Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(94 produits)
- CDK(500 produits)
- Arrêt du cycle cellulaire(4 produits)
- Chk(42 produits)
- DYRK(48 produits)
- Dynamine(23 produits)
- Ferroptose(215 produits)
- HSP(169 produits)
- Intégrine(224 produits)
- Kinésine(66 produits)
- LIM Kinase(19 produits)
- Microtubules associés(261 produits)
- PKC(102 produits)
- PLK(28 produits)
- ROCK(70 produits)
- Rho(2 produits)
- Wee1(15 produits)
- c-Myc(69 produits)
Affichez 10 plus de sous-catégories
3477 produits trouvés pour "Cycle cellulaire/point de contrôle"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
RNA splicing modulator 1
CAS :<p>RNA Splicing Modulator 1 (Compound 233) is a modulator of RNA splicing, exhibiting an AC50 value of less than 100 nM [1].</p>Formule :C19H20N6OSCouleur et forme :SolidMasse moléculaire :380.47MRK-952
<p>MRK-952 is a NUDIX hydrolase inhibitor. NUDIX enzymes play a role in cellular metabolism, homeostasis, and mRNA processing.</p>Formule :C20H20ClF3N6Couleur et forme :SolidMasse moléculaire :436.861Stigmatellin
CAS :<p>Stigmatellin is an antibiotic derived from the cell mass of the myxobacterium, effective against yeasts (yeasts), filamentous fungi (filamentous fungi), and several Gram-positive bacteria (Gram-positive bacteria). Additionally, it serves as a potent inhibitor of photosynthetic electron (photosynthetic electron) transfer. Stigmatellin utilizes various sugars, polysaccharides, and acids from the citric acid cycle as substrates, inhibiting RNA and protein synthesis. It has two different inhibitory sites: one located on the reducing side of photosystem II and the other at the cytochrome b6/f complex. Stigmatellin holds potential for use in antimicrobial and photosynthesis research.</p>Formule :C30H42O7Couleur et forme :SolidMasse moléculaire :514.65CDK5-IN-1
CAS :<p>CDK5-IN-1: Potent CDK5 inhibitor (<10 nM) used in kidney disease research.</p>Formule :C24H25FN6O3SCouleur et forme :SolidMasse moléculaire :496.56Lorutengitide
CAS :<p>Lorutengitide is a transcription-regulating peptide with antiproliferative activity.</p>Formule :C30H50N8O12Couleur et forme :SolidMasse moléculaire :714.764Sarecycline hydrochloride
CAS :<p>Sarecycline hydrochloride is a narrow-spectrum tetracycline antibiotic with antimicrobial and anti-inflammatory activity.</p>Formule :C24H30ClN3O8Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :523.96Rifalazil
CAS :<p>Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity, useful for research on chlamydia infections.</p>Formule :C51H64N4O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :941.07Torvutatug
CAS :<p>Torvutatug is a human IgG1κ monoclonal antibody that acts against FOLR1.</p>Couleur et forme :Liquid5-Methylcytidine 5′-triphosphate trisodium
<p>5-Methylcytidine 5′-triphosphate trisodium (5-Methyl-CTP trisodium), a modified nucleoside triphosphate, enhances translational properties and stability, while</p>Formule :C10H15N3Na3O14P3Couleur et forme :SolidMasse moléculaire :563.13PKMYT1-IN-3
<p>PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.</p>Formule :C24H26FN5O2Couleur et forme :SolidMasse moléculaire :435.49UnyLinker 12 TEA
<p>UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.</p>Formule :C39H35NO10C6H15NCouleur et forme :SolidMasse moléculaire :778.346552-Methylbutyrylcarnitine chloride
<p>2-Methylbutyrylcarnitine (chloride) acts as a gut microbial metabolite that targets integrin α2β1 on platelets, facilitating the activation of cytosolic phospholipase A2 (cPLA2) and enhancing platelet hyperresponsiveness. This compound further augments platelet hyperreactivity and promotes thrombus formation in mice. It is also characterized as a branched-chain acylcarnitine.</p>Formule :C12H24ClNO4Couleur et forme :SolidMasse moléculaire :281.78AURKA against 1
<p>Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.</p>Formule :C28H32FN9O2Couleur et forme :SolidMasse moléculaire :545.61Pseudouridimycin
CAS :<p>Pseudouridimycin: a C-nucleoside antibiotic, inhibits bacterial RNAP, targets Gram-negative and Gram-positive bacteria.</p>Formule :C17H26N8O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :486.445'-O-DMT-PAC-dA
CAS :<p>5’-O-DMT-PAC-dA can be used in the synthesis of oligoribonucleotides[1].</p>Formule :C39H37N5O7Couleur et forme :SolidMasse moléculaire :687.743'-Deoxyuridine-5'-triphosphate trisodium
<p>3'-dUTP trisodium, a nucleotide analogue, inhibits RNA polymerases I/II and UTP integration into RNA (Ki=2.0 μM).</p>Formule :C9H12N2Na3O14P3Couleur et forme :SoildMasse moléculaire :534.08LXY3
CAS :<p>LXY3 (LXY2) is a VLA-3 blocking peptide that inhibits the interaction of neutrophil surface integrin α3β1 (VLA-3) with laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is employed to block the neutrophil-mediated release of nanoparticles from the perivascular pool into the tumor stroma and is frequently used for targeted imaging in breast cancer.</p>Formule :C32H43N11O15S2Couleur et forme :SolidMasse moléculaire :885.88PROTAC CDK9 degrader 4
CAS :<p>PROTAC CDK9 degrader 4 is a CDK9 degrader that targets transcriptional regulation and has potential anticancer activity.</p>Formule :C43H56N10O5Couleur et forme :SolidMasse moléculaire :792.97αVβ8-IN-1
CAS :<p>αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).</p>Formule :C25H32ClN5O4Couleur et forme :SolidMasse moléculaire :502.01Ac-dA Phosphoramidite
CAS :<p>Ac-dA Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.</p>Formule :C42H50N7O7PCouleur et forme :SolidMasse moléculaire :795.878JH-XVI-178
CAS :<p>JH-XVI-178: potent CDK8/19 inhibitor with good pharmacokinetics, low clearance, moderate oral bioavailability.</p>Formule :C22H22ClN7OCouleur et forme :SolidMasse moléculaire :435.92YKL-5-124 TFA
CAS :<p>YKL-5-124 TFA is a potent CDK7 inhibitor (IC50: 53.5 nM), more than 100x selective over CDK9/2, not active on CDK12/13, and disrupts the cell cycle.</p>Formule :C30H34F3N7O5Couleur et forme :SolidMasse moléculaire :629.635'-O-DMT-N4-Bz-2'-F-dC
CAS :<p>5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.</p>Formule :C37H34FN3O7Couleur et forme :SolidMasse moléculaire :651.68α2β1 Integrin Ligand Peptide
CAS :<p>The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular</p>Formule :C14H22N4O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :390.35Ribonuclease T1
CAS :<p>Rnase T1, an endonuclease, degrades single-stranded RNA to yield 3'-GMP oligonucleotides.</p>Couleur et forme :SolidHeliquinomycin
CAS :<p>Heliquinomycin, a Streptomyces metabolite, inhibits DNA helicase (Ki=6.8 μM) and fights Gram-positive bacteria and various cancer cells.</p>Formule :C33H30O17Couleur et forme :SolidMasse moléculaire :698.586(1S,3R,5R)-PIM447 dihydrochloride
<p>(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).</p>Formule :C24H25Cl2F3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :513.385'-O-DMT-ibu-dC
CAS :<p>5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.</p>Formule :C34H37N3O7Couleur et forme :SolidMasse moléculaire :599.67Bz-rC Phosphoramidite
CAS :<p>Bz-rC Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.</p>Formule :C52H66N5O9PSiCouleur et forme :SolidMasse moléculaire :964.185Chrysomycin A
CAS :<p>Chrysomycin A is an antibiotic that can be derived from Streptomyces.</p>Formule :C28H28O9Couleur et forme :SolidMasse moléculaire :508.52IV-361
CAS :<p>IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1</p>Formule :C23H32FN5O2SiCouleur et forme :SolidMasse moléculaire :457.625DHFR-IN-11
<p>DHFR-IN-11 (compound 6b) is a DHFR inhibitor with demonstrated inhibitory efficacy against the M.</p>Couleur et forme :Odour SolidpNP-ADPr
CAS :<p>pNP-ADPr: Used in PARG & ARH3 activity assays; aids in PARP enzyme research.</p>Formule :C21H26N6O16P2Couleur et forme :SolidMasse moléculaire :680.41JB300
CAS :<p>JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.</p>Formule :C43H45ClFN7O10SCouleur et forme :SolidMasse moléculaire :906.375Chk1-IN-6
CAS :<p>Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.</p>Formule :C16H18F3N7Couleur et forme :SolidMasse moléculaire :365.3645-Methylcytidine 5′-triphosphate
CAS :<p>5-Methylcytidine 5′-triphosphate (5-Methyl-CTP), a modified nucleoside triphosphate, enhances translational properties and stability while reducing innate</p>Formule :C10H18N3O14P3Couleur et forme :SolidMasse moléculaire :497.18Xanthosine-5'-Triphosphate
CAS :<p>Xanthosine-5'-Triphosphate (5'-XTP), a nucleotide derived from the deamination of purine bases, plays a crucial role in various biological processes.</p>Formule :C10H15N4O15P3Couleur et forme :SolidMasse moléculaire :524.164Anticancer agent 263
<p>Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.</p>Formule :C13H20N2O6Couleur et forme :SolidMasse moléculaire :300.308Obtustatin
<p>Potent α1β1 integrin inhibitor, 0.8 nM IC50 for IV collagen binding. Selective over other integrins. Inhibits FGF2 angiogenesis; antitumor in mouse models.</p>Formule :C184H284N52O57S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4393.07PDI-IN-4
<p>PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb/IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.</p>Formule :C17H12F3NO2Couleur et forme :SolidMasse moléculaire :319.278Ceftriaxone
CAS :<p>Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.</p>Formule :C18H18N8O7S3Degré de pureté :96.08%Couleur et forme :SolidMasse moléculaire :554.58PLK1-IN-2
CAS :<p>PLK1-IN-2 is a PLK1 kinase inhibitor with an IC 50 value of 0.384 μM.</p>Formule :C24H27FN8OSCouleur et forme :SolidMasse moléculaire :494.59Cytarabine triphosphate
CAS :<p>Ara-CTP, active Cytarabine metabolite, inhibits DNA synthesis, predicts leukemic chemosensitivity.</p>Formule :C9H16N3O14P3Couleur et forme :SolidMasse moléculaire :483.163'-Deoxy-GTP trisodium
<p>3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) trisodium, an analog of GTP, functions as an RNA chain terminator, thereby inhibiting RNA synthesis. It is capable of suppressing dengue virus DENV NS5 RdRp with an IC50 value of 0.02 μM.</p>Couleur et forme :Odour Solidc-Myc inhibitor 7
CAS :<p>c-Myc inhibitor 7 degrades c-MYC, CK1α, GSPT1, IKZF1/2/3 proteins in tumors, for research on related diseases.</p>Formule :C35H30N6O5Couleur et forme :SoildMasse moléculaire :614.65Mps1-IN-6
<p>Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].</p>Formule :C35H39N9O3Couleur et forme :SolidMasse moléculaire :633.74Antibacterial agent 144
<p>Antibacterial Agent 144 (compound 8e) exhibits superior efficacy against multi-resistant Staphylococcus aureus compared to Chloromycin and Amoxicillin.</p>Formule :C26H23N7O3Couleur et forme :SolidMasse moléculaire :481.51CDK9 inhibitor HH1
CAS :<p>CDK9 inhibitor HH1 (8019-9719) is an inhibitor of the human CDK2-cyclin A2 complex with an IC50 value of 2 μM.</p>Formule :C13H15N3OSDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :261.34Carbazole
CAS :<p>Carbazole belongs to the class of carbazole-based organic compounds. Carbazole can form novel DNA small groove complexes, inhibiting the synthesis of new DNA or RNA.</p>Formule :C12H9NDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :167.211Py-MAA-Val-Cit-PAB-DX8951
CAS :<p>Py-MAA-Val-Cit-PAB-DX8951, a purine toxin, serves as an intermediate in the synthesis of antibody-drug conjugates [1].</p>Formule :C57H66FN11O13SCouleur et forme :SolidMasse moléculaire :1164.26
