PDE
Les phosphodiestérases (PDE) sont des enzymes qui hydrolysent les nucléotides cycliques, tels que l'AMPc et le GMPc, en leurs formes inactives, jouant un rôle clé dans la régulation des voies de signalisation intracellulaire. Les inhibiteurs de PDE sont utilisés dans le traitement de diverses affections, notamment les maladies cardiovasculaires, la dysfonction érectile et les troubles respiratoires, en raison de leur capacité à moduler les niveaux de nucléotides cycliques. Chez CymitQuimica, nous proposons une gamme d'inhibiteurs de PDE pour soutenir vos recherches en signalisation cellulaire, pharmacologie et développement thérapeutique.
166 produits trouvés pour "PDE"
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EMD57439
CAS :EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).Formule :C22H23N3O4SDegré de pureté :99.35% - 99.57%Couleur et forme :SolidMasse moléculaire :425.5NSP-805
CAS :NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.Formule :C17H19N3O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :297.35Carbodenafil
CAS :Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).Formule :C24H32N6O3Degré de pureté :98.96% - 99.89%Couleur et forme :SolidMasse moléculaire :452.55ITI-214
CAS :ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members, exhibits potent PDE1 inhibitory activity.Formule :C29H29FN7O5PDegré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :605.56ATX inhibitor 1
CAS :ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).Formule :C21H23Cl2N2O6PDegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :501.3Cilostazol
CAS :Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.Formule :C20H27N5O2Degré de pureté :99.58% - 99.90%Couleur et forme :Off-White SolidMasse moléculaire :369.46Zatolmilast
CAS :Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).Formule :C21H15ClF3NO2Degré de pureté :98.20%Couleur et forme :SolidMasse moléculaire :405.8Roflumilast
CAS :Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potentialFormule :C17H14Cl2F2N2O3Degré de pureté :99.76% - 99.86%Couleur et forme :SolidMasse moléculaire :403.21N-Methylbenzamide
CAS :N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.Formule :C8H9NODegré de pureté :99.83%Couleur et forme :Physical Description Off-White Crystalline Solid (Ntp 1992)Masse moléculaire :135.16Amrinone
CAS :<p>Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.</p>Formule :C10H9N3ODegré de pureté :98.88% - 99.45%Couleur et forme :SolidMasse moléculaire :187.2MR-L2
CAS :MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).Formule :C19H16Cl3FN4ODegré de pureté :98.09% - 98.94%Couleur et forme :SolidMasse moléculaire :441.71Pumafentrine
CAS :<p>Pumafentrine（BY 343） is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.</p>Formule :C29H39N3O3Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :477.64Trapidil
CAS :Trapidil (Avantrin) is a coronary vasodilator agent.Formule :C10H15N5Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :205.26Milrinone
CAS :Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.Formule :C12H9N3ODegré de pureté :99.22% - 99.92%Couleur et forme :SolidMasse moléculaire :211.22Pimobendan
CAS :<p>Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).</p>Formule :C19H18N4O2Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :334.37ONO-8430506
CAS :ONO-8430506 is an orally available, potent autotaxin (ATX)/ENPP2 inhibitor (IC90: 100 nM) that inhibits ATX activity in mouse plasma.Formule :C27H28FN3O3Degré de pureté :98.34%Couleur et forme :SolidMasse moléculaire :461.53PDE10A-IN-5
<p>PDE10A-IN-5 (Compound A30) is an orally active inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 value of 3.5 nM. By inhibiting PDE10A, it activates the cyclic adenosine monophosphate (cAMP)-related signaling pathway, exhibiting activity against pulmonary vascular remodeling. This compound is applicable to research in the field of pulmonary arterial hypertension.</p>Couleur et forme :Odour SolidAcetildenafil
CAS :Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil.Formule :C25H34N6O3Couleur et forme :Off-White To Pale Yelow SolidMasse moléculaire :466.58PDE4B-IN-4
PDE4B-IN-4 is an inhibitor of PDE4B (IC50: 2.82 nM) and TNF-α (IC50: 7.20 nM). It demonstrates anti-inflammatory properties by reducing neutrophilia in a mouse model of lipopolysaccharide (LPS)-induced sepsis.Formule :C26H27N5O5Couleur et forme :SolidMasse moléculaire :489.52Enpp-1-IN-27
Enpp-1-IN-27 is a selective ENPP1 inhibitor with an IC50 of 14.68 nM, exhibiting approximately 410-fold selectivity over ENPP2 and roughly 10-fold selectivity over ENPP3. This compound stabilizes cGAMP levels and activates the STING pathway, leading to cytokine release and an enhanced innate immune response. In addition, Enpp-1-IN-27 activates ISRE and boosts cGAMP-mediated immune responses, demonstrating significant antitumor effects in 4T1 and CT26 syngeneic mouse models. It is applicable to breast cancer and colon cancer research.Couleur et forme :Odour Solid
