Protéases/Protéasome
Les inhibiteurs de protéases et de protéasomes sont des composés qui bloquent l'activité des protéases et du protéasome, impliqués dans la dégradation et le renouvellement des protéines. Ces inhibiteurs sont essentiels pour étudier la régulation de l'homéostasie des protéines, le contrôle du cycle cellulaire et l'apoptose. Les inhibiteurs de protéases et de protéasomes sont également utilisés dans le traitement de maladies telles que le cancer, où une dégradation anormale des protéines joue un rôle dans la progression de la maladie. En inhibant les protéases ou le protéasome, ces composés peuvent induire la mort cellulaire dans les cellules cancéreuses et sont des outils essentiels tant pour la recherche fondamentale que pour le développement thérapeutique. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de protéases et de protéasomes de haute qualité pour soutenir vos recherches en biochimie, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Protéases/Protéasome"
- Acétyl-CoA Carboxylase(38 produits)
- Cystéine protéase(111 produits)
- DPP-4(27 produits)
- Glutaminase(46 produits)
- Protéase du VIH(506 produits)
- PAI-1(26 produits)
- Inhibiteurs de protéase(50 produits)
- Récepteur activé par une protéase(55 produits)
- Protéasome(86 produits)
- Sérine protéase(54 produits)
- p97(15 produits)
Affichez 3 plus de sous-catégories
985 produits trouvés pour "Protéases/Protéasome"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
GLS-1-IN-1
GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.Formule :C26H25FN4OSCouleur et forme :SolidMasse moléculaire :460.57Tilpisertib fosmecarbil
CAS :Tilpisertib fosmecarbil is a potent inhibitor of serine/threonine kinases with anti-inflammatory properties.Formule :C35H36ClN8O7PCouleur et forme :SolidMasse moléculaire :747.14RBx-0597
CAS :RBx-0597 is a selective DPP-IV inhibitor with IC50 values of 32 nM, 31 nM, and 39 nM for human, mouse, and rat plasma DPP-IV, respectively. It is utilized in research focused on type 2 diabetes.Formule :C19H20F2N4O2Couleur et forme :SolidMasse moléculaire :374.384(1R,3S)-THCCA-Asn
(1R,3S)-THCCA-Asn (4j) is a selective inhibitor of thrombin (IC50: 0.07-0.14 μM) with anti-thrombotic effects.Formule :C24H24N4O6Couleur et forme :SolidMasse moléculaire :464.47UK 356618
CAS :UK 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (IC50: 5.9 nM).Formule :C34H43N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :557.72GSK5852
GSK5852, an HCV NS5B inhibitor, has IC50 of 50 nM; potently fights HCV with EC50 of 3.0 nM for GT1a and 1.7 nM for GT1b.Formule :C27H27BF2N2O6SCouleur et forme :SolidMasse moléculaire :556.393-Aminobenzene-1,2-diol
CAS :3-Aminobenzene-1,2-diol (compound C8) is an inhibitor of matrix metalloproteinases (MMP), with IC50 values of 20, 26, 16, and 16.3 μM against MMP-2, MMP-8, MMP-9, and MMP-14, respectively.Formule :C6H7NO2Couleur et forme :SolidMasse moléculaire :125.13HCV-IN-40
CAS :HCV-IN-39 is a potent oral drug inhibiting HCV, effective on GT1a (EC50: 0.259μM), GT1b (EC50: 0.434μM), GT1b CES1 (EC50: 0.069μM) replicons.Formule :C21H26BrFN3O9PCouleur et forme :SolidMasse moléculaire :594.32BAY-7598
CAS :BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).Formule :C28H31N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :505.56HCV NS5B polymerase-IN-2
CAS :HCVNS5B polymerase-IN-2 (Compound 298) is an inhibitor of the Ns5b polymerase. It holds potential for research into the treatment of hepatitis C virus (HCV) infections.Formule :C26H24N2O4Couleur et forme :SolidMasse moléculaire :428.48Isobutylamido thiazolyl resorcinol
CAS :Isobutylamido thiazolyl resorcinol is a tyrosinase (Tyrosinase) inhibitor that prevents pigment deposition induced by ultraviolet radiation.Formule :C13H14N2O3SCouleur et forme :SolidMasse moléculaire :278.33GW311616 hydrochloride
CAS :GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).Formule :C19H32ClN3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :433.99HCV-IN-38
Potent oral HCV inhibitor HCV-IN-38 has 15 nM EC50, 431 SI, high efficacy, and low toxicity.Formule :C22H24ClF3N4O4Couleur et forme :SolidMasse moléculaire :500.9SBI-581
SBI-581: oral, potent TAO3 inhibitor, IC50=42nM, alters TKS5α at RAB11+ vesicles, blocks invadopodia, good mouse pharmacokinetics, anti-tumor.Formule :C24H21N3O2Couleur et forme :SolidMasse moléculaire :383.44MK-8876
CAS :MK-8876 is an Inhibitor of HCV NS5B Site D.Formule :C32H24F2N4O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :614.62Cathepsin C-IN-3
Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).Formule :C28H21F3N6OSCouleur et forme :SolidMasse moléculaire :546.57Plasma kallikrein-IN-2
Plasma kallikrein-IN-2: PKal inhibitor, IC50=0.1 nM. Used in angioedema, diabetic eye disease research.Formule :C28H24ClF3N8O3Couleur et forme :SolidMasse moléculaire :612.99AMG-222 tosylate
CAS :AMG-222 tosylate is a DPP-IV inhibitor in clinical development for type II diabetes.Formule :C39H47N9O6SCouleur et forme :SolidMasse moléculaire :769.91Faldaprevir
CAS :Faldaprevir is an orally effective, selective, non-covalent HCV NS3/4A protease inhibitor with high inhibitory activity against HCV 1a and 1b genotype.Formule :C40H49BrN6O9SDegré de pureté :99.04% - 99.19%Couleur et forme :SolidMasse moléculaire :869.82BI-1915
CAS :BI-1915 is a selective inhibitor of Cathepsin S, with an IC50 of 17 nM. It is utilized in the research of autoimmune diseases.
Formule :C21H37N5O3Couleur et forme :SolidMasse moléculaire :407.55Narlaprevir
CAS :Narlaprevir (SCH 900518) is an HCV NS3 inhibitor with anti-HCV activity, inhibiting SARS-CoV-2, and useful in virus infection research.Formule :C36H61N5O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :707.96MMP-13-IN-1
CAS :MMP-13-IN-1, with an IC50 value of 16 nM, is a potent and selective inhibitor of MMP-13, suitable for atherosclerosis research [1].Formule :C19H16F3N3O3Couleur et forme :SolidMasse moléculaire :391.34TMPRSS6-IN-1 TFA
TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), a member of the TTSP family (a type of transmembrane serine protease). TMPRSS6 is a type II TTSP, and genetically reduced levels of TMPRSS6 have been shown to improve symptoms of hemochromatosis and β-thalassemia in mice.Formule :C35H41F3N8O6S2Couleur et forme :SolidMasse moléculaire :790.875(2S,4R)-Teneligliptin
CAS :(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.Formule :C22H30N6OSCouleur et forme :SolidMasse moléculaire :426.578BI-1942
CAS :BI-1942 is a chymase inhibitor with an IC50 value of 0.4 nM against human chymase. It is applicable for research in ophthalmic diseases.Formule :C24H26N4O4Couleur et forme :SolidMasse moléculaire :434.488Cathepsin K inhibitor 2
CAS :Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.Formule :C30H33F4N5O3Couleur et forme :SolidMasse moléculaire :587.61PNU-248686A
CAS :PNU-248686A is an inhibitor of matrix metalloproteinase (MMP).Formule :C22H18ClNaO5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :484.95UK-370106
CAS :UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-Formule :C35H44N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :572.73Belactin A
CAS :Belactin A acts as an inhibitor of vasohibin-1 [VASH-1] with an IC50 of 0.18 µg/ml.Formule :C17H21ClN2O4Couleur et forme :SolidMasse moléculaire :352.81Kallikrein-IN-1
CAS :Kallikrein-IN-1 (Formula A) is an inhibitor of the kinin-releasing enzyme Kallikrein.Formule :C28H26FN5O4Couleur et forme :SolidMasse moléculaire :515.54GSK-2878175
CAS :GSK-2878175, a NS5B inhibitor, is used potentially for the treatment of HCV infection.Formule :C27H23BClFN2O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :568.81Piceid 6″-O-azelaic acid ester
Piceid 6″-O-azelaic acid ester exhibited strong intracellular tyrosinase inhibition and decolorization activity.Formule :C24H36O10Couleur et forme :SolidMasse moléculaire :484.54Ciluprevir
CAS :Ciluprevir is a selective HCV NS3 protease inhibitor, effective against non-genotype-1 HCV; less potent for genotypes 2/3.Formule :C40H50N6O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :774.93MeO-Suc-Ala-Ala-Pro-Ala-CMK
CAS :MeO-Suc-Ala-Ala-Pro-Ala-CMK (MSACK) is an inhibitor of human neutrophil elastase (HNE) with an IC50 of 20.3 μM. It effectively inhibits the hydrolysis of substrates like lung tissue elastin by HNE and is applicable in studies related to conditions such as chronic obstructive pulmonary disease (COPD).Formule :C20H31ClN4O7Couleur et forme :SolidMasse moléculaire :474.936Valopicitabine dihydrochloride
CAS :Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.Formule :C15H25ClN4O6Couleur et forme :SolidMasse moléculaire :392.84Antiplatelet agent 3
CAS :Antiplatelet agent 3 (Compound K-10) is a compound with antiplatelet aggregation activity, exhibiting IC50 values of 2.55, 3.22, and 2.09 mg/mL for platelet aggregation induced by ADP, AA, and COL, respectively. It holds potential for research in cardiovascular diseases.Formule :C38H32N2O5Couleur et forme :SolidMasse moléculaire :596.671Plodicitinib
CAS :Plodicitinib is an inhibitor of Janus tyrosine kinase 3/TEC family kinase, exhibiting anti-inflammatory properties.Formule :C19H22FN7O2Couleur et forme :SolidMasse moléculaire :399.422Dup-714
CAS :Dup-714 is a thrombin inhibitor.Formule :C21H33BN6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :460.33Freselestat
CAS :Freselestat (ONO-6818) inhibits neutrophil elastase, reduces interleukin 8, C5B-9, and inflammation in cardiopulmonary bypass.Formule :C23H28N6O4Couleur et forme :SolidMasse moléculaire :452.51Cathepsin C-IN-4
Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM).Formule :C21H14ClF3N4SCouleur et forme :SolidMasse moléculaire :446.88SMCypI C31
SMCypIC31, a non-peptide cyclophilin inhibitor, blocks PPIase at 0.1 μM IC50 and fights various HCV genotypes (EC50: 1.20-7.76 μM).Formule :C27H30N4O2SCouleur et forme :SolidMasse moléculaire :474.62TG-2-IN-4
CAS :TG-2-IN-4 (compound 8), an inhibitor of transglutaminase 2 (TG2) with an IC 50 value of less than 0.5 mM, is utilized in the study of inflammatory disorders [1].Formule :C34H40N6O5Couleur et forme :SolidMasse moléculaire :612.72Zetomipzomib
CAS :KZR-616: Immunoproteasome inhibitor targeting LMP7 (IC50: 39/57 nM) & LMP2 (IC50: 131/179 nM), potential in autoimmune disease research.Formule :C30H42N4O8Couleur et forme :SolidMasse moléculaire :586.68Deleobuvir
CAS :Deleobuvir(BI207127) is an inhibitor of non-nucleoside hepatitis C virus NS5B polymerase for the treatment of hepatitis C.Formule :C34H33BrN6O3Couleur et forme :SolidMasse moléculaire :653.57GW311616
CAS :GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).Formule :C19H31N3O4SCouleur et forme :SolidMasse moléculaire :397.53TCL1
CAS :TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.Formule :C19H14BrClN4O2SCouleur et forme :SolidMasse moléculaire :477.762SAR107375
CAS :SAR107375 is a potent, orally active dual inhibitor of thrombin and factor Xa, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively [1].Formule :C24H30ClN5O5S2Couleur et forme :SolidMasse moléculaire :568.11Tyrosinase-IN-29
CAS :Tyrosinase-IN-29 (compound 5c) is an effective inhibitor of abTYR tyrosinase, demonstrating an IC50 value of 6.11 μM. It is suitable for further research into the inhibition of excessive skin pigmentation.Formule :C10H9NO2Couleur et forme :SolidMasse moléculaire :175.18Tyrosinase-IN-20
CAS :Tyrosinase-IN-20 (compound 6a) acts as a potent Tyrosinase inhibitor, demonstrating an IC 50 value of 28.50 μM [1].Formule :C17H18N2O2SCouleur et forme :SolidMasse moléculaire :314.4Napsagatran hydrate
CAS :Napsagatran hydrate is a novel and specific inhibitor of thrombin.Formule :C26H36N6O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :576.66
