Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(96 produits)
- CDK(505 produits)
- Arrêt du cycle cellulaire(4 produits)
- Chk(42 produits)
- DYRK(48 produits)
- Dynamine(23 produits)
- Ferroptose(215 produits)
- HSP(170 produits)
- Intégrine(227 produits)
- Kinésine(68 produits)
- LIM Kinase(19 produits)
- Microtubules associés(261 produits)
- PKC(102 produits)
- PLK(28 produits)
- ROCK(68 produits)
- Rho(2 produits)
- Wee1(15 produits)
- c-Myc(68 produits)
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3495 produits trouvés pour "Cycle cellulaire/point de contrôle"
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UNC-2170
CAS :<p>UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.</p>Formule :C14H21BrN2ODegré de pureté :97.44%Couleur et forme :SolidMasse moléculaire :313.23Inixaciclib
CAS :<p>Inixaciclib is a potent CDK inhibitor, can be used to research anticancer.</p>Formule :C26H30F2N6OCouleur et forme :SolidMasse moléculaire :480.55L 738167
CAS :<p>L 738167 is a potent antagonist of the long-acting fibrinogen receptor.</p>Formule :C25H34N6O6SCouleur et forme :SolidMasse moléculaire :546.64Pencitabine
CAS :<p>Pen is an oral cancer drug that blocks DNA synthesis by inhibiting key enzymes and integrating into DNA.</p>Formule :C15H20F3N3O6Couleur et forme :SolidMasse moléculaire :395.33SC-52012
CAS :<p>SC-52012 is a novel and potent fibrinogen receptor antagonist, an RGD mimetic, which inhibits platelet aggregation.</p>Formule :C25H30N4O6Degré de pureté :97.20%Couleur et forme :SolidMasse moléculaire :482.53CDK9-IN-8
CAS :<p>CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).</p>Formule :C31H32FN7O3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :569.63Balapiravir hydrochloride
CAS :<p>Balapiravir HCl, an NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>Formule :C21H31ClN6O8Couleur et forme :SolidMasse moléculaire :530.96c-Myc inhibitor 8
CAS :<p>c-Myc inhibitor 8 suppresses cell growth in various cancers and is used in research.</p>Formule :C19H12BrClF3NO3S2Couleur et forme :SolidMasse moléculaire :538.79CCT241533 hydrochloride
CAS :CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Formule :C23H28ClFN4O4Degré de pureté :97.13%Couleur et forme :SolidMasse moléculaire :478.95FT206
CAS :<p>FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].</p>Formule :C25H29N5OSCouleur et forme :SolidMasse moléculaire :447.6NTRC 0066-0
CAS :<p>NTRC 0066-0 is a TTK inhibitor that can be used in cancer research.</p>Formule :C33H39N7O2Degré de pureté :98.30%Couleur et forme :SolidMasse moléculaire :565.712'-Deoxypseudoisocytidine
CAS :<p>2'-Deoxypseudoisocytidine is a nucleoside analogue.</p>Formule :C9H13N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :227.22Lotrafiban
CAS :<p>Lotrafiban: Oral GP IIb/IIIa inhibitor for treating coronary and cerebrovascular disease.</p>Formule :C23H32N4O4Couleur et forme :SolidMasse moléculaire :428.52CI 972 anhydrous
CAS :<p>CI 972 anhydrous is an inhibitor of purine nucleoside phosphorylase (PNP) (Ki: 0.83 μM) used as a T cell-selective immunosuppressive agent.</p>Formule :C11H12ClN5OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :297.76ROCK-IN-10
CAS :<p>ROCK-IN-10 (compound 50) serves as a powerful inhibitor of ROCK, exhibiting IC50 values of 6 nM for ROCK1 and 4 nM for ROCK2, respectively. It demonstrates over 100-fold selectivity towards ROCK1 and ROCK2 when compared to other kinases [1].</p>Formule :C25H25N5O3Couleur et forme :SolidMasse moléculaire :443.507BI-1950
CAS :<p>BI-1950: potent inhibitor of LFA-1, key in immune function and drug target.</p>Formule :C32H26Cl2FN7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :646.5DAM-IN-1
CAS :<p>DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor with an IC50 value of 48 μM.</p>Formule :C16H17NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :287.31Solitomab
CAS :<p>Solitomab (AMG 110) is a bispecific antibody targeting CD3 and EpCAM, used in uterine/ovarian carcinosarcoma research.</p>Couleur et forme :LiquidSZ-015268
CAS :<p>SZ-015268: CDK7 inhibitor, IC50=23.56 nM; hinders HCC70, OVCAR-3, HCT116, HCC1806 cell growth; strong anti-tumor effect.</p>Formule :C25H38N8O3Couleur et forme :SolidMasse moléculaire :498.62LX7101 hydrochloride
CAS :<p>LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 μM. The topical administration of LX7101 (3 μl of a 1 mg/ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.</p>Formule :C23H29N7O3HClCouleur et forme :SolidMasse moléculaire :488Lamifiban
CAS :Lamifiban is a nonpeptide glycoprotein IIb/IIIa antagonist. It prevents platelet loss during experimental cardiopulmonary bypass.Formule :C24H28N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.5DNA Gyrase-IN-8
CAS :<p>DNA Gyrase-IN-8 is a potent inhibitor of DNA gyrase, demonstrating antimicrobial activity with an IC50 of 8.45 µM [1].</p>Formule :C19H14BrN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :408.25ROCK2-IN-7
CAS :<p>ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis.</p>Formule :C26H28FN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.53Cdc7-IN-12
CAS :<p>Cdc7-IN-12, a sub-1 nM CDC7 inhibitor, may aid cancer research; hinders COLO205 cell growth (IC50: 100-1000 nM).</p>Formule :C16H14N2O2SCouleur et forme :SolidMasse moléculaire :298.36ML 315 hydrochloride
CAS :<p>ML 315, a selective dual inhibitor targeting CDK (Cyclin-Dependent Kinase) and DYRK (Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase) with IC50 values of 68 nM and 282 nM, respectively, is utilized in research pertaining to cancer and neurological diseases [1].</p>Formule :C18H14Cl3N3O2Couleur et forme :SolidMasse moléculaire :410.682AVG-233
CAS :<p>AVG-233 is an RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity for the study of respiratory syncytial virus infections.</p>Formule :C26H22ClN5O3Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :487.94Voruciclib hydrochloride
CAS :<p>Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).</p>Formule :C22H20Cl2F3NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :506.3H3B-968
CAS :<p>H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, effectively targeting its helicase, ATPase, and exonuclease</p>Formule :C22H18F6N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :548.46Cdk4 Inhibitor
CAS :<p>PD 0332991, an unsymmetrical indolocarbazole compound, is cell-permeable and exhibits antiproliferative effects by functioning as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk4/D1 (IC 50 = 76 nM). Although it can inhibit other Cdks, such as Cdk2/E and Cdk1/B, effectiveness requires higher concentrations (IC 50 = 520 nM and 2.1 µM, respectively) and demonstrates minimal activity against CaMKII, PKA, or GSK-3β (IC 50 ≥ 12.4 µM). PD 0332991 efficiently inhibits tumor cell growth in HCT-116 and NCI-H460 cell lines with an IC 50 < 3.0 µM, primarily through blocking Rb phosphorylation and inducing G1 cell cycle arrest.</p>Formule :C20H10BrN3O2Couleur et forme :SolidMasse moléculaire :404.23-Hydroxyxanthone
CAS :<p>3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical vein</p>Formule :C13H8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :212.2CDK4/6-IN-17
CAS :<p>CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells.</p>Formule :C27H28F4N8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :540.56Sapacitabine
CAS :<p>Sapacitabine (CS682) is a nucleoside analog precursor with anticancer activity used in the study of leukemia.</p>Formule :C26H42N4O5Degré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :490.64Spirofylline
CAS :<p>Spirofylline is an agent of bronchodilator, has the potential for asthma and bronchitis and emphysema treatment.</p>Formule :C24H28N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :480.52TAS-114
CAS :<p>TAS-114 is a dUTPase and DPD inhibitor that modulates catabolic pathways to improve systemic availability of 5-FU.</p>Formule :C21H29N3O6SDegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :451.54DUB-IN-7
CAS :<p>DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].</p>Formule :C17H19N5OCouleur et forme :SolidMasse moléculaire :309.37IIIM-290
CAS :IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).Formule :C23H21Cl2NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.32DHODH-IN-14
CAS :<p>DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.</p>Formule :C15H7F4N3O3Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :353.23TAK 029
CAS :<p>TAK 029 is a local glycoprotein IIb/IIIa receptor inhibitor.</p>Formule :C19H23N5O7Couleur et forme :SolidMasse moléculaire :433.42Diazoketone methotrexate
CAS :<p>Diazoketone methotrexate is an analog of methotrexate with potential antitumor activity.</p>Formule :C21H22N10O4Couleur et forme :SolidMasse moléculaire :478.465-DACTHF
CAS :<p>5,11-methenyltetrahydrohomofolate blocks GAR & AIR transformylase; used as an anti-purine drug.</p>Formule :C19H24N6O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :432.43Antifolate C1
CAS :<p>Antifolate C1 blocks purine creation, favors uptake via folate receptors/PCFT over RFC.</p>Formule :C19H21N5O6SCouleur et forme :SolidMasse moléculaire :447.46Methotrexate-γ-aspartate
CAS :<p>Methotrexate-gamma-aspartate has growth inhibitory effects. It is used in antibody-targeted liposomes.</p>Formule :C24H27N9O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :569.53SHP2/CDK4-IN-1
CAS :<p>SHP2/CDK4-IN-1: dual inhibitor, oral, potent (IC50: SHP2 4.3 nM, CDK4 18.2 nM), hinders TNBC growth, strong antitumor effects in mice.</p>Formule :C33H35ClF2N10OSCouleur et forme :SolidMasse moléculaire :693.21ML-099
CAS :ML-099 is a pan Ras-related GTPases activator that activates Rac1, Ras, GTP-binding protein (Rab7), Rab2A and cell division cycle 42.Formule :C14H13NO2SDegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :259.32AR-13503
CAS :<p>AR-13503, a Netarsudil metabolite, is a ROCK inhibitor, potentially treating glaucoma and lowering eye pressure.</p>Formule :C19H19N3O2Couleur et forme :SolidMasse moléculaire :321.37TC-I 15
CAS :α2β1 integrin inhibitorFormule :C23H28N4O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :520.62KM05382
CAS :<p>KM05382 inhibits CDK9 and the transcription of GAPDH.</p>Formule :C20H19ClN2O3S2Couleur et forme :SolidMasse moléculaire :434.96Riviciclib
CAS :<p>Riviciclib, a CDK inhibitor (CDK9/T1, CDK4/D1, CDK1/B), has IC50s: 20, 63, 79 nM respectively, and fights cisplatin-resistant tumors.</p>Formule :C21H20ClNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.84Homouridine
CAS :<p>Homouridine, an analogue of uridine, functions as an intermediate in the synthesis of MMP-2 inhibitor (compound I, IC50 = 150 μM).</p>Formule :C10H14N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :258.23VER-00158411
CAS :<p>VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).</p>Formule :C31H34N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.64
