Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(94 produits)
- CDK(500 produits)
- Arrêt du cycle cellulaire(4 produits)
- Chk(42 produits)
- DYRK(48 produits)
- Dynamine(23 produits)
- Ferroptose(215 produits)
- HSP(169 produits)
- Intégrine(224 produits)
- Kinésine(66 produits)
- LIM Kinase(19 produits)
- Microtubules associés(261 produits)
- PKC(102 produits)
- PLK(28 produits)
- ROCK(70 produits)
- Rho(2 produits)
- Wee1(15 produits)
- c-Myc(69 produits)
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3477 produits trouvés pour "Cycle cellulaire/point de contrôle"
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2'-Deoxy-2'-fluoro-N1-methyl inosine
CAS :<p>Nucleoside Derivatives - 2’-Modified nucleosides, Fluoro-modified nucleosides, N-Methylated /alkylated nucleosides</p>Formule :C11H13FN4O4Couleur et forme :SolidMasse moléculaire :284.242'-Chloro-2'-deoxyuridine
CAS :<p>2'-Chloro-2'-deoxyuridine is a Halo-nucleoside.</p>Formule :C9H11ClN2O5Couleur et forme :SolidMasse moléculaire :262.652'-Deoxy-N6,N6-dimethyladenosine
CAS :<p>2'-Deoxy-N6,N6-dimethyladenosine is a Nucleoside Derivative - 6-Modified purine nucleoside.</p>Formule :C12H17N5O3Couleur et forme :SolidMasse moléculaire :279.31-(b-D-Xylofuranosyl)-5-methylcytosine
CAS :<p>Nucleoside Derivatives –5-Modified pyrimidine nucleosides；Xylo-nucleosides</p>Formule :C10H15N3O5Couleur et forme :SolidMasse moléculaire :257.243'-O-Methyl-5-methyluridine
CAS :<p>3'-O-Methyl-5-methyluridine is a Nucleoside Derivative - 3'-Modified nucleoside.</p>Formule :C11H16N2O6Couleur et forme :SolidMasse moléculaire :272.251-Amino-7-cyclopropylmethyl-7,8-dihydro-8-oxo-9-(b-D-xylofuranosyl)guanine
CAS :<p>Nucleoside Derivatives - Xylo-nucleosides; 8-Modified purine nucleosides; Amino nucleosides; N-Methylated alkylated nucleosides</p>Formule :C14H20N6O6Couleur et forme :SolidMasse moléculaire :368.356-Chloro-9-(2,3,5-tri-O-benzoyl-2-C-methyl-β-D-ribofuranosyl)-9H-purine
CAS :<p>6-Chloro-9-(2,3,5-tri-O-benzoyl-2-C-methyl-β-D-ribofuranosyl)-9H-purine is a 2'-C-Methyl nucleoside; Halo-nucleoside.</p>Formule :C32H25ClN4O7Couleur et forme :SolidMasse moléculaire :613.021-(b-D-Xylofuranosyl)-5-trifluoromethyluracil
<p>1-(b-D-Xylofuranosyl)-5-trifluoromethyluracil is a Nucleoside Derivative - Xylo-nucleoside, Fluoro-modified nucleoside, 5-Modified pyrimidine nucleoside.</p>Couleur et forme :Soild2-Cyanoadenosine
CAS :<p>Nucleoside Derivatives - 2’-Modified purine nucleosides</p>Formule :C11H12N6O4Couleur et forme :SolidMasse moléculaire :292.255-Iodoarabinouridine
CAS :<p>5-Iodoarabinouridine is a Halo-nucleoside; Arabino-nucleoside.</p>Formule :C9H11IN2O6Couleur et forme :SolidMasse moléculaire :370.1N1-Ethylpseudouridine
CAS :<p>N1-Ethylpseudouridine is a Nucleoside Derivative - C-nucleoside; N-Methylated nucleoside.</p>Formule :C11H16N2O6Couleur et forme :SolidMasse moléculaire :272.252'-Deoxy-O6-[2-(4-nitrophenylethyl)]guanosine
CAS :<p>2'-Deoxy-O6-[2-(4-nitrophenylethyl)]guanosine is a Nucleoside Derivative - 6-Modified purine nucleoside.</p>Formule :C18H20N6O6Couleur et forme :SolidMasse moléculaire :416.39KS15
CAS :<p>KS15 is a cryptochrome (CRY) inhibitor that promotes G1 cell cycle arrest, enhances drug sensitivity in MCF-7 cells, antitumour against human breast cancer.</p>Formule :C20H22BrNO4Couleur et forme :SolidMasse moléculaire :420.33'-O-DMTr-thymidine 5'-CE phosphoramidite
CAS :<p>3'-O-DMTr-thymidine 5'-CE phosphoramidite (2'-OMe-U Phosphoramidite) is a purine nucleoside analog and phosphoramidite derivative .</p>Formule :C40H49N4O8PDegré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :744.81Lifitegrast sodium
CAS :<p>Lifitegrast sodium (SAR-1118-023 sodium) is an integrin antagonist that reduces ocular surface inflammation and can be used to study dry eye.</p>Formule :C29H23Cl2N2NaO7SDegré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :637.46GP-82996
CAS :<p>GP-82996 (CINK4) inhibits CDK4/6; IC50s: 1.5 μM (CDK4/D1), 5.6 μM (CDK6/D1), 25 μM (Cdk5/p35); triggers U2OS cancer cell apoptosis.</p>Formule :C27H32N6ODegré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :456.58HDGFRP2/PSIP1-IN-1
CAS :<p>Compound BPP (HDGFRP2/PSIP1-IN-1) is a dual inhibitor targeting the PWWP domains of Hepatoma-derived Growth Factor Related Protein 2 (HDGFRP2) and its homologue PSIP1. This compound effectively hinders the occurrence and progression of Diffuse Intrinsic Pontine Glioma (DIPG). It demonstrates binding affinity with a Kd value of 7 μM for HDGFRP2, indicative of its efficient ligand efficacy at 0.47. Additionally, Compound BPP exhibits a Kd value of 27 μM when binding to the PSIP1 PWWP domain, and a Kd value of 14 μM against HDGFRP3, confirming its potency as an inhibitor within the HDGFRP2 PWWP subfamily.</p>Formule :C8H6BrN3Couleur et forme :SolidMasse moléculaire :224.06Napropamide
CAS :<p>Napropamide is an acetamide herbicide that inhibits root growth to control annual grasses and broadleaf weeds.</p>Formule :C17H21NO2Degré de pureté :99.14%Couleur et forme :Colorless Crystals; (Tech Brown Solid) White-Like CrystalMasse moléculaire :271.35N-6-Furfurylguanosine
CAS :<p>N-6-Furfurylguanosine (kinetin riboside) is a purine nucleoside analog with cytotoxicity, inhibiting the growth of cancer cells.</p>Formule :C15H18N6O5Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :362.345,6-Dihydrothymidine
CAS :<p>2'-Deoxy-N2-methylguanosine is a purine nucleoside analog that can be used as a chemical probe to study DNA-protein interactions.</p>Formule :C10H16N2O5Degré de pureté :99.90%Couleur et forme :SolidMasse moléculaire :244.24(S)-GNA-T-phosphoramidite
CAS :<p>(S)-GNA-T-phosphoramidite is a nucleoside analog commonly used in the synthesis of other active compounds.</p>Formule :C38H47N4O7PDegré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :702.785-Aza-7-deazaguanine
CAS :<p>5-Aza-7-deazaguanine is a non-natural substituted nucleobase with potential antiviral activity, used in cancer and bacterial infection research.</p>Formule :C5H5N5ODegré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :151.13DTP3
CAS :<p>DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.</p>Formule :C26H35N7O5Couleur et forme :SolidMasse moléculaire :525.62'-Amino-2'-deoxy-b-D-arabino-5-methyl uridine
CAS :<p>2'-Amino-2'-deoxy-b-D-arabino-5-methyl uridine is a purine nucleoside analog with potential antitumor activity.</p>Formule :C10H15N3O5Degré de pureté :96.76%Couleur et forme :SolidMasse moléculaire :257.24A-674563
CAS :<p>A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.</p>Formule :C22H22N4ODegré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :358.44GPRP
CAS :<p>GPRP (Gly-Pro-Arg-Pro) is a fibrin polymerization inhibitor.</p>Formule :C18H31N7O5Couleur et forme :White To Off-White PowderMasse moléculaire :425.48Maleic hydrazide
CAS :<p>Maleic hydrazide is a plant germination inhibitor that participates in nucleic acid metabolism pathways ,inhibiting cell division in the apical meristem.</p>Formule :C4H4N2O2Degré de pureté :98.4%Couleur et forme :Crystals From Water Maleic Hydrazide Is An Odorless White Solid Sinks In Water (Uscg 1999)Masse moléculaire :112.09N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite
CAS :<p>N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite is an adenine nucleoside analog with potential vasodilator activity and anticancer activity.</p>Formule :C47H52N7O7PDegré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :857.932'-O-Methylinosine
CAS :<p>2'-O-Methylinosine (2'-(o-Methyl)-inosine) is an orally bioavailable purine nucleoside analog with antihypertensive activity.</p>Formule :C11H14N4O5Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :282.252',5-Difluoro-2'-deoxy-1-arabinosyluracil
CAS :<p>2',5-Difluoro-2'-deoxy-1-arabinosyluracil (2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine) is a urinary pyrimidine nucleoside analogue with potential antiepileptic</p>Formule :C9H10F2N2O5Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :264.18NU6102
CAS :<p>NU6102 is a CDK2 inhibitor with antitumor activity against CDK1/cyclinB, CDK1/CDK2, CDK4, DYRK1A , PDK1, and ROCKII, and it can be used to study rectal cancer.</p>Formule :C18H22N6O3SDegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :402.47LDC4297
CAS :<p>LDC4297 (LDC044297) is a potent and selective CDK7 inhibitor.</p>Formule :C23H28N8ODegré de pureté :98.25%Couleur et forme :SolidMasse moléculaire :432.52GW406108X
CAS :<p>GW406108X is a Kif15 and ULK1 inhibitor; IC50: 0.82 µM (ATPase), pIC50: 6.37; blocks autophagy.</p>Formule :C20H11Cl2NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :400.21IRES-C11
CAS :<p>IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.</p>Formule :C13H11Cl2NO4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :316.14Poloxime
CAS :<p>Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also has moderate Plk1 inhibitory activity.</p>Formule :C10H13NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :179.22TAME
CAS :<p>Tosyl-L-Arginine Methyl Ester (TAME (N-4-Tosyl-L-arginine methyl ester)) is an APC inhibitor.</p>Formule :C14H22N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :342.41Cilengitide TFA
CAS :<p>Cilengitide, αvβ3/αvβ5 inhibitor, IC50: 4.1/79 nM in vitro. 10x selectivity vs. gpIIbIIIa. Phase 2.</p>Formule :C29H41F3N8O9Couleur et forme :SolidMasse moléculaire :702.68Nolatrexed dihydrochloride
CAS :<p>Nolatrexed dihydrochloride (Thymitaq) is a soluble, lipophilic cancer drug that inhibits DNA replication, causing cell cycle arrest and apoptosis.</p>Formule :C14H14Cl2N4OSDegré de pureté :97.02%Couleur et forme :Tan SolidMasse moléculaire :357.26CCT244747
CAS :<p>CCT244747 is a potent and selective CHK1 inhibitor oral, ATP-competitive, and cytotoxic, abrogating drug-induced S and G2 blockade and inducing apoptosis .</p>Formule :C20H24N8O2Degré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :408.46Ribociclib hydrochloride
CAS :<p>Ribociclib hydrochloride is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively).</p>Formule :C23H31ClN8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :471sAJM589
CAS :<p>sAJM589 is a Myc inhibitor that dose-dependently disrupts Myc-Max heterodimers, thereby decreasing Myc protein levels and inhibiting the cellular proliferation.</p>Formule :C16H10N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :246.26Synucleozid hydrochloride
CAS :<p>Synucleozid hydrochloride inhibits the translation of the intrinsically disordered protein α-synuclein by targeting its structured mRNA.</p>Formule :C22H21ClN6Degré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :404.9N,N-Dimethyl-2'-O-methylcytidine
CAS :<p>N,N-Dimethyl-2'-O-methylcytidine (N4, N4, 2'-O-Trimethylcytidine) is a purine nucleoside analogue with anti-cancer activity.</p>Formule :C12H19N3O5Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :285.38-Chloroinosine
CAS :<p>8-Chloroinosine is a purine nucleoside analog and a metabolite of the anticancer compound 8-chloro-adenosine.</p>Formule :C10H11ClN4O5Degré de pureté :99.37% - 99.56%Couleur et forme :SolidMasse moléculaire :302.67Kinesore
CAS :<p>Kinesore is a cell-permeable modulator that binds to the microtubule motor protein kinesin-1, thereby inhibiting the interaction between KLC2 and SKIP.</p>Formule :C20H16Br2N4O4Degré de pureté :97.24%Couleur et forme :SolidMasse moléculaire :536.175'-O-DMT-N2-ibu-dG
CAS :<p>5'-O-DMT-N2-ibu-dG is a deoxynucleoside served as a building block in oligonucleotide synthesis, with protecting groups to prevent unwanted reactions.</p>Formule :C35H37N5O7Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :639.78-Bromoadenosine
CAS :<p>8-Bromoadenosine is an adenosine derivative. 8-Br-Adenosine inhibitis mitochondrial membrane potential, cytoplasmic Ca²⁺ levels, and RNA and protein synthesis.</p>Formule :C10H12BrN5O4Degré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :346.14NSC 23766
CAS :<p>NSC 23766 is a Rac1 GTPase inhibitor by targeting GEFs, inhibiting cell proliferation.NSC23766 competitively inhibits M2 mAChR-induced Rac1 activation.</p>Formule :C24H35N7Degré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :421.58N2-Isobutyryl-2-deoxyguanosine
CAS :<p>N2-Isobutyryl-2-deoxyguanosine（iBu-dG） is a nucleoside analog that can be used to synthesize oligonucleotides.</p>Formule :C14H19N5O5Degré de pureté :97.03%Couleur et forme :SolidMasse moléculaire :337.33APE1-IN-1
CAS :<p>APE1-IN-1 is a purine/pyrimidine-free endonuclease 1 inhibitor with potential antitumor activity that enhances the toxicity of alkylating agents on cancer cells</p>Formule :C19H21N3OS2Degré de pureté :98.5%Couleur et forme :SolidMasse moléculaire :371.52
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