Méthyltransférase de l’ADN
Les méthyltransférases de l'ADN (DNMT) sont des enzymes qui catalysent l'ajout de groupes méthyles aux résidus de cytosine dans l'ADN, conduisant à la silenciation des gènes. Une méthylation aberrante de l'ADN est associée à diverses maladies, y compris le cancer. Les inhibiteurs de DNMT bloquent l'activité de ces enzymes, réactivant ainsi les gènes silencieux et induisant l'apoptose dans les cellules cancéreuses. Les inhibiteurs de DNMT sont largement utilisés dans la recherche épigénétique et la thérapie contre le cancer. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de DNMT de haute qualité pour soutenir vos recherches en épigénétique, méthylation de l'ADN et biologie du cancer.
422 produits trouvés pour "Méthyltransférase de l’ADN"
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Caffeic Acid
CAS :Formule :C9H8O4Degré de pureté :>98.0%(T)(HPLC)Couleur et forme :White to Orange to Green powder to crystalMasse moléculaire :180.16Procaine Hydrochloride
CAS :Formule :C13H20N2O2·HClDegré de pureté :>98.0%(T)(HPLC)Couleur et forme :White to Almost white powder to crystalMasse moléculaire :272.77Genistein
CAS :Formule :C15H10O5Degré de pureté :>98.0%(HPLC)Couleur et forme :White to Light yellow to Light orange powder to crystalMasse moléculaire :270.245-Azacytidine
CAS :Formule :C8H12N4O5Degré de pureté :>98.0%(T)Couleur et forme :White to Almost white powder to crystalMasse moléculaire :244.21Zebularine
CAS :Formule :C9H12N2O5Degré de pureté :>98.0%(T)(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :228.20Chlorogenic Acid
CAS :Formule :C16H18O9Degré de pureté :>98.0%(T)(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :354.31(-)-Epigallocatechin Gallate Hydrate
CAS :Formule :C22H18O11·xH2ODegré de pureté :>98.0%(HPLC)Couleur et forme :White to Light yellow to Light orange powder to crystalMasse moléculaire :458.38 (as Anhydrous)N-Phthalyl-L-tryptophan
CAS :Formule :C19H14N2O4Degré de pureté :>98.0%(T)(HPLC)Couleur et forme :Light yellow to Amber to Dark green powder to crystalineMasse moléculaire :334.331-Hydrazinophthalazine Hydrochloride
CAS :Formule :C8H8N4·HClDegré de pureté :>99.0%(T)(HPLC)Couleur et forme :White to Almost white powder to crystalMasse moléculaire :196.644-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
CAS :Formule :C8H12N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :244.2047BVT948
CAS :<p>BVT948 is a protein tyrosine phosphatase (PTP) inhibitor.It can also inhibit lysine methyltransferase SETD8 (KMT5A) and several cytochrome P450 (P450) isoforms.</p>Formule :C14H11NO3Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :241.24DC-05
CAS :<p>DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).</p>Formule :C25H25N3ODegré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :383.49Diperodon hydrochloride
CAS :<p>Diperodon hydrochloride (Diperocaine) is a local anesthetic that can be broken down by serolytic enzymes to produce local anesthetic effects.</p>Formule :C22H28ClN3O4Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :433.93Tulmimetostat
CAS :<p>Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advanced</p>Formule :C28H36ClN3O5SDegré de pureté :98.04% - 99.872%Couleur et forme :SolidMasse moléculaire :562.12iso-Azalansta
CAS :(2R,4S)-Azalanstat (Iso-Azalansta) is a selective heme oxygenase (HO) inhibitor that is used in the study of cardiovascular disease.Formule :C22H24ClN3O2SDegré de pureté :99.53% - 99.89%Couleur et forme :SoildMasse moléculaire :429.964H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-
CAS :Formule :C15H10O5Degré de pureté :97%Couleur et forme :SolidMasse moléculaire :270.2369Ref: IN-DA00I8G3
1g26,00€5g24,00€10g31,00€1kg686,00€25g52,00€50g77,00€5kgÀ demander100g114,00€10kgÀ demander250g181,00€500g320,00€100mg26,00€5-Azacytidine
CAS :<p>5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity.</p>Formule :C8H12N4O5Degré de pureté :99.31% - 99.79%Couleur et forme :Crystals From Methanol Physical Description White Crystalline Powder (Ntp 1992)Masse moléculaire :244.2(1S,3R,4R,5R)-3-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,4,5-trihydroxycyclohexane-1-carboxylic acid
CAS :Formule :C16H18O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :354.3087Ref: IN-DA00I681
1g30,00€5g52,00€10g75,00€1kgÀ demander25g153,00€100g489,00€250gÀ demander500gÀ demander50kg41.345,00€250mg26,00€4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
CAS :Formule :C8H12N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :228.2053Ref: IN-DA002NLT
1g99,00€5g255,00€10g563,00€25gÀ demander50gÀ demander5mg30,00€100gÀ demander100mg31,00€250mg53,00€(-)-Epicatechingallate
CAS :Formule :C22H18O10Degré de pureté :%Couleur et forme :SolidMasse moléculaire :442.3723N-Phthalyl-L-tryptophan
CAS :Formule :C19H14N2O4Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :334.3255Decitabine
CAS :<p>Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity.</p>Formule :C8H12N4O4Degré de pureté :98.06% - 99.87%Couleur et forme :Physical Description Fine White Crystalline Powder Used As A DrugMasse moléculaire :228.21MAK683
CAS :MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).Formule :C20H17FN6ODegré de pureté :98.25% - 99.92%Couleur et forme :SolidMasse moléculaire :376.39Dihydro-5-azacytidine FA
Dihydro-5-azacytidine FA (DHAC) is a pyrimidine analog that has antitumor activity, inhibits cell growth, inhibits DNA methylation, and may be used in the study of malignant mesothelioma.Formule :C9H16N4O7Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :292.25Levetiracetam
CAS :<p>Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset</p>Formule :C8H14N2O2Degré de pureté :99.67% - 99.86%Couleur et forme :White Crystalline PowderMasse moléculaire :170.21(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate
CAS :Formule :C22H18O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.3717Ref: IN-DA00IK6L
1g22,00€5g24,00€10g31,00€1kg527,00€25g55,00€50g80,00€5kgÀ demander100g114,00€250g177,00€500g302,00€(E)-3,4-dihydroxycinnamic acid
CAS :Formule :C9H8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :180.1574EBI-2511
CAS :<p>EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).</p>Formule :C34H48N4O4Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :576.77Amodiaquine dihydrochloride dihydrate
CAS :<p>Amodiaquine dihydrochloride dihydrate (Amodiaquin hydrochloride) is an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory effects</p>Formule :C20H28Cl3N3O3Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :464.822(1H)-Pyrimidinone, 1-β-D-ribofuranosyl-
CAS :Formule :C9H12N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :228.2020A-395
CAS :<p>A-395 blocks PRC2 (EZH2-EED-SUZ12) interactions, strongly inhibiting the complex with an IC50 of 18 nM.</p>Formule :C26H35FN4O2SDegré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :486.65Valemetostat
CAS :<p>Valemetostat (DS-3201) is a first-in-class EZH1/2 dual inhibitor, which can be used to study T-cell lymphoma.Cost-effective and quality-assured.</p>Formule :C26H34ClN3O4Degré de pureté :98.38% - 99.08%Couleur et forme :SolidMasse moléculaire :488.02Procaine Hydrochloride
CAS :Formule :C13H21ClN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :272.7710Phthalazine, 1-hydrazinyl-, hydrochloride (1:1)
CAS :Formule :C8H9ClN4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :196.6369WDR5-47
CAS :<p>WDR5-47 is a potent small molecule to disturb the interaction of MLL1-WDR5 with IC50 value of 0.3μM.</p>Formule :C19H20ClFN4O3Degré de pureté :98.15%Couleur et forme :SoildMasse moléculaire :406.84PRMT5-IN-14
CAS :<p>PRMT5-IN-14 is a PRMT5 inhibitor to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.</p>Formule :C18H18Cl2N4O4Couleur et forme :SolidMasse moléculaire :425.27Histone H3K9me3 (1-15) TFA
Histone H3K9me3 (1-15) (H3(1-15)K9me3) TFA is used as a substrate. This post-translational modification (PTM) of histone H3K9me3 is indicative of heterochromatin surrounding the centromere.Formule :C66H124N25O21·xC2HF3O2PRMT5-IN-9
CAS :<p>PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.</p>Formule :C25H23F3N6OCouleur et forme :SolidMasse moléculaire :480.495Larsucosterol Ammonium salt
CAS :Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.Formule :C27H49NO5SDegré de pureté :>99.99% - >99.99%Couleur et forme :SoildMasse moléculaire :499.75PRMT5-IN-13
CAS :<p>PRMT5-IN-13 is a selective inhibitor of protein arginine methyltransferase 5 (prmt5) .</p>Formule :C18H17ClN4O4Couleur et forme :SolidMasse moléculaire :388.81PRMT5-MTA-IN-2
<p>PRMT5-MTA-IN-2 (compound 1) is a synergistic inhibitor of PRMT5 with an IC50 of less than 1.5 nM.</p>Formule :C30H25F2N7O2Couleur et forme :SolidMasse moléculaire :553.56EZH2-IN-4
CAS :<p>EZH2-IN-4, an oral EZH2 inhibitor, targets WT and mutant forms with IC50s of 0.923 nM and 2.65 nM, showing strong anti-cancer effects.</p>Formule :C29H41N3O3SCouleur et forme :SolidMasse moléculaire :511.73TB22
<p>TB22 is a non-nucleoside inhibitor of DOT1LR231Q with anticancer activity. It inhibits the malignant phenotype of lung cancer cells harboring the R231Q mutation via the MAPK/ERK signaling pathway, making it useful for lung cancer research.</p>Couleur et forme :Odour SolidUNC6852
CAS :<p>UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.</p>Formule :C43H48N10O6SDegré de pureté :96.64%Couleur et forme :SolidMasse moléculaire :832.97PARP/EZH2-IN-2
<p>PARP/EZH2-IN-2 (compound 12e) functions as a dual inhibitor targeting both PARP1 and EZH2, with IC50 values of 6.89 and 27.34 nM, respectively. This compound exhibits anticancer activity without toxicity to normal cells, achieving synthetic lethality indirectly by increasing PARP1 sensitivity through EZH2 inhibition, and inducing cell death by modulating excessive autophagy.</p>Formule :C33H31N7O3Masse moléculaire :573.24884LSD1-IN-32
<p>LSD1-IN-32 (compound 11e) is a potent inhibitor of LSD1, with an IC50 value of 0.99 µM. It effectively impedes RANKL-induced osteoclastogenesis, bone resorption, and F-actin ring formation, indicating its potential use in osteoporosis research.</p>Formule :C36H56N2O3Si2Masse moléculaire :620.38295PRMT5-IN-11
CAS :<p>PRMT5-IN-11 demonstrates potent structure-dependent inhibition against the protein methyltransferase PRMT5:MEP50 complex at submicromolar concentrations.</p>Formule :C13H17N5O4Couleur et forme :SolidMasse moléculaire :307.31GpC Methyltransferase
<p>GpC Methyltransferase (GpC) is an enzyme that methylates DNA, specifically targeting cytosine residues within GpC dinucleotides of non-nucleosomal DNA in vitro.</p>Dot1L-IN-9
<p>Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor with an IC50 of 125 nM. It effectively reduces H3K79 dimethylation and is utilized in leukemia research.</p>Couleur et forme :Odour SolidBBDDL2204
<p>BBDDL2204 (compound 13) is a potent and selective covalent inhibitor of EZH2, demonstrating an IC50 of 2.5 nM against EZH2Y641F.</p>Formule :C37H47N5O5SCouleur et forme :SolidMasse moléculaire :673.32979ND-L11B free base
ND-L11B is an effective degrader of the nuclear receptor binding SET domain protein 2 (NSD2) and RE-IIBP, with DC50 values of 1.48 μM and 0.8 μM, respectively, and a Dmax close to 80%.Formule :C37H51F3N10O2Couleur et forme :SolidMasse moléculaire :724.862Dot1L-IN-8
Dot1L-IN-8 (Compound 15) is an effective Dot1L inhibitor. It suppresses the viability of HL-60, K562, MV4-11, HH, and KG-1 cells, with IC50 values of 0.45, 1.03, 0.68, 1.66, and 1.12 μM, respectively.Formule :C41H53N7O3SCouleur et forme :SolidMasse moléculaire :723.97MS049 2HCl (1502816-23-0(free base))
MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.Formule :C15H26Cl2N2ODegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :321.28PARP/EZH2-IN-1
CAS :<p>PARP/EZH2-IN-1: Dual PARP (IC50 6.87 nM) & EZH2 (IC50 36.51 nM) inhibitor, potential for BRCA-wild-type triple-negative breast cancer.</p>Formule :C43H41FN8O5Couleur et forme :SolidMasse moléculaire :768.85EPZ-719
CAS :<p>EPZ-719: Potent SETD2 inhibitor, IC50=0.005μM, high selectivity, potential for targeted epigenetic therapy.</p>Formule :C22H31FN4O3SCouleur et forme :SolidMasse moléculaire :450.57MAK683-CH2CH2COOH hydrochloride
<p>MAK683-CH2CH2COOH, an EED binder, was key in crafting PROTAC EED degrader-1 and -2 targeting VHL-E3 ligase.</p>Formule :C23H22ClFN6O3Couleur et forme :SolidMasse moléculaire :484.91CS-VIP 8 TFA
<p>CS-VIP 8 TFA is a selective allosteric inhibitor of the WDR5 protein (Ki= 0.008 μM). It induces a conformational change in the MLL1 complex, leading to the dissociation of MLL1 from the complex, thereby inhibiting the MLL1 histone methyltransferase activity and modulating HOX gene expression. CS-VIP 8 TFA shows potential for research in hematological disorders such as leukemia.</p>Formule :C45H53F7N12O9Couleur et forme :SolidMasse moléculaire :1038.39467MRTX9768 hydrochloride
<p>MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor.</p>Couleur et forme :SolidFTX-6058 hydrochloride
CAS :<p>FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.</p>Formule :C22H19ClFN5O2Couleur et forme :SolidMasse moléculaire :439.87LLY-284
CAS :LLY-284, a less active PRMT5 inhibitor diastereomer of LLY-283, serves as its negative control.Formule :C17H18N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :342.35XF056-132
CAS :<p>XF056-132 is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader [1] .</p>Formule :C51H57F4N9O7SCouleur et forme :SolidMasse moléculaire :1016.11Aclantate
CAS :<p>Aclantate is a nonsteroidal anti-inflammatory drug.</p>Formule :C15H14ClNO4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :339.79PRMT5-IN-41
CAS :PRMT5-IN-41 (compound 130) is an effective orally active inhibitor of PRMT5. It inhibits the hERG ion channel with an IC50 of 1.36 µM.Formule :C22H16F5N5O2Masse moléculaire :477.39Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH
CAS :<p>Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b), an EZH2 degrader, is employed in lymphoma research [1].</p>Formule :C34H43N3O7Couleur et forme :SolidMasse moléculaire :605.72MS33
CAS :<p>MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.</p>Formule :C64H84F3N11O7SCouleur et forme :SolidMasse moléculaire :1208.5MS8511 HCl
<p>MS8511 HCl is a G9a/GLP inhibitor with anticancer activity that can be used in the study of a variety of cancers including brain cancer.</p>Formule :C28H42ClN5O3Degré de pureté :98.9% - 98.96%Couleur et forme :SolidMasse moléculaire :532.12PRMT3-IN-4
<p>PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.</p>Couleur et forme :Odour SolidMethylation Compound Library
<p>xnum methylation-related compounds that can be used for high-throughput and high-content screening.</p>Couleur et forme :Odour SolidPROTAC EED degrader-2
<p>PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.</p>Formule :C50H58FN11O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :960.13PRMT5-IN-12
CAS :<p>PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .</p>Formule :C32H40N4O4Couleur et forme :SolidMasse moléculaire :544.696MAK-683 hydrochloride
CAS :MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, 26nM measured in EED Alphascreen, ELISA.Cost-effective and quality-assured.Formule :C20H18ClFN6ODegré de pureté :97.02% - >99.99%Couleur et forme :SolidMasse moléculaire :412.85SW2_110A
CAS :<p>SW2_110A: Cell-permeable, CBX8 ChD inhibitor, Kd 800 nM; 5x selective over other CBXs in vitro.</p>Formule :C42H60N6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :760.96MRK-990
MRK-990 is an inhibitor of PRMT that targets both PRMT5 and PRMT9, with IC50 values of 30 nM and 10 nM, respectively.Couleur et forme :Odour SolidDot1L-IN-1 TFA
Dot1L-IN-1 TFA: potent inhibitor, K i =2 pM, IC 50 <0.1 nM; reduces H3K79 dimethylation (IC 50 =3 nM) & HoxA9 promoter activity (IC 50 =17 nM).Formule :C34H37ClF3N9O4SCouleur et forme :SolidMasse moléculaire :760.23WDR5-MYC-IN-1
<p>WDR5-MYC-IN-1 (compound 4o) is an effective inhibitor of the WDR5-MYC interaction, demonstrating a Ki value of 1.0 µM and exhibiting antiproliferative activity.</p>Couleur et forme :Odour SolidEZH2-IN-15
CAS :<p>A compound inhibits EZH2, overexpressed in cancers, affecting Treg activity and innate immunity.</p>Formule :C32H44N4O4Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :548.72FTX-6058
CAS :<p>FTX-6058 is an oral inhibitor of EED that induces HbF and may treat hemoglobinopathies like sickle cell and β-thalassemia.</p>Formule :C22H18FN5O2Couleur et forme :SolidMasse moléculaire :403.417EPZ-025654
CAS :<p>EPZ-025654 is an effective and selective inhibitor of arginine methyltransferase CARM1.</p>Formule :C29H33ClN8O3Couleur et forme :SolidMasse moléculaire :577.08DDO-2093
CAS :<p>DDO-2093 inhibits MLL1-WDR5 interaction (IC50: 8.6 nM, Kd: 11.6 nM), with strong antitumor properties and selectivity.</p>Formule :C29H37ClFN9O3Couleur et forme :SolidMasse moléculaire :614.12EZH2-IN-5
CAS :<p>EZH2-IN-5, potent EZH2 inhibitor; IC50: 1.52 nM (wild-type), 4.07 nM (Tyr641 mutant).</p>Formule :C26H37BrN4O2Couleur et forme :SolidMasse moléculaire :517.512E67-2
CAS :<p>E67-2: Low-toxic, KIAA1718 inhibitor with IC50 of 3.4μM, targets H3K9/H3K4 demethylases.</p>Formule :C21H36N6O2Couleur et forme :SolidMasse moléculaire :404.559DNMT1/HDAC-IN-1
<p>DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.</p>Couleur et forme :Odour SolidUNC4976
<p>UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.</p>Formule :C47H70N6O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :847.09A-893
CAS :<p>A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .</p>Formule :C29H38Cl2N4O4Couleur et forme :SolidMasse moléculaire :577.54GSK 591 dihydrochloride
CAS :<p>Strong PRMT5 inhibitor with 4 nM IC50, surpassing other PRMTs; halts MCL growth in lab tests.</p>Formule :C22H30Cl2N4O2Couleur et forme :SolidMasse moléculaire :453.41PROTAC EED degrader-1
<p>PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.</p>Formule :C55H60FN11O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1054.2GSK3735967
CAS :<p>GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.</p>Formule :C25H31N7OSCouleur et forme :SolidMasse moléculaire :477.62CPI-1328
CAS :<p>CPI-1328 is an EZH2 inhibitor with a K i value of 63 fM.</p>Formule :C28H36ClN3O4SCouleur et forme :SolidMasse moléculaire :546.12UNC2399
CAS :<p>UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its IC</p>Formule :C67H104N10O17SCouleur et forme :SolidMasse moléculaire :1353.68MS9024
<p>MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.</p>Couleur et forme :Odour SolidCARM1/IKZF3 ligand 1
CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.Formule :C27H35ClN6O3Couleur et forme :SolidMasse moléculaire :527.06PRMT5 ligand 1
CAS :<p>PRMT5ligand 1 is a ligand of PRMT5, used as a target protein ligand in the synthesis of the PROTAC degrader MS4322.</p>Formule :C20H26N6O2Couleur et forme :SolidMasse moléculaire :382.459C 21
CAS :PRMT1 inhibitor, IC50=1.8μM; 5x more selective than PRMT6; >250x over PRMT3, CARM1.Formule :C90H161ClN36O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2166.94CM112
<p>CM112 is a selective degrader of protein arginine methyltransferase 1 (PRMT1), which connects a hydrophobic adamantane tag to MS023 via a 5-PEG linker. It induces the degradation of PRMT1 in various solid tumor cell lines. CM112 also targets the non-enzymatic functions of PRMT1 by reducing the stability of the orphan receptor TR3. This compound shows potential for cancer research.</p>Formule :C39H61N5O7Couleur et forme :SolidMasse moléculaire :711.4571MS2133
<p>MS2133 is a DOT1L PROTAC degrader. It facilitates the ubiquitination and degradation of DOT1L in THP-1 and MV4-11 cells, with DC50 values of 56 nM and 25 nM, respectively, and reduces H3K79 methylation. MS2133 also inhibits the growth of MLL-r leukemia cells, demonstrating anticancer activity.</p>Formule :C58H66ClF3N14O11S2Couleur et forme :SolidMasse moléculaire :1290.41175ML234
<p>ML234 is a dual inhibitor targeting EZH2/LSD1, with IC50 values of 0.09 and 0.12 μM, respectively. It demonstrates strong antiproliferative effects on prostate cancer cell lines LNCAP, PC3, and 22RV1. Additionally, ML234 inhibits tumor growth in a 22RV1 xenograft mouse model, showing potential as a research agent in prostate cancer therapeutics.</p>Couleur et forme :Odour SolidPRMT5-IN-15
CAS :<p>PRMT5-IN-15 is a PRMT5 inhibitor with an IC 50 value of 0.84 nM.</p>Formule :C24H23F3N6O2Couleur et forme :SolidMasse moléculaire :484.483SW2_152F
<p>SW2_152F: Potent CBX2 ChD inhibitor, Kd 80 nM, 24-1000x selective over other CBXs in vitro.</p>Formule :C45H62Cl3N7O8Couleur et forme :SolidMasse moléculaire :935.37DC-S239
CAS :<p>Ethyl 2-amino-4-methyl-5-thiophene carboxylate is a SETD7 inhibitor (IC50=4.59μM) with anticancer properties.</p>Formule :C15H15N3O5SDegré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :349.36
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