Protéases/Protéasome
Les inhibiteurs de protéases et de protéasomes sont des composés qui bloquent l'activité des protéases et du protéasome, impliqués dans la dégradation et le renouvellement des protéines. Ces inhibiteurs sont essentiels pour étudier la régulation de l'homéostasie des protéines, le contrôle du cycle cellulaire et l'apoptose. Les inhibiteurs de protéases et de protéasomes sont également utilisés dans le traitement de maladies telles que le cancer, où une dégradation anormale des protéines joue un rôle dans la progression de la maladie. En inhibant les protéases ou le protéasome, ces composés peuvent induire la mort cellulaire dans les cellules cancéreuses et sont des outils essentiels tant pour la recherche fondamentale que pour le développement thérapeutique. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de protéases et de protéasomes de haute qualité pour soutenir vos recherches en biochimie, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Protéases/Protéasome"
- Acétyl-CoA Carboxylase(38 produits)
- Cystéine protéase(111 produits)
- DPP-4(27 produits)
- Glutaminase(46 produits)
- Protéase du VIH(506 produits)
- PAI-1(26 produits)
- Inhibiteurs de protéase(50 produits)
- Récepteur activé par une protéase(55 produits)
- Protéasome(85 produits)
- Sérine protéase(54 produits)
- p97(15 produits)
Affichez 3 plus de sous-catégories
984 produits trouvés pour "Protéases/Protéasome"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Z-DEVD-CMK
CAS :Z-DEVD-CMK irreversibly inhibits various cathepsins in vitro [1].Formule :C27H35ClN4O12Couleur et forme :SolidMasse moléculaire :643.04DCLK1-IN-2
CAS :DCLK1-IN-2 (Compound I-5) is a potent inhibitor of DCLK1, exhibiting an IC50 of 171.3 nM, and demonstrates significant antiproliferative effects on SW1990 cellFormule :C26H32N8O3SCouleur et forme :SolidMasse moléculaire :536.65AZD-7295
CAS :AZD-7295 (A-689) is an NS5A inhibitor that may be used to treat HCV infection.Formule :C32H35F3N4O5SCouleur et forme :SolidMasse moléculaire :644.7ND-378
CAS :ND-378 is a potent and selective inhibitor of MMP-2 with no inhibition on MMP-9 and MMP-14.Formule :C18H19NO4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :377.48ONO 4817
CAS :ONO-4817 suppresses MMPs, limiting plaque progression and aortic hyperplasia in hyperlipidemic rabbits.Formule :C22H28N2O6Couleur et forme :SolidMasse moléculaire :416.47Cathepsin Inhibitor 2
CAS :Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).Formule :C19H21F6N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.38GS-6620
CAS :GS-6620 is a HCV nonstructural protein 5B (NS5B) inhibitor.Formule :C29H37N6O9PCouleur et forme :SolidMasse moléculaire :644.61Ro 32-7315
CAS :Ro 32-7315 is a selective inhibitor of ADAM17.Formule :C22H35N3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :453.6Berotralstat HCl
CAS :Berotralstat HCl is a selective plasma kallikrein inhibitor, reducing pain and swelling in HAE by blocking bradykinin release.Formule :C30H28Cl2F4N6OCouleur et forme :SolidMasse moléculaire :635.4886Kallikrein-IN-2
CAS :Kallikrein-IN-2 (compound 1) is an inhibitor of the kinin-releasing enzyme Kallikrein.Formule :C28H25F3N4O4Couleur et forme :SolidMasse moléculaire :538.52Proteasome-IN-4
Proteasome-IN-4, a potent non-covalent inhibitor (IC50=8.39nM), halts cancer cell growth, useful for oncology studies.Formule :C44H58N6O5Couleur et forme :SolidMasse moléculaire :750.97MMP-7-IN-2
CAS :MMP-7-IN-2 acts as a selective and potent MMP7 inhibitor and can be used to study inflammatory responses and vascular-related diseases.Formule :C28H40ClF3N6O9SDegré de pureté :97.82%Couleur et forme :SolidMasse moléculaire :729.17Cathepsin K inhibitor 3
CAS :Cathepsin K inhibitor 3: Selective, IC50 of 0.5 nM, good pharmacokinetics, potential for OA research.Formule :C30H31FN4O4SCouleur et forme :SolidMasse moléculaire :562.65MMP-9 Inhibitor I
CAS :MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively).Formule :C27H33N3O5SCouleur et forme :SolidMasse moléculaire :511.63NK3201
CAS :NK3201, a specific chymase inhibitor, suppresses bleomycin-induced pulmonary fibrosis in hamsters.Formule :C31H29N5O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :567.59Ravidasvir HCl
CAS :Ravidasvir, also known as PPI-668 and ASC16, is a second-generation, orally active, potent and selective HCV NS5A protein inhibitor.Formule :C42H52Cl2N8O6Couleur et forme :SolidMasse moléculaire :835.828Atecegatran metoxil
CAS :Atecegatran Metoxil (AZD0837), an oral thrombin inhibitor in development for stroke prevention in atrial fibrillation, is well-tolerated with favorable PK.Formule :C22H23ClF2N4O5Couleur et forme :SolidMasse moléculaire :496.89Cyclotheonellazole A
CAS :Cyclotheonellazole A inhibits elastase (IC50=0.034nM) & chymotrypsin (IC50=0.62nM), a natural macrocyclic peptide.Formule :C44H54N9NaO14S2Couleur et forme :SolidMasse moléculaire :1020.07Inogatran
CAS :Inogatran is a synthetic thrombin inhibitor, developed for the possible treatment and prophylaxis of venous and arterial thrombotic diseases.Formule :C21H38N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.56Petesicatib
CAS :Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.Formule :C25H23F6N5O4SDegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :603.54Ref: TM-T16474
1mg100,00€5mg236,00€10mg371,00€25mg735,00€50mg1.134,00€100mg1.468,00€200mg1.972,00€1mL*10mM (DMSO)314,00€LY52
CAS :LY52 is a matrix metalloproteinase-2 inhibitor. It acts by suppressing tumor invasion and metastasis.Formule :C22H24N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.45FK706
CAS :FK706, a human neutrophil elastase inhibitor (IC50: 83 nM, Ki: 4.2 nM), also blocks mouse and porcine elastases. Anti-inflammatory.Formule :C26H33F3N4NaO7Couleur et forme :SolidMasse moléculaire :593.556XL-784
CAS :XL-784 is a selective MMP inhibitor with low IC50s for MMP-1,2,3,8,9,13, modulating extracellular matrix remodeling, tumor invasion, and metastasis in cancer.Formule :C42H42Cl2F4MgN6O16S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1122.15ABP 25
CAS :ABP 25 is a highly potent and selective activity-based probe (ABP) for cathepsin K imaging.Formule :C55H66ClN5O3Couleur et forme :SolidMasse moléculaire :880.6KCC009
CAS :KCC009 is a potent and selective Transglutaminase 2 Inhibitor.Formule :C21H22BrN3O5Couleur et forme :SolidMasse moléculaire :476.32JTK-853
CAS :JTK-853: novel non-nucleoside HCV polymerase inhibitor with strong antiviral activity (EC50: 0.38 μM genotype 1a, 0.035 μM 1b).Formule :C28H23F7N6O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :704.64PTC725
CAS :PTC725 is a selective HCV 1b replicons inhibitor. It has been shown to target the nonstructural protein 4B.Formule :C23H18F4N6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :518.49MK-3281
CAS :MK-3281: Oral, potent HCV NS5B inhibitor with promising properties and efficacy in replication trials, suitable for clinical use.Formule :C29H37N3O3Couleur et forme :SolidMasse moléculaire :475.62Cipemastat
CAS :Cipemastat is a competitive inhibitor of human collagenases 1, 2, and 3 (Kis: 3.0, 4.4, and 3.4 nM).Formule :C22H36N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :436.55Collagen proline hydroxylase inhibitor
CAS :Collagen proline hydroxylase inhibitor is an inhibitor collagen proline hydroxylase and useful for antifibrotic proliferative agents.Formule :C18H18N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :354.36NCI-B16
CAS :NCI-B16 is a small-molecule RNA binder that inhibits HCV (hepatitis C virus) replication [1].Formule :C27H26N8O4Couleur et forme :SolidMasse moléculaire :526.55DS-1040 Tosylate
CAS :DS-1040 Tosylate is a thrombin-activated fibrinolysis inhibitor (TAFI) inhibitor and a fibrinolysis enhancer, used for researching thromboembolic diseases.Formule :C23H35N3O5SCouleur et forme :SolidMasse moléculaire :465.61Z-PDLDA-NHOH
CAS :Z-PDLDA-NHOH is a potent, specific vertebrate collagenase inhibitor [1].Formule :C22H32N4O6Couleur et forme :SolidMasse moléculaire :448.51GSK-2485852
CAS :GSK-2485852, a NS5B inhibitor, is used potentially for treatment of HCV infection.Formule :C27H25BF2N2O6SCouleur et forme :SolidMasse moléculaire :554.37XL-784 free base
CAS :XL-784 free base selectively inhibits MMPs with IC50: MMP-1 (1.9µM), MMP-2 (0.81nM), MMP-3 (120nM), MMP-8 (10.8nM), MMP-9 (18nM), MMP-13 (0.56nM).Formule :C21H22ClF2N3O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :549.93MDL-101146, (R)-
CAS :MDL-101146, (R)- is an effective orally active inhibitor of human neutrophil elastase.Formule :C29H37F5N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :632.62SSR 69071
CAS :SSR69071: selective neutrophil elastase inhibitor, stronger for humans (Ki=0.0168 nM), may treat COPD, asthma, and reduce heart injury.Formule :C27H32N4O7SCouleur et forme :SolidMasse moléculaire :556.63Phe-Pro-Ala-pNA
CAS :Phe-Pro-Ala-pNA is a chromogenic substrate utilized for assessing tripeptidyl peptidase activity.Formule :C23H27N5O5Couleur et forme :SolidMasse moléculaire :453.49MDL 27324
CAS :MDL 27324 is an inhibitor of human neutrophil elastase.Formule :C29H38F3N5O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :641.7MMP-7-IN-3
CAS :MMP-7-IN-3 (compound 15) is a potent and selective MMP-7 inhibitor, inhibiting renal fibrosis in a unilateral ureteral obstruction mouse model.Formule :C34H43ClF3N7O9SDegré de pureté :99.915%Couleur et forme :SolidMasse moléculaire :818.26BAY-678
CAS :BAY-678: Oral selective human neutrophil elastase inhibitor; IC50: 20 nM; SGC-approved chemical probe.Formule :C20H15F3N4O2Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :400.35Ref: TM-T10473
5mg37,00€10mg60,00€25mg119,00€50mg173,00€100mg264,00€200mg374,00€1mL*10mM (DMSO)42,00€Z-FG-NHO-BzOME
CAS :Z-FG-NHO-BzOME is a chemical compound functioning as a cysteine protease inhibitor, selectively targeting and inhibiting cathepsin B, cathepsin L, cathepsin S,Formule :C27H27N3O7Couleur et forme :SolidMasse moléculaire :505.52KB-R7785
CAS :KB-R7785 is a novel ADAM12/MMP inhibitor improving heart function and insulin sensitivity by blocking HB-EGF and TNF-alpha.Formule :C18H27N3O4Couleur et forme :SolidMasse moléculaire :349.42MDL 101146
CAS :MDL 101146 is an orally active neutrophil elastase inhibitor.Formule :C29H37F5N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :632.62O-Benzoylhydroxylamine
CAS :O-Benzoyl hydroxylamine exhibits properties as a dipeptidyl peptidase-IV (DPP-IV) inhibitor and demonstrates antidiabetic effects[1].Formule :C7H7NO2Couleur et forme :SolidMasse moléculaire :137.14Mergetpa
CAS :Mergetpa, a carboxypeptidase inhibitor, impedes the conversion of kinins and B2 receptor antagonists into metabolites devoid of the C-terminal arginine [1].Formule :C7H15N3O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :237.34Neurodegenerative Disorder-Targeting Compound 1
CAS :Neurodegenerative Disorder-Targeting Compound 1 is an inhibitor of calpain [1].Formule :C28H28N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :484.55LU-002i
CAS :LU-002i is a selective inhibitor targeting the human proteasome subunits β2c and β2i, demonstrating an inhibitory concentration (IC50) of 220 nM for β2i [1].Formule :C35H52N4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :640.81MMP-145
CAS :MMP-145 is used as a protease inhibitor.Formule :C20H20N2O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :432.45BMS-189664
CAS :BMS-189664 is an inhibitor of thrombin.Formule :C22H34N6O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :478.61MMP-3 Inhibitor VIII
CAS :Matrix metalloproteinase-3 (MMP-3), also known as stromelysin-1, is a critical enzyme involved in tissue remodeling and repair through its role in degrading extracellular matrix proteins, facilitating cell migration. This enzyme has been implicated in various physiological processes including vascular remodeling associated with aneurysm formation, wound healing, the progression of atherosclerosis, and tumor initiation. MMP-3 inhibitor VIII, a cell-permeable sulfonamide-based hydroxamic acid, effectively inhibits MMP-3 by binding to its active site (Ki = 23 nM), thus blocking its enzymatic activity. Additionally, this inhibitor has been demonstrated to suppress the activity of mouse macrophage metalloelastase MME/MMP-12, with an IC50 value of 13 nM, highlighting its potential utility in research on tissue remodeling and disease processes involving MMPs.Formule :C20H26N2O5SCouleur et forme :SolidMasse moléculaire :406.5GSK-625433
CAS :GSK-625433: Homochiral inhibitor blocks HCV genotypes 1a/1b polymerase.Formule :C26H32N4O5SCouleur et forme :SolidMasse moléculaire :512.62Proteasome-IN-5
CAS :Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].Formule :C20H30BN5O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :463.29Dim16
CAS :Dim16, a dual inhibitor of PCSK9/HMG-CoAR, demonstrates potent activity with an IC50 of 19 nM against PCSK9 and significantly impedes PCSK9-LDLR interactionFormule :C29H38IN5Couleur et forme :SolidMasse moléculaire :583.55HCV-IN-43
CAS :HCV-IN-43 (compound 2), an HCV NS5B protein inhibitor, efficiently inhibits HCV virus replication and is utilized in the study of HCV infection [1].Formule :C26H26FN3O5SCouleur et forme :SolidMasse moléculaire :511.57Proteasome β2c/i-IN-1
CAS :Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].Formule :C32H48N4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :600.75Beclabuvir HCl
CAS :Beclabuvir (BMS-791325) is an HCV inhibitor targeting NS5B polymerase with sub-28 nM potency for genotypes 1, 3, 4, 5.Formule :C36H46ClN5O5SCouleur et forme :SolidMasse moléculaire :696.3Paltimatrectinib
CAS :Paltimatrectinib (PBI-200) is a tyrosine kinase inhibitor with anticancer activity, and is used in the study of bladder, breast, and colorectal cancers.Formule :C20H15F5N6Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :434.37H-Gly-Pro-Hyp-OH acetate
CAS :H-Gly-Pro-Hyp-OH, a peptide dipeptidyl peptidase 4 (DPP-4) inhibitor with an inhibition concentration (IC50) of 2.51 mM, effectively hinders the activity of the DPP-4 enzyme.Formule :C12H19N3O5C2H4O2Couleur et forme :SolidMasse moléculaire :345.35LMP7-IN-2
CAS :LMP7-IN-2 is an inhibitor of LMP7 and may be utilized in the treatment of associated inflammatory diseases and disorders [1].Formule :C28H27N3O3SCouleur et forme :SolidMasse moléculaire :485.6LU-005i
CAS :LU-005i is a powerful inhibitor targeting the β5i subunit of immunoproteasomes, displaying a high potency with an IC 50 value of 6.6 nM, and exhibits selectivity by preferring β5i over the β5c subunit, which has an IC 50 value of 287 nM [1].Formule :C31H46N4O7Couleur et forme :SolidMasse moléculaire :586.72MMP-9-IN-8
CAS :MMP-9-IN-8 (Compound 3), an MMP-9 inhibitor, exhibits inhibitory activities of 42.16% at 10 μM and 58.28% at 50 μM.Formule :C20H21F4N7OCouleur et forme :SolidMasse moléculaire :451.42ASP-8497
CAS :ASP8497 is a potent DPP-IV inhibitor enhancing GLP-1, used for type 2 diabetes and glucose intolerance.Formule :C18H27FN4O7SCouleur et forme :SolidMasse moléculaire :462.49LONP1-IN-2
CAS :LONP1-IN-2: Potent LONP1 inhibitor, IC50=0.187μM; weak on 20S proteasome (>10μM); for cancer research.Formule :C16H27BN4O4Couleur et forme :SolidMasse moléculaire :350.22Z-LVG
CAS :Z-LVG, an irreversible cysteine protease inhibitor and a tripeptide derivative of cystatin C, serves as an inhibitor of viral replication and is utilized inFormule :C21H31N3O6Couleur et forme :SolidMasse moléculaire :421.49Cardanol diene
CAS :Cardanol diene: phenol in cashew shells; anti-tyrosinase (IC50=52.5μM); used to make anti-E. coli biofilm complexes.Formule :C21H32OCouleur et forme :SolidMasse moléculaire :300.48MK-0674
CAS :MK-0674 is a cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S for metabolism-related diseases.Formule :C26H27F6N3O2Degré de pureté :97.3% - 99.91%Couleur et forme :SolidMasse moléculaire :527.5γ-Glu-Tyr
CAS :gamma-Glu-Tyr (gamma-Glutamyltyrosine) is a kokumi peptide against dipeptidyl peptidase-IV (DPP-IV) and is used in the study of diabetes mellitus.Formule :C14H18N2O6Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :310.3HIV-1 inhibitor-54
CAS :HIV-1 inhibitor-54: potent anti-HIV (EC50: 32 nM), targets WT HIV-1 IIIB in MT-4 cells for infection research.Formule :C27H30N6O4SDegré de pureté :98.05% - 99.39%Couleur et forme :SoildMasse moléculaire :534.63ZED-1227
CAS :ZED-1227 (TAK-227) is a TG2 inhibitor with anticancer activity that blocks inflammation-induced TG2 expression and activation for the treatment of Celiac Diseas
Formule :C26H36N6O6Degré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :528.6BMS-212122
CAS :BMS-212122 inhibits MTP, reduces lipids and plaque in animal tests.Formule :C43H36F6N4O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :754.76Ref: TM-T30506
1mg315,00€5mg745,00€10mg1.018,00€25mg1.431,00€50mg1.783,00€100mg2.250,00€500mg4.410,00€Collagen proline hydroxylase inhibitor-1
CAS :Collagen proline hydroxylase inhibitor-1 具有抗纤维增生活性。Formule :C24H21N5O4Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :443.45Aderamastat
CAS :Aderamastat (FP-025) is an orally active matrix metalloproteinase 12 (MMP-12) inhibitor indicated for the study of allergic asthma, COPD and pulmonary fibrosis.Formule :C21H18N2O4SDegré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :394.44Nesbuvir
CAS :Nesbuvir: HCV NS5B polymerase inhibitor, IC50 9 nM against HCV 1b replicon in liver cancer cells.Formule :C22H23FN2O5SDegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :446.49Ref: TM-TQ0090
1mg60,00€2mg88,00€5mg133,00€10mg173,00€25mg301,00€50mg442,00€100mg577,00€200mg780,00€1mL*10mM (DMSO)147,00€VBY-825
CAS :VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.Formule :C23H29F4N3O5SDegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :535.55Freselestat quarterhydrate
ONO-6818 quarterhydrate: oral neutrophil elastase inhibitor, Ki 12.2 nM; >100x less effective on other proteases; strong anti-inflammatory.Formule :C23H30N6O5Couleur et forme :SolidMasse moléculaire :457.03Immunoproteasome activator 1
CAS :Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.Formule :C24H23N3O3Couleur et forme :SolidMasse moléculaire :401.46Anti-infective agent 10
CAS :Anti-infective agent 10 (Compound Example 30) is an ns5b polymerase inhibitor that functions as an anti-HCV agent.Formule :C26H25N3O7SCouleur et forme :SolidMasse moléculaire :523.56DPP-4-IN-15
CAS :DPP-4-IN-15 (Compound 22) is a non-competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 value of 8.24 μM.Formule :C17H14F3N3O2SCouleur et forme :SolidMasse moléculaire :381.372Gemigliptin tartrate hydrate
CAS :Gemigliptin (LC15-0444) tartrate hydrate is a selective, reversible, and competitive inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 value of 10.3 nM for human recombinant DPP-4. It exhibits strong anti-glycation properties and is used in research on advanced glycation end product-related diabetic complications.Formule :C22H27F8N5O9Couleur et forme :SolidMasse moléculaire :657.47Valopicitabine dihydrochloride
CAS :Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.Formule :C15H25ClN4O6Couleur et forme :SolidMasse moléculaire :392.84Antiplatelet agent 3
CAS :Antiplatelet agent 3 (Compound K-10) is a compound with antiplatelet aggregation activity, exhibiting IC50 values of 2.55, 3.22, and 2.09 mg/mL for platelet aggregation induced by ADP, AA, and COL, respectively. It holds potential for research in cardiovascular diseases.Formule :C38H32N2O5Couleur et forme :SolidMasse moléculaire :596.671Plodicitinib
CAS :Plodicitinib is an inhibitor of Janus tyrosine kinase 3/TEC family kinase, exhibiting anti-inflammatory properties.Formule :C19H22FN7O2Couleur et forme :SolidMasse moléculaire :399.422SBI-581
SBI-581: oral, potent TAO3 inhibitor, IC50=42nM, alters TKS5α at RAB11+ vesicles, blocks invadopodia, good mouse pharmacokinetics, anti-tumor.Formule :C24H21N3O2Couleur et forme :SolidMasse moléculaire :383.44RXP03
CAS :RXP03 is an MMPs inhibitor with K_i values of 20 nM for MMP-2, 2.5 nM for MMP-8, 10 nM for MMP-9, 5 nM for MMP-11, and 105 nM for MMP-14 [1].Formule :C39H43N4O6PCouleur et forme :SolidMasse moléculaire :694.76Dup-714
CAS :Dup-714 is a thrombin inhibitor.Formule :C21H33BN6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :460.33Duazomycin sodium
CAS :Duazomycin (Duazomycin A) sodium acts as a glutamine antagonist. It significantly enhances the efficacy of 6-Mercaptopurine (6-MP) in treating experimental autoimmune encephalomyelitis (EAE) without increasing toxicity.Formule :C8H10N3NaO4Couleur et forme :SolidMasse moléculaire :235.17Cyclophilin inhibitor 1
CAS :Cyclophilin inhibitor 1: orally available, Kd 5 nM, potent against HCV, EC50 for HCV 2a is 98 nM.Formule :C31H39N5O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :593.67ABT-072
CAS :ABT-072 is a nonnucleoside NS5B polymerase inhibitor and a candidate drug evaluated for treatment of hepatitis C virus.Formule :C24H27N3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.55RDN2150
CAS :RDN2150 (Compound 25), a ZAP-70 inhibitor with an IC50 of 14.6 nM, covalently binds to the C346 residue of ZAP-70, suppressing the expression of CD25 and CD69Formule :C28H29ClN8O4Couleur et forme :SolidMasse moléculaire :577.03Cathepsin C-IN-5
CAS :Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.Formule :C21H17ClN6OSCouleur et forme :SolidMasse moléculaire :436.92HsClpP activator-1
CAS :HsClpP activator-1 (compound 24) is a potent activator of HsClpP, with an EC50 of 0.22 μM. It effectively inhibits cancer cell growth, exhibiting IC50 values ranging from 0.1 to 1 μM.Formule :C23H20F5N3O2Couleur et forme :SolidMasse moléculaire :465.42Pyridoxatin
CAS :Pyridoxatin: fungal metabolite; blocks TBARS production, prevents AAPH-induced hemolysis, and acts against C. albicans.Formule :C15H21NO3Couleur et forme :SolidMasse moléculaire :263.33PLGLAG
CAS :PLGLAG is a peptide chain that acts as a linker in activatable cell-penetrating peptides (ACPPs). ACPPs containing the PLGLAG linker are primarily sensitive to MMP-2 and MMP-9 in vivo. PLGLAG is applicable in cancer research.Formule :C24H42N6O7Couleur et forme :SolidMasse moléculaire :526.63MMP-13-IN-1
CAS :MMP-13-IN-1, with an IC50 value of 16 nM, is a potent and selective inhibitor of MMP-13, suitable for atherosclerosis research [1].Formule :C19H16F3N3O3Couleur et forme :SolidMasse moléculaire :391.34UK-370106
CAS :UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-Formule :C35H44N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :572.73NAPAP
CAS :NAPAP is a thrombin inhibitor with potent anticoagulant activity (Ki: 2.1 nM). It selectively inhibits thrombin through a rapid binding mechanism while exhibiting weaker inhibition of trypsin, Factor Xa, and plasmin. NAPAP can be utilized for research into thrombotic conditions, including venous thrombosis and myocardial infarction.Formule :C27H31N5O4SCouleur et forme :SolidMasse moléculaire :521.63Zetomipzomib
CAS :KZR-616: Immunoproteasome inhibitor targeting LMP7 (IC50: 39/57 nM) & LMP2 (IC50: 131/179 nM), potential in autoimmune disease research.Formule :C30H42N4O8Couleur et forme :SolidMasse moléculaire :586.68Feniralstat
CAS :Feniralstat (KVD-824) is a selective and potent kallikrein (kallikrein) inhibitor, useful in immune system diseases and cardiovascular disease research.Formule :C26H25F2N5O4Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :509.51HCV-IN-7
CAS :HCV-IN-7: potent oral HCV NS5A inhibitor, pan-genotypic, IC50s 3-47 pM, good pharmacokinetics, favorable liver uptake.Formule :C40H48N8O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :768.92
