Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(114 produits)
- CDK(546 produits)
- Arrêt du cycle cellulaire(5 produits)
- Chk(48 produits)
- DYRK(47 produits)
- Dynamine(27 produits)
- Ferroptose(226 produits)
- HSP(179 produits)
- Intégrine(251 produits)
- Kinésine(87 produits)
- LIM Kinase(20 produits)
- Microtubules associés(274 produits)
- PKC(124 produits)
- PLK(25 produits)
- ROCK(62 produits)
- Rho(6 produits)
- Wee1(14 produits)
- c-Myc(76 produits)
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3870 produits trouvés pour "Cycle cellulaire/point de contrôle"
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Cimpuciclib
CAS :Cimpuciclib is a cyclin-dependent kinase(CDK) inhibitor and antineoplastic.Formule :C30H35FN8OCouleur et forme :SolidMasse moléculaire :542.6635'-O-TBDMS-dU
CAS :5'-O-TBDMS-dU can be used in the synthesis of oligoribonucleotides.Formule :C15H26N2O5SiCouleur et forme :SolidMasse moléculaire :342.467AURKA against 1
Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.Formule :C28H32FN9O2Couleur et forme :SolidMasse moléculaire :545.61Antibacterial agent 271
Antibacterialagent 271 is an antimicrobial compound that significantly inhibits Escherichia coli, with a minimum inhibitory concentration (MIC) of 2.2 μM. It disrupts bacterial membrane integrity, reducing metabolic activity. By binding to DNA grooves, it inhibits replication and induces reactive oxygen species (ROS) accumulation, leading to bacterial death. Antibacterialagent 271 shows considerable potential in combating bacterial infections.Couleur et forme :Odour SolidFarletuzumab
CAS :Farletuzumab (MORAb-003), a humanized antibody, inhibits FRα-expressing cell growth for cancer research.Degré de pureté :> 95%Couleur et forme :LiquidMasse moléculaire :145.36 kDam7GpppGmpG
CAS :m7GpppGmpG, a trinucleotide 5′ cap analog, exhibits capping efficiencies of 86% for the RNAs obtained [1].Formule :C32H43N15O25P4Couleur et forme :SolidMasse moléculaire :1161.66CDK9 ligand 3
CAS :CDK9ligand 3 is a ligand for CDK9 and can be utilized in the synthesis of PROTAC degraders, specifically PROTAC CDK9degrader-11.Formule :C18H18BrCl2N5O3Couleur et forme :SolidMasse moléculaire :503.177JAMM protein inhibitor 2
CAS :JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.Formule :C21H26N2O2Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :338.44CDK1-IN-2
CAS :CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM.Formule :C17H11ClN2ODegré de pureté :98.53%Couleur et forme :SoildMasse moléculaire :294.73Ref: TM-T64373
1mg50,00€5mg107,00€10mg170,00€25mg354,00€50mg567,00€100mg810,00€500mg1.644,00€1mL*10mM (DMSO)103,00€KWR137
KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.Formule :C33H31ClF3N9O4Couleur et forme :SolidMasse moléculaire :710.105PROTAC CDK9 degrader-8
PROTAC CDK9 Degrader-8 (Compound 21) is a potent degrader of CDK9 with an IC50 of 0.01 μM, utilized in cancer research [1].Formule :C44H52Cl2N10O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :903.85CTP Synthetase-IN-1 Ammonium salt
CTP Synthetase-IN-1 Ammonium salt is a CTPS inhibitor with potential antibacterial, anti-inflammatory, and antitumor activity for the study of SARS-CoV-2 viral infectionsFormule :C20H22F3N7O3S2Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :529.56Py-MAA-Val-Cit-PAB-DX8951
CAS :Py-MAA-Val-Cit-PAB-DX8951, a purine toxin, serves as an intermediate in the synthesis of antibody-drug conjugates [1].Formule :C57H66FN11O13SCouleur et forme :SolidMasse moléculaire :1164.262'-Deoxy-2'-fluoro-N3-[(pyrid-2-yl)methyl]uridine
2’-Deoxy-2’-fluoro-N3-[(pyrid-2-yl)methyl]uridine, a uridine analogue, exhibits potential for antiepileptic applications.Formule :C15H16FN3O5Couleur et forme :SolidMasse moléculaire :337.3SMS 121
CAS :SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.Formule :C20H21NO5Degré de pureté :98.29%Couleur et forme :SoildMasse moléculaire :355.38HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt
CAS :HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt inhibits pre-miR-21 RNA, potential for cancer research.Formule :C57H62N8O10SCouleur et forme :SolidMasse moléculaire :1051.21Ribonuclease T1
CAS :Rnase T1, an endonuclease, degrades single-stranded RNA to yield 3'-GMP oligonucleotides.
Couleur et forme :Solidwrwyar-NH2 TFA
wrwyar-NH2 (TFA) serves as the control peptide for wrwycr-NH2.Couleur et forme :Odour SolidDemycarosyl-3D-β-D-digitoxosylmithramycin SK
CAS :Demycarosyl-3D-β-D-digitoxosylmithramycin SK, an analog of Mithramycin, exhibits potent anti-tumor activity.Formule :C50H72O23Couleur et forme :SolidMasse moléculaire :1041.099-(5(R)-C-Methyl-2,3,5-tri-O-benzoyl-D-ribofuranosyl)-6-chloropurine
9-(5(R)-C-Methyl-2,3,5-tri-O-benzoyl-D-ribofuranosyl)-6-chloropurine: A purine analog with antitumor effects, inhibiting DNA synthesis and inducing apoptosis.Formule :C32H25ClN4O7Couleur et forme :SolidMasse moléculaire :613.025-Methylcytidine 5′-triphosphate
CAS :5-Methylcytidine 5′-triphosphate (5-Methyl-CTP), a modified nucleoside triphosphate, enhances translational properties and stability while reducing innateFormule :C10H18N3O14P3Couleur et forme :SolidMasse moléculaire :497.18DIZ-3
CAS :DIZ-3: Selective G4 ligand, stabilizes structure, inhibits ALT cancer cell growth by inducing cell cycle arrest and apoptosis.Formule :C46H44F2N8Couleur et forme :SolidMasse moléculaire :746.89N3-[(Pyrid-4-yl)methyl]uridine
N3-[(Pyrid-4-yl)methyl]uridine, a uridine analog, may have antiepileptic properties and aid in researching anticonvulsants and anxiolytics.Formule :C15H17N3O6Couleur et forme :SolidMasse moléculaire :335.31Ceftriaxone
CAS :Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.Formule :C18H18N8O7S3Degré de pureté :96.08%Couleur et forme :SolidMasse moléculaire :554.58DNA Gyrase-IN-12
DNA Gyrase-IN-12 (Compound 6d) is an inhibitor of DNA gyrase. It exhibits antibacterial activity with MIC values ranging from 0.031 to 0.0625 μg/mL against Vancomycin-Intermediate Staphylococcus aureus (VISA) and Enterococcus faecium.Couleur et forme :Odour SolidSubquinocin
Subquinocin is a CYLD inhibitor that suppresses deubiquitinating enzymes (DUB) of the USP family. By inhibiting CYLD, Subquinocin enhances the activation of the NF-κB and IFN pathways. Additionally, Subquinocin facilitates the activation of IRF3 and/or IRF7 in the RIG-I-mediated interferon pathway.Formule :C20H27N3O4SCouleur et forme :SolidMasse moléculaire :405.17223Endo-1,4-β-xylanase
CAS :Endo-1,4-β-xylanase (CtXyn11A) is a type of xylan hydrolase that hydrolyzes the β-1,4-glycosidic bond of the xylan molecule.Couleur et forme :Solidm7GpppUmpG
CAS :m7GpppUmpG, a trinucleotide cap analogue, enables RNA synthesis with cap 0 or 1 structures.Formule :C31H42N12O26P4Couleur et forme :SolidMasse moléculaire :1122.63Ac-MRGDH-NH2
Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.Formule :C25H41N11O8SCouleur et forme :SolidMasse moléculaire :655.727α2β1 Integrin Ligand Peptide
CAS :The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellularFormule :C14H22N4O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :390.35Echistatin
CAS :Potent αVβ3 integrin blocker, stops osteoclast binding & bone loss, hinders platelet aggregation. Ki=0.27 nM, IC50s: 0.1 nM (bone), 30 nM (platelets).Formule :C217H341N71O74S9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5417.12'-OMe-Ac-C Phosphoramidite
CAS :2'-OMe-Ac-C Phosphoramidite, a modified phosphoramidite, is utilized in the synthesis of oligonucleotides.Formule :C42H52N5O9PCouleur et forme :SolidMasse moléculaire :801.86GS-443902 trisodium
CAS :GS-443902 trisodium, a strong RdRp blocker, inhibits RSV/HCV with IC50 of 1.1/5 μM and is Remdesivir's active form.Formule :C12H16N5O13P3·xNaCouleur et forme :SolidRev 2'-O-MOE-5MeC(Bz)-5'-amidite
Rev 2’-O-MOE-5MeC(Bz)-5’-amidite, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Formule :C50H60N5O10PCouleur et forme :SolidMasse moléculaire :922.01Clofarabine-5'-diphosphate
CAS :Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK). It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Formule :C10H13ClFN5O9P2Couleur et forme :SolidMasse moléculaire :463.64GK13S
G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.Formule :C21H22N6O2Couleur et forme :SolidMasse moléculaire :390.446-Amino-4-hydrozino-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine
6-Amino-4-hydrozino-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine, a pyrimidine nucleoside analog, boasts a broad spectrum of biochemical andFormule :C10H17N7O3Couleur et forme :SolidMasse moléculaire :283.29PROTAC CDK9 degrader-11
CAS :PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC CDK9 degrader with a DC50 of 1.09 nM. This compound exhibits cytotoxicity in small cell lung cancer (SCLC) cells, with IC50 values in the nanomolar range. It induces cell cycle arrest at the G0/G1 phase and inhibits cell invasion in DMS114 and DMS53 cells. In addition, PROTAC CDK9 degrader-11 shows antitumor activity in an NCI-H446 xenograft mouse model. (Pink: ligand for target protein CDK9 ligand 3; Black: linker; Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56)Formule :C39H48Cl2N10O5Couleur et forme :SolidMasse moléculaire :807.768PKMYT1-IN-3
PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.Formule :C24H26FN5O2Couleur et forme :SolidMasse moléculaire :435.49TFMU-ADPr triethylamine
TFMU-ADPr triethylamine is a substrate for PARG activity measurement, releasing a fluorophore to indicate PAR hydrolase activity.Formule :C25H26F3N5O16P2·5C6H15NCouleur et forme :SolidMasse moléculaire :1024.42YKL-5-124 TFA
CAS :YKL-5-124 TFA is a potent CDK7 inhibitor (IC50: 53.5 nM), more than 100x selective over CDK9/2, not active on CDK12/13, and disrupts the cell cycle.Formule :C30H34F3N7O5Couleur et forme :SolidMasse moléculaire :629.63Viquidacin
CAS :NXL-101, an oral/IV antibiotic for Gram-positive bacteria like MRSA, was discontinued by Novexel in 2008.Formule :C25H29FN2O4S2Couleur et forme :SolidMasse moléculaire :504.64IRE1-IN-2
IRE1-IN-2 (compound G15) functions as a potent inhibitor of IRE1. It effectively suppresses lipid accumulation induced by FFA, exhibiting an IC50 value of 2.06 μM.Formule :C16H20O6Couleur et forme :SolidMasse moléculaire :308.125995'-O-DMTr-2'-O-MOE inosine 3'-P-methyl phosphonamidite
5’-O-DMTr-2’-O-MOE inosine 3’-P-methyl phosphonamidite, a purine nucleoside analog, exhibits extensive antitumor activity specific to indolent lymphoidFormule :C41H52N5O8PCouleur et forme :SolidMasse moléculaire :773.85Garenoxacin
CAS :Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.Formule :C23H20F2N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.41ddGTP trisodium
ddGTP trisodium, a ddNTP, inhibits or serves as a substrate for DNA polymerase α, halting DNA chain elongation.Formule :C10H13N5Na3O12P3Couleur et forme :SolidMasse moléculaire :557.13CD532 hydrochloride
CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.Couleur et forme :SolidPseudouridimycin
CAS :Pseudouridimycin: a C-nucleoside antibiotic, inhibits bacterial RNAP, targets Gram-negative and Gram-positive bacteria.Formule :C17H26N8O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :486.44Censavudine
CAS :Censavudine (OBP-601) is an HIV-1/2 treatment and prevention drug, a reverse transcriptase inhibitor with EC50 of 30-890 nM.Formule :C12H12N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :248.23Filanesib TFA
CAS :Filanesib (ARRY-520) inhibits KSP, triggering mitotic arrest and cell death in dividing tumor cells.
Formule :C22H23F5N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :534.5
