Protéases/Protéasome
Les inhibiteurs de protéases et de protéasomes sont des composés qui bloquent l'activité des protéases et du protéasome, impliqués dans la dégradation et le renouvellement des protéines. Ces inhibiteurs sont essentiels pour étudier la régulation de l'homéostasie des protéines, le contrôle du cycle cellulaire et l'apoptose. Les inhibiteurs de protéases et de protéasomes sont également utilisés dans le traitement de maladies telles que le cancer, où une dégradation anormale des protéines joue un rôle dans la progression de la maladie. En inhibant les protéases ou le protéasome, ces composés peuvent induire la mort cellulaire dans les cellules cancéreuses et sont des outils essentiels tant pour la recherche fondamentale que pour le développement thérapeutique. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de protéases et de protéasomes de haute qualité pour soutenir vos recherches en biochimie, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Protéases/Protéasome"
- Acétyl-CoA Carboxylase(34 produits)
- Cystéine protéase(96 produits)
- DPP-4(20 produits)
- Glutaminase(40 produits)
- Protéase du VIH(447 produits)
- PAI-1(25 produits)
- Inhibiteurs de protéase(50 produits)
- Récepteur activé par une protéase(54 produits)
- Protéasome(94 produits)
- Sérine protéase(50 produits)
- p97(14 produits)
Affichez 3 plus de sous-catégories
1045 produits trouvés pour "Protéases/Protéasome"
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(1R,4S)-Yimitasvir diphosphate
CAS :<p>Yimitasvir diphosphate, also known as Emitasvir, is an orally-administered inhibitor of the hepatitis C virus (HCV) nonstructural protein 5A (NS5A).</p>Formule :C49H64N8O14P2Couleur et forme :SolidMasse moléculaire :1051.03Tyropeptin A-4
CAS :<p>Tyropeptin A-4 is used as a proteasome inhibitor.</p>Formule :C31H41N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :551.67BMS-189664
CAS :<p>BMS-189664 is an inhibitor of thrombin.</p>Formule :C22H34N6O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :478.61HCV-IN-44
CAS :<p>HCV-IN-44 (compound 28) is an inhibitor of the HCV NS5B protein, efficacious in suppressing HCV virus replication and useful for researching HCV infection [1].</p>Formule :C24H26FN3O5SCouleur et forme :SolidMasse moléculaire :487.54HCV-IN-43
CAS :<p>HCV-IN-43 (compound 2), an HCV NS5B protein inhibitor, efficiently inhibits HCV virus replication and is utilized in the study of HCV infection [1].</p>Formule :C26H26FN3O5SCouleur et forme :SolidMasse moléculaire :511.57Reverse transcriptase-IN-1
CAS :<p>Reverse transcriptase-IN-1 is a diarylbenzopyrimidine (DABP) analogue and a potent inhibitor of HIV-1 nonnucleoside reverse transcriptase with an IC50of 13.7</p>Formule :C25H17N7O2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :447.45Cathepsin K inhibitor 3
CAS :<p>Cathepsin K inhibitor 3: Selective, IC50 of 0.5 nM, good pharmacokinetics, potential for OA research.</p>Formule :C30H31FN4O4SCouleur et forme :SolidMasse moléculaire :562.65Mergetpa
CAS :<p>Mergetpa, a carboxypeptidase inhibitor, impedes the conversion of kinins and B2 receptor antagonists into metabolites devoid of the C-terminal arginine [1].</p>Formule :C7H15N3O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :237.34Cathepsin Inhibitor 2
CAS :<p>Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).</p>Formule :C19H21F6N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.38LY52
CAS :<p>LY52 is a matrix metalloproteinase-2 inhibitor. It acts by suppressing tumor invasion and metastasis.</p>Formule :C22H24N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.45Atecegatran metoxil
CAS :<p>Atecegatran Metoxil (AZD0837), an oral thrombin inhibitor in development for stroke prevention in atrial fibrillation, is well-tolerated with favorable PK.</p>Formule :C22H23ClF2N4O5Couleur et forme :SolidMasse moléculaire :496.89HIV-1 protease-IN-11
CAS :<p>HIV-1 protease-IN-11 (compound 34a), an HIV-1 protease inhibitor, demonstrates potent inhibition with an IC50 of 0.41 nM and maintains substantial efficacy</p>Formule :C26H37N3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :503.65MMP-3 Inhibitor VIII
CAS :<p>Matrix metalloproteinase-3 (MMP-3), also known as stromelysin-1, is a critical enzyme involved in tissue remodeling and repair through its role in degrading extracellular matrix proteins, facilitating cell migration. This enzyme has been implicated in various physiological processes including vascular remodeling associated with aneurysm formation, wound healing, the progression of atherosclerosis, and tumor initiation. MMP-3 inhibitor VIII, a cell-permeable sulfonamide-based hydroxamic acid, effectively inhibits MMP-3 by binding to its active site (Ki = 23 nM), thus blocking its enzymatic activity. Additionally, this inhibitor has been demonstrated to suppress the activity of mouse macrophage metalloelastase MME/MMP-12, with an IC50 value of 13 nM, highlighting its potential utility in research on tissue remodeling and disease processes involving MMPs.</p>Formule :C20H26N2O5SCouleur et forme :SolidMasse moléculaire :406.5Dim16
CAS :<p>Dim16, a dual inhibitor of PCSK9/HMG-CoAR, demonstrates potent activity with an IC50 of 19 nM against PCSK9 and significantly impedes PCSK9-LDLR interaction</p>Formule :C29H38IN5Couleur et forme :SolidMasse moléculaire :583.55DS-1040 Tosylate
CAS :<p>DS-1040 Tosylate is a thrombin-activated fibrinolysis inhibitor (TAFI) inhibitor and a fibrinolysis enhancer, used for researching thromboembolic diseases.</p>Formule :C23H35N3O5SCouleur et forme :SolidMasse moléculaire :465.61M867
CAS :<p>M867 is a selective, reversible caspase-3 inhibitor, possessing an IC50 of 1.4 nM and a Ki value of 0.7 nM, demonstrating anti-apoptotic activity [1].</p>Formule :C27H43N7O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :561.67LM-030
CAS :<p>LM-030, also known as BPR277, is a novel inhibitor of kallikrein-related peptidase 7 (KLK7) and epidermal elastase 2 (ELA2).</p>Formule :C46H72N8O12Couleur et forme :SolidMasse moléculaire :929.11MMP-9 Inhibitor I
CAS :<p>MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively).</p>Formule :C27H33N3O5SCouleur et forme :SolidMasse moléculaire :511.63M190S
CAS :<p>M109S is a novel small molecule that shields cells from mitochondria-dependent apoptosis, demonstrating effectiveness both in vitro and in vivo.</p>Formule :C21H21N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :375.42NS5A-IN-3
CAS :<p>NS5A-IN-3 is a potent NS5A inhibitor with high efficacy against HCV 1b, good activity on 3a, and strong metabolic stability; superior to daclatasvir.</p>Formule :C44H44N6O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :784.86PNU-103017
CAS :<p>PNU-103017 is an inhibitor of HIV protease.</p>Formule :C28H28N2O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :504.6L-689502
CAS :<p>L-689502 is a potent HIV-l protease inhibitor (IC50: 1 nM).</p>Formule :C39H51N3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :673.84GSK-625433
CAS :<p>GSK-625433: Homochiral inhibitor blocks HCV genotypes 1a/1b polymerase.</p>Formule :C26H32N4O5SCouleur et forme :SolidMasse moléculaire :512.62Petesicatib
CAS :<p>Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.</p>Formule :C25H23F6N5O4SDegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :603.54SID 26681509
CAS :<p>SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).</p>Formule :C27H33N5O5SDegré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :539.65MMP3 inhibitor 1
CAS :<p>MMP3 inhibitor 1 is a potent and highly selective inhibitor of MMP-3 (IC50 of 1 nM).</p>Formule :C23H31N3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :477.57FK706
CAS :<p>FK706, a human neutrophil elastase inhibitor (IC50: 83 nM, Ki: 4.2 nM), also blocks mouse and porcine elastases. Anti-inflammatory.</p>Formule :C26H33F3N4NaO7Couleur et forme :SolidMasse moléculaire :593.556PDDC inhibitor
CAS :<p>PDDC inhibitor (Phenyl (R)-(1-(3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl)pyrrolidin-3-yl)carbamate) is an nSMase2 inhibitor.</p>Formule :C27H29N5O4Degré de pureté :96.09% - 99.39%Couleur et forme :SolidMasse moléculaire :487.55Filibuvir
CAS :<p>Filibuvir (PF-00868554) inhibits HCV polymerase genotypes 1a/1b, EC50s 59 nM.</p>Formule :C29H37N5O3Degré de pureté :99.28% - >99.99%Couleur et forme :SolidMasse moléculaire :503.64Ac-YVAD-AOM
CAS :<p>Ac-YVAD-AOM is a selective and potent caspase-1 inhibitor showing antitumor activity and potential analgesic activity.</p>Formule :C33H42N4O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :654.71Collagen proline hydroxylase inhibitor-1
CAS :<p>Collagen proline hydroxylase inhibitor-1 具有抗纤维增生活性。</p>Formule :C24H21N5O4Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :443.45ZED-1227
CAS :<p>ZED-1227 (TAK-227) is a TG2 inhibitor with anticancer activity that blocks inflammation-induced TG2 expression and activation for the treatment of Celiac Diseas</p>Formule :C26H36N6O6Degré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :528.6γ-Glu-Tyr
CAS :<p>gamma-Glu-Tyr (gamma-Glutamyltyrosine) is a kokumi peptide against dipeptidyl peptidase-IV (DPP-IV) and is used in the study of diabetes mellitus.</p>Formule :C14H18N2O6Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :310.3HIV-1 inhibitor-54
CAS :<p>HIV-1 inhibitor-54: potent anti-HIV (EC50: 32 nM), targets WT HIV-1 IIIB in MT-4 cells for infection research.</p>Formule :C27H30N6O4SDegré de pureté :98.05% - 99.44%Couleur et forme :SoildMasse moléculaire :534.63Aderamastat
CAS :<p>Aderamastat (FP-025) is an orally active matrix metalloproteinase 12 (MMP-12) inhibitor indicated for the study of allergic asthma, COPD and pulmonary fibrosis.</p>Formule :C21H18N2O4SDegré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :394.44Nesbuvir
CAS :<p>Nesbuvir: HCV NS5B polymerase inhibitor, IC50 9 nM against HCV 1b replicon in liver cancer cells.</p>Formule :C22H23FN2O5SDegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :446.49BMS-212122
CAS :<p>BMS-212122 inhibits MTP, reduces lipids and plaque in animal tests.</p>Formule :C43H36F6N4O2Degré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :754.76MK-0674
CAS :<p>MK-0674 is a cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S for metabolism-related diseases.</p>Formule :C26H27F6N3O2Degré de pureté :97.3% - 99.91%Couleur et forme :SolidMasse moléculaire :527.5VBY-825
CAS :<p>VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.</p>Formule :C23H29F4N3O5SDegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :535.55HCV NS5B polymerase-IN-2
CAS :<p>HCVNS5B polymerase-IN-2 (Compound 298) is an inhibitor of the Ns5b polymerase. It holds potential for research into the treatment of hepatitis C virus (HCV) infections.</p>Formule :C26H24N2O4Couleur et forme :SolidMasse moléculaire :428.48(2R,3S)-Emricasan
CAS :<p>(2R,3S)-Emricasan ((2R,3S)-PF 03491390) is an isomer of Emricasan. This compound acts as an orally effective irreversible pan-caspase inhibitor. (2R,3S)-Emricasan inhibits the increase in caspase-3 activity induced by Zika virus (ZIKV) and protects human cortical neural progenitor cells.</p>Formule :C26H27F4N3O7Couleur et forme :SolidMasse moléculaire :569.5Beclabuvir
CAS :<p>Beclabuvir blocks HCV NS5B polymerase at thumb site 1, effective on genotypes 1, 3, 4, 5 with IC50 <28 nM.</p>Formule :C36H45N5O5SDegré de pureté :99.87% - 99.93%Couleur et forme :SolidMasse moléculaire :659.84Immunoproteasome activator 1
CAS :<p>Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.</p>Formule :C24H23N3O3Couleur et forme :SolidMasse moléculaire :401.46UK-370106
CAS :<p>UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-</p>Formule :C35H44N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :572.73Isobutylamido thiazolyl resorcinol
CAS :<p>Isobutylamido thiazolyl resorcinol is a tyrosinase (Tyrosinase) inhibitor that prevents pigment deposition induced by ultraviolet radiation.</p>Formule :C13H14N2O3SCouleur et forme :SolidMasse moléculaire :278.33LK-732
CAS :<p>LK-732 is a thrombin inhibitor with antithrombotic activity. It exhibits dose-dependent inhibition in models of hypercoagulability, with an IC50 value of 1.3 mg/kg. LK-732 is used in cardiovascular and cerebrovascular research.</p>Formule :C25H29N5O3SCouleur et forme :SolidMasse moléculaire :479.59Boc3Arg
<p>Boc 3 Arg is a tert-butyl carbamate-protected arginine compound. It serves as an efficient tag that induces degradation by directly targeting proteins to the 20S proteasome.</p>Formule :C21H39N5O7Couleur et forme :SolidMasse moléculaire :473.563-Aminobenzene-1,2-diol
CAS :<p>3-Aminobenzene-1,2-diol (compound C8) is an inhibitor of matrix metalloproteinases (MMP), with IC50 values of 20, 26, 16, and 16.3 μM against MMP-2, MMP-8, MMP-9, and MMP-14, respectively.</p>Formule :C6H7NO2Couleur et forme :SolidMasse moléculaire :125.13TGase2-IN-1
CAS :<p>TGase2-IN-1 (Compound 22) is an orally effective TGase2 inhibitor with an IC50 of 1.12 µM. It inhibits TGase2 in human retinal microvascular endothelial cells with a strikingly lower IC50 of 0.07 µM. The oral bioavailability of TGase2-IN-1 is 74.6%. Additionally, it can suppress retinal vascular leakage in a mouse model of diabetes induced by Streptozotocin.</p>Formule :C23H25N3O3Couleur et forme :SolidMasse moléculaire :391.46Tyrosinase-IN-39
<p>Tyrosinase-IN-39 (compound 5r) is a competitive inhibitor of tyrosinase, with an IC50 of 6.4 μM, and is used in the study of skin diseases.</p>Formule :C23H19N5O4S2Couleur et forme :SolidMasse moléculaire :493.56
