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Tyrosine Kinase/Adaptateurs

Tyrosine Kinase/Adaptateurs

Les inhibiteurs des tyrosines kinases et des adaptateurs sont des composés qui ciblent les tyrosines kinases et leurs protéines adaptatrices associées, jouant des rôles essentiels dans la signalisation cellulaire, la croissance et la différenciation. Ces inhibiteurs sont des outils essentiels dans la recherche sur le cancer, car de nombreuses tyrosines kinases sont impliquées dans les voies de signalisation qui favorisent la croissance tumorale et les métastases. En inhibant les tyrosines kinases, ces composés peuvent bloquer des cascades de signalisation cruciales, offrant ainsi des stratégies thérapeutiques potentielles pour divers cancers et autres maladies impliquant une signalisation cellulaire anormale. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de tyrosines kinases et d'adaptateurs de haute qualité pour soutenir vos recherches en oncologie, biologie moléculaire et développement de thérapies ciblées.

Sous-catégories appartenant à la catégorie "Tyrosine Kinase/Adaptateurs"

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1375 produits trouvés pour "Tyrosine Kinase/Adaptateurs"

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  • EGFR-IN-159
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    EGFR-IN-159

    CAS :
    <p>EGFR-IN-159 (compound 12) is a dihydropyrimidine and a potent EGFR inhibitor with an IC50 of 29.00 nM. It exhibits dose-dependent inhibition of EGFR and HER2. The compound shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC50 values of 16.07 μg/mL and 35.98 μg/mL, respectively. EGFR-IN-159 does not cross the blood-brain barrier (BBB) and demonstrates significant anticancer activity.</p>
    Formule :C21H23N3O5
    Couleur et forme :Solid
    Masse moléculaire :397.424

    Ref: TM-T206989

  • EGFR-IN-38
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    EGFR-IN-38

    CAS :
    <p>EGFR-IN-38: low-toxic acrylamide-derived EGFR inhibitor, targets NSCLC, patented for research on EGFR mutation-related diseases.</p>
    Formule :C25H24ClN7O2
    Couleur et forme :Solid
    Masse moléculaire :489.96

    Ref: TM-T63283

  • EGFR-IN-125
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    EGFR-IN-125

    CAS :
    <p>EGFR-IN-125 (example 37) is a potent EGFR inhibitor with IC50 values of &lt;0.3 nM for EGFR(d746-750/T790M/C797S), 0.52 nM for EGFR(L858R/T790M/C797S), 0.5 nM for EGFR(d746-750/C797S), 0.69 nM for EGFR(L858R/C797S), and 0.92 nM for EGFR (wild type).</p>
    Formule :C30H26N8O
    Couleur et forme :Solid
    Masse moléculaire :514.58

    Ref: TM-T204450

  • Le logo de CymitQuimica
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    EGFR-IN-58

    <p>EGFR-IN-58 is a potent, selective, ATP-competitive inhibitor of EGFR. EGFR-IN-58 exhibits significant cytotoxicity against melanoma, colon and blood cancers.</p>
    Formule :C31H30FN7O
    Couleur et forme :Solid
    Masse moléculaire :535.61

    Ref: TM-T63774

  • HER2-IN-7
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    HER2-IN-7

    CAS :
    <p>HER2-IN-7 is a potent HER2 inhibitor with potential for researching ErbB-related diseases, especially cancer.</p>
    Formule :C28H26F3N7O3
    Couleur et forme :Solid
    Masse moléculaire :565.55

    Ref: TM-T64003

  • EGFR-IN-34
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    EGFR-IN-34

    <p>EGFR-IN-34 is a low-toxicity, acrylamide derivative antitumor agent that is a potent inhibitor of EGFR.</p>
    Formule :C26H27ClN6O2
    Couleur et forme :Solid
    Masse moléculaire :490.98

    Ref: TM-T63300

  • Sacibertinib
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    Sacibertinib

    CAS :
    <p>Sacibertinib inhibits Trk, targeting EGFR-TK (EC50 110 nM) &amp; HER2 (EC50 244 nM), with anticancer properties.</p>
    Formule :C32H31ClN6O4
    Couleur et forme :Solid
    Masse moléculaire :599.08

    Ref: TM-T64225

  • VEGFR2-IN-1
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    VEGFR2-IN-1

    CAS :
    <p>VEGFR2-IN-1 is a VEGFR2 inhibitor with antitumor activity used in the study of breast cancer.</p>
    Formule :C22H18N6S
    Degré de pureté :98.15%
    Couleur et forme :Solid
    Masse moléculaire :398.48

    Ref: TM-T61899

  • Le logo de CymitQuimica
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    EGFR/HER2-IN-8

    <p>EGFR/HER2-IN-8 inhibits EGFR, HER2, DHFR (IC50: 0.45, 0.244, 5.669 μM); useful in cancer research, safe and selective.</p>
    Formule :C16H16N4O2S
    Couleur et forme :Solid
    Masse moléculaire :328.39

    Ref: TM-T60938

  • Tesevatinib tosylate
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    Tesevatinib tosylate

    CAS :
    <p>Tesevatinib tosylate (XL-647 tosylate) is an orally administered epidermal growth factor receptor (EGFR) inhibitor that can cross the blood-brain barrier. It significantly reduces cell viability with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Additionally, Tesevatinib tosylate inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM), demonstrating antitumor activity by inhibiting tumor proliferation.</p>
    Formule :C31H33Cl2FN4O5S
    Couleur et forme :Solid
    Masse moléculaire :663.59

    Ref: TM-T201865

  • Le logo de CymitQuimica
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    DDR1-IN-8

    CAS :
    <p>DDR1-IN-8 (compound 7s) is a potent inhibitor of DDR1/2, exhibiting IC50 values of 0.045 μM and 0.126 μM, respectively, and possesses antitumor activity.</p>
    Formule :C23H24F3N5O2
    Masse moléculaire :459.46

    Ref: TM-T209082

  • Le logo de CymitQuimica
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    HER2-IN-9

    <p>HER2-IN-9, an oral HER2 inhibitor (IC50: 0.03 μM), hinders growth and spread of HER2+ breast cancer.</p>
    Formule :C19H14BrF3N2O
    Couleur et forme :Solid
    Masse moléculaire :423.23

    Ref: TM-T62271

  • BNN-20
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    BNN-20

    CAS :
    <p>BNN-20 is a synthetic micro-neurotrophic factor that mimics Brain-Derived Neurotrophic Factor (BDNF) and exhibits region-specific neuroprotective and neurogenesis-promoting effects. It is applicable in research related to Parkinson's disease.</p>
    Formule :C20H30O2
    Couleur et forme :Solid
    Masse moléculaire :302.45

    Ref: TM-T201864

  • EGFR-IN-135
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    EGFR-IN-135

    <p>EGFR-IN-135 (compound 3d) is an EGFR inhibitor with an IC50 value of 0.086 µM. It inhibits cell growth and arrests the cell cycle in the S phase in breast cancer cell lines.</p>
    Formule :C12H14N4OS2
    Couleur et forme :Solid
    Masse moléculaire :294.4

    Ref: TM-T201484

  • Le logo de CymitQuimica
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    c-Fms-IN-15

    CAS :
    <p>c-Fms-IN-15 (compound 8g) is a potent inhibitor of FMS kinase, with an IC50 of 563 nM.</p>
    Formule :C29H28F3N7O2
    Masse moléculaire :563.57

    Ref: TM-T210059

  • Le logo de CymitQuimica
    Targetmol
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    Protein kinase inhibitor 4

    CAS :
    <p>Protein kinase inhibitor 4 (Compound 3) is a chemical that acts as a protein kinase inhibitor, specifically targeting TRK-A with an IC50 of 3.0 nM, and ROS1 with an IC50 of 104 nM.</p>
    Formule :C25H24F2N6O3S
    Masse moléculaire :526.56

    Ref: TM-T209488

  • BML-265
    Targetmol
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    BML-265

    CAS :
    <p>BML-265 is a potent inhibitor of EGFR tyrosine kinase (EGFR tyrosine kinase). It disrupts Golgi apparatus integrity in human cells and hinders the transport of secretory proteins across various substances. In contrast, BML-265 does not affect the integrity and transport of the Golgi apparatus in rodent cells.</p>
    Formule :C18H15N3O2
    Couleur et forme :Solid
    Masse moléculaire :305.331

    Ref: TM-T204769

  • EGFR/VEGFR2-IN-2
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    EGFR/VEGFR2-IN-2

    <p>EGFR/VEGFR2-IN-2 (compound 4b) serves as a dual inhibitor of VEGFR-2 and EGFR.</p>
    Formule :C24H15FO3
    Couleur et forme :Solid
    Masse moléculaire :370.37

    Ref: TM-T201505

  • CL-A3-7
    Targetmol
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    CL-A3-7

    CAS :
    <p>CL-A3-7 is a viral-cell fusion inhibitor targeting the RSVF protein. It functions by blocking the interaction between the virus and the host's IGF1R, effectively inhibiting the infection of both wild-type and K394R mutant strains of RSV. This compound is suitable for use in antiviral drug development and resistance studies related to RSV.</p>
    Formule :C24H22Br2F2N2O3
    Couleur et forme :Solid
    Masse moléculaire :584.25

    Ref: TM-T201641

  • 2-Methyl-3-phenylquinoxaline
    Targetmol
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    2-Methyl-3-phenylquinoxaline

    CAS :
    <p>2-Methyl-3-phenylquinoxaline (compound 38) serves as an effective inhibitor of the Platelet-Derived Growth Factor Receptor Tyrosine Kinase (PDGF-RTK), exhibiting significant inhibitory activity against the full-length PDGFR kinase in intact cells (IC50 greater than 100 μM).</p>
    Formule :C15H12N2
    Couleur et forme :Solid
    Masse moléculaire :220.27

    Ref: TM-T201514