Méthyltransférase de l’ADN
Les méthyltransférases de l'ADN (DNMT) sont des enzymes qui catalysent l'ajout de groupes méthyles aux résidus de cytosine dans l'ADN, conduisant à la silenciation des gènes. Une méthylation aberrante de l'ADN est associée à diverses maladies, y compris le cancer. Les inhibiteurs de DNMT bloquent l'activité de ces enzymes, réactivant ainsi les gènes silencieux et induisant l'apoptose dans les cellules cancéreuses. Les inhibiteurs de DNMT sont largement utilisés dans la recherche épigénétique et la thérapie contre le cancer. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de DNMT de haute qualité pour soutenir vos recherches en épigénétique, méthylation de l'ADN et biologie du cancer.
459 produits trouvés pour "Méthyltransférase de l’ADN".
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Procaine Hydrochloride
CAS :Formule :C13H20N2O2·HClDegré de pureté :>98.0%(T)(HPLC)Couleur et forme :White to Almost white powder to crystalMasse moléculaire :272.77(-)-Epigallocatechin Gallate Hydrate
CAS :Formule :C22H18O11·xH2ODegré de pureté :>98.0%(HPLC)Couleur et forme :White to Light yellow to Light orange powder to crystalMasse moléculaire :458.38 (as Anhydrous)5-Aza-2'-deoxycytidine
CAS :Formule :C8H12N4O4Degré de pureté :>98.0%(HPLC)Couleur et forme :White to Almost white powder to crystalMasse moléculaire :228.211-Hydrazinophthalazine Hydrochloride
CAS :Formule :C8H8N4·HClDegré de pureté :>99.0%(T)(HPLC)Couleur et forme :White to Almost white powder to crystalMasse moléculaire :196.64Genistein
CAS :Formule :C15H10O5Degré de pureté :>98.0%(HPLC)Couleur et forme :White to Light yellow to Light orange powder to crystalMasse moléculaire :270.24Chlorogenic Acid
CAS :Formule :C16H18O9Degré de pureté :>95.0%(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :354.31N-Phthalyl-L-tryptophan
CAS :Formule :C19H14N2O4Degré de pureté :>98.0%(T)(HPLC)Couleur et forme :Light yellow to Amber to Dark green powder to crystalineMasse moléculaire :334.33Caffeic Acid
CAS :Formule :C9H8O4Degré de pureté :>98.0%(T)(HPLC)Couleur et forme :White to Orange to Green powder to crystalMasse moléculaire :180.165-Azacytidine
CAS :Formule :C8H12N4O5Degré de pureté :>98.0%(T)Couleur et forme :White to Almost white powder to crystalMasse moléculaire :244.21iso-Azalansta
CAS :(2R,4S)-Azalanstat (Iso-Azalansta) is a selective heme oxygenase (HO) inhibitor that is used in the study of cardiovascular disease.Formule :C22H24ClN3O2SDegré de pureté :99.53% - 99.89%Couleur et forme :SoildMasse moléculaire :429.964-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
CAS :Formule :C8H12N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :228.2053A-395
CAS :A-395 blocks PRC2 (EZH2-EED-SUZ12) interactions, strongly inhibiting the complex with an IC50 of 18 nM.Formule :C26H35FN4O2SDegré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :486.65Valemetostat
CAS :Valemetostat (DS-3201) is a first-in-class EZH1/2 dual inhibitor, which can be used to study T-cell lymphoma.Cost-effective and quality-assured.Formule :C26H34ClN3O4Degré de pureté :98.38% - 99.83%Couleur et forme :SolidMasse moléculaire :488.02Ref: TM-T13279L
1mg89,00€5mg177,00€1mL*10mM (DMSO)197,00€10mg313,00€25mg520,00€50mg742,00€100mg982,00€4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
CAS :Formule :C8H12N4O5Degré de pureté :96%Couleur et forme :SolidMasse moléculaire :244.2047Ref: IN-DA003824
1g25,00€250mg25,00€5g56,00€10g78,00€25g139,00€100g503,00€250g822,00€500g1.736,00€1kg3.236,00€(E)-3,4-dihydroxycinnamic acid
CAS :Formule :C9H8O4Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :180.1574Ref: IN-DA0033IN
5g20,00€10g23,00€25g27,00€50g37,00€100g50,00€250g91,00€500g137,00€1kg179,00€5kg702,00€10kg1.395,00€25kg3.685,00€(-)-Epicatechingallate
CAS :Formule :C22H18O10Degré de pureté :%Couleur et forme :SolidMasse moléculaire :442.37234H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-
CAS :Formule :C15H10O5Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :270.2369Ref: IN-DA00I8G3
5g24,00€1g26,00€100mg26,00€10g28,00€25g55,00€50g70,00€100g127,00€250g162,00€1kg259,00€5kg1.203,00€Procaine Hydrochloride
CAS :Formule :C13H21ClN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :272.7710Amodiaquine dihydrochloride dihydrate
CAS :Amodiaquine dihydrochloride dihydrate (Amodiaquin hydrochloride) is an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory effectsFormule :C20H28Cl3N3O3Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :464.82(1S,3R,4R,5R)-3-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,4,5-trihydroxycyclohexane-1-carboxylic acid
CAS :Formule :C16H18O9Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :354.3087Ref: IN-DA00I681
500gÀ demander1g20,00€250mg20,00€5g40,00€10g60,00€25g107,00€50g163,00€100g218,00€250g657,00€1kg920,00€Phthalazine, 1-hydrazinyl-, hydrochloride (1:1)
CAS :Formule :C8H9ClN4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :196.6369Dihydro-5-azacytidine FA
Dihydro-5-azacytidine FA (DHAC) is a pyrimidine analog that has antitumor activity, inhibits cell growth, inhibits DNA methylation, and may be used in the study of malignant mesothelioma.Formule :C9H16N4O7Degré de pureté :>99.99%Couleur et forme :White SolidMasse moléculaire :292.25(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate
CAS :Formule :C22H18O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.3717Ref: IN-DA00IK6L
1g22,00€5g24,00€10g28,00€25g50,00€50g73,00€100g129,00€1kg283,00€5kg1.094,00€10kg2.082,00€2(1H)-Pyrimidinone, 1-β-D-ribofuranosyl-
CAS :Formule :C9H12N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :228.2020MAK683
CAS :MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).Formule :C20H17FN6ODegré de pureté :98.25% - 99.92%Couleur et forme :SolidMasse moléculaire :376.39Levetiracetam
CAS :Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onsetFormule :C8H14N2O2Degré de pureté :99.67% - 99.86%Couleur et forme :SolidMasse moléculaire :170.21Decitabine
CAS :Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity.Formule :C8H12N4O4Degré de pureté :98.06% - 99.87%Couleur et forme :SolidMasse moléculaire :228.21Diperodon hydrochloride
CAS :Diperodon hydrochloride (Diperocaine) is a local anesthetic that can be broken down by serolytic enzymes to produce local anesthetic effects.Formule :C22H28ClN3O4Degré de pureté :99.91%Couleur et forme :White SolidMasse moléculaire :433.93EBI-2511
CAS :EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).Formule :C34H48N4O4Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :576.775-Azacytidine
CAS :5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity.Formule :C8H12N4O5Degré de pureté :99.31% - 99.87%Couleur et forme :White SolidMasse moléculaire :244.2Tulmimetostat
CAS :Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advancedFormule :C28H36ClN3O5SDegré de pureté :98.04% - 99.87%Couleur et forme :SolidMasse moléculaire :562.12BVT948
CAS :BVT948 is a protein tyrosine phosphatase (PTP) inhibitor.It can also inhibit lysine methyltransferase SETD8 (KMT5A) and several cytochrome P450 (P450) isoforms.Formule :C14H11NO3Degré de pureté :98.87%Couleur et forme :Red SolidMasse moléculaire :241.24Ref: TM-T14841
1mg35,00€2mg50,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg99,00€25mg148,00€50mg200,00€100mg319,00€SW2_110A
CAS :SW2_110A: Cell-permeable, CBX8 ChD inhibitor, Kd 800 nM; 5x selective over other CBXs in vitro.Formule :C42H60N6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :760.96DC-05
CAS :DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).Formule :C25H25N3ODegré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :383.49Ref: TM-T15080
1mg66,00€5mg145,00€1mL*10mM (DMSO)158,00€10mg236,00€25mg515,00€50mg858,00€100mg1.251,00€200mg1.684,00€Larsucosterol Ammonium salt
CAS :Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.Formule :C27H49NO5SDegré de pureté :>99.99% - >99.99%Couleur et forme :SolidMasse moléculaire :499.75UNC6852
CAS :UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.Formule :C43H48N10O6SDegré de pureté :98.69%Couleur et forme :SolidMasse moléculaire :832.97Ref: TM-T13954
1mg126,00€5mg260,00€1mL*10mM (DMSO)358,00€10mg409,00€25mg660,00€50mg888,00€100mg1.224,00€PTD2
PTD2 (Ac-Gly-Val-Nle-Arg-Ile-NH2) serves as a potent and selective WHSC1 inhibitor, exhibiting micromolar affinity for this target [1].Couleur et forme :Odour SolidSKLB-03220
CAS :SKLB-03220 is an oral covalent EZH2 inhibitor, abolishing H3K27me3 marks and serving as a potent small-molecule tool for cancer epigenetics research.Formule :C33H40N4O4Degré de pureté :97.01%Couleur et forme :SoildMasse moléculaire :556.71MS2133
MS2133 is a DOT1L PROTAC degrader. It facilitates the ubiquitination and degradation of DOT1L in THP-1 and MV4-11 cells, with DC50 values of 56 nM and 25 nM, respectively, and reduces H3K79 methylation. MS2133 also inhibits the growth of MLL-r leukemia cells, demonstrating anticancer activity.Formule :C58H66ClF3N14O11S2Couleur et forme :SolidMasse moléculaire :1290.41175LLC0424
LLC0424 is a potent and selective degrader of the nuclear receptor-binding SET domain 2 (NSD2), with a DC50 of 20 nM. It reduces H3K36me2 levels and inhibits the growth of acute lymphoblastic leukemia (ALL) cell lines, making it useful for research in ALL.Couleur et forme :Odour SolidG9D-4
G9D-4 is an effective degrader of G9a with a DC50 value of 0.1 μM in PANC-1 cells, and it does not directly interfere with GLP proteins (DC50 greater than 10 μM). This compound plays a significant role in pancreatic cancer research.Couleur et forme :Odour SolidEZH2-IN-5
CAS :EZH2-IN-5, potent EZH2 inhibitor; IC50: 1.52 nM (wild-type), 4.07 nM (Tyr641 mutant).Formule :C26H37BrN4O2Couleur et forme :SolidMasse moléculaire :517.512PRMT5-IN-43
CAS :PRMT5-IN-43 (compound 4A) is an inhibitor of PRMT5, primarily utilized in cancer research.Formule :C22H17ClF3N5O2Couleur et forme :SolidMasse moléculaire :475.85EEDi-5285
CAS :EEDi-5285: potent EED inhibitor, orally active, IC50=0.2nM, targets EED protein, anti-cancer properties.Formule :C24H22FN5O3SDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :479.53AS-99 TFA
CAS :AS-99 TFA is an ASH1L inhibitor (IC50=0.79 μM) with anti-leukemic activity. It induces apoptosis, downregulates MLL target genes, and reduces leukemia burden in vivo.Formule :C29H31F6N5O5S2Couleur et forme :Yellow SolidMasse moléculaire :707.71PRMT5 ligand 1
CAS :PRMT5ligand 1 is a ligand of PRMT5, used as a target protein ligand in the synthesis of the PROTAC degrader MS4322.Formule :C20H26N6O2Couleur et forme :SolidMasse moléculaire :382.459SW2_152F
SW2_152F: Potent CBX2 ChD inhibitor, Kd 80 nM, 24-1000x selective over other CBXs in vitro.Formule :C45H62Cl3N7O8Couleur et forme :SolidMasse moléculaire :935.37PRMT3-IN-4
PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.Couleur et forme :Odour SolidUNC4976 TFA
UNC4976 TFA boosts CBX7 chromodomain interaction with nucleic acids and blocks gene-specific H3K27me3 binding, while enhancing DNA/RNA attachment.Formule :C49H71F3N6O10Couleur et forme :SolidMasse moléculaire :961.12ML234
ML234 is a dual inhibitor targeting EZH2/LSD1, with IC50 values of 0.09 and 0.12 μM, respectively. It demonstrates strong antiproliferative effects on prostate cancer cell lines LNCAP, PC3, and 22RV1. Additionally, ML234 inhibits tumor growth in a 22RV1 xenograft mouse model, showing potential as a research agent in prostate cancer therapeutics.Couleur et forme :Odour Solid
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