Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(104 produits)
- CDK(521 produits)
- Arrêt du cycle cellulaire(4 produits)
- Chk(46 produits)
- DYRK(48 produits)
- Dynamine(25 produits)
- Ferroptose(218 produits)
- HSP(176 produits)
- Intégrine(249 produits)
- Kinésine(77 produits)
- LIM Kinase(19 produits)
- Microtubules associés(282 produits)
- PKC(107 produits)
- PLK(25 produits)
- ROCK(67 produits)
- Rho(2 produits)
- Wee1(14 produits)
- c-Myc(74 produits)
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3685 produits trouvés pour "Cycle cellulaire/point de contrôle"
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MOMA-341
CAS :MOMA-341 is a highly selective inhibitor targeting the Werner RecQ-like helicase (WRN). It exerts a dual mechanism of allosteric regulation and ATP competitive inhibition by binding to the cysteine 727 site of the WRN protein. In mouse models with mismatch repair deficiency (dMMR) or high microsatellite instability (MSI-H), MOMA-341 can induce DNA damage, cell apoptosis, and promote tumor shrinkage. This compound exhibits significant anti-tumor activity and has potential application prospects in the study of advanced and metastatic solid tumors.Formule :C28H26F4N6O3Masse moléculaire :570.54CDK9-IN-9
CAS :<p>CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).</p>Formule :C22H23F2N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :459.51Sapacitabine
CAS :Sapacitabine (CS682) is a nucleoside analog precursor with anticancer activity used in the study of leukemia.Formule :C26H42N4O5Degré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :490.64UNC2170 maleate
CAS :53BP1-binding protein 1 (53BP1) engages with dimethylated lysine 20 on histone 4 (H4K20me2) through its tandem tudor domains within a homodimer configuration, crucial for the DNA damage response. UNC2170, a micromolar 53BP1 ligand, selectively interacts with this site, demonstrating at least 17-fold preference for 53BP1 over similar proteins. This interaction occurs in a pocket formed by the 53BP1's tudor domains. Moreover, UNC2170 acts as an antagonist to 53BP1 in cellular lysates, effectively inhibiting class switch recombination, a process dependent on the functional 53BP1 tudor domain, thus confirming its cellular activity.Formule :C14H21BrN2OC4H4O4Couleur et forme :SolidMasse moléculaire :429.315-Iodo-indirubin-3'-monoxime
CAS :5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50sFormule :C16H10IN3O2Couleur et forme :SolidMasse moléculaire :403.17Halofuginone hydrochloride
CAS :Halofuginone hydrochloride (RU-19110), a derivative of Febrifugine, functions as a competitive inhibitor of prolyl-tRNA synthetase, displaying a Ki value of 18.3 nM. This compound effectively inhibits type-I collagen synthesis, providing therapeutic benefits in osteoarthritis (OA) by impeding TGF-β signaling. Additionally, it serves as a potent pulmonary vasodilator, mainly through the activation of Kv channels and the inhibition of various calcium channels including voltage-gated, receptor-operated, and store-operated ones. Beyond its vascular effects, Halofuginone hydrochloride exhibits a broad spectrum of biological activities, including anti-malarial, anti-inflammatory, anti-cancer, and anti-fibrotic properties, supported by multiple studies.Formule :C16H18BrCl2N3O3Couleur et forme :SolidMasse moléculaire :451.148-NH2-ATP tetrasodium
CAS :<p>8-NH2-ATP tetrasodium, an inactive ATP variant, originates from 8-NH2-Ado tetrasodium, which triggers the apoptosis-associated cleavage of poly (ADP-ribose) polymerase [1] [2].</p>Formule :C10H13N6Na4O13P3Couleur et forme :SolidMasse moléculaire :610.12PLK4-IN-4
CAS :<p>PLK4-IN-4 (compound 22), a potent inhibitor of PLK4, exhibits an IC50 value of 7.9 nM, suggesting its potential use in cancer research [1].</p>Formule :C21H23F2N9Couleur et forme :SolidMasse moléculaire :439.46RAD51-IN-4
CAS :RAD51-IN-4, a potent RAD51 inhibitor, may be useful in researching mitochondrial defect-related conditions.Formule :C31H34FN5O5S2Couleur et forme :SolidMasse moléculaire :639.76Tirofiban HCl
CAS :<p>Tirofiban HCl is an antagonist of platelet glycoprotein-IIb/IIIa receptor.</p>Formule :C22H37ClN2O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :477.06BMT-090605
CAS :BMT-090605: AAK1 inhibitor (IC50=0.6 nM), also affects BIKE (45 nM) and GAK (60 nM), has antinociceptive properties.Formule :C21H24N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :364.44AVG-233
CAS :AVG-233 is an RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity for the study of respiratory syncytial virus infections.Formule :C26H22ClN5O3Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :487.94SZ-015268
CAS :SZ-015268: CDK7 inhibitor, IC50=23.56 nM; hinders HCC70, OVCAR-3, HCT116, HCC1806 cell growth; strong anti-tumor effect.Formule :C25H38N8O3Couleur et forme :SolidMasse moléculaire :498.62TC-A 2317 hydrochloride
CAS :<p>TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.</p>Formule :C19H29ClN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.93αvβ1 integrin-IN-2
CAS :<p>αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively.</p>Formule :C29H38N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :506.64DNA gyrase B-IN-3
CAS :DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against GramFormule :C14H9Cl2N3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :386.21CDK/HDAC-IN-3
CAS :<p>CDK/HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3,</p>Formule :C24H18Cl2N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :509.34PD-1/PD-L1-IN-33
CAS :PD-1/PD-L1-IN-33 (Compound N11), a PD-1/PD-L1 inhibitor, effectively impedes the interaction between PD-1 and PD-L1 with an IC50 of 6.3 nM.Formule :C26H27N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.53Cytarabine 5′-monophosphate
CAS :Cytarabine 5′-monophosphate (ara-CMP), an active metabolite of the nucleoside analog cytarabine formed by deoxycytidine kinase, is incorporated into DNA by DNA polymerase α, significantly slowing DNA synthesis. It inhibits nuclear and mitochondrial DNA replication in S. cerevisiae at 15 mM and improves survival in an L1210 murine leukemia model at 3.5-75.1 mg/kg.Formule :C9H14N3O8PCouleur et forme :SolidMasse moléculaire :323.198T521
CAS :T521 is a selective inhibitor of the PBD of Plk1 and shows no inhibitory effect on Plk2 and Plk3.Formule :C17H14FNO5S2Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :395.435′-Guanylyl methylenediphosphonate sodium
CAS :5′-Guanylyl methylenediphosphonate (sodium) serves as a GTP analogue and acts as a specific, competitive inhibitor of the GTP reaction in protein synthesis [1].Formule :C11H15N5Na3O13P3Couleur et forme :SolidMasse moléculaire :587.15Pencitabine
CAS :Pen is an oral cancer drug that blocks DNA synthesis by inhibiting key enzymes and integrating into DNA.Formule :C15H20F3N3O6Couleur et forme :SolidMasse moléculaire :395.33N-desmethyl Netupitant
CAS :<p>N-desmethyl Netupitant is a metabolite of Netupitant and a potential Substance-P receptor agonist.</p>Formule :C29H30F6N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :564.57DHX9-IN-4
CAS :DHX9-IN-4 is an ATP-dependent RNA helicase DHX9 inhibitor used in cancer research.Formule :C21H22ClN5O4S2Degré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :508.01NVS-SM2
CAS :NVS-SM2 boosts SMN2 splicing, enhances exon 7 inclusion, and raises SMN protein levels orally.Formule :C23H30N6OCouleur et forme :SolidMasse moléculaire :406.52Senexin C
CAS :Senexin C is a CDK8/19 inhibitor with anticancer activity.Senexin C inhibits the growth of MV4-11 leukemia cells.Formule :C28H27N5ODegré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :449.55DHX9-IN-6
CAS :DHX9-IN-6 is a highly effective ATP-dependent RNA helicase A (DHX9) inhibitor, used in cancer research.Formule :C23H18ClFN4O4S2Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :533CI 972 anhydrous
CAS :CI 972 anhydrous is an inhibitor of purine nucleoside phosphorylase (PNP) (Ki: 0.83 μM) used as a T cell-selective immunosuppressive agent.Formule :C11H12ClN5OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :297.76SB-743921 free base
CAS :SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).Formule :C31H33ClN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.06MU-380
CAS :MU-380 is an effective and selective inhibitor of CHK1.Formule :C15H15BrF3N7Couleur et forme :SolidMasse moléculaire :430.23PLK1-IN-4
CAS :<p>PLK1-IN-4: strong PLK1 blocker (<0.508 nM IC50), inhibits cancer cell growth, triggers G2/M arrest and apoptosis.</p>Formule :C24H25F3N6O4SCouleur et forme :SolidMasse moléculaire :550.55Solitomab
CAS :Solitomab (AMG 110) is a bispecific antibody targeting CD3 and EpCAM, used in uterine/ovarian carcinosarcoma research.Degré de pureté :95%Couleur et forme :LiquidCCT-271850
CAS :CCT-271850 is an inhibitor of the spindle checkpoint function of Monospindle 1.Formule :C24H29N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :431.53CCT-251921
CAS :CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).Formule :C21H23ClN6ODegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :410.98-Azahypoxanthine
CAS :8-Azahypoxanthine (NSC-22709) inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase and has antimalarial properties.Formule :C4H3N5ODegré de pureté :99.66%Couleur et forme :Light Yellow To Light Beige Fine CrystallineMasse moléculaire :137.1Voruciclib hydrochloride
CAS :Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).Formule :C22H20Cl2F3NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :506.3CDK7-IN-22
CAS :CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].Formule :C22H25F3N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.47G4/HDAC-IN-1
<p>G4/HDAC-IN-1, a G4/HDAC dual inhibitor, IC50 1.1 µM, blocks TNBC growth, useful in cancer research.</p>Formule :C36H49ClFN7O4Couleur et forme :SolidMasse moléculaire :698.27CDK7-IN-14
CAS :<p>CDK7-IN-14, a potent CDK7 inhibitor from pyrimidines, may treat transcriptionally dysregulated cancers (CN114249712A).</p>Formule :C22H24F3N6OPCouleur et forme :SolidMasse moléculaire :476.43ICAM-1-IN-1
CAS :<p>ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.</p>Formule :C15H11BrN2O2SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :363.23NITD008
CAS :<p>NITD008 (7-Deaza-2'-C-acetylene-adenosine) is an adenosine nucleoside inhibitor with antiviral activity that inhibits dengue and Zika viruses.</p>Formule :C13H14N4O4Degré de pureté :98.04%Couleur et forme :SolidMasse moléculaire :290.27Amotosalen free base
CAS :Amotosalen is a Dermatologic Agent.Formule :C17H19NO4Couleur et forme :SolidMasse moléculaire :301.34(S)-Cdc7-IN-18
CAS :'(S)-Cdc7-IN-18 from patent WO2020239107A1 inhibits CDC7, curbing MCM2 and tumor growth.'Formule :C19H21N5OSCouleur et forme :SolidMasse moléculaire :367.47TAK 029
CAS :TAK 029 is a local glycoprotein IIb/IIIa receptor inhibitor.Formule :C19H23N5O7Couleur et forme :SolidMasse moléculaire :433.42CCT251455
CAS :<p>CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.</p>Formule :C26H26ClN7O2Degré de pureté :99.1% - 99.1%Couleur et forme :SolidMasse moléculaire :503.98DHODH-IN-14
CAS :DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.Formule :C15H7F4N3O3Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :353.23ROCK2-IN-7
CAS :<p>ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis.</p>Formule :C26H28FN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.53GSK2850163
CAS :<p>GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).</p>Formule :C24H29Cl2N3ODegré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :446.41GSK2163632A
CAS :GSK2163632A is an insulin-like growth factor 1 receptor inhibitor that acts by binding to a novel region of the GRK active site cleft.Formule :C27H32N8O3SCouleur et forme :SolidMasse moléculaire :548.66Alatrofloxacin
CAS :Alatrofloxacin is a prodrug of trovafloxacin.Formule :C26H25F3N6O5Couleur et forme :SolidMasse moléculaire :558.51
