Altération de l'ADN/réparation de l'ADN
Les inhibiteurs de la réparation des dommages à l'ADN sont des composés qui interfèrent avec les processus impliqués dans la détection et la réparation des dommages à l'ADN. Ces inhibiteurs sont essentiels pour étudier les mécanismes de la stabilité génomique, de la mutagenèse et de la réponse aux dommages à l'ADN. Ils sont également importants dans la recherche sur le cancer, car de nombreuses tumeurs dépendent de voies spécifiques de réparation de l'ADN pour survivre. En inhibant ces voies, les inhibiteurs de la réparation des dommages à l'ADN peuvent améliorer l'efficacité de la chimiothérapie et de la radiothérapie. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité de la réparation des dommages à l'ADN pour soutenir vos recherches en biologie moléculaire, oncologie et pharmacologie.
Sous-catégories appartenant à la catégorie "Altération de l'ADN/réparation de l'ADN"
- ATM/ATR(71 produits)
- Alkylation de l'ADN(11 produits)
- Méthyltransférase de l’ADN(421 produits)
- Gyrase de l’ADN(11 produits)
- ADN-PK(51 produits)
- MTH1(1 produits)
- Antimétabolite nucléosidique/analogue(1.388 produits)
- Transcriptase inverse(43 produits)
- Sirtuine(88 produits)
- Télomérase(33 produits)
- Topoisomérase(136 produits)
Affichez 3 plus de sous-catégories
957 produits trouvés pour "Altération de l'ADN/réparation de l'ADN"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
GED-0507-34 Levo
CAS :<p>GED-0507-34 Levo,(S)-3-(4-Aminophenyl)-2-methoxypropanoic acid,an orally available PPARγ modulator for amelioration of inflammation-driven intestinal fibrosis.</p>Formule :C10H13NO3Degré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :195.22MC3482
CAS :<p>MC3482 is a specific inhibitor of sirtuin5 (SIRT5).</p>Formule :C33H38N4O8Degré de pureté :98% - 99.90%Couleur et forme :SoildMasse moléculaire :618.68Carboplatin
CAS :<p>Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor.</p>Formule :C6H12N2O4PtDegré de pureté :98% - 99.72%Couleur et forme :White Crystalline PowderMasse moléculaire :371.25SIRT-IN-2
CAS :<p>SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).</p>Formule :C15H21N5O3S2Degré de pureté :98.26%Couleur et forme :SolidMasse moléculaire :383.49Bendamustine hydrochloride
CAS :<p>Bendamustine hydrochloride (EP-3101) (IC50 of 50 μM) is an alkylating agent associated with DNA damage.</p>Formule :C16H21Cl2N3O2·HClDegré de pureté :97.71%Couleur et forme :SolidMasse moléculaire :394.72Ciprofloxacin
CAS :<p>Ciprofloxacin (Bay-09867) mainly targets bacterial DNA Gyrase (IC50=0.22-0.31 µM) and topoisomerase IV (IC50=0.3-1.9 µM). antibiotic. High-Quality, Low-Cost!</p>Formule :C17H18FN3O3Degré de pureté :98.77% - 99.91%Couleur et forme :White PowderMasse moléculaire :331.34Ceramides Mixture
CAS :<p>Ceramides Mixture: endogenous, regulates cell cycle, growth, and telomerase activity, with hydroxy/non-hydroxy fatty acids.</p>Formule :C36H71NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :581.967Gimeracil
CAS :<p>Gimeracil (Gimestat) is a competitive, reversible inhibitor of dihydropyrimidine dehydrogenase.</p>Formule :C5H4ClNO2Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :145.54Ganciclovir
CAS :<p>Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus.</p>Formule :C9H13N5O4Degré de pureté :99.55% - 99.58%Couleur et forme :White PowderMasse moléculaire :255.23Adenine
CAS :<p>Adenine: a purine nucleobase vital for ATP, NAD, FAD production, and DNA/RNA synthesis.</p>Formule :C5H5N5Degré de pureté :99.39% - 99.95%Couleur et forme :SolidMasse moléculaire :135.13Gatifloxacin
CAS :<p>Gatifloxacin (CG5501), a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA gyrase and topoisomerase IV.</p>Formule :C19H22FN3O4Degré de pureté :99.50% - 99.85%Couleur et forme :White PowderMasse moléculaire :375.39Zidovudine
CAS :<p>Zidovudine, a synthetic dideoxynucleoside, blocks DNA replication by inhibiting DNA polymerase after activation.</p>Formule :C10H13N5O4Degré de pureté :99.84% - 99.91%Couleur et forme :White To Off-White CrystalsMasse moléculaire :267.245-Azacytidine
CAS :<p>5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity.</p>Formule :C8H12N4O5Degré de pureté :99.31% - 99.79%Couleur et forme :Crystals From Methanol Physical Description White Crystalline Powder (Ntp 1992)Masse moléculaire :244.2BRD 4354
CAS :<p>BRD 4354 is an inhibitor of HDAC5 and HDAC9. For HDAC5 and HDAC9, the IC50s values are 0.85 and 1.88 μM, respectively.</p>Formule :C21H23ClN4ODegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :382.89Norfloxacin
CAS :<p>Norfloxacin (MK-0366)(Norxacin) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.</p>Formule :C16H18FN3O3Degré de pureté :98.54% - 99.83%Couleur et forme :White To Light-Yellow Crystalline Powder SolidMasse moléculaire :319.33Methotrexate
CAS :<p>Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR.</p>Formule :C20H22N8O5Degré de pureté :96.84% - 99.91%Couleur et forme :Orange-Brown Crystalline Powder Chemotherapy Drug That Interferes With Dna And Rna SynthesisMasse moléculaire :454.44Hydroxychloroquine sulfate
CAS :<p>Hydroxychloroquine sulfate (Acidum iopanoicum) inhibits plasmodial heme polymerase.</p>Formule :C18H26ClN3O·H2SO4Degré de pureté :98.92% - 99.88%Couleur et forme :Odorless SolidMasse moléculaire :433.95NTP42
CAS :<p>NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)</p>Formule :C25H23F2N3O5SDegré de pureté :97.55%Couleur et forme :SolidMasse moléculaire :515.53Abexinostat
CAS :<p>Abexinostat (PCI-24781) is a pan-HDAC inhibitor, strongest on HDAC1; less so on HDACs 2, 3, 6, 10. Very select for HDAC8. In Phase 1/2 trials.</p>Formule :C21H23N3O5Degré de pureté :98.19% - 98.43%Couleur et forme :SolidMasse moléculaire :397.42Ifosfamide
CAS :<p>Ifosfamide (NSC-109724), a prodrug, is a cyclophosphamide analog with antineoplastic action by DNA alkylation and crosslinking.</p>Formule :C7H15Cl2N2O2PDegré de pureté :99.86% - ≥95%Couleur et forme :SolidMasse moléculaire :261.09Altretamine
CAS :<p>Altretamine (ENT-50852) is an alkylating agent with antineoplastic activity.</p>Formule :C9H18N6Degré de pureté :99.54%Couleur et forme :Less Crystalline Solid Insoluble In Water (Ntp 1992) Physical Description Colorless Crystalline Solid Insoluble In Water (Ntp 1992)Masse moléculaire :210.28MSDC-0602K
CAS :<p>MSDC-0602K, a Ps-TZD, targets PPARγ (IC50: 18.25 μM) and MPC, may help study fatty liver, lipid imbalance, inflammation, and insulin issues.</p>Formule :C19H16KNO5SDegré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :409.5Nalidixic acid
CAS :<p>Nalidixic acid (NSC-82174), a synthetic antimicrobial, targets bacterial DNA gyrase A, with a narrow bactericidal range.</p>Formule :C12H12N2O3Degré de pureté :99.9% - 99.95%Couleur et forme :Pale Buff Crystalline Powder Physical Description Cream-Colored Powder (Ntp 1992)Masse moléculaire :232.24AES-135
CAS :<p>AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity.</p>Formule :C33H29F6N3O5SDegré de pureté :97.72%Couleur et forme :SolidMasse moléculaire :693.66Sparfloxacin
CAS :<p>Sparfloxacin (CI-978) is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.</p>Formule :C19H22F2N4O3Degré de pureté :99.67% - >99.99%Couleur et forme :Light Yellow PowderMasse moléculaire :392.40Acyclovir
CAS :<p>Acyclovir (Aciclovir) is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2,</p>Formule :C8H11N5O3Degré de pureté :99.77% - >99.99%Couleur et forme :Crystals From Methanol SolidMasse moléculaire :225.2Levetiracetam
CAS :<p>Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset</p>Formule :C8H14N2O2Degré de pureté :99.67% - 99.86%Couleur et forme :White Crystalline PowderMasse moléculaire :170.21Ledoxantrone trihydrochloride
CAS :<p>Ledoxantrone trihydrochloride is a Top II inhibitor with anticancer activity and is used in the study of digestive disorders and urologic disorders.</p>Formule :C21H30Cl3N5OSDegré de pureté :98.13%Couleur et forme :SoildMasse moléculaire :506.92Abacavir
CAS :<p>Abacavir (Ziagen) is a nucleoside reverse transcriptase inhibitor analog of guanosine.</p>Formule :C14H18N6ODegré de pureté :99.36% - 99.81%Couleur et forme :White PowderMasse moléculaire :286.33Elimusertib hydrochloride(1876467-74-1 free base)
<p>Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumor</p>Formule :C20H22ClN7ODegré de pureté :98.8% - 99.03%Couleur et forme :SolidMasse moléculaire :411.89RBN-2397
CAS :<p>RBN-2397 is a potent, selective and orally active accross species NAD+ competitive PARP7 inhibitor with IC50 less than 3 nM.</p>Formule :C20H23F6N7O3Degré de pureté :98.48% - 99.8%Couleur et forme :SolidMasse moléculaire :523.43Enoxacin
CAS :<p>Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.</p>Formule :C15H17FN4O3Degré de pureté :98.68% - 99.89%Couleur et forme :Off-White To Yellow CrystalsMasse moléculaire :320.32Foscarnet sodium
CAS :<p>Foscarnet sodium (Phosphonoformate) is an antiviral agent used in the treatment of cytomegalovirus retinitis.</p>Formule :CNa3O5PDegré de pureté :98.52%Couleur et forme :White Or Almost White Crystalline PowderMasse moléculaire :191.95NSC 31150
CAS :<p>Indomethacin sodium hydrate (Indometacin sodium hydrate) is a COX1/2 inhibitor that induces migraine headaches and may be used in studies of rheumatoid joints.</p>Formule :C10H5Cl2NO2SDegré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :274.12STL127705
CAS :<p>STL127705 inhibits Ku 70/80 protein & DNA-PKCS kinase, IC50s: 3.5 μM & 2.5 μM.</p>Formule :C22H20FN5O4Degré de pureté :99.53% - 99.81%Couleur et forme :SolidMasse moléculaire :437.42Niraparib (R-enantiomer)
CAS :<p>Niraparib R-enantiomer (MK 4827 R-enantiomer) is an inhibitor of PARP1(IC50 of 2.4 nM).</p>Formule :C19H20N4ODegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :320.39Gemfibrozil
CAS :<p>Gemfibrozil, a fibric acid derivative, stimulates PPARalpha, boosts fatty acid oxidation, LPL, lowers VLDL-C, apoC-III, and raises HDL-C.</p>Formule :C15H22O3Degré de pureté :99.53% - 99.88%Couleur et forme :Crystals From Hexane SolidMasse moléculaire :250.33Enoxacin hydrate
CAS :<p>Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.</p>Formule :C15H17FN4O3H2ODegré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :347.34Thio-TEPA
CAS :<p>Thio-TEPA (Tiofosyl) is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.</p>Formule :C6H12N3PSDegré de pureté :98.45% - 99.07%Couleur et forme :White Crystals Or PowderMasse moléculaire :189.22Ramatroban
CAS :<p>Ramatroban (BAY u3405) (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis.</p>Formule :C21H21FN2O4SDegré de pureté :98.75% - >99.99%Couleur et forme :Crystalline SolidMasse moléculaire :416.47LTURM34
CAS :<p>LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM.</p>Formule :C24H18N2O3SDegré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :414.48XR-11576 HCl
<p>XR-11576 HCl is a novel orally active dual topoisomerase I and II inhibitor with antitumor activity.</p>Formule :C23H25ClN4O2Degré de pureté :98.52%Couleur et forme :SoildMasse moléculaire :424.92Flumequine
CAS :<p>Flumequine (R-802) is a broad-spectrum antibiotic targeting DNA gyrase and topoisomerase IV in Gram-positive and Gram-negative bacteria.</p>Formule :C14H12FNO3Degré de pureté :98.92% - 99.4%Couleur et forme :White Crystalline Powder SolidMasse moléculaire :261.25Ciprofloxacin monohydrochloride
CAS :<p>Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.</p>Formule :C17H18FN3O3·HClDegré de pureté :99.5% - >99.99%Couleur et forme :White Or Light Yellow Crystalline PowderMasse moléculaire :367.80Telomerase-IN-2
CAS :<p>Telomerase-IN-2 (Telomerase inhibitor 2) shows potent inhibitory activity against telomerase by decreasing the expression of dyskerin (IC50: 0.89 µM).</p>Formule :C34H39N3O9Degré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :633.69LY518674
CAS :<p>LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis.</p>Formule :C23H27N3O4Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :409.48Topixantrone 2HCl
CAS :<p>Topixantrone 2HCl is a DNA topoisomerase inhibitor with antitumor activity for the study of gastric and prostate cancer.</p>Formule :C21H28Cl2N6O2Degré de pureté :99.96% - >99.99%Couleur et forme :SoildMasse moléculaire :467.39Lomefloxacin
CAS :<p>Lomefloxacin (SC47111A) is a synthetic broad-spectrum fluoroquinolone with antibacterial activity.</p>Formule :C17H19F2N3O3Degré de pureté :98.59%Couleur et forme :Off-White To Yellow CrystalsMasse moléculaire :351.35Clofibric acid
CAS :<p>Clofibric acid (Chlorofibrinic acid) is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.</p>Formule :C10H11ClO3Degré de pureté :99.47% - 99.8%Couleur et forme :Pale Yellow SolidMasse moléculaire :214.65Tallimustine HCl
CAS :<p>Tallimustine HCl, an AT-specific alkylating agent, treats leukemia in immunodeficiency mouse models.</p>Formule :C32H39Cl3N10O4Degré de pureté :98.52%Couleur et forme :SoildMasse moléculaire :734.08Pefloxacin Mesylate
CAS :<p>Pefloxacin Mesylate (Pefloxacinium mesylate) is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-</p>Formule :C18H24FN3O6SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :429.46Ofloxacin
CAS :<p>Ofloxacin (Oxaldin) is a fluoroquinolone antibacterial antibiotic.</p>Formule :C18H20FN3O4Degré de pureté :99.33% - 99.87%Couleur et forme :Off-White SolidMasse moléculaire :361.37Nalidixic acid sodium salt
CAS :<p>Nalidixic acid sodium salt (Baktogram) is an antimicrobial agent with a limited bacteriocidal spectrum.</p>Formule :C12H11N2NaO3Degré de pureté :99.72% - 99.95%Couleur et forme :White To Off-White PowderMasse moléculaire :254.22Chlorambucil
CAS :<p>Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard.</p>Formule :C14H19Cl2NO2Degré de pureté :97.37% - 98.45%Couleur et forme :Off-White Slightly Granular Powder Melting Point 65-69°CMasse moléculaire :304.21Lurtotecan
CAS :<p>Lurtotecan (GI147211) is a semisynthetic Camptothecin analog. Lurtotecan is a topoisomerase I inhibitor with anticancer effects.</p>Formule :C28H30N4O6Degré de pureté :99.18%Couleur et forme :SoildMasse moléculaire :518.561-Naphthohydroxamic acid
CAS :<p>1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1</p>Formule :C11H9NO2Degré de pureté :99.19%Couleur et forme :SolidMasse moléculaire :187.19G150
CAS :<p>G150 suppresses DSDNA-induced interferon; IC50: 10.2 nM. It's a potent, selective H-CGAS inhibitor.</p>Formule :C18H16Cl2N4O2Degré de pureté :97.75%Couleur et forme :SolidMasse moléculaire :391.25Dihydro-5-azacytidine FA
<p>Dihydro-5-azacytidine FA (DHAC) is a pyrimidine analog that has antitumor activity, inhibits cell growth, inhibits DNA methylation, and may be used in the study of malignant mesothelioma.</p>Formule :C9H16N4O7Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :292.25Teniposide
CAS :<p>Teniposide (VM26), a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II and</p>Formule :C32H32O13SDegré de pureté :97.7% - 99.45%Couleur et forme :White Or Off-White Crystalline PowderMasse moléculaire :656.65Cetaben
CAS :<p>Cetaben, a non-fibrotic drug, lowers cholesterol and triglycerides without PPARα activation.</p>Formule :C23H39NO2Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :361.56Moxifloxacin hydrochloride
CAS :<p>Moxifloxacin hydrochloride (BAY12-8039 HCl) is a fourth generation fluoroquinolone with expanded activity against gram-positive bacteria and atypical pathogens.</p>Formule :C21H25ClFN3O4Degré de pureté :99.91% - >99.99%Couleur et forme :SolidMasse moléculaire :437.89Cisplatin
CAS :<p>Cisplatin (CDDP) is a DNA cross-linking agent.</p>Formule :Cl2H6N2PtDegré de pureté :97.13% - 99.63%Couleur et forme :Orange-Yellow To Deep Yellow Solid Or PowderMasse moléculaire :300.04Candesartan
CAS :<p>Candesartan (CV 11974) is an angiotensin II receptor blocker used widely in the therapy of hypertension and heart failure.</p>Formule :C24H20N6O3Degré de pureté :98.3% - 99.55%Couleur et forme :Colorless Solid CrystallineMasse moléculaire :440.47Decitabine
CAS :<p>Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity.</p>Formule :C8H12N4O4Degré de pureté :98.06% - 99.87%Couleur et forme :Physical Description Fine White Crystalline Powder Used As A DrugMasse moléculaire :228.21HDAC-IN-40
CAS :<p>HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with Ki of 60 nM and 30 nM for HDAC2 and HDAC6, respectively. HDAC-IN-40 had antitumor effects</p>Formule :C15H22N2O6Degré de pureté :99.04%Couleur et forme :SoildMasse moléculaire :326.35Levofloxacin hydrate
CAS :<p>Levofloxacin hydrate (Cravit hydrate) is a third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.</p>Formule :C18H20FN3O4H2ODegré de pureté :98.26%Couleur et forme :Pale Yellow SolidMasse moléculaire :370.38YPX-C-05
CAS :<p>YPX-C-05, an isohydroxamic acid derivative, is an HDAC inhibitor with vasodilatory and antihypertensive activity.CAS 번호134608-84-5</p>Formule :C21H19N3O4Degré de pureté :98.09%Couleur et forme :SoildMasse moléculaire :377.39DRF-1042 HCl
<p>DRF-1042 HCl is an orally active camptothecin analog with antitumor activity, inhibits DNA topoisomerase I, and is used in the study of refractory solid tumors.</p>Formule :C22H21ClN2O6Degré de pureté :97.93%Couleur et forme :SolidMasse moléculaire :444.87FEN1-IN-1
CAS :<p>FEN1-IN-1 (LNT-1), a FEN1 active site inhibitor, partly works by coordinating Mg2+ ions.</p>Formule :C15H12N2O5SDegré de pureté :99.65% - 99.80%Couleur et forme :SolidMasse moléculaire :332.33Oxaquin TEA
<p>Oxaquin TEA (MCB-3837 TEA), a precursor compound to MCB3681, is a DNA topoisomerase inhibitor that can be used to study Clostridium difficile infections and</p>Formule :C37H48F2N5O11PDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :807.77Fleroxacin
CAS :<p>Fleroxacin (RO 23-6240) is a broad-spectrum antimicrobial fluoroquinolone. It strongly inhibits the DNA-supercoiling activity of DNA gyrase.</p>Formule :C17H18F3N3O3Degré de pureté :99.58% - 99.79%Couleur et forme :White Needle-Like CrystalsMasse moléculaire :369.34CG347B
CAS :<p>CG347B is a selective inhibitor of HDAC6.</p>Formule :C16H17N3O2Degré de pureté :98.34%Couleur et forme :SolidMasse moléculaire :283.33Balofloxacin
CAS :<p>Balofloxacin, a quinolone antibiotic, can inhibit the synthesis of bacterial DNA by interfering with the DNA gyrase.</p>Formule :C20H24FN3O4Degré de pureté :99.62% - 99.98%Couleur et forme :Crystalline SolidMasse moléculaire :389.42Procarbazine hydrochloride
CAS :<p>Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities.</p>Formule :C12H19N3O·HClDegré de pureté :96.99% - ≥98%Couleur et forme :(Ntp 1992)Masse moléculaire :257.76DC-05
CAS :<p>DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).</p>Formule :C25H25N3ODegré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :383.49Dithranol
CAS :<p>Dithranol (cignoline) is an anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially</p>Formule :C14H10O3Degré de pureté :93.49% - 99.33%Couleur et forme :Physical Description Lemon Yellow Leaflets Or Plates Or An Orange Powder MeltingMasse moléculaire :226.23TRF1-TIN2 interaction-IN-1
<p>TRF1-TIN2 interaction-IN-1 (Compound 40) is an inhibitor of the TRF1-TIN2 interaction. It binds to the TRFH domain of TRF1 (KD= 29 μM) and competitively inhibits the binding of the TIN2 peptide (IC50= 67 μM). By occupying a hotspot at the TRF1-TIN2 interface, TRF1-TIN2 interaction-IN-1 disrupts the interaction between TRF1 and TIN2. This compound can remove TRF1 from the shelterin complex, making it useful for research on shelterin-related cancers.</p>Formule :C19H18O6SCouleur et forme :SolidMasse moléculaire :374.41HDAC6-IN-50
<p>HDAC6-IN-50 (Compound 4) is an effective inhibitor of HDAC6 with an IC50 value of 35 nM. It is utilized in the study of Parkinson's disease (PD) and Alzheimer's disease (AD).</p>Couleur et forme :Odour SolidDB1255 2TFA
<p>DB1255 2TFA is an ERG/DNA binding inhibitor with an unusual and potent monomer binding pattern at the minor groove site for the study of genetic disorders.</p>Formule :C26H20F6N4O4S2Degré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :630.58SIRT2-IN-16
<p>SIRT2-IN-16 (compound 17) is a SIRT2 inhibitor targeted at prostate-specific membrane antigen (PSMA).</p>Formule :C55H91N9O15SCouleur et forme :SolidMasse moléculaire :1150.43Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
CAS :<p>3-Methoxybenzamide derivative modulates sirtuins; may boost cell lifespan and treat diseases.</p>Formule :C20H15N3O2SDegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :361.42CA-M11
<p>CA-M11 (compound CA-M11) is capable of entering the liver's bile salt transport system to release Mirin.</p>Formule :C34H46N2O6SCouleur et forme :SolidMasse moléculaire :610.80NHC-diphosphate triammonium
<p>NHC-triphosphate triammonium is a phosphorylated metabolite of NHC, incorporated into HCV RNA by viral polymerase.</p>Couleur et forme :SolidPB200
<p>PB200, an HDAC6 inhibitor, demonstrates significant antidepressant effects with an IC50 value of 1.97 nM. It operates by normalizing aberrant HDAC6 expression levels and alleviating neuroinflammation.</p>Formule :C17H18FN3O2Couleur et forme :SolidMasse moléculaire :315.34ACT-387042
CAS :<p>ACT-387042 is a Bacterial Topoisomerase Inhibitor, it has broad-spectrum activity against Gram-positive and Gram-negative bacteria.</p>Formule :C23H26FN5O4SCouleur et forme :SolidMasse moléculaire :487.55GW 1929 hydrochloride
CAS :<p>Oral PPARγ agonist with pEC50 of 8.05; low affinity for PPARα, PPARδ. Reduces blood glucose, fatty acids, triglycerides in vivo.</p>Formule :C30H30ClN3O4Couleur et forme :SolidMasse moléculaire :532.04HDAC9-IN-1
<p>HDAC9-IN-1 (Compound 7g) is a potent inhibitor of HDAC9, exhibiting an IC50 of 40 nM. This compound effectively suppresses various human cancer cell lines, induces apoptosis, modulates caspase-related proteins and p38, and results in DNA damage.</p>Formule :C27H22N4O3SCouleur et forme :SolidMasse moléculaire :482.55MST-312
CAS :<p>MST-312, a telomerase inhibitor derived from green tea's EGCG, has research potential in cancer, including MM.</p>Formule :C20H16N2O6Degré de pureté :99.61% - 99.68%Couleur et forme :SolidMasse moléculaire :380.35Topo I/II-IN-1
<p>Topo I/II-IN-1 (compound 7t) is an effective dual inhibitor of Topo I and Topo II. It exhibits significant cytotoxicity against the MCF-7 breast cancer cell line, with an IC50 value of 7.45 μM.</p>Formule :C15H13N3S2Couleur et forme :SolidMasse moléculaire :299.414Tertomotide hydrochloride
CAS :<p>Tertomotide (GV1001) hydrochloride is a peptide vaccine composed of a 16-amino acid sequence from human telomerase reverse transcriptase (hTERT). It exhibits neuroprotective properties and has potential for research in Alzheimer's disease.</p>Formule :C85H147ClN26O21Couleur et forme :SolidMasse moléculaire :1904.69AuL1
<p>AuL1 is a topoisomerase IIα (Top II) inhibitor with DNA intercalating properties. It exhibits cytotoxic effects on tumor cells, making it a potential subject for anticancer agent research.</p>Formule :C29H50AuCl2N5Couleur et forme :SolidMasse moléculaire :736.61WAY-323061
CAS :<p>WAY-323061 is a SIRT2 inhibitor.</p>Formule :C25H21N5O2SDegré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :455.53Melphalan
CAS :<p>Melphalan is an alkylating agent. It has been used in combination with the HDAC inhibitor as a drug for the treatment of multiple myeloma (MM) cell lines and as a chemotherapy agent for breast cancer cell lines.</p>Formule :C13H18Cl2N2O2Masse moléculaire :305.219-Nitrooleate
CAS :<p>Nitrated fatty acids like nitrolinoleate and nitrooleate serve as PPARγ ligands and release NO; found in plasma, they aid adipocyte differentiation.</p>Formule :C18H33NO4Couleur et forme :SolidMasse moléculaire :327.465BML-278
CAS :<p>BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and</p>Formule :C24H25NO4Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :391.46Ketopioglitazone
CAS :<p>Ketopioglitazone is an active metabolite of pioglitazone.</p>Formule :C19H18N2O4SCouleur et forme :SolidMasse moléculaire :370.42FKB04
<p>FKB04 is a telomeric repeat binding factor 2 (TRF2) inhibitor that exerts its antitumor activity by disrupting the telomere maintenance mechanisms in hepatocellular carcinoma cells. This leads to T-loop defects, inducing telomere shortening and cellular senescence. Additionally, FKB04 inhibits tumor growth in a human liver cancer xenograft mouse model (by implanting Huh-7 cells in BALB/c mice). This compound is utilized in research focused on liver cancer.</p>Couleur et forme :Odour Solid(±)4(5)-DiHDPA lactone
CAS :<p>(±)5(6)-DiHET lactone is a 1,5 cyclic ester derived from (±)5(6)-DiHET , which, in turn, is a potential derivative of epoxidation of arachidonic acid at the α-5</p>Formule :C22H32O3Couleur et forme :SolidMasse moléculaire :344.495Heliotrine N-oxide
CAS :<p>Heliotrine N-oxide, a PA N-oxide, triggers pyrrolic DNA adducts and may cause liver tumors.</p>Formule :C16H27NO6Couleur et forme :SolidMasse moléculaire :329.393PNU-142586
CAS :<p>PNU-142586 is a bio-active chemical.</p>Formule :C16H20FN3O6Couleur et forme :SolidMasse moléculaire :369.34TAK1 inhibitor
CAS :<p>TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively.</p>Formule :C22H19ClN6O2SDegré de pureté :98%Couleur et forme :SoildMasse moléculaire :466.94Elomotecan hydrochloride
CAS :<p>Elomotecan hydrochloride (BN 80927), a potent hCPT analog, inhibits topoisomerases I/II, outperforming other anticancer drugs.</p>Formule :C29H33Cl2N3O4Couleur et forme :SolidMasse moléculaire :558.51-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC
CAS :<p>Phospholipid with stearic and docosahexaenoic acids used in membrane studies; decreases in ALS mouse model.</p>Formule :C48H84NO8PCouleur et forme :SolidMasse moléculaire :834.16Topoisomerase I/II inhibitor 5
<p>TopoisomeraseI/II inhibitor 5 (compound 1) stabilizes G4 structures through binding and concurrently inhibits the relaxation activities of TopoI and II.</p>Couleur et forme :Odour SolidCP 84364
CAS :<p>CP 84364 is a metabolite of CP-80794.</p>Formule :C14H18N2O4Couleur et forme :SolidMasse moléculaire :278.30Elinafide
CAS :<p>Elinafide, a dinaphthylimide cytotoxic agent, is a DNA-targeted anticancer agent that has shown antitumor activity in in vitro and in vivo assays.</p>Formule :C31H28N4O4Degré de pureté :97.29%Couleur et forme :SolidMasse moléculaire :520.58Murrayanol
<p>Murrayanol is a useful organic compound for research related to life sciences and the catalog number is T125851.</p>Formule :C24H29NO2Couleur et forme :SolidMasse moléculaire :363.501Hippeastrine
CAS :<p>Hippeastrine is an alkaloid that inhibits Top I dose-dependently with a 7.25 μg/mL IC50 and has anticancer properties.</p>Formule :C17H17NO5Couleur et forme :SolidMasse moléculaire :315.32Diflomotecan
CAS :<p>Diflomotecan (BN 80915) is a strong oral topoisomerase I inhibitor with high plasma stability and significant preclinical anti-cancer efficacy.</p>Formule :C21H16F2N2O4Couleur et forme :SolidMasse moléculaire :398.36DNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Couleur et forme :Odour SolidCUDA disodium
<p>CUDA disodium is an effective, soluble epoxide hydrolase (sEH) inhibitor, with IC50 values of 11.1 nM for murine sEH and 112 nM for human sEH. It selectively enhances the activity of peroxisome proliferator-activated receptor PPARalpha. CUDA disodium may be valuable for cardiovascular disease research.</p>Couleur et forme :Odour Solid1-Methyladenosine-d3
<p>1-Methyladenosine-d3 hydrochloride is the hydrochloride salt form of deuterium-labeled 1-Methyladenosine. This compound is a modification of RNA that serves as a biomarker for tumors, with elevated levels in the body linked to cancer development. Upon methylation, 1-Methyladenosine upregulates the expression of PPARδ, regulates cholesterol metabolism, and activates the Hedgehog signaling pathway, thereby driving the onset of liver tumors.</p>Couleur et forme :Odour SolidPyronaridine tetraphosphate
CAS :<p>Pyronaridine tetraphosphate is a DNA topoisomerase 2 inhibitor with antimalarial and antitumor activity for the treatment of P. falciparum infection.</p>Formule :C29H44ClN5O18P4Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :910.03HDAC3/8 ligand-1
<p>HDAC3/8 ligand-1 (compound 40) serves as a ligand for the target protein of PROTAC, utilized in the synthesis of YX968.</p>Formule :C14H22N4OCouleur et forme :SolidMasse moléculaire :262.35DST Crosslinker
CAS :<p>DST is a cleavable, bifunctional crosslinker; it doesn't disrupt protein disulfides, breaks with oxidizers.</p>Formule :C12H12N2O10Couleur et forme :SolidMasse moléculaire :344.232Banoxantrone-d12 dihydrochloride
CAS :<p>Banoxantrone D12, a deuterium-labeled version, transforms into DNA-binding topoisomerase II inhibitor AQ4 upon reduction.</p>Formule :C22H30Cl2N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :529.48Methylation Compound Library
<p>xnum methylation-related compounds that can be used for high-throughput and high-content screening.</p>Couleur et forme :Odour SolidSpCas9 D10A Nickase
<p>SpCas9 D10A Nickase is a variant of the Cas9 protein. This mutation retains the functionality of one cleavage domain of the Cas9 nuclease, allowing it to specifically nick a target single strand. Additionally, SpCas9 D10A Nickase is effective in reducing off-target effects.</p>Anticancer agent 177
<p>Anticanceragent 177 (Compound 11b) is an NAMPT inhibitor and DNA alkylating agent with antitumor activity both in vitro and in vivo.</p>Formule :C28H36Cl2N4O2Masse moléculaire :530.22153GJ071 oxalate
CAS :<p>GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.</p>Formule :C20H29N3O7SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :455.53Corydamine
<p>Corydamine is a useful organic compound for research related to life sciences and the catalog number is T124768.</p>Formule :C20H18N2O4Couleur et forme :SolidMasse moléculaire :350.374(±)4-HDHA
CAS :<p>(±)4-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.</p>Formule :C22H32O3Degré de pureté :97.97%Couleur et forme :SolidMasse moléculaire :344.49Dichlorogelignate
CAS :<p>Dichlorogelignate (compound 4) acts as a selective inhibitor of topoisomerase II (Topo II), achieving 100% inhibition at 50 μM [1].</p>Formule :C32H34O18Couleur et forme :SolidMasse moléculaire :706.6PDPH Crosslinker
CAS :<p>PDPH crosslinker(SPDP Hydrazide) is a lytic heterobisfunctional protein crosslinker.</p>Formule :C8H11N3OS2Couleur et forme :SolidMasse moléculaire :229.32HDAC-IN-52
CAS :<p>HDAC-IN-52: Pyridine-based inhibitor for HDAC1/2/3/10 with IC50s 0.189-0.446 μM, used in cancer studies.</p>Formule :C24H20N4O2Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :396.4415-LOX-IN-2
<p>15-LOX-IN-2 (Compound 2a) is an orally active inhibitor of COX-2/15-LOX and a partial agonist of PPARγ. It exhibits anti-inflammatory activity by inhibiting levels of 20-HETE, IL-1β, and TNF-α in LPS-treated RAW 264.7 cells. Additionally, it significantly enhances glucose uptake without the presence of insulin and is applicable in metabolic disease research.</p>Couleur et forme :Odour Solid20-carboxy Arachidonic Acid
CAS :<p>20-COOH-AA, 20-HETE metabolite, inhibits kidney ion transport, relaxes constricted vessels, and activates PPARα/γ.</p>Formule :C20H30O4Couleur et forme :SolidMasse moléculaire :334.456Amorfrutin B
CAS :<p>Amorfrutin B is a useful organic compound for research related to life sciences. The catalog number is T124211 and the CAS number is 78916-42-4.</p>Formule :C26H32O4Couleur et forme :SolidMasse moléculaire :408.538ABP/PPAR modulator 1
<p>ABP/PPAR modulator 1 is an orally active multi-regulator of FABP and PPAR, exhibiting IC50 values of 0.65 μM for FABP1 and 1.08 μM for FABP4, and EC50 values of 9.19 μM, 2.20 μM, and 1.58 μM for PPARα, PPARγ, and PPARδ, respectively. It demonstrates potent activity against metabolic dysfunction-associated steatohepatitis (MASH). Additionally, ABP/PPAR modulator 1 dose-dependently improves various pathological features of fatty liver in a WD + Carbon tetrachloride-induced MASH mouse model.</p>Formule :C33H39NO7Couleur et forme :SolidMasse moléculaire :561.67Gimatecan HCl
<p>Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.</p>Formule :C25H26ClN3O5Degré de pureté :97.04%Couleur et forme :SoildMasse moléculaire :483.94GpC Methyltransferase
<p>GpC Methyltransferase (GpC) is an enzyme that methylates DNA, specifically targeting cytosine residues within GpC dinucleotides of non-nucleosomal DNA in vitro.</p>AsCas12a Nuclease
<p>AsCas12a Nuclease is a CRISPR nuclease capable of specifically cleaving double-stranded DNA. It is used in gene editing research.</p>25-Hydroxytachysterol3
CAS :<p>25-Hydroxytachysterol3 is a metabolite of Vitamin D3 that inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts while promoting the differentiation of keratinocytes and the expression of antioxidant-related genes. It activates receptors including the vitamin D receptor (VDR), aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXRα/β), and peroxisome proliferator-activated receptor γ (PPARγ), and enhances the expression of CYP24A1.</p>Formule :C27H44O2Couleur et forme :SolidMasse moléculaire :400.64Chimmitecan
CAS :<p>Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent inhibitor of topoisomerase I and displays outstanding activity in vitro and in vivo.</p>Formule :C23H20N2O5Degré de pureté :98.35%Couleur et forme :SoildMasse moléculaire :404.42NHC-diphosphate
CAS :<p>NHC-diphosphate, a phosphorylated β-d-N4-Hydroxycytidine metabolite, is a potent antiviral against VEEV, CHIKV, and HCV.</p>Formule :C9H15N3O12P2Couleur et forme :SolidMasse moléculaire :419.18Larsucosterol Ammonium salt
CAS :<p>Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.</p>Formule :C27H49NO5SDegré de pureté :>99.99% - >99.99%Couleur et forme :SoildMasse moléculaire :499.75nTZDpa
CAS :<p>nTZDpa is an antibiotic with antimicrobial activity.</p>Formule :C22H15Cl2NO2SCouleur et forme :SolidMasse moléculaire :428.33Abd110
CAS :<p>Abd110 (compound 42i), a Lenalidomide-based PROTAC ATR kinase degrader, selectively reduces levels of ATR and phospho-ATR while not impacting the related kinases ATM and DNA-PKcs [1].</p>Formule :C41H42N8O7SCouleur et forme :SolidMasse moléculaire :790.89Pericosine A
CAS :<p>Pericosine A, a fungal metabolite from P. byssoides, shows anticancer effects (GI50s = 0.05-24.55 μM) and EGFR inhibition (40-70% at 100 μg/ml).</p>Formule :C8H11ClO5Couleur et forme :SolidMasse moléculaire :222.62N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide
CAS :<p>N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide: binds CB1 (Ki=365 nM), activates PPARα (EC50=698 nM), reduces rat food intake, no FAAH inhibition.</p>Formule :C27H45NO3Couleur et forme :SolidMasse moléculaire :431.661(iso)-BRD20322
CAS :<p>(iso)-BRD20322 is an isomer of BRD20322, a novel potent inhibitor of spCas9，disrupts the binding of spCas9 to DNA and reduces non-specific DNA editing events.</p>Formule :C27H31N3O2Degré de pureté :99.60% - 99.60%Couleur et forme :SoildMasse moléculaire :429.5517-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
CAS :<p>Aspirin-enhanced COX-2 metabolite of DHA, activates Nrf2 and PPARγ, inhibits inflammation, with EC50 ~200 nM, effective at 5-25 μM.</p>Formule :C22H30O3Couleur et forme :SolidMasse moléculaire :342.479HDAC1/6-IN-2
<p>HDAC1/6-IN-2 (I-c4), a dual inhibitor of HDAC1 and HDAC6, exhibits potent activity with IC50 values of 3.1 nM for HDAC1 and 2.95 nM for HDAC6. This compound demonstrates notable antitumor activity.</p>Formule :C22H17FN4O3Couleur et forme :SolidMasse moléculaire :404.39NHC-triphosphate tetrasodium
<p>NHC-triphosphate tetrasodium, a metabolite of β-d-N4-Hydroxycytidine, acts as a viral polymerase substrate affecting HCV RNA replication.</p>Formule :C9H12N3Na4O15P3Couleur et forme :SolidMasse moléculaire :587.08Banoxantrone (D12)
CAS :<p>Banoxantrone D12, deuterium-labeled version, reduces to AQ4 - a stable DNA-targeting topoisomerase II inhibitor.</p>Formule :C22H28N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :456.55Mca-VDQVDGW-Lys(Dnp)-NH2
<p>Mca-VDQVDGW-Lys(Dnp)-NH2, a fluorogenic substrate specific to caspase-7, facilitates the quantification of caspase-7 activity.</p>Formule :C60H74N14O21Couleur et forme :SolidMasse moléculaire :1327.31Cytidine 5'-diphosphate trisodium salt
CAS :<p>CDP, a trisodium salt, helps synthesize DNA/RNA by aiding phosphoryl transfer from ATP to CMP via UMPK.</p>Formule :C9H15N3Na3O11P2Degré de pureté :99.55%Couleur et forme :White Crystalline PowderMasse moléculaire :472.15Antitumor agent-63
CAS :<p>Compound 40, a non-toxic 20(S)-O-CPT glycoconjugate, is stable, with low Topo I inhibition.</p>Formule :C38H46N4O18Couleur et forme :SolidMasse moléculaire :846.79Berzosertib
CAS :<p>Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity. Cost-effective and quality-assured.</p>Formule :C24H25N5O3SDegré de pureté :97.34% - >99.99%Couleur et forme :SolidMasse moléculaire :463.55Anti-obesity agent 1
<p>Compound 4 (Anti-obesity agent 1) demonstrates potential for enhanced lipolysis, highlighting its anti-obesity characteristics.</p>Formule :C21H22N2O6Couleur et forme :SolidMasse moléculaire :398.409Wistin
CAS :<p>Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist [1] [2] .</p>Formule :C23H24O10Couleur et forme :SolidMasse moléculaire :460.43Topoisomerases/ribosomes-IN-1
<p>Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory actions against constitutively macrolide-resistant bacteria. This compound effectively suppresses bacterial protein synthesis (IC 50 : 0.647 μM) and hampers DNA replication (IC 50 : 0.218 μM).</p>Formule :C53H83FN6O15Couleur et forme :SolidMasse moléculaire :1063.26Monascin
CAS :<p>Monascin: azaphilonoid in red-mold rice; anti-tumor and anti-inflammatory.</p>Formule :C21H26O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :358.43Nanaomycin A
CAS :<p>Nanaomycin A, a quinone antibiotic, reactivates cancer suppressor genes and inhibits DNMT3B (IC50=500nM).</p>Formule :C16H14O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :302.28VH 032 amide-PEG1-acid
CAS :<p>VHL ligand for PROTAC R&D; E3 ligase with PEG1 linker and carboxylic acid for target conjugation.</p>Formule :C28H38N4O7SCouleur et forme :SolidMasse moléculaire :574.69Silatecan
CAS :<p>Silatecan is a useful organic compound for research related to life sciences. The catalog number is T67968 and the CAS number is 220913-32-6.</p>Formule :C26H30N2O5SiCouleur et forme :SoildMasse moléculaire :478.61SMPB Crosslinker
CAS :<p>SMPB crosslinker reacts with sulfhydryl/amino groups, has a longer chain than MBS, and a non-cleavable spacer arm.</p>Formule :C18H16N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.33Amrubicin
CAS :<p>The compound is a synthetic anthracycline antibiotic. It inhibits DNA topoisomerase II.</p>Formule :C25H25NO9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :483.47DMT-dG(ib) Phosphoramidite
CAS :<p>DMT-dG(ib) Phosphoramidite can be used to synthesize DNA.</p>Formule :C44H54N7O8PDegré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :839.92MS9024
<p>MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.</p>Couleur et forme :Odour SolidCHDI 00484077
CAS :<p>CHDI 00484077 is a highly selective, central nervous system (CNS) permeable Class IIa HDAC inhibitor, and can be used to study Huntington's disease.</p>Formule :C18H21F3N4O2Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :382.38ARN24139
<p>ARN24139: a topoisomerase II poison; IC50=7.3μM. Inhibits DU145, HeLa, A549 cell growth; IC50s=4.7, 3.8, 3.1μM.</p>Couleur et forme :SolidSJ-106C
<p>SJ-106C, a SIRT inhibitor, exhibits IC50 values of 0.59, 0.12, and 0.49 μM against SIRT1/2/3, respectively. This compound specifically targets mitochondria and inhibits the growth of DLBCL tumors.</p>Couleur et forme :Odour SolidHDAC-IN-76
<p>HDAC-IN-76 (compound 6i), a histone deacetylase (HDAC) inhibitor, demonstrates robust antimalarial activity, particularly against the asexual blood stages of Plasmodium. The compound exhibits potent efficacy with IC 50 values of 30 nM and 98 nM against Pf3D7 (chloroquine drug-susceptible strain) and PfDd2 (chloroquine drug-resistant strain), respectively. Moreover, HDAC-IN-76 shows selective inhibition towards parasites, displaying IC 50 values of 7 nM and 9 nM against human HDAC1 and HDAC6, respectively, and effectively inhibits PfHDAC1.</p>Formule :C27H26N4O4Couleur et forme :SolidMasse moléculaire :470.52SIRT3 activator 2
<p>SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.</p>Formule :C22H24N2O9SCouleur et forme :SolidMasse moléculaire :492.5Leriglitazone
CAS :<p>Leriglitazone, pioglitazone's metabolite, is a PPARγ agonist (Ki:1.2μM, EC50:680nM), enhancing transcription and stabilizing AF-2.</p>Formule :C19H20N2O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.4423-epi-26-Deoxyactein
CAS :<p>23-epi-26-Deoxyactein is a naturally occurring compound exhibiting anti-obesity and anti-cancer properties when administered orally [1] [2] [3].</p>Formule :C37H56O10Couleur et forme :SolidMasse moléculaire :660.83CAY10599
CAS :<p>CAY10599 has a wide range of applications in life science related research.</p>Formule :C38H41NO5Couleur et forme :SolidMasse moléculaire :591.748STAT3/HDAC-IN-2
<p>STAT3/HDAC-IN-2 (compound 18), a dual inhibitor of STAT3 and HDAC, promotes autophagy and apoptosis. This compound features an amphiphilic hydroxamic acid hybrid structure, derived from the natural product isopropanol lactone (IAL), and functions as a nanoscale anticancer agent. It has the ability to self-assemble into nanoparticles in aqueous environments, leading to enhanced tumor tissue accumulation, increased cellular uptake, and improved anticancer efficacy compared to its free state.</p>Formule :C28H32N2O7Couleur et forme :SolidMasse moléculaire :508.56CL2-MMT-SN38
CAS :<p>CL2-MMT-SN38 is a derivative of SN-38, which is a potent anticancer agent and the active metabolite of Irinotecan (CPT-11), a Topoisomerase I inhibitor.</p>Formule :C102H122N12O24Couleur et forme :SolidMasse moléculaire :1900.15817-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
CAS :<p>DPA metabolite 17-oxo-DPA, found in fish oil, spurs antioxidant genes, modulates inflammation, and activates PPARγ (EC50 ≈ 200 nM).</p>Formule :C22H32O3Couleur et forme :SolidMasse moléculaire :344.495CH-0793076
CAS :<p>CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).</p>Formule :C26H26N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.51Top1/2-IN-1
<p>Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.</p>Formule :C21H21N3O2Couleur et forme :SolidMasse moléculaire :347.4115-deoxy-Δ-12,14-Prostaglandin J2
CAS :<p>15-deoxy-Δ-12,14-Prostaglandin J2 is a PPARγ agonist.</p>Formule :C20H28O3Degré de pureté :98%Couleur et forme :Neat OilMasse moléculaire :316.43Leriglitazone hydrochloride
CAS :<p>Leriglitazone hydrochloride, a pioglitazone metabolite, is a PPARγ agonist with Ki of 1.2 μM and EC50 of 680 nM.</p>Formule :C19H21ClN2O4SCouleur et forme :SolidMasse moléculaire :408.90SP4e
<p>SP4e is a PPAR-γ activator.SP4e was effective in decreasing blood glucose, total cholesterol, triglycerides and LDL levels and increasing HDL levels.</p>Formule :C22H17ClN2O2S2Degré de pureté :99.79%Couleur et forme :SoildMasse moléculaire :440.97NSC 370284
CAS :<p>NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.</p>Formule :C21H25NO6Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :387.43Topoisomerase IIα-IN-9
CAS :<p>Compound EN300-20599, with CAS No. 16346-97-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound EN300-20599 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Formule :C14H14O4SCouleur et forme :SolidMasse moléculaire :278.32Saroglitazar Magnesium
CAS :<p>Saroglitazar Magnesium: a PPAR agonist, strong on PPARα (EC50 0.65pM), moderate on PPARγ (EC50 3nM).</p>Formule :C50H56MgN2O8S2Degré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :901.43Elomotecan
CAS :<p>Elomotecan (BN 80927 free base) is a potent inhibitor of topoisomerases I and II.Cost-effective and quality-assured.</p>Formule :C29H32ClN3O4Couleur et forme :SolidMasse moléculaire :522.04Prednimustine
CAS :<p>Prednimustine (Leo 1031; NSC 134087), an ester of Prednisolone and Chlorambucil, is used in leukemia and lymphoma studies.</p>Formule :C35H45Cl2NO6Couleur et forme :SolidMasse moléculaire :646.64(R)-VX-984
CAS :<p>(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent inhibitor of DNA-PK.</p>Formule :C23H21D2N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.49Tibesaikosaponin V
CAS :<p>TKV, a triterpene diglycoside from Bupleurum chinense, curbs lipid build-up and fat content in adipocytes without harm and hinders fat cell differentiation.</p>Formule :C42H68O15Couleur et forme :SolidMasse moléculaire :812.98PPARγ/GR modulator 1
<p>PPARγ/GR Modulator 1, an orally active dual agonist for the Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) and Glucocorticoid Receptor (GR), exhibits</p>Formule :C14H10FNO4Couleur et forme :SolidMasse moléculaire :275.23Et-29
CAS :<p>Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.</p>Formule :C34H46N6O6SDegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :666.83PPAR agonist 6
<p>PPAR agonist6 (compound 5a) acts as an agonist for PPAR, exhibiting EC50 values of 3.6 μM and 2.6 μM for PPARα and PPARβ/δ respectively. Additionally, PPAR agonist6 inhibits the transactivation of a TNFα-dependent NF-κB-driven reporter gene in L929 cells [1].</p>Couleur et forme :Odour SolidSibiromycin
CAS :<p>Sibiromycin: natural, potent antitumor PBD that binds DNA's minor groove at guanine NH2.</p>Formule :C24H33N3O7Couleur et forme :SolidMasse moléculaire :475.542Hippeastrine Hydrobromide
CAS :<p>Hippeastrine hydrobromide is a natural alkaloid which demonstrates significant cytotoxicity against a panel of human and murine tumor cell lines.</p>Formule :C17H18BrNO5Couleur et forme :SolidMasse moléculaire :396.237AZD-5099
CAS :<p>AZD-5099 is a DNA gyrase modulator potentially for the treatment of bacterial infection.</p>Formule :C21H27Cl2N5O6SCouleur et forme :SolidMasse moléculaire :548.44PARP/HDAC-IN-1
<p>PARP/HDAC-IN-1 is a PARP and HDAC inhibitor that inhibits PARP1, PARP2, and HDAC1, and may be used to study pancreatic cancer.</p>Formule :C36H32F2N6O3Degré de pureté :95.00%Couleur et forme :SolidMasse moléculaire :634.67GSK3735967
CAS :<p>GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.</p>Formule :C25H31N7OSCouleur et forme :SolidMasse moléculaire :477.62Sulotroban
CAS :<p>sulotroban is a TXA2 receptor antagonist that acts synergistically with iloprost to inhibit TXA2-dependent platelet activation.</p>Formule :C16H17NO5SDegré de pureté :98.86% - 99.88%Couleur et forme :SolidMasse moléculaire :335.37Antitumor agent-28
CAS :<p>Antitumor agent-28 inhibits ATM kinase, blocking ATM disease progression and showing anti-cancer effects.</p>Formule :C25H32N6O4SCouleur et forme :SolidMasse moléculaire :512.63Multi-target kinase inhibitor 4
<p>Multi-target kinase inhibitor 4 (Compound 2) is a PI3K/DNA-PK inhibitor and a potent chemosensitizer that enhances the number of DNA double-strand breaks induced by Doxorubicin. It serves as an effective multidrug resistance (MDR) inhibitor, demonstrating inhibitory activity against P-glycoprotein (P-gp) mediated drug efflux. Multi-target kinase inhibitor 4 can be encapsulated in PEG-coated lipid nanoparticles.</p>Couleur et forme :Odour Solid1-O-Hexadecyl-Rac-Glycerol
CAS :<p>1-O-Hexadecyl-Rac-Glycerol (1-O-Hexadecylglycerol) is a marine derived natural products found in Tritoniella belli.</p>Formule :C19H40O3Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :316.52Ciprofibrate impurity A
CAS :<p>Ciprofibrate impurity A is an impurity of Ciprofibrate. Ciprofibrate is a PPARα agonist[1].</p>Formule :C12H14O3Couleur et forme :SolidMasse moléculaire :206.241Z26395438
CAS :<p>Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.</p>Formule :C17H15FN2ODegré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :282.31Becatecarin
CAS :<p>Becatecarin, water-soluble and anti-cancer, inhibits topoisomerases I/II and induces DNA cleavage and apoptosis; has myelosuppressive effects; ABCG2 substrate.</p>Formule :C33H34Cl2N4O7Couleur et forme :SolidMasse moléculaire :669.56Colibactin 742
CAS :<p>Colibactin 742, a stable derivative of colibactin, efficiently induces DNA interstrand cross-links, activates the Fanconi Anemia DNA repair pathway, and leads</p>Formule :C37H42N8O5S2Couleur et forme :SolidMasse moléculaire :742.91Macrocalin B
CAS :<p>Macrocalin B is a diterpenoid against tumor cell proliferation and telomerase activity.</p>Formule :C20H26O6Couleur et forme :SolidMasse moléculaire :362.42
![Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT60001.webp&w=3840&q=75)
