moléculaire :483.16DSPE-PEG2000-cRGD
DSPE-PEG2000-cRGD is a PEG compound composed of DSPE and an αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to αvβ3 on the surface of various cancer cells and neovascular cells. This compound can be utilized for drug delivery.Couleur et forme :Odour SolidUridine triphosphate 13C9,15N2 sodium
CAS :Uridine triphosphate 13C9,15N2 sodium is an isotopically labeled.UTP is a key in RNA synthesis molecule a substrate for RNA polymerase.Formule :C9H1415N2NaO15P3Couleur et forme :SolidMasse moléculaire :517.04wrwycr-NH2 TFA
wrwycr-NH2 (TFA) is a peptide that exhibits cytotoxic properties against various cancer cells, inducing DNA damage and cell cycle arrest without causing endoplasmic reticulum stress. It possesses antitumor activity, and its efficacy is enhanced when used in combination with DNA-damaging agents.Couleur et forme :Odour SolidDSPE-PEG2000-iRGD
DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.Couleur et forme :Odour Solid5'(R)-C-Methyl-5-fluorouridine
5’(R)-C-Methyl-5-fluorouridine, a uridine analogue, possesses potential antiepileptic properties.Formule :C10H13FN2O6Couleur et forme :SolidMasse moléculaire :276.22Nusinersen
CAS :Nusinersen (nusinersen) is a antisense oligonucleotide (ASO) for the treatment of pediatric and adult spinal muscular atrophy (SMA) and increases SMN proteinss.Degré de pureté :98.62%Couleur et forme :SolidN7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium
CAS :N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].
Formule :C21H35N12O17P3Couleur et forme :SolidMasse moléculaire :820.49CCT241533 dihydrochloride
CAS :Potent Chk2 inhibitor with 3 nM IC50, 63-fold more selective over Chk1, affects 84 kinases, reduces DNA damage response and apoptosis in cells.Formule :C23H29Cl2FN4O4Couleur et forme :SolidMasse moléculaire :515.412'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
CAS :dGMP is a substrate for DNA synthesis, phosphorylated to dGDP and dGTP, and linked to mitochondrial DNA depletion syndrome in humans.Formule :C10H14N5Na2O8PCouleur et forme :SolidMasse moléculaire :409.202DSPE-PEG1000-cRGD
DSPE-PEG1000-cRGD is a PEG compound composed of DSPE and the αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to the αvβ3 receptors present on the surfaces of various cancer cells and angiogenic vascular cells. DSPE-PEG1000-cRGD is applicable in drug delivery.Couleur et forme :Odour SolidBarasertib
CAS :AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Formule :C26H31FN7O6PDegré de pureté :99.92% - 99.97%Couleur et forme :SolidMasse moléculaire :587.54Rachelmycin
CAS :Rachelmycin, a potent antibiotic and antitumor agent from Streptomyces zelensis, binds to DNA's minor groove.Formule :C37H33N7O8Couleur et forme :SolidMasse moléculaire :703.712SNX7
CAS :SNX7 (WAY-323879) inhibits CDKI pathway; useful for studying aging and related diseases.Formule :C15H14N2ODegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :238.28N6-Methyl-2'-O-(2-methoxyethyl) adenosine
N6-Methyl-2’-O-(2-methoxyethyl) adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Formule :C14H21N5O5Couleur et forme :SolidMasse moléculaire :339.35ONX 0801 trisodium
CAS :ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.Formule :C32H30N5Na3O10Couleur et forme :SolidMasse moléculaire :713.58STX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Degré de pureté :97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)Couleur et forme :Odour LiquidXY028-133
CAS :XY028-133 is a PROTAC-based CDK4/6 degrader for the study of tumors.
Formule :C53H67N11O7SDegré de pureté :97.11%Couleur et forme :SolidMasse moléculaire :1002.23RNA polymerase II-IN-2
RNA Pol II-IN-2 (20iii) strongly inhibits Pol II (Ki=9.5 nM), is more toxic to CHO/HEK293 than α-amanitin.Formule :C41H58N10O12SCouleur et forme :SolidMasse moléculaire :915.02Xanthosine-5'-Triphosphate
CAS :Xanthosine-5'-Triphosphate (5'-XTP), a nucleotide derived from the deamination of purine bases, plays a crucial role in various biological processes.Formule :C10H15N4O15P3Couleur et forme :SolidMasse moléculaire :524.164Lorutengitide
CAS :Lorutengitide is a transcription-regulating peptide with antiproliferative activity.Formule :C30H50N8O12Couleur et forme :SolidMasse moléculaire :714.764
