Protéases/Protéasome
Les inhibiteurs de protéases et de protéasomes sont des composés qui bloquent l'activité des protéases et du protéasome, impliqués dans la dégradation et le renouvellement des protéines. Ces inhibiteurs sont essentiels pour étudier la régulation de l'homéostasie des protéines, le contrôle du cycle cellulaire et l'apoptose. Les inhibiteurs de protéases et de protéasomes sont également utilisés dans le traitement de maladies telles que le cancer, où une dégradation anormale des protéines joue un rôle dans la progression de la maladie. En inhibant les protéases ou le protéasome, ces composés peuvent induire la mort cellulaire dans les cellules cancéreuses et sont des outils essentiels tant pour la recherche fondamentale que pour le développement thérapeutique. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de protéases et de protéasomes de haute qualité pour soutenir vos recherches en biochimie, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Protéases/Protéasome"
- Acétyl-CoA Carboxylase(38 produits)
- Cystéine protéase(111 produits)
- DPP-4(27 produits)
- Glutaminase(46 produits)
- Protéase du VIH(506 produits)
- PAI-1(26 produits)
- Inhibiteurs de protéase(50 produits)
- Récepteur activé par une protéase(55 produits)
- Protéasome(86 produits)
- Sérine protéase(54 produits)
- p97(15 produits)
Affichez 3 plus de sous-catégories
985 produits trouvés pour "Protéases/Protéasome"
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Suc-AAP-Abu-pNA
CAS :Suc-AAP-Abu-pNA is a specific substrate for pancreatic elastase (Km = 100 μM; Kcat/Km = 35,300 s-1 M-1 for rat pancreatic elastase; Km = 30 μM; Kcat/Km = 351,Formule :C25H34N6O9Couleur et forme :SolidMasse moléculaire :562.57Paritaprevir dihydrate
CAS :Paritaprevir dihydrate: potent oral HCV NS3/4A inhibitor (EC50: 0.21-1 nM), SARS-CoV-3CL blocker (IC50: 1.31 μM), metabolized by CYP3A, boosted by Ritonavir.Formule :C40H47N7O9SCouleur et forme :SolidMasse moléculaire :801.91PS 915
CAS :PS 915 is a substrate for colorimetric assay. It was used for plasma antithrombin.Formule :C27H36ClN7O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :590.08Tyrosinase/elastase-IN-1
Tyrosinase/elastase-IN-1, a triterpenoid extracted from the leaves of Rubus fraxinifolius, exhibits inhibitory activities against both tyrosinase and elastaseFormule :C33H52O5Couleur et forme :SolidMasse moléculaire :528.76N-CBZ-Phe-Arg-AMC TFA
N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.Formule :C35H37F3N6O8Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :726.7APC-6860
CAS :APC-6860, a serine protease inhibitor, targets multiple enzymes; most potent against human urokinase (Ki: 0.1 µM). Used in cancer research.Formule :C9H7IN2SCouleur et forme :SolidMasse moléculaire :302.13L 659286
CAS :L 659286 is one kind of cephalosporin derivative.Formule :C17H21N5O7S2Couleur et forme :SolidMasse moléculaire :471.51Plasma kallikrein-IN-1
CAS :Plasma kallikrein-IN-1 is a PKK inhibitor with an IC 50 value of 0.5 nM.Formule :C23H25F2N7OCouleur et forme :SolidMasse moléculaire :453.498C1 Esterase Inhibitor (Human)
C1 Esterase Inhibitor (Human) is a glycoprotein derived from human plasma and acts as a serine protease inhibitor. It inactivates enzymes like C1r, C1s, and mannose-binding lectin-associated serine proteases (MASP) through covalent binding. This compound possesses anti-inflammatory properties and is utilized to prevent angioedema attacks associated with hereditary angioedema.Couleur et forme :Odour LiquidEllipyrone A
Ellipyrone A: γ-pyrone macrocycle, inhibits DPP-4 (IC50=0.35mM), α-glucosidase (IC50=0.74mM), α-amylase (IC50=0.59mM).Formule :C25H34O8Couleur et forme :SolidMasse moléculaire :462.53Fluostatin A sodium
CAS :Fluostatin A, a fluorenone compound initially isolated from Streptomyces, demonstrates selective inhibition towards dipeptidyl peptidase 3 (DPP-3) compared toFormule :C18H9O5·NaCouleur et forme :SolidMasse moléculaire :328.25Dansyl-Glu-Gly-Arg-Chloromethylketone
CAS :Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor that specifically impedes serine/threonine proteases and has been shown to inhibit activatedFormule :C26H36ClN7O7SCouleur et forme :SolidMasse moléculaire :626.12VPLSLYSG
CAS :VPLSLYSG, an octapeptide, degraded by MMP-9, MMP-1, MMP-2; potential MMP substrate uses.Formule :C39H62N8O12Couleur et forme :SolidMasse moléculaire :834.96Z-Arg-Arg-βNA acetate
CAS :Z-Arg-Arg-βNA acetate serves as a sensitive dipeptide substrate for Cathepsin B protease, while demonstrating resistance to proteases H and L. This compound is crucial for differentiating non-Cathepsin B type proteins.Formule :C32H43N9O6Couleur et forme :SolidMasse moléculaire :649.74FFAGLDD
"FFAGLDD: MMP9 peptide for controlled DOX delivery inside cells."Formule :C37H49N7O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :783.82Anticancer agent 114
Anticancer agent 114: oral dipeptide boronic acid, proteasome inhibitor, IC 50 = 2.2 nM, halts RPMI-8226 cell growth, for multiple myeloma research.Formule :C28H33BF6N2O7Couleur et forme :SolidMasse moléculaire :634.37Histatin 5 TFA
Histatin 5 TFA effectively inhibits host matrix metalloproteinases (MMP-2) and (MMP-9), demonstrating inhibition concentrations (IC 50s) of 0.57 μM and 0.25 μMFormule :C135H196N51F3O35Couleur et forme :SolidMasse moléculaire :3150.31Enzyme-IN-1
CAS :Enzyme-IN-1（compound 1）为基于肽的N端亲核试剂（Ntn）水解酶抑制剂，特别针对20S蛋白酶体的糜胰蛋白酶样活性（CT-L）进行抑制，可能展现出抗炎特性。Formule :C36H50N4O7Couleur et forme :SolidMasse moléculaire :650.8CRA-2059 hydrochloride
CRA-2059 hydrochloride is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].Couleur et forme :SolidMMP-9/MMP-13 Inhibitor I
CAS :MMP-9/MMP-13 Inhibitor I is a dual inhibitor of MMP-9 and MMP-13 with IC50 of both 0.9 nM.Formule :C25H25N3O6SCouleur et forme :SolidMasse moléculaire :495.55TR-107
CAS :TR-107 (Anticancer agent 230) is a mitochondrial protease ClpP activator that inhibits tumor growth in the MDA-MB-231 xenograft model.Formule :C22H19ClN4OCouleur et forme :SoildMasse moléculaire :390.87Talabostat isomer mesylate
Talabostat isomer mesylate, a PT100/Val-boroPro variant, is a potent oral DPP-IV inhibitor (Ki: 0.18 nM).Formule :C10H23BN2O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :310.18Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2
CAS :Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2, a melanotropin derivative and melanocyte-stimulating hormone, activates tyrosinase and demonstrates a thermoregulatory effectFormule :C47H64N14O10Couleur et forme :SolidMasse moléculaire :985.1Phosphorylase Kinase β-Subunit Fragment (420-436)
CAS :Phosphorylase Kinase β-Subunit Fragment (420-436) is a peptide fragment (430-436) derived from the β-Subunit of phosphorylase kinase.Formule :C79H131N31O25SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1947.14CRA-2059 TFA
CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].Couleur et forme :SolidDPP8/9-IN-1
DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.Couleur et forme :Odour SolidHCVP-IN-1
CAS :HCVP-IN-1 (compound 1) is a hepatitis C viral polymerase (HCVP) inhibitor.Formule :C30H34FN5O3Couleur et forme :SolidMasse moléculaire :531.632Histatin 5
CAS :Histatin 5, a human saliva peptide, blocks MMP-2 and MMP-9 at IC50s of 0.57/0.25 μM and kills fungi.Formule :C133H195N51O33Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3036.29MK-6169
CAS :MK-6169 is an effective Pan-Genotype Hepatitis C Virus NS5A inhibitor. It also has Optimized Activity against Common Resistance-Associated Substitutions.Formule :C54H62FN9O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1016.2Fotagliptin benzoate
CAS :Fotagliptin benzoate, a DPP-4 inhibitor (IC50=2.27 nM), is safe in rats/dogs, useful for Type 2 diabetes research.Formule :C24H25FN6O3Couleur et forme :SolidMasse moléculaire :464.49Sofosbuvir impurity J
CAS :Sofosbuvir impurity J is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.Formule :C22H30FN4O8PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.47LM11
LM11 is a transglutaminase 2 (TG2) inhibitor that exhibits activity against glioblastoma cells by maintaining TG2 in a cytotoxic conformational state.
Formule :C26H18Cl2N4O5Masse moléculaire :536.06543Cerpegin
CAS :Cerpegin, a pyridine ketone fused c-lactone, acts as an inhibitor of the 20S proteasome. It possesses pharmacological properties as a neuropsychiatric sedative, anti-inflammatory, analgesic, and exhibits anti-ulcer activity.Formule :C10H11NO3Couleur et forme :SolidMasse moléculaire :193.2Cathepsin L-IN-5
CathepsinL-IN-5 (D6-3) is a potent inhibitor of Cathepsin L (CatL) with an IC50 value of 0.27 nM. It effectively blocks the function of CatL and significantly impedes the entry of SARS-CoV-2 pseudovirus into cells by inhibiting the cleavage of the spike protein. CathepsinL-IN-5 is applicable for research on infections.Tyrosinase-IN-32
Tyrosinase-IN-32 (compound 11), a hydroxamate-based alkaloid extracted from black pepper (Piper nigrum L.), functions as an inhibitor of mushroom tyrosinase. In addition to its inhibitory properties, it exhibits antioxidant activity.Formule :C15H19NO3Couleur et forme :SolidMasse moléculaire :261.32Acetyl-Calpastatin(184-210)(human) TFA
Acetyl-Calpastatin(184-210)(human) TFA inhibits μ-calpain (Ki 0.2 nM) and cathepsin L (Ki 6 μM) selectively and reversibly.Formule :C144H231F3N36O46SCouleur et forme :SolidMasse moléculaire :3291.65Elastatinal
CAS :Elastatinal is an elastase inhibitor. It is found in culture filtrates of various species of actinomyces.Formule :C21H36N8O7Couleur et forme :Yellowish SolidMasse moléculaire :512.56Fotagliptin
CAS :Fotagliptin is a dipeptidyl peptidase IV inhibitor.Formule :C17H19FN6OCouleur et forme :SolidMasse moléculaire :342.37Sitagliptin fenilalanil hydrochloride
CAS :Sitagliptin phenylalanine hydrochloride, a dipeptidyl peptidase-4 (DPP-4) inhibitor [1], is a chemical compound utilized in medical applications.Formule :C25H25ClF6N6O2Couleur et forme :SolidMasse moléculaire :590.95Phaeosphaone D
CAS :Phaeosphaone D, a thiodiketopiperazine from Phaeosphaeria fuckelii fungus, inhibits mushroom tyrosinase (IC50 = 33.2 μM).Formule :C20H27N3O3S2Couleur et forme :SolidMasse moléculaire :421.58AAF-CMK (trifluoroacetate salt)
CAS :TPPII, a serine peptidase, cleaves tripeptides from oligopeptides. AAF-CMK irreversibly inhibits TPPII at 10-100 μM, sparing proteasome activity.Formule :C18H23ClF3N3O5Couleur et forme :SolidMasse moléculaire :453.84Trivalent hydroxyarsinothricn
Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible inhibitor of kidney-type glutaminase (KGA). It binds to the glutamine binding site and forms a covalent bond with the cysteine residue at the active site. This compound selectively kills triple-negative breast cancer (TNBC) cells without being cytotoxic to control cell lines. KGA is an enzyme that regulates glutamine metabolism and is associated with tumor malignancy.Formule :C4H10AsNO4Masse moléculaire :210.98258Carboxypeptidase C
CAS :Carboxypeptidase C removes COOH-terminal amino acids and others in peptides for biochemical studies.Couleur et forme :SolidLonodelestat TFA
Lonodelestat TFA, an oral peptide, selectively inhibits hNE, potentially aiding in CF research.Formule :C73H112F3N15O21Couleur et forme :SolidMasse moléculaire :1592.75Nostosin G
Nostosin G, a linear peptide with Hpla, Hty, and argininal, inhibits trypsin effectively (IC50 = 0.1 μM).Formule :C25H33N5O6Couleur et forme :SolidMasse moléculaire :499.56L-Methionine-DL-sulfoximine
CAS :MSO blocks glutamine synthetase, impacts astroglia, and is used in convulsant research.Formule :C5H12N2O3SDegré de pureté :99.56% - ≥98%Couleur et forme :White Crystalline PowderMasse moléculaire :180.23Proteasome-IN-7
Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.Formule :C48H56N6O10SCouleur et forme :SolidMasse moléculaire :909.06(R)-BAY-85-8501
(R)-BAY-85-8501 is the less active enantiomer of BAY-85-8501. BAY-85-8501 is a selective and potent Human Neutrophil Elastase (HNE)inhibitor(IC50 of 65 pM).Formule :C22H17F3N4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.46PF 00356231
CAS :PF 00356231 is a selectivity inhibitor MMP-12 and can be used in studies about the treatment of emphysema and chronic obstructive pulmonary disease (COPD).
Formule :C25H20N2O3SDegré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :428.5ZG36
ZG36, a human Caseinolytic protease P (ClpP) agonist, non-selectively degrades respiratory chain complexes and reduces mitochondrial DNA, causing mitochondrialCouleur et forme :Odour Solid
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