Protéasome
Les inhibiteurs du protéasome sont des composés qui inhibent le protéasome, un grand complexe protéique responsable de la dégradation des protéines indésirables ou endommagées dans la cellule. L'inhibition du protéasome conduit à l'accumulation de protéines, ce qui peut induire l'arrêt du cycle cellulaire et l'apoptose, en particulier dans les cellules à division rapide comme les cellules cancéreuses. Les inhibiteurs du protéasome sont essentiels dans la recherche sur le cancer et la thérapie, en particulier dans le traitement du myélome multiple et d'autres hémopathies malignes. Chez CymitQuimica, nous proposons des inhibiteurs du protéasome pour soutenir vos recherches en oncologie, biologie cellulaire et développement de médicaments.
89 produits trouvés pour "Protéasome"
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Trelagliptin
CAS :Trelagliptin (SYR-472) is a highly specific and long-acting DPP-4 inhibitor.Formule :C18H20FN5O2Degré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :357.38UT-34
CAS :UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wildFormule :C15H12F4N4O2Degré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :356.27Ref: TM-T13273
1mg50,00€5mg113,00€10mg177,00€25mg334,00€50mg505,00€100mg782,00€1mL*10mM (DMSO)124,00€RA190
CAS :RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.Formule :C28H23Cl5N2O2Degré de pureté :97.7%Couleur et forme :SolidMasse moléculaire :596.76Ref: TM-T13858
1mg54,00€5mg109,00€10mg159,00€25mg233,00€50mg414,00€100mg608,00€1mL*10mM (DMSO)142,00€Gly-Pro-pNA hydrochloride
CAS :Gly-Pro-pNA hydrochloride (Gly-Pro p-nitroanilide hydrochloride) is a dipeptidyl peptidase inhibitor that inhibits dipeptidyl peptidase II, dipeptidyl peptidaseFormule :C13H17ClN4O4Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :328.75Arimoclomol maleate
CAS :Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.Formule :C18H24ClN3O7Degré de pureté :99.44% - 99.98%Couleur et forme :SolidMasse moléculaire :429.85Pepstatin
CAS :Pepstatin (Pepsin Inhibitor S 735A) is a specific and orally aspartate protease inhibitor that also inhibits HIV protease activity. Cost effective and quality assured.Formule :C34H63N5O9Degré de pureté :96.74% - 99.94%Couleur et forme :SolidMasse moléculaire :685.89ML604440
CAS :ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.Formule :C17H24BF3N2O4Degré de pureté :97.06%Couleur et forme :SolidMasse moléculaire :388.19Ref: TM-T12079
1mg109,00€2mg158,00€5mg259,00€10mg409,00€25mg677,00€50mg954,00€100mg1.288,00€200mg1.728,00€1mL*10mM (DMSO)285,00€Gabexate mesylate
CAS :Gabexate mesylate (FOY) inhibits thrombin, plasmin, kallikrein; used for pancreatitis, DIC, hemodialysis anticoagulant.Formule :C17H27N3O7SDegré de pureté :99.2% - 99.64%Couleur et forme :White CrystalMasse moléculaire :417.48RAMB4
CAS :RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.Formule :C19H13Cl4NODegré de pureté :98.89% - 99.38%Couleur et forme :SolidMasse moléculaire :413.12LMP7/LMP2-IN-1
CAS :LMP7/LMP2-IN-1 (Compound 19) is an orally effective inhibitor targeting the immunoproteasome subunits LMP7 and LMP2, with respective IC50 values of 257 and 10 nM. This compound reduces the production of antibodies and downregulates the B cells in the germinal centers of the spleen and plasma cells in NP-OVA immunized mice. It has potential applications in the study of autoimmune diseases.Formule :C16H27BN4O3Couleur et forme :SoildMasse moléculaire :334.22Dazcapistat
CAS :Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.Formule :C21H18FN3O4Degré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :395.38Ref: TM-T9710
1mg92,00€5mg192,00€10mg289,00€25mg522,00€50mg732,00€100mg1.018,00€1mL*10mM (DMSO)212,00€Acetyl-Calpastatin(184-210)(human), Negative Control
Acetyl-Calpastatin(184-210)(human), Negative Control is a control scrambled peptide corresponding to Acetyl-Calpastatin(184-210)(human). Acetyl-Calpastatin(184-210)(human) functions as a potent, selective, and reversible calpain inhibitor.Formule :C142H230N36O44SMasse moléculaire :3175.65874DPP8/9-IN-1
DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.Couleur et forme :Odour SolidAcetyl-Calpastatin(184-210)(human) TFA
Acetyl-Calpastatin(184-210)(human) TFA inhibits μ-calpain (Ki 0.2 nM) and cathepsin L (Ki 6 μM) selectively and reversibly.Formule :C144H231F3N36O46SCouleur et forme :SolidMasse moléculaire :3291.65Acetyl-Calpastatin(184-210)(human)
CAS :Calpain inhibitor, Ki 0.2 nM for calpain I/II, doesn't affect papain/trypsin/cat L. Raises Aβ42, Aβ40 secretion & Aβ42/Aβ40 ratio.Formule :C142H230N36O44SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3177.65DPP-4-IN-14
DPP-4-IN-14 (compound 30) is an inhibitor of DPP-4, with an IC50 value of 12.82 nM.Formule :C33H27N7O3Couleur et forme :SolidMasse moléculaire :569.613VAMP
VAMP is a tetrapeptide that acts as a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor, exhibiting an IC50 of 1.00 μM and a Kd of 6.89 μM. It effectively targets the DPP-IV-GLP-1 axis and is utilized in the research of type 2 diabetes.Formule :C18H32N4O5SCouleur et forme :SolidMasse moléculaire :416.535LXE408 fumarate
LXE408 fumarate: orally available, selective kinetoplastid proteasome inhibitor with IC50/EC50 of 0.04 μM for L. donovani; potentially aids in VL research.
Formule :C27H22FN7O6Degré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :559.51Proteasome-IN-7
Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.Formule :C48H56N6O10SCouleur et forme :SolidMasse moléculaire :909.06Bortezomib analog
Bortezomibanalog (Compound 13) is an analog of Bortezomib, functioning as an active control ligand for the 20S proteasome subunit β5.Couleur et forme :Odour Solid
