CymitQuimica logo
Tyrosine Kinase/Adaptateurs

Tyrosine Kinase/Adaptateurs

Les inhibiteurs des tyrosines kinases et des adaptateurs sont des composés qui ciblent les tyrosines kinases et leurs protéines adaptatrices associées, jouant des rôles essentiels dans la signalisation cellulaire, la croissance et la différenciation. Ces inhibiteurs sont des outils essentiels dans la recherche sur le cancer, car de nombreuses tyrosines kinases sont impliquées dans les voies de signalisation qui favorisent la croissance tumorale et les métastases. En inhibant les tyrosines kinases, ces composés peuvent bloquer des cascades de signalisation cruciales, offrant ainsi des stratégies thérapeutiques potentielles pour divers cancers et autres maladies impliquant une signalisation cellulaire anormale. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de tyrosines kinases et d'adaptateurs de haute qualité pour soutenir vos recherches en oncologie, biologie moléculaire et développement de thérapies ciblées.

Sous-catégories appartenant à la catégorie "Tyrosine Kinase/Adaptateurs"

Affichez 13 plus de sous-catégories

1372 produits trouvés pour "Tyrosine Kinase/Adaptateurs"

Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
produits par page.
  • EGFR-IN-149
    Targetmol
    + Info

    EGFR-IN-149

    CAS :
    <p>EGFR-IN-149 (Compound 3-OH) is an EGFR inhibitor with an IC50 value of 0.42 nM.</p>
    Formule :C16H15N3OS
    Couleur et forme :Solid
    Masse moléculaire :297.375

    Ref: TM-T205658

  • NS-062
    Targetmol
    + Info

    NS-062

    CAS :
    <p>NS-062 is an orally effective, irreversible covalent inhibitor targeting EGFR, demonstrating antiproliferative activity in the resistant double mutant H1975 cells with an IC50 of 0.19 μM. It also exhibits antitumor activity in a murine H1975 xenograft model.</p>
    Formule :C28H30Cl2F2N6O4
    Couleur et forme :Solid
    Masse moléculaire :623.48

    Ref: TM-T201773

  • FGFR-IN-15
    Targetmol
    + Info

    FGFR-IN-15

    <p>FGFR-IN-15 (compound 18i) acts as a pan-FGFR inhibitor, exhibiting potent inhibitory activity against FGFR1-4.</p>
    Formule :C22H23N5O5S
    Couleur et forme :Solid
    Masse moléculaire :469.51

    Ref: TM-T201821

  • Tesevatinib tosylate
    Targetmol
    + Info

    Tesevatinib tosylate

    CAS :
    <p>Tesevatinib tosylate (XL-647 tosylate) is an orally administered epidermal growth factor receptor (EGFR) inhibitor that can cross the blood-brain barrier. It significantly reduces cell viability with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Additionally, Tesevatinib tosylate inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM), demonstrating antitumor activity by inhibiting tumor proliferation.</p>
    Formule :C31H33Cl2FN4O5S
    Couleur et forme :Solid
    Masse moléculaire :663.59

    Ref: TM-T201865

  • Le logo de CymitQuimica
    Targetmol
    + Info

    EGFR/HER2-IN-5

    <p>EGFR/HER2-IN-5: Irreversible, oral dual EGFR inhibitor, IC50 0.6 nM, targets L858R/T790M mutations, anti-tumor in vivo for lung cancer study.</p>
    Couleur et forme :Solid

    Ref: TM-T64254

  • EGFR-IN-35
    Targetmol
    + Info

    EGFR-IN-35

    CAS :
    <p>EGFR-IN-35, an acrylamide-based EGFR inhibitor, shows promise for EGFR mutation-related cancers like NSCLC.</p>
    Formule :C25H24ClN7O2
    Couleur et forme :Solid
    Masse moléculaire :489.96

    Ref: TM-T63282

  • LSD1/EGFR-IN-1
    Targetmol
    + Info

    LSD1/EGFR-IN-1

    CAS :
    <p>LSD1/EGFR-IN-1 (compound L-1) is an effective inhibitor of LSD1, EGFRT790M/L858R, and EGFRL858R/T790M/C797S, with IC50 values of 6.24, 2.06, and 5.01 μM, respectively. This compound plays a significant role in cancer research.</p>
    Formule :C21H20ClN3O4
    Couleur et forme :Solid
    Masse moléculaire :413.854

    Ref: TM-T204471

  • Le logo de CymitQuimica
    Targetmol
    + Info

    EGFR-IN-48

    <p>EGFR-IN-48: potent EGFR inhibitor, oral, IC50: 0.193-66.7 nM, blocks EGFR mutants &amp; BaF3/PC-9 cell proliferation.</p>
    Couleur et forme :Solid

    Ref: TM-T64255

  • MerTK/Axl-IN-1
    Targetmol
    + Info

    MerTK/Axl-IN-1

    CAS :
    <p>MerTK/Axl-IN-1 (Compound A-910) is a potent and selective dual inhibitor of MerTK/Axl, exhibiting IC50 values of 4.2 nM and 8.8 nM in Ba/F3 cells, and 0.2 nM and 0.9 nM in HTRF cells, respectively. It effectively inhibits pMerTK in vivo and possesses a long half-life and high oral bioavailability.</p>
    Formule :C40H47FN6O4
    Couleur et forme :Solid
    Masse moléculaire :694.84

    Ref: TM-T200517

  • UniPR500
    Targetmol
    + Info

    UniPR500

    CAS :
    <p>UniPR500, a derivative of UniPR129, is a competitive antagonist for the EphA2 receptor, with a Ki of 0.78 μM. It reduces the binding of biotinylated Ephrin-A1 to EphA2 in a dose-dependent manner, exhibiting an IC50 value of 1.1 μM.</p>
    Formule :C36H51N3O4
    Couleur et forme :Solid
    Masse moléculaire :589.808

    Ref: TM-T204989

  • EGFR-IN-147
    Targetmol
    + Info

    EGFR-IN-147

    CAS :
    <p>EGFR-IN-147 (compound ID-5841161) is a potent EGFR inhibitor, demonstrating a 14% inhibition rate at a concentration of 1μM. It holds promise for cancer research applications.</p>
    Formule :C13H13N5O
    Couleur et forme :Solid
    Masse moléculaire :255.275

    Ref: TM-T204935

  • HER2-IN-21
    Targetmol
    + Info

    HER2-IN-21

    CAS :
    <p>HER2-IN-21 (compound 657994) is an inhibitor of the human epidermal growth factor receptor 2 (HER2) with an IC50 value of 3.85 μM.</p>
    Formule :C20H18N4O3S
    Couleur et forme :Solid
    Masse moléculaire :394.447

    Ref: TM-T205331

  • EG31
    Targetmol
    + Info

    EG31

    CAS :
    <p>EG31 is an EGFR inhibitor that effectively suppresses the proliferation of triple-negative breast cancer (TNBC) cells by inhibiting the EGFR signaling pathway. It demonstrates a GI50 value of 498.90 nM for MDA-MB-231 cells and 740.73 nM for Hs578T cells, while also inducing apoptosis. Additionally, EG31 retains its antiproliferative activity against 5-fluorouracil (5-FU) resistant TNBC cells, with a GI50 of 519.5 nM. EG31 is applicable in research on TNBC resistance.</p>
    Formule :C30H13Br2N3O6
    Couleur et forme :Solid
    Masse moléculaire :671.25

    Ref: TM-T207269

  • Tyrphostin 63
    Targetmol
    + Info

    Tyrphostin 63

    CAS :
    <p>Tyrphostin 63 (compound 13) is an epidermal growth factor receptor (EGFR) inhibitor, with an IC50 of 375 μM and a Ki of 123 μM.</p>
    Formule :C10H8N2O
    Couleur et forme :Solid
    Masse moléculaire :172.183

    Ref: TM-T204167

  • TYRA-300
    Targetmol
    + Info

    TYRA-300

    CAS :
    <p>TYRA-300 is an oral and selective FGFR3 inhibito, in the Ba/F3 cell line for the treatment of metastatic uroepithelial carcinomas (mUCs) and chondrodysplasia.</p>
    Formule :C25H24Cl2N6O3S
    Degré de pureté :99.66%
    Couleur et forme :Solid
    Masse moléculaire :559.47

    Ref: TM-T88841

  • TrkA-IN-9
    Targetmol
    + Info

    TrkA-IN-9

    CAS :
    <p>TrkA-IN-9 (VMD-928) is an orally active and selective inhibitor of tropomyosin receptor kinase A (TrkA). It disrupts downstream signaling pathways activated by nerve growth factor (NGF) binding to TrkA, thereby inhibiting cell proliferation and invasion, and promoting cancer cell death. TrkA-IN-9 shows potential for research in various cancers, including prostate cancer, thymic carcinoma, mesothelioma, head and neck squamous cell carcinoma, lung cancer, ovarian cancer, and hepatocellular carcinoma.</p>
    Formule :C31H32N4O4
    Couleur et forme :Solid
    Masse moléculaire :524.61

    Ref: TM-T206381

  • Pimicotinib hydrochloride
    Targetmol
    + Info

    Pimicotinib hydrochloride

    CAS :
    <p>Pimicotinib hydrochloride is an inhibitor of CSF1R, displaying antitumor activity.</p>
    Formule :C22H25ClN6O3
    Couleur et forme :Solid
    Masse moléculaire :456.925

    Ref: TM-T204920

  • EGFR-IN-23
    Targetmol
    + Info

    EGFR-IN-23

    CAS :
    <p>EGFR-IN-23, identified as compound 8 in WO2021244502A1, is a potent EGFR tyrosine kinase inhibitor (TKI) demonstrating an inhibitory concentration (IC50) of 8.</p>
    Formule :C36H44BrN10O3P
    Couleur et forme :Solid
    Masse moléculaire :775.68

    Ref: TM-T73104

  • FMP-API-1
    Targetmol
    + Info

    FMP-API-1

    CAS :
    <p>FMP-API-1 is an inhibitor of the A-kinase anchoring protein (AKAP)-PKA interaction. It binds to the allosteric site of the PKAR subunit, enhancing the activity of PKA and AQP2 in PKA knockout cell lines of the renal cortex collecting duct (mpkCCD cells). FMP-API-1 holds potential for studying nephrogenic diabetes insipidus (NDI).</p>
    Formule :C13H14N2O2
    Couleur et forme :Solid
    Masse moléculaire :230.262

    Ref: TM-T204439

  • GENZ-882706
    Targetmol
    + Info

    GENZ-882706

    CAS :
    <p>GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor.</p>
    Formule :C26H25N5O3
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :455.51

    Ref: TM-T11390