Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(96 produits)
- CDK(505 produits)
- Arrêt du cycle cellulaire(4 produits)
- Chk(42 produits)
- DYRK(48 produits)
- Dynamine(23 produits)
- Ferroptose(215 produits)
- HSP(170 produits)
- Intégrine(227 produits)
- Kinésine(68 produits)
- LIM Kinase(19 produits)
- Microtubules associés(261 produits)
- PKC(102 produits)
- PLK(28 produits)
- ROCK(68 produits)
- Rho(2 produits)
- Wee1(15 produits)
- c-Myc(68 produits)
Affichez 10 plus de sous-catégories
3495 produits trouvés pour "Cycle cellulaire/point de contrôle"
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PVZB1194
CAS :<p>PVZB1194, a biphenyl-type inhibitor of Kinesin spindle protein Eg5 (KIF11), exhibits anticancer potential by inducing cell cycle arrest and apoptosis through</p>Formule :C13H9F4NO2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.28αvβ6 integrin inhibitor 2
CAS :<p>αvβ6 Integrin Inhibitor 2 is a potent inhibitor of αvβ6 integrin, demonstrating an inhibition concentration (IC50) of 96.5 nM.</p>Formule :C21H30N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :386.49CDK9-IN-2
CAS :CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.Formule :C23H25ClFN5Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :425.93ON 108600
CAS :<p>ON 108600 is a chemical inhibitor targeting CK2 (Casein Kinase 2), TNIK, and DYRK1, demonstrating IC50 values of 0.016 μM and 0.007 μM for DYRK1A and DYRK1B, 0.</p>Formule :C22H14Cl2N2O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :537.39Kif15-IN-2
CAS :<p>Kif15-IN-2 is a kinesin Kif15 inhibitor with potential anticancer activity and can be used in prostate cancer research.</p>Formule :C20H20N6O4SDegré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :440.48CT1113
CAS :<p>CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDX</p>Formule :C25H29N5O2SCouleur et forme :SolidMasse moléculaire :463.6Trovafloxacin mesylate
CAS :<p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>Formule :C21H19F3N4O6SDegré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :512.46Luvixasertib hydrochloride
CAS :<p>CFI-402257 hydrochloride, a highly selective and orally bioavailable inhibitor targeting TTK/Mps1, demonstrates an in vitro IC50 value of 1.7 nM against TTK. This compound exhibits anti-cancer activity [1].</p>Formule :C28H31ClN6O3Couleur et forme :SolidMasse moléculaire :535.04LDC3140
CAS :<p>LDC3140 is a potent inhibitor of Cyclin-dependent kinase 7 (CDK7).</p>Formule :C23H33N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :423.55USP1-IN-3
CAS :<p>USP1-IN-3 is a selective inhibitor of USPI that inhibits USPI-UAFI (IC50<30 nM). USP1-IN-3 can be used to study cancer.</p>Formule :C27H24F3N7OCouleur et forme :SolidMasse moléculaire :519.52Lerociclib
CAS :<p>Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.</p>Formule :C26H34N8ODegré de pureté :99%Couleur et forme :SolidMasse moléculaire :474.6WRN inhibitor 5
CAS :<p>WRN Inhibitor 5 (Example 157), a cyclic vinyl sulfone-based compound, serves as an inhibitor of Werner Syndrome ATP-dependent helicase enzyme (WRN).</p>Formule :C23H20N2O6SCouleur et forme :SolidMasse moléculaire :452.48WEE1-IN-4
CAS :<p>Wee1 Inhibitor I is an ATP-binding site-targeting Wee1 inhibitor.</p>Formule :C20H11ClN2O3Couleur et forme :SolidMasse moléculaire :362.77Palmitoyl 3-carbacyclic phosphatidic acid
CAS :<p>Palmitoyl 3-carbacyclic phosphatidic acid, a palmitoylated Carba-like cyclophosphatidic acid and LPA (lysophosphatidic acid) analog, possesses distinct biological activities compared to LPA, including the inhibition of RhoA activation and melanoma cell migration. This compound has demonstrated efficacy in inhibiting experimental lung metastasis and reducing tumor nodule counts in a B16-F0 xenograft mouse model [1].</p>Formule :C20H39O5PCouleur et forme :SolidMasse moléculaire :390.49KY386
CAS :<p>KY386 is a potent and selective DHX33 helicase inhibitor with an IC50 value of 19 nM.</p>Formule :C21H19N5O2SCouleur et forme :SolidMasse moléculaire :405.47Mevociclib
CAS :Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.Formule :C31H35ClN8O2Degré de pureté :98.02% - 98.02%Couleur et forme :SolidMasse moléculaire :587.11L-739758
CAS :<p>L-739758 is a glycoprotein IIb/IIIa inhibitor.</p>Formule :C22H26N4O5S3Couleur et forme :SolidMasse moléculaire :522.66TNP-351
CAS :<p>Tnp 351 is a novel antifolate drug being assessed for chemotherapy of lung cancer.</p>Formule :C21H24N6O5Couleur et forme :SolidMasse moléculaire :440.458-NH2-ATP tetrasodium
CAS :<p>8-NH2-ATP tetrasodium, an inactive ATP variant, originates from 8-NH2-Ado tetrasodium, which triggers the apoptosis-associated cleavage of poly (ADP-ribose) polymerase [1] [2].</p>Formule :C10H13N6Na4O13P3Couleur et forme :SolidMasse moléculaire :610.12(2S,3R)-Voruciclib
CAS :<p>(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor.</p>Formule :C22H19ClF3NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.84AAPK-25
CAS :<p>AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.</p>Formule :C21H13Cl2N3O2SDegré de pureté :97.05%Couleur et forme :SolidMasse moléculaire :442.32L-Methioninamide hydrochloride
CAS :<p>L-Methioninamide hydrochloride is a potent inhibitor of methionyl-tRNA synthetase that reduces the toxicity of CDDP.</p>Formule :C5H13ClN2OSDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :184.69Halofuginone hydrochloride
CAS :<p>Halofuginone hydrochloride (RU-19110), a derivative of Febrifugine, functions as a competitive inhibitor of prolyl-tRNA synthetase, displaying a Ki value of 18.3 nM. This compound effectively inhibits type-I collagen synthesis, providing therapeutic benefits in osteoarthritis (OA) by impeding TGF-β signaling. Additionally, it serves as a potent pulmonary vasodilator, mainly through the activation of Kv channels and the inhibition of various calcium channels including voltage-gated, receptor-operated, and store-operated ones. Beyond its vascular effects, Halofuginone hydrochloride exhibits a broad spectrum of biological activities, including anti-malarial, anti-inflammatory, anti-cancer, and anti-fibrotic properties, supported by multiple studies.</p>Formule :C16H18BrCl2N3O3Couleur et forme :SolidMasse moléculaire :451.149-Deazaguanine
CAS :<p>9-Deazaguanine is a nucleoside analogue exhibiting inhibitory activity against bovine purine nucleoside phosphorylase (PNP).</p>Formule :C6H6N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :150.14Tirofiban HCl
CAS :<p>Tirofiban HCl is an antagonist of platelet glycoprotein-IIb/IIIa receptor.</p>Formule :C22H37ClN2O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :477.06m-Se3
CAS :<p>m-Se3 is a potent, selective inhibitor of c-MYC transcription with demonstrated capability to inhibit tumor growth and exhibit anti-cancer activity [1].</p>Formule :C29H23IN2SeDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :605.37Senexin A hydrochloride
CAS :<p>Senexin A hydrochloride functions as a selective inhibitor of CDK8/19, with an IC 50 of 280 nM for CDK8, and specifically inhibits p21-induced transcription without affecting other biological effects of p21. Additionally, it suppresses CMV-GFP induction and the stimulatory activity of the consensus NF-κB-dependent promoters [1] [2].</p>Formule :C17H15ClN4Couleur et forme :SolidMasse moléculaire :310.78Nε-(1-Carboxyethyl)-L-lysine
CAS :<p>Nε-(1-Carboxyethyl)-L-lysine (CEL) is an advanced glycation end-product (AGE). Exposure to CEL reduces glutamate uptake and S100B secretion in the hippocampus.</p>Formule :C9H18N2O4Couleur et forme :SolidMasse moléculaire :218.25ASC-69
CAS :<p>ASC-69 (APY69) is a promising potent inhibitor of the PD-1/PD-L1 signaling pathway, classified as a small-molecule compound [1].</p>Formule :C19H19N7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :345.4USP1-IN-5
CAS :<p>USP1-IN-5 (compound 10) is a potent inhibitor of both USP1, with an IC50 of less than 50 nM, and MDA-MB-436 cells, where it also exhibits an IC50 of less than</p>Formule :C27H23F3N8OCouleur et forme :SolidMasse moléculaire :532.52Emzadirib
CAS :<p>Emzadirib (RAD51-IN-2) is a potent RAD51 inhibitor with potential anticancer activity for the study of DNA damage repair.</p>Formule :C27H40N4O6S2Degré de pureté :99.79% - 99.9%Couleur et forme :SolidMasse moléculaire :580.76Gly-Arg-Gly-Asp-Ser TFA
CAS :<p>Gly-Arg-Gly-Asp-Ser (TFA), osteopontin domain, binds αvβ3 and αvβ5 integrins; IC50s: ~5 μM, ~6.5 μM.</p>Formule :C19H31F3N8O11Couleur et forme :SolidMasse moléculaire :604.49DNA polymerase-IN-3
CAS :<p>DNA polymerase-IN-3 (Compd 5b), a coumarin derivative, demonstrates inhibitory activity against Taq DNA polymerase and has potential applications in</p>Formule :C13H12O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :232.23CCG-232964
CAS :<p>CCG-232964 is an orally active Rho/MRTF/SRF inhibitor that suppresses LPA-induced CTGF gene expression [1].</p>Formule :C15H15ClN2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :338.818-Azahypoxanthine
CAS :<p>8-Azahypoxanthine (NSC-22709) inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase and has antimalarial properties.</p>Formule :C4H3N5ODegré de pureté :99.66%Couleur et forme :Light Yellow To Light Beige Fine CrystallineMasse moléculaire :137.1CCT-271850
CAS :<p>CCT-271850 is an inhibitor of the spindle checkpoint function of Monospindle 1.</p>Formule :C24H29N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :431.53Bisindolylmaleimide X hydrochloride
CAS :<p>Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).</p>Formule :C26H25ClN4O2Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :460.96Alatrofloxacin
CAS :<p>Alatrofloxacin is a prodrug of trovafloxacin.</p>Formule :C26H25F3N6O5Couleur et forme :SolidMasse moléculaire :558.51Lotrafiban hydrochloride
CAS :<p>Lotrafiban hydrochloride is an platelet glycoprotein IIb/IIIa blocker with oral activity.</p>Formule :C23H33ClN4O4Couleur et forme :SolidMasse moléculaire :464.99CDK7-IN-14
CAS :<p>CDK7-IN-14, a potent CDK7 inhibitor from pyrimidines, may treat transcriptionally dysregulated cancers (CN114249712A).</p>Formule :C22H24F3N6OPCouleur et forme :SolidMasse moléculaire :476.43Cdc7-IN-7
CAS :<p>Cdc7-IN-7 is a potent inhibitor of Cdc7 kinase.</p>Formule :C21H22N4O5Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :410.42Integrin Antagonists 27
CAS :<p>Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist. It has a binding affinity of 18 nM and as a novel anticancer agent.</p>Formule :C24H20N4O5Couleur et forme :SolidMasse moléculaire :444.44OXA-06 hydrochloride
CAS :<p>OXA-06 hydrochloride, an ATP-competitive ROCK inhibitor, impedes anchorage-dependent growth and invasion in non-small cell lung cancer cell lines. It effectively inhibits cofilin phosphorylation without inducing apoptosis [1].</p>Formule :C21H20Cl2FN3Couleur et forme :SolidMasse moléculaire :404.31Galidesivir hydrochloride
CAS :Galidesivir hydrochloride is an inhibitor of viral RNA-dependent RNA polymerase (RdRp). It inhibits SARS-CoV-2 by tightly binding to its RdRp.Formule :C11H16ClN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :301.73(S)-Cdc7-IN-18
CAS :<p>'(S)-Cdc7-IN-18 from patent WO2020239107A1 inhibits CDC7, curbing MCM2 and tumor growth.'</p>Formule :C19H21N5OSCouleur et forme :SolidMasse moléculaire :367.47G-5758
CAS :<p>G-5758 is an orally active IRE1α inhibitor with an IC50 of 38 nM for XBP1s. It is used in studies involving multiple myeloma models [KMS-11], demonstrating good tolerance in rats at oral doses up to 500 mg/kg. G-5758 exhibits pharmacodynamic effects comparable to those induced by IRE1 knockdown.</p>Formule :C27H24F4N6O3SCouleur et forme :SolidMasse moléculaire :588.58CCT-251921
CAS :<p>CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).</p>Formule :C21H23ClN6ODegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :410.9MU-380
CAS :<p>MU-380 is an effective and selective inhibitor of CHK1.</p>Formule :C15H15BrF3N7Couleur et forme :SolidMasse moléculaire :430.23αvβ1 integrin-IN-2
CAS :<p>αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively.</p>Formule :C29H38N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :506.64CDK9-IN-29
CAS :<p>CDK9-IN-29 (compound Z11) is a potent inhibitor of CDK9, exhibiting high kinase selectivity and an IC50 value of 3.20 nM.</p>Formule :C29H33F2N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.6
