GPCR/G-Protéine
Les inhibiteurs des GPCR/protéines G sont des composés qui ciblent les récepteurs couplés aux protéines G (GPCR) et les protéines G associées, qui jouent un rôle crucial dans la transmission des signaux de l'extérieur vers l'intérieur des cellules. Ces inhibiteurs sont essentiels pour étudier les voies de signalisation médiées par les GPCR, impliquées dans de nombreux processus physiologiques, y compris la perception sensorielle, la réponse immunitaire et la neurotransmission. Les inhibiteurs des GPCR sont également importants dans le développement de médicaments, car de nombreux agents thérapeutiques ciblent ces récepteurs. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de GPCR/protéines G de haute qualité pour soutenir vos recherches en pharmacologie, biologie cellulaire et domaines connexes.
Sous-catégories appartenant à la catégorie "GPCR/G-Protéine"
- récepteur 5-HT(1.025 produits)
- Récepteur d'adénosine(251 produits)
- Récepteur adrénergique(3.028 produits)
- Récepteur de la bombésine(35 produits)
- Récepteur de la bradykinine(61 produits)
- CXCR(158 produits)
- CaSR(34 produits)
- Récepteur cannabinoïde(218 produits)
- Cholécystokinine(1 produits)
- Récepteur de la dopamine(445 produits)
- Récepteur de l'endothéline(86 produits)
- Récepteur GNRH(84 produits)
- GPCR19(36 produits)
- GRK(33 produits)
- GTPase(23 produits)
- Récepteur du glucagon(195 produits)
- Hérisson/Smoothened(49 produits)
- Récepteur de l'histamine(385 produits)
- Récepteur LPA(21 produits)
- Récepteur de la mélatonine(26 produits)
- Récepteur OX(41 produits)
- Récepteur opioïde(327 produits)
- PAFR(14 produits)
- PKA(61 produits)
- Récepteur S1P(18 produits)
- SGLT(31 produits)
- Récepteur Sigma(46 produits)
Affichez 19 plus de sous-catégories
6011 produits trouvés pour "GPCR/G-Protéine"
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Pipoxazole
CAS :Pipoxazole, an adrenergic receptor antagonist, is used potentially for the treatment of depression.Formule :C14H20N4ODegré de pureté :98.58% - 99.53%Couleur et forme :SolidMasse moléculaire :260.33UNC0006
CAS :UNC0006 is a β-arrestin-biased dopamine D2 ligand.
Formule :C24H29Cl2N3O2Degré de pureté :99.35% - 99.97%Couleur et forme :SolidMasse moléculaire :462.41TASP0390325
CAS :TASP0390325, a potent and orally active V1B receptor antagonist, has antidepressant and anxiolytic activities in rodents.Formule :C25H30Cl2FN5O4Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :554.44Fosnetupitant chloride monohydrochloride
CAS :Fosnetupitant chloride monohydrochloride (Pro-netupitant chloride monohydrochloride) is a selective NK1 antagonist exhibiting high affinity for the human NK1Formule :C31H37Cl2F6N4O5PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :761.525-HT2 agonist-1 free base
CAS :Compound 24 (5-HT2 agonist-1 free base) is a potent agonist for 5-HT2A, 5-HT2B, and 5-HT2C receptors, exhibiting IC50 values of 10 nM, 8.3 nM, and 1.6 nM,Formule :C19H22N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :310.39GW-597901
CAS :GW-597901, an β2 adrenergic receptor agonist, is used potentially for the treatment of asthma and chronic obstructive.Formule :C25H38N2O6SCouleur et forme :SolidMasse moléculaire :494.64S1P1 agonist 6 hemicalcium
CAS :Compound I (S1P1 agonist 6 hemicalcium) is an S1P1 agonist that diminishes autoimmune activity by inhibiting lymphocyte trafficking, and serves as anFormule :C25H26F3NO3CaDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :465.51(+)-Fluprostenol
CAS :(+)-Fluprostenol (AL-5848), an analogue of prostaglandin F2 alpha, is a prostaglandin F2α receptor PTGFR agonist and decreases the expression of OviductalFormule :C23H29F3O6Degré de pureté :97.35%Couleur et forme :SolidMasse moléculaire :458.47Ref: TM-T21224
1mg80,00€5mg170,00€1mL*10mM (DMSO)177,00€10mg281,00€25mg520,00€50mg750,00€100mg1.035,00€200mg1.378,00€AH13205
CAS :AH13205 is an agonist of EP2 prostanoid receptor.Formule :C24H36O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :388.54RXFP1 receptor agonist-5
CAS :RXFP1 receptor agonist-5 (Example 98) is an agonist that targets the RXFP1 receptor and demonstrates its bioactivity by inhibiting cAMP production in HEK293Formule :C30H23F6N3O7Couleur et forme :SolidMasse moléculaire :651.514-Chloro-L-phenylalanine
CAS :4-Chloro-L-phenalanine (L-PCPA) is an inhibitor of 5-HT biosynthesis and a non-specific antagonist of tryptophan hydroxylases (TPH1 and TPH2).Formule :C9H10ClNO2Degré de pureté :99.76% - 99.96%Couleur et forme :SolidMasse moléculaire :199.63JNJ-19567470
CAS :JNJ-19567470 is a selective, non-peptide CRF receptor 1 antagonist.Formule :C22H27BrN4OCouleur et forme :SolidMasse moléculaire :443.38PNU109291
CAS :PNU109291, a potent and selective agonist of the 5-HT1D receptor, effectively mitigates dural plasma extravasation induced by trigeminal ganglion stimulation.Formule :C24H31N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :409.52Aganepag isopropyl
CAS :Aganepag isopropyl can be used to treat Glaucoma.Formule :C27H37NO4SCouleur et forme :SolidMasse moléculaire :471.6515-epi Prostaglandin A1
CAS :15-epiProstaglandin A1 (15-epiPGA1) is an R-stereoisomer of PGA1, belonging to the A-series prostaglandins derived from gorgonian soft corals. PGA1 is known for its effects on renal vasodilation, promoting sodium excretion through urine, and reducing arterial pressure in hypertensive individuals. However, the specific biological activities of 15-epiPGA1 have not yet been documented in published reports.Formule :C20H32O4Couleur et forme :SolidMasse moléculaire :336.472Cipralisant maleate
CAS :Cipralisant maleate is a potent, selective Histamine H3 receptor antagonist.Formule :C18H24N2O4Couleur et forme :SolidMasse moléculaire :332.394-Amino-PPHT Hydrobromide
CAS :4-Amino-PPHT Hydrobromide is a precursor for fluorescent labeled Dopamine D2 receptors agonist.Formule :C21H28N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :324.46GSK-554418A
CAS :GSK-554418A, a novel azaindole CB(2) agonists, is used for the treatment of chronic pain. It is efficacious in the acute model and the chronic joint pain model.Formule :C19H19ClN4O2Couleur et forme :SolidMasse moléculaire :370.83N-5984
CAS :N-5984, a β3-adrenergic receptor agonist, is used potentially for the treatment of obesity, overactive bladder and type 2 diabetes.
Formule :C20H22ClNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :391.85Timiperone
CAS :Timiperone exhibits a high affinity for cerebral dopamine D2 receptors, demonstrating antipsychotic activity as it mitigates stereotyped behavior.Formule :C22H24FN3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :397.51Domesticine, (-)-
CAS :Domesticine, (-)- is an antagonist of alpha-1D-adrenoceptor.Formule :C19H19NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :325.36ONO-2050297
CAS :ONO-2050297 is the first potent dual CysLT1 and CysLT2 antagonist with IC50 values of 0.017 μM (CysLT1) and 0.00087 μM (CysLT2), respectively.Formule :C31H34N2O7Couleur et forme :SolidMasse moléculaire :546.61Sonepiprazole
CAS :Sonepiprazole (PNU-101387G) is a chemical compound known for its selective antagonistic properties toward D4 dopamine receptors, exhibiting dissociationFormule :C21H27N3O3SDegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :401.525-HT2A&5-HT2C agonist-1
CAS :5-HT2A&5-HT2C agonist-1 (Example 2) is a dual-acting agent targeting the 5-HT2A and 5-HT2C receptors with respective IC50 values of 196 nM and 0.9 nM.Formule :C14H20N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :232.32O-Arachidonoyl glycidol
CAS :O-Arachidonoyl glycidol (compound 1), a 2-arachidonoylglycerol (2-AG) analog, effectively inhibits the hydrolysis of cytosolic 2-oleoylglycerol (2-OG) with an IC50 value of 4.5 µM, and also blocks 2-OG and anandamide hydrolysis in membrane fractions with IC50 values of 19 µM and 12 µM, respectively [1].Formule :C23H36O3Couleur et forme :SolidMasse moléculaire :360.53LX-1031
CAS :LX-1031 is an effective inhibitor of tryptophan 5-hydroxylase. LX-1031 decreases serotonin (5-HT) synthesis peripherally.Formule :C28H25F3N4O4Degré de pureté :97.123% - 98.97%Couleur et forme :SolidMasse moléculaire :538.52Ref: TM-T15796
1mg55,00€5mg120,00€1mL*10mM (DMSO)143,00€10mg187,00€25mg376,00€50mg597,00€100mg938,00€200mg1.264,00€FR-181877
CAS :FR-181877: nonprostanoid PGI2 agonist, ADP-induced platelet aggregation inhibitor (IC50=0.081μM), orally bioavailable (56%), long half-life (4.3h) in rats.Formule :C30H28N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :480.55SKF 81297
CAS :SKF 81297 is a selective and potent agonist for the dopamine D1 receptor [1].Formule :C16H16ClNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :289.76Butanoyl PAF
CAS :Oxidized low-density lipoprotein (oxLDL) encompasses low molecular weight entities that facilitate monocyte differentiation and activate polymorphonuclear leukocytes. A substance, recently isolated and purified from oxLDL and identified as azelaoyl PC, exemplifies this. Similarly, Butanoyl PAF, a compound closely related to azelaoyl PC, maintains over 10% of the agonist potency of platelet-activating factor (PAF). Notably, Butanoyl PAF's concentration in oxLDL surpasses that of enzymatically generated PAF by more than 100-fold, making it a significant signalling molecule within oxLDL.Formule :C28H58NO7PCouleur et forme :SolidMasse moléculaire :551.75-HT2C agonist-3 free base
CAS :5-HT2C agonist-3 ((+)-19) free base, a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM), exhibits antipsychotic drug-like activity and inhibits Amphetamine-Formule :C19H22FNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :315.38Ubrogepant
CAS :Ubrogepant (MK-1602) is an antagonist of calcitonin gene-related peptide receptor that can be used in the acute treatment of migraine studies.Formule :C29H26F3N5O3Degré de pureté :99.452% - 99.78%Couleur et forme :SolidMasse moléculaire :549.54Ref: TM-T17194
1mg144,00€5mg358,00€1mL*10mM (DMSO)432,00€10mg565,00€25mg880,00€50mg1.161,00€100mg1.594,00€MK 0893
CAS :MK 0893 is a potent and selective Glucagon Receptor (GR) antagonist competitive, reversible cAMP activity, which attenuates blood glucose elevation.Formule :C32H27Cl2N3O4Degré de pureté :98.79%Couleur et forme :SolidMasse moléculaire :588.48Phentolamine Analogue 1
CAS :Phentolamine Analogue 1 is an analogue of phentolamine. Phentolamine is a nonselective antagonist of α-adrenergic.Formule :C17H19N3ODegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :281.35Ref: TM-T12444
1mg81,00€1mL*10mM (DMSO)163,00€5mg168,00€10mg245,00€25mg404,00€50mg567,00€100mg767,00€200mg1.018,00€CP 154526 hydrochloride
CAS :CP 154526 hydrochloride is a blood-brain barrier-penetrant, selective CRF1 antagonist (Ki = 2.7 nM), with anxiolytic and antidepressant activities.Formule :C23H33ClN4Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :400.99Ref: TM-T22682
1mg50,00€5mg107,00€1mL*10mM (DMSO)109,00€10mg167,00€25mg369,00€50mg604,00€100mg850,00€SAD-448
CAS :SAD-448 is a cannabinoid receptor type 1 (CB1) agonist. SAD-448 controls spasticity via action on the peripheral nerve CB1 receptor.Formule :C24H28N4O8SCouleur et forme :SolidMasse moléculaire :532.57Bunazosin Hydrochloride
CAS :Bunazosin Hydrochloride (E 1015) is an alpha(1)-adrenoceptor antagonist used as a systemic antihypertensive and an ocular hypotensive drug.Formule :C19H28ClN5O3Degré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :409.915α-Pregnane-3α,20α-diol
CAS :5α-Pregnane-3α,20α-diol, an active metabolite of progesterone, is synthesized through intermediates 5α-pregnane-20α-ol-3-one and 5α-pregnane-3α-ol-20-one fromFormule :C21H36O2Couleur et forme :SolidMasse moléculaire :320.51RBC10
CAS :RBC10 inhibits the binding of Ral to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-Formule :C24H25ClN2O2Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :408.92Oleoyl-L-α-lysophosphatidic acid sodium salt
CAS :Oleoyl-L-alpha-lysophosphatidic acid sodium salt is an essential cell membrane biosynthetic metabolite that mediates signal transduction by interacting with GFormule :C21H42NaO7PCouleur et forme :SoildMasse moléculaire :460.524YM348
CAS :YM348 is an effective and orally active 5-HT2C receptor agonist. YM348 also shows a high affinity for the cloned human 5-HT2C receptor (Ki: 0.89 nM).Formule :C14H17N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :243.3O-2050
CAS :O-2050: strong CB1 antagonist (Ki 2.5 nM), CB2 inhibitor (Ki 0.2 nM); reduces mouse food intake, increases activity.Formule :C23H31NO4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :417.56BMS-960
CAS :BMS-960 is an S1P agonist with potential anti-tumour activity for cancer research.Formule :C26H23F3N4O5Degré de pureté :97.66% - 98.69%Couleur et forme :SolidMasse moléculaire :528.48TASP 0277308
CAS :NH2-UAMC1110 TFA is an aminobutoxy derivative of UAMC1110 used in the synthesis of FAPI-QS. UAMC1110 is a fibroblast activating protein (fap) inhibitor.Formule :C23H28Cl2N6O3SCouleur et forme :SolidMasse moléculaire :539.48APJ receptor agonist 5
CAS :Potent oral APJ agonist (EC 50:0.4 nM); improves cardiac function in HF, with good pharmacokinetics and safety.Formule :C26H29N3O6Couleur et forme :SolidMasse moléculaire :479.52PAC1R antagonist 1
CAS :PAC1R antagonist 1 is a PAC1 receptor antagonist that inhibits the activation of peptides by pituitary adenylate cyclase and can be used to study tumours.Formule :C17H17ClN6O2Degré de pureté :98.43% - 99.56%Couleur et forme :SolidMasse moléculaire :372.81Ref: TM-T78105
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander1mL*10mM (DMSO)À demander1mg87,00€BIM-23056 TFA
CAS :BIM 23056 TFA, a potent linear octapeptide antagonist of sst3 and sst5 somatostatin receptors, exhibits inhibition constants (K_i) of 10.8 for sst3 and 5.7 forFormule :C73H82F3N11O11Couleur et forme :SolidMasse moléculaire :1346.49AZD2423
CAS :AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM forFormule :C20H29ClFN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.93Apelin agonist 1
CAS :Apelin agonist 1 is an orally available APJ receptor agonist with an EC50 value of 3.2 nM. Apelin agonist 1 is used in the study of cardiovascular disease.Formule :C23H20FN5O5SDegré de pureté :97.69% - 99.07%Couleur et forme :SolidMasse moléculaire :497.5Cyanopindolol fumarate
CAS :Cyanopindolol fumarate is a 5-HT receptor antagonist [1].Formule :C16H21N3O2C4H4O4Couleur et forme :SolidMasse moléculaire :345.4Vatinoxan hydrochloride
CAS :Vatinoxan hydrochloride is an antagonist of the peripheral α2 adrenergic receptors.Formule :C20H27ClN4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :454.97iso-TRAP-6
CAS :iso-TRAP-6 (iso-SFLLRN), a hexapeptide made from isoserine instead of serine, is a PAR1 agonist that activates platelets via PAR-1.Formule :C34H56N10O9Degré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :748.87LY108742
CAS :LY108742 is an antagonist of 5-HT2.Formule :C21H28N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.46ACT 335827
CAS :ACT-335827: oral, brain-penetrant OXR1 selective antagonist; IC50: 6 nM (OXR1), 417 nM (OXR2); for neurological research.Formule :C31H38N2O5Couleur et forme :SolidMasse moléculaire :518.64TM-N1324
CAS :TM-N1324 is a GPR39 agonist; 280 nM potency without Zn2+, 9 nM with; similar effects on murine GPR39 (EC50s: 180 nM/5 nM).Formule :C18H13ClFN7ODegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :397.79Ref: TM-T17103
1mg49,00€2mg64,00€5mg90,00€1mL*10mM (DMSO)92,00€10mg170,00€25mg371,00€50mg557,00€100mg792,00€Ono-RS 347
CAS :Ono-RS 347 is a leukotriene antagonists with the activity of SRS-A antagonist.Formule :C26H25N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.51PSNCBAM-1
CAS :PSNCBAM-1 (PSNCBAM 1) is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo.Formule :C22H21ClN4ODegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :392.88SKI2496
CAS :SKI2496: potent, oral GnRH receptor antagonist, hGnRHR IC50=0.46nM, 84% LH inhibition at 12h, 76% at 24h, selective for humans over monkeys/rats.Formule :C35H36F7N5O5Couleur et forme :SolidMasse moléculaire :739.68VKGILS-NH2 TFA
CAS :VKGILS-NH2 TFA, a non-impacting control peptide for PAR2 agonist SLIGKV-NH2, doesn't affect DNA synthesis.Formule :C30H55F3N8O9Couleur et forme :SolidMasse moléculaire :728.8CCR2 antagonist 4
CAS :CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nMFormule :C21H21ClF3N3O2Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :439.86Ref: TM-T13114
1mg52,00€5mg120,00€1mL*10mM (DMSO)133,00€10mg188,00€25mg329,00€50mg490,00€100mg697,00€Wf-516
CAS :Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressantFormule :C25H25Cl2N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :502.39Tricosanoyl Ethanolamide
CAS :Tricosanoyl ethanolamide, a fatty N-acyl ethanolamine within the endocannabinoid family, has an ethanolamine metabolite whose significance remains to be established.Formule :C25H51NO2Couleur et forme :SolidMasse moléculaire :397.688β3-AR agonist 1
CAS :β3-AR agonist 1 is a highly selective, and orally available agonist of β3-adrenergic receptor (EC50: 18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/Formule :C22H28N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :444.55Pentiapine
CAS :Pentiapine (CGS 10746) is a novel inhibitor of dopamine release.Formule :C15H17N5SDegré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :299.39Ref: TM-T12405
1mg487,00€5mg753,00€1mL*10mM (DMSO)938,00€10mg1.216,00€25mg1.691,00€50mg2.262,00€100mg3.068,00€PD-140548
CAS :PD-140548 is a potent, CCKA receptor-selective antagonist.Formule :C33H39N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :557.682-Chloro-ATP
CAS :2-Chloro-ATP is a soluble inhibitor of guanylate cyclase (guanylate cyclase) that can increase intracellular calcium ion concentrations at low concentrations through a mechanism independent of inositol phosphate production.Formule :C10H15ClN5O13P3Couleur et forme :SolidMasse moléculaire :541.63APD-916
CAS :APD-916, an H3 receptor antagonist, exhibits favorable pharmacokinetic properties. Oral administration of APD-916 has been demonstrated to enhance wakefulness in various animal models.Formule :C23H31NO3SCouleur et forme :SolidMasse moléculaire :401.56CB1 antagonist 1
CAS :CB1 antagonist 1 is a CB1 receptor antagonist, used in the research of obesity and metabolic syndrome, neuroinflammatory disorders, cognitive disorders, andFormule :C26H22Cl2N4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.39SB-649701
CAS :SB-649701 is a potent antagonist of the human CCR8 receptor, exhibiting a pIC50 value of 7.7, and is utilized in asthma research [1].Formule :C27H28N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :456.54IPG7236
CAS :IPG7236, a selective CCR8 antagonist, demonstrates notable tumor suppression in a mouse xenograft model of human breast cancer and is applicable in cancerFormule :C23H31N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :429.58Prostaglandin F2α ethyl amide
CAS :Prostaglandin F2αethyl amide (PGF2α-NEt), a PGF2α analog featuring an N-ethyl amide modification at the C-1 carboxyl group, possesses ocular hypotensive activity similar to PG esters. Introduced as alternative prostaglandin ocular hypotensive prodrugs, PGF2α-NEt and other PG N-ethyl amides, contrary to claims of not converting to free acids in vivo, have been demonstrated by our laboratory studies to undergo conversion by bovine and human corneal tissue into the respective free acids at a rate of approximately 2.5 µg/g corneal tissue/hr. This suggests PGF2α-NEt is expected to elicit typical PGF2α free acid intraocular effects, albeit with slower hydrolysis kinetics characteristic of PG N-amides.Formule :C22H39NO4Couleur et forme :SolidMasse moléculaire :381.6SORT-PGRN interaction inhibitor 2
CAS :SORT-PGRN Interaction Inhibitor 2 is a compound that downregulates SORT1 protein expression and enhances extracellular progranulin (PGRN) secretion in variousFormule :C19H31NOCouleur et forme :SolidMasse moléculaire :289.46RXFP1 receptor agonist-4
CAS :RXFP1 receptor agonist-4 (Example 268) is an agonist for the RXFP1 receptor, demonstrated to suppress cAMP production in HEK293 cells that stably express theFormule :C32H24F7N3O5SCouleur et forme :SolidMasse moléculaire :695.6Minocromil
CAS :Minocromil is a new agent of Anti-asthmatic.Formule :C18H16N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.33Droxicam
CAS :Droxicam (Droxicamum) is a non-steroidal anti-inflammatory compound and can be used for research on the relief of inflammation and pain in musculoskeletalFormule :C16H11N3O5SDegré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :357.34Ginkgolic acid 2-phosphate
CAS :Ginkgolic acid 2-phosphate, a potent sphingosine 1-phosphate (S1P) agonist, induces ERK phosphorylation and interacts with S1P1 [1].Formule :C22H37O6PCouleur et forme :SolidMasse moléculaire :428.5CMPD167
CAS :CMPD167 (MRK-1) is a potent, orally active inhibitor of CCR5 with significant in vitro antiviral efficacy [1].Formule :C35H47FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :574.77O-2545 hydrochloride
CAS :O-2545 is a potent water-soluble central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptor agonist with Ki values of 1.5 and 0.32 nM, respectively. Typically, cannabinoid agonists are highly lipophilic and require solubilization through surfactant agents or binding to water miscible substances like albumin, Tween 80, or Emulphor for use. When dissolved in saline, O-2545 has shown high efficacy in mouse behavioral models, administered either intravenously or intracerebroventricularly.Formule :C26H36N2O2HClCouleur et forme :SolidMasse moléculaire :445BMS-763534
CAS :BMS-763534 is a potent antagonist of corticotropin-releasing factor/hormone receptor 1 (CRHR-1).Formule :C18H21ClF2N4O3Couleur et forme :SolidMasse moléculaire :414.83RXFP1 receptor agonist-3
CAS :RXFP1 receptor agonist-3 (Example 223) is an agonist of the RXFP1 receptor that inhibits cyclic AMP (cAMP) production in HEK293 cells stably expressing humanFormule :C42H34F9N3O5Couleur et forme :SolidMasse moléculaire :831.72PF-03550096
CAS :PF-03550096, an orally active synthetic cannabinoid (CB), selectively binds to peripheral CB2 receptors with a Ki value of 7.9 nM, demonstrating analgesic activity [1].Formule :C19H28N4O4Couleur et forme :SolidMasse moléculaire :376.451-Carboxycyclohexaneacetic Acid
CAS :1-Carboxycyclohexaneacetic acid may be present as a potential impurity in commercial gabapentin, an antiepileptic drug. Furthermore, it serves as a precursor for synthesizing antagonists targeting the serotonin (5-HT) receptor subtype 5-HT2A.Formule :C9H14O4Couleur et forme :SolidMasse moléculaire :186.207Hedgehog IN-2
CAS :Hedgehog IN-2 (Compound 20) functions as an inhibitor of the Hedgehog signaling pathway, exhibiting an IC50 of <0.003 μM in C3H10T1/2 cells [1].Formule :C24H22N4O2Couleur et forme :SolidMasse moléculaire :398.46Prostaglandin F2α 1,9-lactone
CAS :Prostaglandin F2α (PGF2α) 1,9-lactone, a lipid-soluble internal ester of PGF2α, demonstrates resistance to hydrolysis by human plasma esterases, maintaining its structure even after 20 hours of incubation under physiological conditions. Unlike PGF2α, this compound exhibits minimal antifertility and vasoactivity.Formule :C20H32O4Couleur et forme :SolidMasse moléculaire :336.5(±)-Fabesetron hydrochloride
CAS :FK1052 hydrochloride is a potent 5-HT3 and 5-HT4 receptor dual antagonist.Formule :C18H20ClN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :329.82Dibenamine hydrochloride
CAS :Dibenamine hydrochloride is a competitive and irreversible blocking agent of the β-adrenergic receptor.Formule :C16H19Cl2NDegré de pureté :96.43%Couleur et forme :Oily Liquid SolidMasse moléculaire :296.23Ciprostene (calcium salt)
CAS :Ciprostene, a PGI2 stable analog, is less potent, induces hypotension, tachycardia, and inhibits platelet aggregation in monkeys.Formule :C44H74CaO8Couleur et forme :SolidMasse moléculaire :771.146BAY 60-2770
CAS :BAY 60-2770: oral sGC activator, NO-independent, antifibrotic, boosts sGC activity.Formule :C35H33F4NO5Couleur et forme :SolidMasse moléculaire :623.63CP-96486
CAS :CP-96486 is a potent and orally active antagonist of leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor (Kis: 20 and 24 nM).Formule :C31H23ClN4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :502.99RXFP1 receptor agonist-6
CAS :RXFP1 receptor agonist-6 (Example 7) serves as an agonist for the RXFP1 receptor and effectively suppresses cAMP production in HEK293 cells that stably expressFormule :C38H32F5N3O7Couleur et forme :SolidMasse moléculaire :737.67LM-1484
CAS :LM-1484 displays a higher affinity for 3H-LTC4 sites and is an antagonist of CysLT1 receptor.Formule :C28H24N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.52L 691678
CAS :L 691678 is a potent leukotriene biosynthesis inhibitor.Formule :C36H30IN5O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :771.63UNC9994
CAS :UNC9994 is a β-arrestin-biased dopamine D₂ receptor agonist (β-arrestin EC50 = 50 nM; Emax = 97%) with robust in vivo antipsychotic drug-like activities.Formule :C21H22Cl2N2OSCouleur et forme :SolidMasse moléculaire :421.38(15R)-Bimatoprost
CAS :"(15R)-Bimatoprost (15(R)-17-phenyl trinor PGF2α ethyl amide), an isomer of Bimatoprost characterized by an inverted (β) hydroxyl group on C-15 [1], is a prostaglandin analog employed in the treatment of glaucoma and ocular hypertension."Formule :C25H37NO4Couleur et forme :SolidMasse moléculaire :415.57RO5527239
CAS :RO5527239 is a potent, orally available GPBAR1 agonist agent.Formule :C28H31N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :457.5617-Phenyl-18,19,20-trinor-PGD2
CAS :17-Phenyl-18,19,20-trinor-PGD2 (17-Phenyl-PGD2), an analogue of prostaglandin D2 (PGD2), acts as a potent inhibitor of platelet aggregation induced by adenosine diphosphate (ADP), exhibiting an IC50 value of 8.4 μM, compared to PGD2's IC50 of 18.6 nM. Additionally, it serves as a weak agonist for cyclic AMP accumulation [1].Formule :C23H30O5Couleur et forme :SolidMasse moléculaire :386.48S1P5 receptor agonist-1
CAS :S1P5 Receptor Agonist-1 (example 6) is a highly potent and selective agonist for the S1P5 receptor, exhibiting an EC50 value of 20 nM.Formule :C20H24F3NO3Couleur et forme :SolidMasse moléculaire :383.4Tafluprost ethyl ester
CAS :Tafluprost, an analog of prostaglandin F2α (PGF2α) that primarily targets the FP receptor, is employed in glaucoma treatment. Tafluprost (free acid) serves as a potent FP receptor agonist with a Ki value of 0.4 nM. Its derivative, tafluprost ethyl ester, potentially offers enhanced lipid solubility relative to its free acid form, possibly leading to superior tissue absorption and reduced effective concentration requirements.Formule :C24H32F2O5Couleur et forme :SolidMasse moléculaire :438.512RP-23618
CAS :RP-23618 is a non-peptidic antagonist of RANTES.Formule :C30H35N5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :577.76(R)-Casopitant
CAS :(R)-Casopitant ((R)-GW679769), an NK1-receptor antagonist, is used in chemotherapy-induced nausea research.Formule :C30H35F7N4O2Couleur et forme :SolidMasse moléculaire :616.61ASP6432
CAS :ASP6432 is an antagonist of type 1 lysophosphatidic acid receptor (LPA1). For human LPA1 and rat LPA1, the IC50s are 11 nM and 30 nM , respectively.Formule :C26H32KN4O6S2Couleur et forme :SolidMasse moléculaire :599.78
