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Tyrosine Kinase/Adaptateurs

Tyrosine Kinase/Adaptateurs

Les inhibiteurs des tyrosines kinases et des adaptateurs sont des composés qui ciblent les tyrosines kinases et leurs protéines adaptatrices associées, jouant des rôles essentiels dans la signalisation cellulaire, la croissance et la différenciation. Ces inhibiteurs sont des outils essentiels dans la recherche sur le cancer, car de nombreuses tyrosines kinases sont impliquées dans les voies de signalisation qui favorisent la croissance tumorale et les métastases. En inhibant les tyrosines kinases, ces composés peuvent bloquer des cascades de signalisation cruciales, offrant ainsi des stratégies thérapeutiques potentielles pour divers cancers et autres maladies impliquant une signalisation cellulaire anormale. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de tyrosines kinases et d'adaptateurs de haute qualité pour soutenir vos recherches en oncologie, biologie moléculaire et développement de thérapies ciblées.

Sous-catégories appartenant à la catégorie "Tyrosine Kinase/Adaptateurs"

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1372 produits trouvés pour "Tyrosine Kinase/Adaptateurs"

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  • CH6953755
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    CH6953755

    CAS :
    <p>CH6953755: oral YES1 kinase inhibitor, IC50 1.8 nM, potent, selective, anticancer, halts cell proliferation.</p>
    Formule :C26H22F2N6O4S
    Degré de pureté :98.03%
    Couleur et forme :Solid
    Masse moléculaire :552.55

    Ref: TM-T10784

  • Sevabertinib
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    Sevabertinib

    CAS :
    <p>Sevabertinib (BAY 2927088) is an EGFR tyrosine kinase inhibitor, with anticancer activity, used in research on non-small cell lung cancer.</p>
    Formule :C24H25ClN4O5
    Degré de pureté :99.81%
    Couleur et forme :Solid
    Masse moléculaire :484.93

    Ref: TM-T200964

  • Src Inhibitor 3
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    Src Inhibitor 3

    CAS :
    <p>Src Inhibitor 3 blocks c-Src kinase (IC50 &lt;3 nM CSK HTRF, &lt;4 nM Caliper), boosting T cell growth from receptor signals.</p>
    Formule :C34H32ClFN8O4
    Degré de pureté :98.35%
    Couleur et forme :Solid
    Masse moléculaire :671.12

    Ref: TM-T13000

  • EGFR-IN-8
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    EGFR-IN-8

    CAS :
    <p>EGFR-IN-8, a dual inhibitor targeting both EGFR and c-Met, shows potential as a promising candidate for further development in treating EGFR TKI-resistant NSCLC</p>
    Formule :C32H23ClF3N7O4
    Degré de pureté :99.51%
    Couleur et forme :Solid
    Masse moléculaire :662.02

    Ref: TM-T11162

  • AZ-23
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    AZ-23

    CAS :
    <p>AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C.</p>
    Formule :C17H19ClFN7O
    Degré de pureté :99.4%
    Couleur et forme :Solid
    Masse moléculaire :391.83

    Ref: TM-T14363

  • IGF-1R inhibitor-4
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    IGF-1R inhibitor-4

    CAS :
    <p>IGF-1Rinhibitor-4 (compound 22) is a potent inhibitor of IGF-1R, demonstrating an inhibition rate of 63% at a concentration of 10 μM. This compound plays a significant role in cancer research.</p>
    Formule :C13H15ClN4O
    Couleur et forme :Solid
    Masse moléculaire :278.737

    Ref: TM-T204141

  • AZ8010
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    AZ8010

    CAS :
    AZ8010 (AZ12908010) serves as an effective inhibitor of FGFR1-3 and exhibits antiproliferative properties, making it useful for cancer research.
    Formule :C27H34N4O3
    Couleur et forme :Solid
    Masse moléculaire :462.58

    Ref: TM-T89951

  • Andamertinib
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    Andamertinib

    CAS :
    <p>Andamertinib is an EGFR inhibitor with antitumor activity.</p>
    Formule :C31H36N8O3
    Couleur et forme :Solid
    Masse moléculaire :568.669

    Ref: TM-T206579

  • PF-06273340
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    PF-06273340

    CAS :
    <p>PF-06273340 是一种口服具有活力的、具有选择性的外周限制性Trk 泛抑制剂。</p>
    Formule :C23H22ClN7O3
    Degré de pureté :98% - 98.00%
    Couleur et forme :Solid
    Masse moléculaire :479.92

    Ref: TM-T19649

  • KRC-00715
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    KRC-00715

    CAS :
    <p>KRC-00715 is an orally effective inhibitor of c-Met, exhibiting high selectivity with an IC50 of 9.0 nM. This compound specifically inhibits the growth of gastric cancer cell lines with high c-Met expression by inducing G1/S phase block, and reduces the activity of downstream signals, including Akt, Erk, and c-Met itself. In the gastric cancer cell line Hs746T, KRC-00715 demonstrates cytotoxicity with an IC50 of 39 nM and selectively inhibits the proliferation of cell lines that overexpress c-Met. Additionally, KRC-00715 decreases tumor size in Hs746T xenograft mouse models.</p>
    Formule :C25H25F3N8O3
    Couleur et forme :Solid
    Masse moléculaire :542.51

    Ref: TM-T200380

  • ROS1-IN-2
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    ROS1-IN-2

    CAS :
    <p>ROS1-IN-2 (Compound 3), a ROS1 inhibitor, is utilized in cancer research.</p>
    Formule :C29H37ClN5O2P
    Couleur et forme :Solid
    Masse moléculaire :554.06

    Ref: TM-T89912

  • SST0116CL1
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    SST0116CL1

    CAS :
    <p>SST0116CL1 is an HSP90 inhibitor (IC50: 0.21 μM) that targets the ATP-binding pocket of Hsp90, disrupting its chaperone function and leading to the degradation of client proteins (EGFR, CDK4, and AKT). It induces the degradation of Her2 in BT-474 cells (IC50: 0.2 μM) and exhibits antiproliferative activity, inhibiting tumor growth.</p>
    Formule :C22H31ClN4O6
    Couleur et forme :Solid
    Masse moléculaire :482.96

    Ref: TM-T200022

  • ONO-7579
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    ONO-7579

    CAS :
    <p>ONO-7579, an orally active TRKA inhibitor, effectively suppresses tumor growth by inhibiting TRKA phosphorylation. In KM12 colorectal cancer cells, it exhibits an EC 50 of 17.6 ng/g, indicating that a concentration of 17.6 ng per gram of tumor tissue reduces the activity of phosphorylated TRKA by 50%. This compound is utilized in cancer research.</p>
    Formule :C24H18ClF3N6O4S
    Couleur et forme :Solid
    Masse moléculaire :578.95

    Ref: TM-T200301

  • HS-345
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    HS-345

    CAS :
    <p>HS-345, a TrkA/Akt inhibitor, exhibits potent anti-pancreatic cancer properties. This compound inhibits the growth and proliferation of pancreatic cancer cells by blocking the TrkA/Akt signaling pathway and induces cell apoptosis (Apoptosis). Additionally, HS-345 inhibits angiogenesis by reducing the expression of HIF-1α and VEGF. It holds promise for use in pancreatic cancer research.</p>
    Formule :C19H18N6O2S
    Couleur et forme :Solid
    Masse moléculaire :394.45

    Ref: TM-T200230

  • Le logo de CymitQuimica
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    EGFR/BRAF-IN-1

    <p>EGFR/BRAF-IN-1 inhibits EGFR/BRAF (BRAFV600E IC50: 45 nM, GI50: 35 nM) and has antioxidant properties.</p>
    Formule :C26H28ClN3O4
    Couleur et forme :Solid
    Masse moléculaire :481.97

    Ref: TM-T63189

  • Neptinib
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    Neptinib

    CAS :
    <p>Neptinib (NEP010), a derivative of Afatinib, exhibits enhanced antitumor properties and improved pharmacokinetics when administered orally. It demonstrates a notable suppression of tumor expansion in mouse models of non-small cell lung cancer harboring various EGFR mutations. Furthermore, Neptinib effectively inhibits the EGFR kinase family, exhibiting IC 50 values of 0.24 nM for EGFR wt, 7.25 nM for EGFR L858R/T790M, 0.46 nM for EGFR L858R, and 1.79 nM for EGFR T790M.</p>
    Formule :C22H23ClFN5O2
    Couleur et forme :Solid
    Masse moléculaire :443.90

    Ref: TM-T89923

  • DDR1/2 inhibitor-3
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    DDR1/2 inhibitor-3

    CAS :
    <p>DDR1/2 inhibitor-3 (5n) is an inhibitor of DDR1/2, with IC50 values of 9.4 nM and 20.4 nM, respectively. It is applicable in anti-inflammatory research.</p>
    Formule :C31H31F3N6O
    Couleur et forme :Solid
    Masse moléculaire :560.613

    Ref: TM-T204457

  • EGFR-IN-139
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    EGFR-IN-139

    CAS :
    <p>EGFR-IN-139 (compound PD 18) is an EGFR inhibitor with IC50 values of 12.88 nM (wild type), 10.84 nM (L858R/T790M), and 42.68 nM (L858R/T790M/C797S). It demonstrates significant anticancer activity against the A549 and H1975 cancer cell lines, which express high levels of EGFR. EGFR-IN-139 exhibits strong selectivity for cancer cells and can be utilized in research on non-small cell lung cancer (NSCLC).</p>
    Formule :C27H25ClN2O4
    Couleur et forme :Solid
    Masse moléculaire :476.951

    Ref: TM-T204772

  • Tarloxotinib bromide
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    Tarloxotinib bromide

    CAS :
    <p>Tarloxotinib bromide (TH-4000) is an irreversible inhibitor of EGFR/HER2.</p>
    Formule :C24H24Br2ClN9O3
    Degré de pureté :99.52%
    Couleur et forme :Solid
    Masse moléculaire :681.77

    Ref: TM-T13088

  • NMS-P626
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    NMS-P626

    CAS :
    <p>NMS-P626 functions as an inhibitor targeting TRKA, TRKB, and TRKC, exhibiting IC 50 values of 8 nM, 7 nM, and 3 nM respectively. It effectively suppresses KM12 cell growth by inhibiting the phosphorylation of TPM3-TRKA and the subsequent downstream signaling, demonstrating an IC 50 of 19 nM specifically for KM12 cells. This compound is applicable in the study of colorectal cancer.</p>
    Formule :C28H35F2N7O4S
    Couleur et forme :Solid
    Masse moléculaire :603.68

    Ref: TM-T200149