Protéases/Protéasome
Les inhibiteurs de protéases et de protéasomes sont des composés qui bloquent l'activité des protéases et du protéasome, impliqués dans la dégradation et le renouvellement des protéines. Ces inhibiteurs sont essentiels pour étudier la régulation de l'homéostasie des protéines, le contrôle du cycle cellulaire et l'apoptose. Les inhibiteurs de protéases et de protéasomes sont également utilisés dans le traitement de maladies telles que le cancer, où une dégradation anormale des protéines joue un rôle dans la progression de la maladie. En inhibant les protéases ou le protéasome, ces composés peuvent induire la mort cellulaire dans les cellules cancéreuses et sont des outils essentiels tant pour la recherche fondamentale que pour le développement thérapeutique. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de protéases et de protéasomes de haute qualité pour soutenir vos recherches en biochimie, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Protéases/Protéasome"
- Acétyl-CoA Carboxylase(38 produits)
- Cystéine protéase(111 produits)
- DPP-4(27 produits)
- Glutaminase(46 produits)
- Protéase du VIH(506 produits)
- PAI-1(26 produits)
- Inhibiteurs de protéase(50 produits)
- Récepteur activé par une protéase(55 produits)
- Protéasome(86 produits)
- Sérine protéase(54 produits)
- p97(15 produits)
Affichez 3 plus de sous-catégories
984 produits trouvés pour "Protéases/Protéasome"
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20S Proteasome activator 1
CAS :20S Proteasome activator 1: IC50—0.3 μM (trypsin), 0.7 μM (chymotrypsin), 1.8 μM (caspase); reduces alpha-synuclein A53T, aids neurodegenerative studies.Formule :C27H19ClF2N2OSDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :492.97Gemigliptin
CAS :Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)Formule :C18H19F8N5O2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :489.36Ref: TM-T7369
2mg38,00€5mg57,00€10mg93,00€25mg148,00€50mg245,00€100mg385,00€500mg873,00€1mL*10mM (DMSO)84,00€TY-51469
CAS :TY-51469 is an inhibitor of chymase (IC50s for simian and human chymases: 0.4 and 7.0 nM, respectively).Formule :C20H15FN2O6S4Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :526.6VRK-IN-1
CAS :VRK-IN-1 is a potent and selective inhibitor of cowpox-associated kinase 1 (VRK1), which can be used in the study of neurological disorders.Formule :C18H11F4NO2Degré de pureté :99.18% - 99.25%Couleur et forme :SolidMasse moléculaire :349.28Ref: TM-T35863
1mg98,00€5mg225,00€10mg359,00€25mg710,00€50mg1.071,00€100mg1.431,00€200mg1.953,00€1mL*10mM (DMSO)245,00€UK-396082
CAS :UK-396082 is a TAFI inhibitor that inhibits Carboxypeptidase B and can be used in the study of thrombosis, atherosclerosis, cancer and fibrotic conditions.Formule :C12H21N3O2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :239.31UPGL00004
CAS :UPGL00004: potent GAC inhibitor, IC50=29 nM, Kd=27 nM, suppresses triple-negative breast cancer cell growth.Formule :C25H26N8O2S2Degré de pureté :97.93%Couleur et forme :SolidMasse moléculaire :534.66Lenacapavir
CAS :Lenacapavir (GS-6207) is the first HIV-1 capsid inhibitor approved by the U.S. Food and Drug Administration, the European Medicines Agency, and Health Canada for the treatment of MDR HIV-1 infection.Cost-effective and quality-assured.Formule :C39H32ClF10N7O5S2Degré de pureté :99.61% - 99.87%Couleur et forme :SolidMasse moléculaire :968.28Ref: TM-T11465
1mg187,00€5mg376,00€10mg565,00€25mg998,00€50mg1.388,00€100mg1.882,00€200mg2.622,00€1mL*10mM (DMSO)615,00€BDCRB
BDCRB disrupts HCMV DNA maturation by altering terminase cleavage, extending packaging 30 kb until second site.Formule :C12H11BrCl2N2O4Degré de pureté :99.41% - 99.85%Couleur et forme :SoildMasse moléculaire :398.04BILB-1941
CAS :BILB-1941 (BILB-1941ZW) is an inhibitor of HCV NS5B polymerase and can be used in studies about HCV infection.Formule :C34H34N4O4Degré de pureté :99.51% - 99.65%Couleur et forme :SolidMasse moléculaire :562.66Ref: TM-T26815
1mg296,00€5mg718,00€10mg982,00€25mg1.485,00€50mg2.008,00€100mg2.637,00€1mL*10mM (DMSO)1.044,00€DB04760
CAS :DB04760: selective MMP-13 inhibitor, non-zinc-chelating, IC50=8nM, reduces paclitaxel neurotoxicity, anticancer.Formule :C22H20F2N4O2Degré de pureté :99.93% - 99.99%Couleur et forme :SolidMasse moléculaire :410.42Ref: TM-T15055
1mg84,00€5mg205,00€10mg309,00€25mg522,00€50mg747,00€100mg1.035,00€500mg2.052,00€1mL*10mM (DMSO)178,00€JNJ-10311795
CAS :JNJ-10311795 (RWJ-355871) is an inhibitor of neutrophil elastase G and mast cell chymase, demonstrating significant anti-inflammatory effects.Formule :C40H35N2O6PDegré de pureté :97.43%Couleur et forme :SolidMasse moléculaire :670.69Setrobuvir
CAS :Setrobuvir (ANA-598) is an orally active non-nucleoside HCV NS5B polymerase inhibitor with inhibitory effects on de novo RNA synthesis and primer extension withFormule :C25H25FN4O6S2Degré de pureté :99.95% - 99.97%Couleur et forme :SolidMasse moléculaire :560.62Ref: TM-T28762
1mg229,00€5mg570,00€10mg812,00€25mg1.216,00€50mg1.663,00€100mg2.242,00€500mg4.494,00€1mL*10mM (DMSO)737,00€Sovaprevir
CAS :Sovaprevir is a non-structural 3 (NS3) protease inhibitor with antiviral activity for the treatment of HCV infection.Formule :C43H53N5O8SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :799.97Ref: TM-T28830
1mg253,00€5mg620,00€10mg884,00€25mg1.314,00€50mg1.773,00€100mg2.385,00€1mL*10mM (DMSO)982,00€Melagatran
CAS :Melagatran is an orally available, direct synthetic thrombin inhibitor that does not require endogenous cofactors other than thrombin.Cost-effective and quality-assured.Formule :C22H31N5O4Degré de pureté :98.29% - >99.99%Couleur et forme :SolidMasse moléculaire :429.51Ref: TM-T11994
1mg487,00€5mg1.134,00€10mg1.468,00€25mg2.215,00€50mg2.962,00€100mg4.024,00€1mL*10mM (DMSO)1.071,00€MMP2-IN-3
CAS :MMP2-IN-3 is a potent inhibitor of matrix metalloproteinases (MMP-2) (IC50: 31 μM).Formule :C23H21N3ODegré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :355.43Ref: TM-T61271
1mg64,00€5mg132,00€10mg195,00€25mg315,00€50mg439,00€100mg590,00€200mg793,00€1mL*10mM (DMSO)140,00€Sirpiglenastat
CAS :Sirpiglenastat (DRP-104) is a glutamine antagonist, a prodrug of DON, with antitumor activity that acts by suppressing the adaptive immune system.Formule :C22H27N5O5Degré de pureté :98.01% - 98.37%Couleur et forme :SolidMasse moléculaire :441.48Isatoribine
CAS :Isatoribine(ANA245) free base is a potent TLR7 receptor agonist with anti-hepatitis C virus infection activity for the study of HCV infection.Formule :C10H12N4O6SDegré de pureté :98.99% - 99.75%Couleur et forme :SolidMasse moléculaire :316.29AGPS-IN-2i
CAS :AGPS-IN-2i inhibits alkylglycerol phosphate synthase, affecting ether lipid metabolism and reducing cancer cell migration and proliferation.Formule :C18H17F2N3O2Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :345.34Ref: TM-T69685
1mg74,00€5mg188,00€10mg311,00€25mg525,00€50mg747,00€100mg1.017,00€1mL*10mM (DMSO)154,00€HIV-1 integrase inhibitor 8
CAS :HIV-1 integrase inhibitor 8 is an inhibitor of HIV-1 integrase. Integration is a required step in HIV replication [1].
Formule :C21H24O2Degré de pureté :98.91%Couleur et forme :SolidMasse moléculaire :308.41MMP-2/MMP-9 Inhibitor I
CAS :MMP-2/MMP-9-IN-1: oral IV collagenase inhibitor; IC50: 0.24 μM (MMP-9), 0.31 μM (MMP-2); targets cancer.Formule :C21H19NO4SDegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :381.44Ref: TM-T21512
1mg56,00€5mg119,00€10mg177,00€25mg356,00€50mg590,00€100mg888,00€200mg1.198,00€1mL*10mM (DMSO)133,00€MK-8325
CAS :MK-8325 is a potent and orally available HCV NS5A inhibitor with replicative activity against a wide range of genotypes.MK-8325 has demonstrated bioavailabilityFormule :C43H54Cl2F2N8O6SiDegré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :915.93BAY-43-9695
CAS :BAY-43-9695 is a non-nucleoside compound with anti-human cytomegalovirus (HCMV) activity. It is the major metabolite of BAY-38-4766.Formule :C22H25N3O4SDegré de pureté :99.50% - 99.98%Couleur et forme :SolidMasse moléculaire :427.52BMS-929075
CAS :BMS-929075 is an orally active HCV NS5B replicase (HCV NS5B replicase) palm site variant inhibitor with potency, high oral bioavailability and pharmacokineticFormule :C31H24F2N4O3Degré de pureté :99.81% - 99.94%Couleur et forme :SolidMasse moléculaire :538.54Ref: TM-T26863
1mg172,00€5mg432,00€10mg618,00€25mg973,00€50mg1.333,00€100mg1.791,00€500mg3.529,00€1mL*10mM (DMSO)538,00€P32/98 hemifumarate
CAS :P32/98 hemifumarate is a DPP4 inhibitor with hypoglycemic properties and is used in the study of type 2 diabetes.Formule :C22H40N4O6S2Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :520.71CP-544439
CAS :CP-544439 is an inhibitor of matrix metalloproteinase-13, which has an effect on adipose tissue development.Formule :C18H19FN2O6SDegré de pureté :95.02% - 98.66%Couleur et forme :SolidMasse moléculaire :410.42Uprifosbuvir
CAS :Uprifosbuvir is an inhibitor of uridine nucleotide analog HCV NS5B polymerase.Formule :C22H29ClN3O9PDegré de pureté :99.73% - >99.99%Couleur et forme :SolidMasse moléculaire :545.91TS-021
CAS :TS-021 is a selective dipeptidyl peptidase 4 (DPP-4) inhibitor with antidiabetic activity for the study of type 2 diabetes.Formule :C17H24FN3O5SDegré de pureté :>99.99% - >99.99%Couleur et forme :SolidMasse moléculaire :401.45Etarotene
CAS :Etarotene (Arotinoid ethyl sulphone) is an ethylsulfonyl derivative of aloe acid with differentiation-inducing and potentially antitumor activity.Etarotene is aFormule :C25H32O2SDegré de pureté :99.58% - 99.98%Couleur et forme :SolidMasse moléculaire :396.59ND-378
CAS :ND-378 is a potent and selective inhibitor of MMP-2 with no inhibition on MMP-9 and MMP-14.Formule :C18H19NO4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :377.48Atecegatran metoxil
CAS :Atecegatran Metoxil (AZD0837), an oral thrombin inhibitor in development for stroke prevention in atrial fibrillation, is well-tolerated with favorable PK.Formule :C22H23ClF2N4O5Couleur et forme :SolidMasse moléculaire :496.89Cyclotheonellazole A
CAS :Cyclotheonellazole A inhibits elastase (IC50=0.034nM) & chymotrypsin (IC50=0.62nM), a natural macrocyclic peptide.Formule :C44H54N9NaO14S2Couleur et forme :SolidMasse moléculaire :1020.07AA74-1
CAS :AA74-1 is a potent, selective APEH inhibitor that significantly enhances T-cell proliferation by inhibiting APEH activity [1].Formule :C16H28N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :308.42Inogatran
CAS :Inogatran is a synthetic thrombin inhibitor, developed for the possible treatment and prophylaxis of venous and arterial thrombotic diseases.Formule :C21H38N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.56JW 480
CAS :JW480 is a potent and selective inhibitor of KIAA1363, a serine hydrolase enzyme.Formule :C22H23NO2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :333.42Ref: TM-T22883
2mg35,00€5mg49,00€10mg79,00€25mg160,00€50mg259,00€100mg416,00€200mg587,00€1mL*10mM (DMSO)57,00€NS5A-IN-3
CAS :NS5A-IN-3 is a potent NS5A inhibitor with high efficacy against HCV 1b, good activity on 3a, and strong metabolic stability; superior to daclatasvir.Formule :C44H44N6O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :784.86Petesicatib
CAS :Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.Formule :C25H23F6N5O4SDegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :603.54Ref: TM-T16474
1mg100,00€5mg236,00€10mg371,00€25mg735,00€50mg1.134,00€100mg1.468,00€200mg1.972,00€1mL*10mM (DMSO)314,00€LU-005i
CAS :LU-005i is a powerful inhibitor targeting the β5i subunit of immunoproteasomes, displaying a high potency with an IC 50 value of 6.6 nM, and exhibits selectivity by preferring β5i over the β5c subunit, which has an IC 50 value of 287 nM [1].Formule :C31H46N4O7Couleur et forme :SolidMasse moléculaire :586.72LY52
CAS :LY52 is a matrix metalloproteinase-2 inhibitor. It acts by suppressing tumor invasion and metastasis.Formule :C22H24N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.45FK706
CAS :FK706, a human neutrophil elastase inhibitor (IC50: 83 nM, Ki: 4.2 nM), also blocks mouse and porcine elastases. Anti-inflammatory.Formule :C26H33F3N4NaO7Couleur et forme :SolidMasse moléculaire :593.556XL-784
CAS :XL-784 is a selective MMP inhibitor with low IC50s for MMP-1,2,3,8,9,13, modulating extracellular matrix remodeling, tumor invasion, and metastasis in cancer.Formule :C42H42Cl2F4MgN6O16S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1122.15BMS-538305 HCl
CAS :BMS-538305 is a potent, selective inhibitor of dipeptidyl peptidase IV (DPP-IV).Formule :C17H27ClN2O2Couleur et forme :SolidMasse moléculaire :326.86(Rac)-Neurodegenerative Disorder-Targeting Compound 1
CAS :(Rac)-Neurodegenerative Disorder-Targeting Compound 1 is a calpain inhibitor.Formule :C28H28N4O4Couleur et forme :SolidMasse moléculaire :484.55KCC009
CAS :KCC009 is a potent and selective Transglutaminase 2 Inhibitor.Formule :C21H22BrN3O5Couleur et forme :SolidMasse moléculaire :476.32JTK-853
CAS :JTK-853: novel non-nucleoside HCV polymerase inhibitor with strong antiviral activity (EC50: 0.38 μM genotype 1a, 0.035 μM 1b).Formule :C28H23F7N6O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :704.64MMP-9-IN-8
CAS :MMP-9-IN-8 (Compound 3), an MMP-9 inhibitor, exhibits inhibitory activities of 42.16% at 10 μM and 58.28% at 50 μM.Formule :C20H21F4N7OCouleur et forme :SolidMasse moléculaire :451.42Z-DEVD-CMK
CAS :Z-DEVD-CMK irreversibly inhibits various cathepsins in vitro [1].Formule :C27H35ClN4O12Couleur et forme :SolidMasse moléculaire :643.04DCLK1-IN-2
CAS :DCLK1-IN-2 (Compound I-5) is a potent inhibitor of DCLK1, exhibiting an IC50 of 171.3 nM, and demonstrates significant antiproliferative effects on SW1990 cellFormule :C26H32N8O3SCouleur et forme :SolidMasse moléculaire :536.65BMS-189664 HCl
CAS :BMS-189664 HCl is a selective and orally active thrombin active site inhibitor.Formule :C22H35ClN6O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.07Ravidasvir HCl
CAS :Ravidasvir, also known as PPI-668 and ASC16, is a second-generation, orally active, potent and selective HCV NS5A protein inhibitor.Formule :C42H52Cl2N8O6Couleur et forme :SolidMasse moléculaire :835.828Z-LVG
CAS :Z-LVG, an irreversible cysteine protease inhibitor and a tripeptide derivative of cystatin C, serves as an inhibitor of viral replication and is utilized inFormule :C21H31N3O6Couleur et forme :SolidMasse moléculaire :421.49
