
Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(114 produits)
- CDK(546 produits)
- Arrêt du cycle cellulaire(5 produits)
- Chk(48 produits)
- DYRK(47 produits)
- Dynamine(27 produits)
- Ferroptose(227 produits)
- HSP(180 produits)
- Intégrine(269 produits)
- Kinésine(87 produits)
- LIM Kinase(20 produits)
- Microtubules associés(274 produits)
- PKC(126 produits)
- PLK(25 produits)
- ROCK(62 produits)
- Rho(6 produits)
- Wee1(14 produits)
- c-Myc(76 produits)
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3904 produits trouvés pour "Cycle cellulaire/point de contrôle"
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Y16 acetate(429653-73-6 free base)
Y16 acetate(429653-73-6 free base) is a G-protein–coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoAFormule :C51H74N14O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1091.24A-205804
CAS :A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.Formule :C15H12N2OS2Degré de pureté :98.07% - 98.52%Couleur et forme :SolidMasse moléculaire :300.4Ref: TM-T2254
2mg42,00€5mg50,00€10mg77,00€25mg152,00€50mg258,00€100mg505,00€500mg1.108,00€1mL*10mM (DMSO)67,00€Aurora kinase inhibitor-3
CAS :Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK,Formule :C21H18F3N5ODegré de pureté :98.91%Couleur et forme :SolidMasse moléculaire :413.4Ref: TM-T5524
1mg70,00€2mg95,00€5mg160,00€10mg250,00€25mg424,00€50mg612,00€100mg842,00€200mg1.159,00€1mL*10mM (DMSO)170,00€TR-14035
CAS :TR-14035 (MDK-1191) is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).Formule :C24H21Cl2NO5Degré de pureté :98.98%Couleur et forme :SolidMasse moléculaire :474.33Ref: TM-T5310
1mg50,00€5mg99,00€10mg152,00€25mg245,00€50mg353,00€100mg492,00€200mg700,00€1mL*10mM (DMSO)102,00€LDC-4297 HCl (1453834-21-3(free base))
LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM.
Formule :C23H29ClN8ODegré de pureté :100%Couleur et forme :SolidMasse moléculaire :469.022′-Deoxy-2′-fluoroguanosine
CAS :2′-Deoxy-2′-fluoroguanosine is a nucleoside analog that potently inhibits influenza virus A and B strains(EC90 <0.35 μM).Formule :C10H12FN5O4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :285.23BMS-5
CAS :BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.Formule :C17H14Cl2F2N4OSDegré de pureté :98.01% - 99.88%Couleur et forme :SolidMasse moléculaire :431.29Ref: TM-T4598
1mg40,00€2mg52,00€5mg79,00€10mg116,00€25mg188,00€50mg281,00€100mg420,00€1mL*10mM (DMSO)87,00€Fosifloxuridine nafalbenamide
CAS :Fosifloxuridine nafalbenamide (NUC 3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor.
Formule :C29H29FN3O9PDegré de pureté :95.87%Couleur et forme :SolidMasse moléculaire :613.53Atuveciclib
CAS :Atuveciclib Racemate is an oral CDK9 inhibitor with a 13 nM IC50, targeting P-TEFb/CDK9 selectively.Formule :C18H18FN5O2SDegré de pureté :98.8%Couleur et forme :SolidMasse moléculaire :387.43Ref: TM-T10464L
1mg84,00€2mg114,00€5mg192,00€10mg313,00€25mg580,00€50mg773,00€100mg1.063,00€1mL*10mM (DMSO)212,00€Cilengitide
CAS :Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.Formule :C27H40N8O7Degré de pureté :98% - 99.8%Couleur et forme :SolidMasse moléculaire :588.66Danusertib
CAS :Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.Formule :C26H30N6O3Degré de pureté :97.88% - 98.79%Couleur et forme :White PowderMasse moléculaire :474.55KW-2449
CAS :KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.Formule :C20H20N4ODegré de pureté :98.43% - 99.69%Couleur et forme :SolidMasse moléculaire :332.4Silver sulfadiazine
CAS :Silver sulfadiazine (Dermazin) is a sulfonamide-based topical agent with antibacterial and antifungal activity.Formule :C10H9AgN4O2SDegré de pureté :99.04% - 99.58%Couleur et forme :SolidMasse moléculaire :357.14Arginine-glycine-aspartic acid
CAS :RGD (RGD (Arg-Gly-Asp) Peptides) (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.Formule :C12H22N6O6Degré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :346.34YKL-5-124
CAS :YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displaysFormule :C28H33N7O3Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :515.61Ref: TM-T22461
1mg96,00€2mg135,00€5mg188,00€10mg341,00€25mg548,00€50mg782,00€100mg1.035,00€1mL*10mM (DMSO)225,00€PTC-209 hydrobromide
CAS :PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in
Formule :C17H13Br2N5OS·HBrDegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :576.1Ref: TM-T6178
1mg37,00€5mg78,00€10mg124,00€25mg265,00€50mg465,00€100mg753,00€200mg1.035,00€1mL*10mM (DMSO)89,00€Bredinin aglycone
CAS :Bredinin aglycone (SM-108) is a purine nucleotide analog.Formule :C4H5N3O2Degré de pureté :99.06%Couleur et forme :SolidMasse moléculaire :127.1WEE1-IN-3
CAS :WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.Formule :C28H31N7O2Degré de pureté :98.33%Couleur et forme :SolidMasse moléculaire :497.59Ref: TM-T8916
1mg66,00€5mg147,00€10mg225,00€25mg398,00€50mg532,00€100mg767,00€200mg1.018,00€1mL*10mM (DMSO)161,00€HALOFUGINONE LACTATE
CAS :HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D.Formule :C19H23BrClN3O6Degré de pureté :99.70% - 99.96%Couleur et forme :SolidMasse moléculaire :504.8Ref: TM-T8785
2mg39,00€5mg56,00€10mg89,00€25mg123,00€50mg197,00€100mg294,00€200mg437,00€1mL*10mM (DMSO)63,00€dGTP
CAS :dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, andFormule :C10H16N5O13P3Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :507.182'-Fluoro-2'-Deoxyadenosine
CAS :2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP).Formule :C10H12FN5O3Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :269.23Carotegrast methyl
CAS :Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.Formule :C28H26Cl2N4O5Degré de pureté :99.26% - 99.72%Couleur et forme :SolidMasse moléculaire :569.44Levomefolate calcium
CAS :Levomefolate calcium is an artificial form of folate. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements.Formule :C20H23CaN7O6Degré de pureté :97.35%Couleur et forme :Off-White To Pale Yellow SolidMasse moléculaire :497.52AZD-7762
CAS :AZD-7762, an effective and specific inhibitor of Chk1(IC50=5 nM), is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.Formule :C17H19FN4O2SDegré de pureté :98.96% - 99.19%Couleur et forme :SolidMasse moléculaire :362.42Ref: TM-T6093
1mg35,00€2mg50,00€5mg77,00€10mg90,00€25mg167,00€50mg265,00€100mg424,00€1mL*10mM (DMSO)84,00€CCG-100602
CAS :CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM).Formule :C21H17ClF6N2O2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :478.82Ref: TM-T22062
5mg35,00€10mg54,00€25mg108,00€50mg178,00€100mg286,00€200mg425,00€1mL*10mM (DMSO)40,00€Abemaciclib
CAS :Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity.Formule :C27H32F2N8Degré de pureté :99.43% - 99.87%Couleur et forme :SolidMasse moléculaire :506.59NY2267
CAS :NY2267 (Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethylFormule :C38H43N3O6Degré de pureté :99.16% - 99.27%Couleur et forme :SolidMasse moléculaire :637.76NSC23005 Sodium
CAS :NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.Formule :C13H16NNaO4SDegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :305.32BS-181 hydrochloride
CAS :BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM.Formule :C22H32N6·HClDegré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :416.99Ref: TM-T6162
1mg37,00€2mg52,00€5mg79,00€10mg116,00€25mg250,00€50mg416,00€100mg645,00€200mgÀ demander1mL*10mM (DMSO)87,00€Triazavirin
CAS :Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent.Formule :C5H7N6NaO5SDegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :286.2NSC 617145
CAS :NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependentFormule :C13H10Cl4N2O4Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :400.04Ref: TM-T9168
1mg34,00€2mg49,00€5mg73,00€10mg90,00€25mg164,00€50mg227,00€100mg358,00€500mg842,00€1mL*10mM (DMSO)80,00€Natalizumab
CAS :Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.Degré de pureté :97.15% (SDS-PAGE); 97.2% (SEC-HPLC) - 98.00%Couleur et forme :LiquidMasse moléculaire :146.19 kDaJNJ-7706621
CAS :JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.Formule :C15H12F2N6O3SDegré de pureté :99.1% - 99.85%Couleur et forme :SolidMasse moléculaire :394.36Ref: TM-T6126
1mg48,00€5mg100,00€10mg155,00€25mg268,00€50mg432,00€100mg595,00€200mg833,00€1mL*10mM (DMSO)94,00€6-Bromo-2-hydroxy-3-methoxybenzaldehyde
CAS :6-Bromo-2-hydroxy-3-methoxybenzaldehyde (NSC-95682) is an inhibitor of IRE-1α (IC50 : 0.08 μM).Formule :C8H7BrO3Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :231.04Empesertib
CAS :Empesertib (BAY 1161909) is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.Formule :C29H26FN5O4SDegré de pureté :97.45% - 99.4%Couleur et forme :SolidMasse moléculaire :559.61Ref: TM-T8487
1mg86,00€5mg173,00€10mg261,00€25mg425,00€50mg583,00€100mg803,00€200mg1.063,00€1mL*10mM (DMSO)231,00€4μ8C
CAS :4μ8C (IRE1 Inhibitor III)(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor.Formule :C11H8O4Degré de pureté :97.48% - 98.45%Couleur et forme :SolidMasse moléculaire :204.18Isoindigotin
CAS :Isoindigotin is used in the therapy of Y.
Formule :C16H10N2O2Degré de pureté :98.14% - ≥95%Couleur et forme :SolidMasse moléculaire :262.26Pyridostatin Trihydrochloride
CAS :Pyridostatin Trihydrochloride (RR-82 Trihydrochloride) is a G-quadruplexe stabilizer, with a Kd of 490 nM.Formule :C31H35Cl3N8O5Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :706.026-Thioinosine
CAS :6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent.Formule :C10H12N4O4SDegré de pureté :97.74%Couleur et forme :SolidMasse moléculaire :284.29CCG-203971
CAS :CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.Formule :C23H21ClN2O3Degré de pureté :98.82% - 99.50%Couleur et forme :SolidMasse moléculaire :408.88RI-1
CAS :RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor (IC50: 5-30 μM).Formule :C14H11Cl3N2O3Degré de pureté :99.3% - 99.62%Couleur et forme :SolidMasse moléculaire :361.61TMPyP4 tosylate
CAS :TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.Formule :C72H66N8O12S4Degré de pureté :98.61% - 99.85%Couleur et forme :SolidMasse moléculaire :1363.6Pyridostatin
CAS :Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome orFormule :C31H32N8O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :596.64Adavosertib
CAS :Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.Formule :C27H32N8O2Degré de pureté :98.65% - 99.86%Couleur et forme :SolidMasse moléculaire :500.6Ref: TM-T2077
5mg46,00€10mg66,00€25mg81,00€50mg96,00€100mg110,00€200mg161,00€500mg260,00€1mL*10mM (DMSO)49,00€CK7
CAS :CK7, a Cdk2/9 inhibitor, is instrumental in the synthesis of Nek1 inhibitors BSc5231 and BSc5367.Formule :C14H12N6O2SDegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :328.35Ref: TM-T9615
1mg50,00€5mg114,00€10mg177,00€25mg356,00€50mg557,00€100mg858,00€200mg1.153,00€1mL*10mM (DMSO)126,00€Indisulam
CAS :Indisulam (E 7070) is a dual-action anticancer drug, blocking G1/S cell cycle transition by degrading cyclin E and activating p53/p21.Formule :C14H12ClN3O4S2Degré de pureté :98.68% - 99.77%Couleur et forme :SolidMasse moléculaire :385.85Ref: TM-T4321
1mg34,00€2mg43,00€5mg63,00€10mg88,00€25mg130,00€50mg198,00€100mg298,00€1mL*10mM (DMSO)69,00€Risdiplam
CAS :Risdiplam (RG7916) is a centrally and peripherally distributed and orally administrable small molecule SMN2 pre-mRNA splicing modifier.Cost-effective and quality-assured.Formule :C22H23N7ODegré de pureté :98.68% - 99.64%Couleur et forme :SolidMasse moléculaire :401.46Ro3280
CAS :Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).Formule :C27H35F2N7O3Degré de pureté :97.1% - >99.99%Couleur et forme :SolidMasse moléculaire :543.61HAMNO
CAS :HAMNO (NSC-111847) is a protein interaction inhibitor of replication protein A (RPA).Formule :C17H13NO2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :263.29IMT1B
CAS :IMT1B (LDC203974) is an oral POLRMT inhibitor that curbs mtDNA expression and has anti-cancer properties.Formule :C24H21ClFNO6Degré de pureté :98.26% - 99.83%Couleur et forme :SolidMasse moléculaire :473.88Ref: TM-T8842
1mg138,00€5mg295,00€10mg505,00€25mg733,00€50mg888,00€100mg1.251,00€1mL*10mM (DMSO)309,00€
