Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(114 produits)
- CDK(545 produits)
- Arrêt du cycle cellulaire(5 produits)
- Chk(48 produits)
- DYRK(47 produits)
- Dynamine(27 produits)
- Ferroptose(226 produits)
- HSP(179 produits)
- Intégrine(249 produits)
- Kinésine(87 produits)
- LIM Kinase(20 produits)
- Microtubules associés(274 produits)
- PKC(124 produits)
- PLK(25 produits)
- ROCK(62 produits)
- Rho(6 produits)
- Wee1(14 produits)
- c-Myc(76 produits)
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3860 produits trouvés pour "Cycle cellulaire/point de contrôle"
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DNA Gyrase-IN-17
DNA Gyrase-IN-17 (Compound 5C) is an inhibitor of DNA gyrase. It demonstrates significant antimicrobial activity against a range of Gram-positive and Gram-negative strains, including Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa, with a MIC value of 62.5 μg/mL. By inhibiting bacterial DNA gyrase, DNA Gyrase-IN-17 disrupts DNA replication. This compound can be useful in the development of antibiotics, particularly for studying resistant strains.Formule :C18H15ClFN5OCouleur et forme :SolidMasse moléculaire :371.09492HSDVHK-NH2
CAS :Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.Formule :C30H48N12O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :720.78LDV FITC
CAS :fluorescent ligand that binds to the α4β1 integrin (VLA-4)Formule :C69H81N11O17SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1368.53Dihydro-5-azacytidine
CAS :Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties.Formule :C8H14N4O5Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :246.22JB-11 isethionate
CAS :JB-11 isethionate is a bioactive chemical.Formule :C21H29N5O7SCouleur et forme :SolidMasse moléculaire :495.55LXY3
CAS :LXY3 (LXY2) is a VLA-3 blocking peptide that inhibits the interaction of neutrophil surface integrin α3β1 (VLA-3) with laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is employed to block the neutrophil-mediated release of nanoparticles from the perivascular pool into the tumor stroma and is frequently used for targeted imaging in breast cancer.Formule :C32H43N11O15S2Couleur et forme :SolidMasse moléculaire :885.88DENV-IN-2
CAS :DENV-IN-2 inhibits dengue virus replication (EC50: 0.016 nM), affects all serotypes (EC50: 0.013-0.029 nM). Derived from WO2018215315A1 6AB.Formule :C29H26ClF3N2O6Couleur et forme :SolidMasse moléculaire :590.98dCeMM3
CAS :dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.
Formule :C14H11ClN4OSDegré de pureté :98.48% - 99.41%Couleur et forme :SolidMasse moléculaire :318.78(S)-DI-87
CAS :(S)-DI-87 is an isomer of DI-87, a oral dCK inhibitor，reduce dNTP production and cell cycle arrest. significantly inhibits tumor growth with thymidine.Formule :C23H30N6O3S2Degré de pureté :99.42%Couleur et forme :SoildMasse moléculaire :502.65Ref: TM-T39550L
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.415,00€100mg1.872,00€200mg2.555,00€LEB-03-146
CAS :LEB-03-146: WEE1 DUBTAC linking AZD1775 to OTUB1 via PEG2; stabilizes WEE1 in HEP3B cells.Formule :C46H57N11O8Couleur et forme :SolidMasse moléculaire :892.01wrwyar-NH2 TFA
wrwyar-NH2 (TFA) serves as the control peptide for wrwycr-NH2.Couleur et forme :Odour SolidhuATN-658
huATN-658 (MNPR-101) is a humanized monoclonal antibody inhibitor targeting the urokinase-type plasminogen activator receptor (uPAR). It effectively disrupts the interaction between uPAR and integrins, thereby inhibiting tumor cell proliferation, invasion, and migration. huATN-658 shows potential for research in breast cancer, particularly in cases of triple-negative breast cancer.Couleur et forme :Odour LiquidLL-K8-22
LL-K8-22: potent CDK8/cyclin C degrader; DC50 ~2.5μM; hinders STAT1 phosphorylation; curbs E2F/MYC cancer pathways; for TNBC study.Formule :C37H43N5OCouleur et forme :SolidMasse moléculaire :573.77BSJ-04-132
Selective Cdk4 degrader. Degrades Cdk4 in Molt-4 cells, with no effect on Cdk6 levels. Displays cereblon-dependent degradation.Couleur et forme :Liquid2'-(2-Nitrobenzyl)-ATP trisodium
2'-(2-Nitrobenzyl)-ATP trisodium is an rATP analogue that acts as a transcription terminator. It inhibits T7 RNA polymerase from continuing RNA chain extension.Formule :C17H18N6Na3O15P3Couleur et forme :SolidMasse moléculaire :707.97361pNP-ADPr
CAS :pNP-ADPr: Used in PARG & ARH3 activity assays; aids in PARP enzyme research.Formule :C21H26N6O16P2Couleur et forme :SolidMasse moléculaire :680.41HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt
CAS :HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt inhibits pre-miR-21 RNA, potential for cancer research.Formule :C57H62N8O10SCouleur et forme :SolidMasse moléculaire :1051.21Ascochlorin A
CAS :Ascochlorin A, a compound with a dissociation constant (K D) of 3.29 μM, serves as a novel and potent human dihydroorotate dehydrogenase (hDHODH) inhibitorFormule :C23H31ClO4Couleur et forme :SolidMasse moléculaire :406.95Torvutatug
CAS :Torvutatug is a human IgG1κ monoclonal antibody that acts against FOLR1.Couleur et forme :LiquidSD49-7
CAS :SD49-7 is an inhibitor of histone lysine demethylase 4 (KDM4) with an IC50 of 0.19 µM.Formule :C18H14N2O3Degré de pureté :99.91%Couleur et forme :SoildMasse moléculaire :306.32Ref: TM-T67781
1mg57,00€5mg124,00€10mg178,00€25mg359,00€50mg520,00€100mg745,00€500mg1.485,00€1mL*10mM (DMSO)141,00€RNA splicing modulator 1
CAS :RNA Splicing Modulator 1 (Compound 233) is a modulator of RNA splicing, exhibiting an AC50 value of less than 100 nM [1].
Formule :C19H20N6OSCouleur et forme :SolidMasse moléculaire :380.47Obtustatin
Potent α1β1 integrin inhibitor, 0.8 nM IC50 for IV collagen binding. Selective over other integrins. Inhibits FGF2 angiogenesis; antitumor in mouse models.Formule :C184H284N52O57S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4393.07CBR-2092
CAS :CBR-2092 is a DNA-directed RNA polymerase and DNA topoisomerase inhibitor.Formule :C65H81FN6O15Couleur et forme :SolidMasse moléculaire :1205.388(1S,3R,5R)-PIM447 dihydrochloride
(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).Formule :C24H25Cl2F3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :513.38R-1479
CAS :R-1479 (4'-Azidocytidine) is an RdRp inhibitor with an IC50 value of 1.28 μM for HCV RNA replication in the HCV subgenomic replicon system.Formule :C9H12N6O5Degré de pureté :98.11% - 99.95%Couleur et forme :SolidMasse moléculaire :284.23Ref: TM-TQ0162
1mg104,00€5mg258,00€10mg358,00€25mg595,00€50mg842,00€100mg1.134,00€200mg1.521,00€1mL*10mM (DMSO)318,00€GK13S
G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.Formule :C21H22N6O2Couleur et forme :SolidMasse moléculaire :390.44N1-Methylxylo-guanosine
N1-Methylxylo-guanosine, a purine analog, targets lymphoid cancer via DNA synthesis inhibition and apoptosis.Formule :C11H15N5O5Couleur et forme :SolidMasse moléculaire :297.27JH-XVI-178
CAS :JH-XVI-178: potent CDK8/19 inhibitor with good pharmacokinetics, low clearance, moderate oral bioavailability.Formule :C22H22ClN7OCouleur et forme :SolidMasse moléculaire :435.92WAY-647802
CAS :WAY-647802 is a CDK inhibitor.Formule :C11H14N4O3Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :250.25NUAK1-IN-2
NUAK1-IN-2 (Compound 24) is an inhibitor of NUAK1 with an IC50 of 3.162 nM, as well as an inhibitor of CDK2/4/6. It is applicable in research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.Formule :C24H30N6OCouleur et forme :SolidMasse moléculaire :418.535FF-10502
CAS :FF-10502, a pyrimidine analog of Gemcitabine, inhibits DNA polymerases α/β, targeting dormant cancer cells.Formule :C9H12FN3O3SCouleur et forme :SolidMasse moléculaire :261.272'-Fluoro-2'-deoxy-arabinoadenosine 5'-triphosphate triethylamine
2’-Fluoro-2’-deoxy-arabinoadenosine 5’-triphosphate (triethylamine) is a purine nucleoside analog with significant antitumor properties, particularly effectiveFormule :C34H75FN9O12P3Couleur et forme :SolidMasse moléculaire :913.93c(phg-isoDGR-(NMe)k) TFA
C(phg-isoDGR-(NMe)k) TFA is a selective and potent ligand for α5β1-integrin, exhibiting an IC50 of 2.9 nM [1].Formule :C29H42F3N9O9Couleur et forme :SolidMasse moléculaire :717.69Fuzapladib
CAS :Fuzapladib (IS-741) is a PLA2 inhibitor that reduces Mac-1 expression to prevent inflammation and pancreatitis.
Formule :C15H20F3N3O3SDegré de pureté :99.87%Couleur et forme :SoildMasse moléculaire :379.4Cytidine 5'-diphosphate trisodium salt
CAS :CDP, a trisodium salt, helps synthesize DNA/RNA by aiding phosphoryl transfer from ATP to CMP via UMPK.Formule :C9H15N3Na3O11P2Degré de pureté :99.55%Couleur et forme :White Crystalline PowderMasse moléculaire :472.15IBU-DC Phosphoramidite
CAS :IBU-DC Phosphoramidite is used for synthesis of oligonucleotides.Formule :C43H54N5O8PCouleur et forme :SolidMasse moléculaire :799.906CDK7-IN-7
CAS :CDK7-IN-7: Selective CDK7 inhibitor, IC50 < 50 nM (Patent CN112661745A).Formule :C20H20BrF3N6O2Couleur et forme :SolidMasse moléculaire :513.319Emicoron
CAS :Importazole is an inhibitor of the transport receptor importin-β. It specifically inhibits importin-β likely by altering its interaction with RanGTP.Formule :C52H58N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :831.05Garenoxacin
CAS :Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.Formule :C23H20F2N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.41PROTAC CDK9 degrader-11
CAS :PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC CDK9 degrader with a DC50 of 1.09 nM. This compound exhibits cytotoxicity in small cell lung cancer (SCLC) cells, with IC50 values in the nanomolar range. It induces cell cycle arrest at the G0/G1 phase and inhibits cell invasion in DMS114 and DMS53 cells. In addition, PROTAC CDK9 degrader-11 shows antitumor activity in an NCI-H446 xenograft mouse model. (Pink: ligand for target protein CDK9 ligand 3; Black: linker; Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56)Formule :C39H48Cl2N10O5Couleur et forme :SolidMasse moléculaire :807.768Sarecycline hydrochloride
CAS :Sarecycline hydrochloride is a narrow-spectrum tetracycline antibiotic with antimicrobial and anti-inflammatory activity.Formule :C24H30ClN3O8Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :523.96αVβ8-IN-1
CAS :αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).Formule :C25H32ClN5O4Couleur et forme :SolidMasse moléculaire :502.01Ribonuclease T1
CAS :Rnase T1, an endonuclease, degrades single-stranded RNA to yield 3'-GMP oligonucleotides.
Couleur et forme :Solid5'-ODMT cEt G Phosphoramidite (Amidite)
CAS :5'-ODMT cEt G Amidite is a safe, effective nucleic acid analog with strong antisense activity.Formule :C46H56N7O9PCouleur et forme :SolidMasse moléculaire :881.95IV-361
CAS :IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1Formule :C23H32FN5O2SiCouleur et forme :SolidMasse moléculaire :457.625Rifalazil
CAS :Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity, useful for research on chlamydia infections.Formule :C51H64N4O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :941.07AURKA against 1
Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.Formule :C28H32FN9O2Couleur et forme :SolidMasse moléculaire :545.61Chrysomycin A
CAS :Chrysomycin A is an antibiotic that can be derived from Streptomyces.Formule :C28H28O9Couleur et forme :SolidMasse moléculaire :508.52Endo-1,4-β-xylanase
CAS :Endo-1,4-β-xylanase (CtXyn11A) is a type of xylan hydrolase that hydrolyzes the β-1,4-glycosidic bond of the xylan molecule.Couleur et forme :Solid5-Methylcytidine 5′-triphosphate
CAS :5-Methylcytidine 5′-triphosphate (5-Methyl-CTP), a modified nucleoside triphosphate, enhances translational properties and stability while reducing innateFormule :C10H18N3O14P3Couleur et forme :SolidMasse moléculaire :497.18
