GPCR/G-Protéine
Les inhibiteurs des GPCR/protéines G sont des composés qui ciblent les récepteurs couplés aux protéines G (GPCR) et les protéines G associées, qui jouent un rôle crucial dans la transmission des signaux de l'extérieur vers l'intérieur des cellules. Ces inhibiteurs sont essentiels pour étudier les voies de signalisation médiées par les GPCR, impliquées dans de nombreux processus physiologiques, y compris la perception sensorielle, la réponse immunitaire et la neurotransmission. Les inhibiteurs des GPCR sont également importants dans le développement de médicaments, car de nombreux agents thérapeutiques ciblent ces récepteurs. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de GPCR/protéines G de haute qualité pour soutenir vos recherches en pharmacologie, biologie cellulaire et domaines connexes.
Sous-catégories appartenant à la catégorie "GPCR/G-Protéine"
- récepteur 5-HT(1.025 produits)
- Récepteur d'adénosine(249 produits)
- Récepteur adrénergique(3.024 produits)
- Récepteur de la bombésine(35 produits)
- Récepteur de la bradykinine(61 produits)
- CXCR(158 produits)
- CaSR(34 produits)
- Récepteur cannabinoïde(217 produits)
- Cholécystokinine(1 produits)
- Récepteur de la dopamine(445 produits)
- Récepteur de l'endothéline(86 produits)
- Récepteur GNRH(84 produits)
- GPCR19(33 produits)
- GRK(33 produits)
- GTPase(23 produits)
- Récepteur du glucagon(194 produits)
- Hérisson/Smoothened(49 produits)
- Récepteur de l'histamine(385 produits)
- Récepteur LPA(21 produits)
- Récepteur de la mélatonine(26 produits)
- Récepteur OX(41 produits)
- Récepteur opioïde(327 produits)
- PAFR(14 produits)
- PKA(60 produits)
- Récepteur S1P(18 produits)
- SGLT(31 produits)
- Récepteur Sigma(46 produits)
Affichez 19 plus de sous-catégories
5990 produits trouvés pour "GPCR/G-Protéine"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
TG6-129
CAS :TG6-129 is an EP2 receptor antagonist, blocking PGE2 effects, reducing inflammatory markers with 1.6 µM IC50.Formule :C20H18FN5O3S3Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :491.58Ref: TM-T28958
1mg114,00€5mg227,00€1mL*10mM (DMSO)321,00€10mg404,00€25mg665,00€50mg888,00€100mg1.251,00€500mg2.538,00€Tedalinab
CAS :Tedalinab is an effective and selective cannabinoid receptor 2 agonist.Formule :C19H21F2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :345.39ASP6432
CAS :ASP6432 is an antagonist of type 1 lysophosphatidic acid receptor (LPA1). For human LPA1 and rat LPA1, the IC50s are 11 nM and 30 nM , respectively.Formule :C26H32KN4O6S2Couleur et forme :SolidMasse moléculaire :599.78(±)-Fabesetron hydrochloride
CAS :FK1052 hydrochloride is a potent 5-HT3 and 5-HT4 receptor dual antagonist.Formule :C18H20ClN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :329.82Dothiepin
CAS :Dothiepin (Dosulepin; Dothep), an antidepressant with sedative/anxiolytic properties, preferentially inhibits noradrenaline over serotonin uptake, enhancingFormule :C19H21NSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :295.44CCR2 antagonist 4
CAS :CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nMFormule :C21H21ClF3N3O2Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :439.86Ref: TM-T13114
1mg52,00€5mg120,00€1mL*10mM (DMSO)133,00€10mg188,00€25mg329,00€50mg490,00€100mg697,00€Butriptyline
CAS :Butriptyline (Butriptylene), a tricyclic antidepressant, is effective when administered orally [1].Formule :C21H27NCouleur et forme :SolidMasse moléculaire :293.45Crisdesalazine
CAS :Crisdesalazine (AAD 2004) is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1).Formule :C16H14F3NO3Degré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :325.28GSA-10
CAS :GSA-10 is a potent Smoothened (Smo) receptor agonist with an EC50 of 1.2 μM.Formule :C26H30N2O5Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :450.53LTB4 antagonist 1
CAS :LTB4 Antagonist 1, a carboxamide-acid derivative, potently inhibits Leukotriene B4 (LTB4) activity with an IC50 value of 288 nM and exhibits notable anti-Formule :C26H23NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.46Tradipitant
CAS :Tradipitant (VLY-686) is an antagonist of neurokinin-1.Formule :C28H16ClF6N5ODegré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :587.9Ref: TM-T17156
1mg60,00€2mg85,00€5mg119,00€1mL*10mM (DMSO)157,00€10mg187,00€25mg329,00€50mg490,00€100mg700,00€PF-06748962
CAS :PF-06748962 is a potent and selective lactam-based prostaglandin EP3 receptor antagonist.Formule :C21H21N3O2Couleur et forme :SolidMasse moléculaire :347.41BMY-42393
CAS :BMY-42393 is an oral prostacyclin agonist and platelet aggregation inhibitor with IC50 of 0.3-2μM and stimulates adenylate cyclase (EC50 = 25nM).Formule :C25H21NO4Couleur et forme :SolidMasse moléculaire :399.44Bivamelagon
CAS :MC-4R Agonist 2 (Example 1), a melanocortin 4 receptor (MC4R) agonist, is employed in the research of conditions such as obesity, diabetes, inflammation, andFormule :C35H53ClN4O4Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :629.275-HT2C agonist-3 free base
CAS :5-HT2C agonist-3 ((+)-19) free base, a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM), exhibits antipsychotic drug-like activity and inhibits Amphetamine-Formule :C19H22FNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :315.38LTB4 antagonist 2
CAS :LTB4 antagonist 2, a carboxamide-acid compound, serves as an antagonist to leukotriene B4 (LTB4), possessing potential anti-inflammatory properties.Formule :C26H23NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.46TP0438836
CAS :TP0438836: potent SGLT1 inhibitor, low absorption, for type 2 diabetes; IC50: 28nM (hSGLT1), 7nM (hSGLT2).Formule :C27H38N2O10Couleur et forme :SolidMasse moléculaire :550.6Selatogrel
CAS :Selatogrel (ACT-246475) is a P2Y12 receptor antagonist with antithrombotic activity and inhibits platelet aggregation.Formule :C28H39N6O8PDegré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :618.62Vidupiprant
CAS :Vidupiprant (AMG 853) is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of 8 nM and 35 nM in human plasma.Formule :C28H27Cl2FN2O6SDegré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :609.49Ref: TM-T17232
1mg63,00€5mg137,00€1mL*10mM (DMSO)178,00€10mg207,00€25mg375,00€50mg560,00€100mg797,00€500mg1.603,00€AY 77
CAS :AY 77: Potent, selective PAR2 agonist, favors Ca2+ (ec50=40nM) & ERK1/2 (ec50=2μM), boosts breast cancer cell migration.
Formule :C21H32N4O4Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :404.5INT-777
CAS :INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM.Formule :C27H46O5Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :450.65Ref: TM-T11662L
1mg130,00€5mg313,00€1mL*10mM (DMSO)343,00€10mg447,00€25mg715,00€50mg999,00€100mg1.395,00€(±)-Prenalterol
CAS :(±)-Prenalterol (H 80/62) is an agonist of beta-2- and beta-1-adrenergic receptors and is used to study chronic congestive heart failure.Formule :C12H19NO3Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :225.28ST-1006
CAS :ST-1006: histamine H4 agonist, pKi 7.94, anti-inflammatory, anti-pruritic, promotes basophil migration.Formule :C16H20Cl2N6Degré de pureté :99.96% - 99.98%Couleur et forme :SolidMasse moléculaire :367.28Ref: TM-T34709
1mg86,00€1mL*10mM (DMSO)187,00€5mg188,00€10mg299,00€25mg487,00€50mg600,00€100mg743,00€200mg990,00€α1 adrenoceptor-MO-1
CAS :α1 adrenoceptor-MO-1 (S enantiomer) has affinity at alpha 1 adrenergic receptor with alphalytic activity and analgesic action.Formule :C20H24ClN5ODegré de pureté :99.20% - 99.29%Couleur et forme :SolidMasse moléculaire :385.89Ref: TM-T10003
1mg188,00€5mg371,00€1mL*10mM (DMSO)442,00€10mg513,00€25mg743,00€50mg1.018,00€100mg1.378,00€200mg1.863,00€AS2717638
CAS :AS2717638: oral LPA5 antagonist, IC50 38 nM, reduces PGF2α/PGE2/AMPA allodynia.Formule :C25H25N3O5Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :447.48Ref: TM-T10381
1mg56,00€5mg118,00€1mL*10mM (DMSO)131,00€10mg190,00€25mg379,00€50mg612,00€100mg964,00€200mg1.305,00€GI 181771
CAS :GI 181771 is an agonist of the cholecystokinin 1 receptor. GI 181771 can be used in studies about obesity.Formule :C34H31N5O6Degré de pureté :95.02%Couleur et forme :SolidMasse moléculaire :605.64TAK-441
CAS :TAK-441: oral Hedgehog signal blocker, potent anticancer, IC50=4.4 nM, reduces Gli1 mRNA & tumor growth.Formule :C28H31F3N4O6Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :576.56Talibegron hydrochloride
CAS :Talibegron hydrochloride: β3 adrenoceptor agonist, pD2 3.72, relaxes rat arteries, reduces leptin in mice.Formule :C18H22ClNO4Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :351.83Calindol hydrochloride
CAS :Calindol (hydrochloride) is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM.Formule :C21H21ClN2Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :336.86WAY-607695
CAS :WAY-607695 is a potential 5-HT1A receptor agonist.Formule :C13H12FNO2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :233.24Enerisant
CAS :Enerisant (TS-091) is a histamine H3 receptor antagonist that promotes pro-cognitive effects and reverses scopolamine-induced cognitive deficits.Formule :C22H30N4O3Degré de pureté :99.7%Couleur et forme :SoildMasse moléculaire :398.50Ref: TM-T67828
1mg49,00€2mg67,00€5mg102,00€1mL*10mM (DMSO)111,00€10mg166,00€25mg339,00€50mg439,00€100mg610,00€200mg827,00€WAY-639889
CAS :WAY-639889 is a small molecule compound with selective and potent inhibitory effects on neuropeptide Y-5 receptors.Formule :C25H27N5ODegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :413.51GW 833972A
CAS :GW 833972A: selective CB2 agonist; reduces neural depolarization and citric acid cough in animals.
Formule :C18H14Cl2F3N5ODegré de pureté :99.93%Couleur et forme :SoildMasse moléculaire :444.24Lotiglipron
CAS :Lotiglipron (PF-07081532) is a GLP-1R agonist that lowers blood glucose and may be used in the study of type 2 diabetes mellitus (T2DM) and excess obesity.Formule :C31H31ClN4O5Degré de pureté :98.3%Couleur et forme :SolidMasse moléculaire :575.05Didesmethyl cariprazine
CAS :Didesmethyl cariprazine, Cariprazine's active metabolite, treats schizophrenia/bipolar with D3/D2 affinity; half-life 1-3 weeks.Formule :C19H28Cl2N4ODegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :399.36PSB-603
CAS :PSB-603 is a selective antagonist of Adenosine A2B receptor(Ki = 0.553 nM) with anti-inflammatory effects.
Formule :C24H25ClN6O4SDegré de pureté :97.13%Couleur et forme :SolidMasse moléculaire :529.01GV150013
CAS :GV150013 is an antagonist of cholecystokinin-2 (CCK2) receptor.Formule :C33H34N4O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :534.65Ref: TM-T27503
1mg177,00€5mg432,00€10mg587,00€1mL*10mM (DMSO)610,00€25mg892,00€50mg1.198,00€100mg1.575,00€200mg2.133,00€LGD-6972
CAS :LGD-6972 is an antagonist of glucagon receptor.Formule :C43H46N2O5SDegré de pureté :98.8% - 99.62%Couleur et forme :SolidMasse moléculaire :702.9Ref: TM-T11845
1mg84,00€5mg177,00€10mg260,00€1mL*10mM (DMSO)268,00€25mg447,00€50mg655,00€100mg888,00€Ertugliflozin L-pyroglutamic acid
CAS :Ertugliflozin is a potent oral hSGLT2 inhibitor (IC50: 0.877 nM) for type 2 diabetes treatment studies.Formule :C27H32ClNO10Degré de pureté :99.88% - 99.94%Couleur et forme :SolidMasse moléculaire :566Ref: TM-T15244
5mg44,00€1mL*10mM (DMSO)50,00€10mg57,00€25mg85,00€50mg90,00€100mg133,00€200mg188,00€500mg323,00€K777
CAS :K777: Oral cysteine protease inhibitor, CYP3A4 blocker (IC50=60 nM), CCR4 antagonist, anti-Trypanosoma cruzi, antiviral, halts EBOV/SARS-CoV entry (IC50<1 nM).Formule :C32H38N4O4SDegré de pureté :98.43% - 99.14%Couleur et forme :SolidMasse moléculaire :574.73Clazosentan
CAS :Clazosentan (Ro 61-1790) is a selective ET_A receptor antagonist that inhibits ET-1 vasoconstriction and prevents cerebral vasospasm.Formule :C25H23N9O6SDegré de pureté :95.39% - >99.99%Couleur et forme :SolidMasse moléculaire :577.57Ref: TM-T64084
1mg71,00€5mg167,00€1mL*10mM (DMSO)205,00€10mg258,00€25mg565,00€50mg888,00€100mg1.161,00€OPC-28326
CAS :OPC-28326: an α2-adrenergic blocker; dilates blood vessels; inhibits α2A/B/C receptors with Ki 2040/285/55 nM.Formule :C26H35N3O2Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :421.58Ref: TM-T13804
1mg177,00€5mg432,00€1mL*10mM (DMSO)537,00€10mg587,00€25mg892,00€50mg1.198,00€100mg1.575,00€200mg2.133,00€Selvigaltin
CAS :Selvigaltin (GB1211) is a Gal-3 inhibitor with potential anticancer activity. Selvigaltin is used in the study of cirrhosis and cancer.Formule :C19H16BrF3N4O4SDegré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :533.32Deriglidole
CAS :Deriglidole (SL 86-0715), an alpha2 receptor inhibitor, blocks colistin/Idazoxan but not prazosin/α2-adrenergic receptors.Formule :C16H21N3Degré de pureté :98.12% - 99.03%Couleur et forme :SolidMasse moléculaire :255.36Adomeglivant
CAS :Adomeglivant (LY2409021) is a potent and selective glucagon receptor antagonist. Which is used in clinical trial for type 2 diabetes mellitus.Formule :C32H36F3NO4Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :555.63A2B receptor antagonist 1
CAS :A2B receptor antagonist 1 (EXAMPLE 9B) is a potent A2B adenosine receptor antagonist.Formule :C21H24N6O2Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :392.45Ref: TM-T10058
1mg349,00€5mg697,00€1mL*10mM (DMSO)800,00€10mg888,00€25mg1.395,00€50mg1.783,00€100mg2.530,00€Osemozotan HCl
CAS :Osemozotan is a 5-HT1A receptor agonist potentially for the treatment of generalized anxiety disorder.Formule :C19H22ClNO5Degré de pureté :98.87% - 99.63%Couleur et forme :SolidMasse moléculaire :379.84CCR3 antagonist 1
CAS :CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.Formule :C19H21Cl2N3O4S2Degré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :490.42Ref: TM-T10156
1mg96,00€5mg178,00€1mL*10mM (DMSO)212,00€10mg289,00€25mg462,00€50mg622,00€100mg837,00€CGP-20712
CAS :CGP-20712 is a selective β 1-adrenoceptor antagonist with an IC50 of 0.7 nM.Formule :C23H25F3N4O5Degré de pureté :99.40% - 99.58%Couleur et forme :SolidMasse moléculaire :494.46Ref: TM-T30846
1mg315,00€5mg745,00€10mg1.018,00€25mg1.431,00€50mg1.783,00€100mg2.250,00€500mg4.410,00€SB 216641 hydrochloride
CAS :SB 216641 hydrochloride (SB-216641A) is a 5-HT1B/D receptor antagonist with anxiolytic properties.Formule :C28H31ClN4O4Degré de pureté :98.06% - 99.23%Couleur et forme :SolidMasse moléculaire :523.02NMI 8739
CAS :NMI 8739 (n-docosahexaenoyl dopamine) is an agonist of D2 autoreceptor.Formule :C30H41NO3Degré de pureté :98.51%Couleur et forme :SolidMasse moléculaire :463.65Ref: TM-T11079
1mg38,00€5mg80,00€1mL*10mM (DMSO)82,00€10mg114,00€25mg195,00€50mg286,00€100mg424,00€200mg617,00€PAOPA
CAS :dopamine D2 receptor modulatorFormule :C11H18N4O3Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :254.29SAG 21k
CAS :SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration.Formule :C29H28ClF2N3O2SDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :556.07Azelaprag
CAS :Azelaprag (Example 263.0) is a candidate active molecule (EC50= 0.32 nM) for an apelin receptor agonist. treat nervous system diseases. High-Quality, Low-Cost!Formule :C25H29N7O4SDegré de pureté :98.04% - >99.99%Couleur et forme :SolidMasse moléculaire :523.610990CL
CAS :0990CL is an effective heterotrimer Gαi subunit specific inhibitor, which can interact with purified Go± in GDP-bound state, and can block α2AR mediated cAMPFormule :C21H21N5Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :343.42Ref: TM-T13983
1mg192,00€5mg485,00€1mL*10mM (DMSO)507,00€10mg700,00€25mg1.063,00€50mg1.459,00€100mg1.963,00€SB-616234-A
CAS :SB-616234-A is a selective and orally bioavailable antagonist of 5-HT1B receptor, with anxiolytic and antidepressant activity.Formule :C32H36ClN5O3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :574.11Lumateperone
CAS :Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).Formule :C24H28FN3ODegré de pureté :99.68% - 99.91%Couleur et forme :SolidMasse moléculaire :393.5PSB 1115
CAS :PSB 1115 is an A2B receptor antagonist and can counteract the inhibitory effect of NECA.Formule :C14H14N4O5SDegré de pureté :98.69% - >99.99%Couleur et forme :SolidMasse moléculaire :350.35INCB3344
CAS :INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8Formule :C29H34F3N3O6Degré de pureté :98% - 98.2%Couleur et forme :SolidMasse moléculaire :577.59Ref: TM-TQ0103
1mg66,00€5mg144,00€1mL*10mM (DMSO)178,00€10mg230,00€25mg358,00€50mg512,00€100mg707,00€200mg973,00€SR 142948
CAS :SR 142948 is a neurotensin (NT) receptor antagonist.Formule :C39H51N5O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :685.85Oral antiplatelet agent 1
CAS :Oral antiplatelet agent 1 is a potent antiplatelet agent with an IC50 of 2.94 μM in vitro.Formule :C23H24N4O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.53CBR Agonist-2
CBR Agonist-2: CB1 receptor agonist, EC50 - 960 nM, Ki - 970 nM, useful for hCB1R-related disease research.Formule :C27H27FN4OCouleur et forme :SolidMasse moléculaire :442.53SEP-363856 mesylate
CAS :SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.Formule :C10H17NO4S2Couleur et forme :SolidMasse moléculaire :279.38M1069
M1069 is an oral A2A/A2B receptor antagonist, 100x more selective over A1/A3, with antitumor properties by blocking adenosine's immunosuppressive effects.Formule :C25H30N4O8SCouleur et forme :SolidMasse moléculaire :546.59RU 52583
CAS :RU 52583 is an alpha 2-adrenergic receptor antagonist.Formule :C18H20N2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :264.36BW A868C
CAS :BW A868C is a potent, selective PGD2 antagonist and a BW245C analogue, inert to other prostaglandin receptors.Formule :C25H37N3O5Couleur et forme :SolidMasse moléculaire :459.58MRGPRX2 modulator-3
CAS :MRGPRX2 modulator-3 (Compound 4-400) is a quinoline derivative and an MRGPRX2 regulator. It is utilized in the investigation of MRGPRX2-related conditions, including allergies, itching, pain, inflammation, and autoimmune diseases.Formule :C21H21ClF3N5OCouleur et forme :SolidMasse moléculaire :451.87S1PR1 agonist 1
CAS :S1PR1 agonist 1 is a potent agonist of S1PR1. S1PR1 agonist 1 has potential in autoimmune diseases.Formule :C29H30N4O4Couleur et forme :SolidMasse moléculaire :498.57Dopamine D4 receptor ligand 3
CAS :Dopamine D4 receptor ligand 3 (Compound 16) functions as a dopamine D4 receptor (D4R) antagonist with a pKi of 8.86. In HEK-293T cells, it shows pIC50 values of 5.78, 5.55, and 6.17 for Go, Gi, and βArr2 sensors, respectively. This compound inhibits the activity of human glioma cell lines U87 MG, T98G, and U251 MG, and it induces ROS production and mitochondrial dysfunction in these glioma cells.Formule :C28H31N3O5Couleur et forme :SolidMasse moléculaire :489.56VGD071
CAS :VGD071, a compound that targets sortilin, presents a promising avenue for forthcoming research utilizing mouse models of breast cancer.Formule :C32H41N3O4S2Couleur et forme :SolidMasse moléculaire :595.82Monlunabant
CAS :Monlunabant ((S)-MRI-1891), a solid dispersion compound, functions as an inhibitor of the cannabinoid CB1 receptor [1].Formule :C26H22ClF3N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :591.00Vibegron
CAS :Vibegron (MK-4618) is an effective and selective Beta 3 adrenergic receptor agonist, used to treat overactive bladder (OAB).Formule :C26H28N4O3Couleur et forme :SolidMasse moléculaire :444.53KARI 201 hydrochloride
CAS :KARI 201 hydrochloride is a selective, brain-penetrant, competitive inhibitor of acid sphingomyelinase (ASM) with an IC50 of 338.3 nM. It also acts as an agonist for the growth hormone-releasing peptide receptor (ghrelin receptor). Additionally, KARI 201 hydrochloride can enhance the neuropathological features of Alzheimer's disease.Formule :C14H29ClN4O2Couleur et forme :SolidMasse moléculaire :320.86LTD4 antagonist 1
CAS :LTD4 antagonist 1 is a potent and orally active antagonist of leukotriene D4 (LTD4; Ki: 0.57 nM).Formule :C31H32F3N3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :615.665-HT6R/MAO-B modulator 1
5-HT6R/MAO-B modulator 1 blocks 5-HT6R and permanently inhibits MAO-B, protects glial cells, and reverses memory loss.Formule :C33H38N4O3SCouleur et forme :SolidMasse moléculaire :570.74Cendifensine
CAS :Cendifensine functions as a monoamine reuptake inhibitor, targeting the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT).Formule :C14H17Cl2NOCouleur et forme :SolidMasse moléculaire :286.197Rivenprost
CAS :Rivenprost, selective EP4 agonist (Ki: 0.7 nM), promotes bone growth, osteoblast differentiation, and aids wound healing.Formule :C24H34O6SCouleur et forme :SolidMasse moléculaire :450.59U75302
CAS :U75302 is an antagonist of thymosin beta-4 (TB4) receptor with a Ki value of 159 nM on guinea pig lung membranes.Formule :C22H35NO3Degré de pureté :98%Couleur et forme :Light Yellow OilMasse moléculaire :361.52CP-199330
CAS :CP-199330: non-toxic alternative to Zafirlukast & Pranlukast, blocks cysteyl LT1 receptors.Formule :C28H24ClF3N2O6SCouleur et forme :SolidMasse moléculaire :609.01ChemR23-IN-3
ChemR23-IN-3 is a potent thiazole-based ChemR23 inhibitor with an IC 80 value of 12 nM.Formule :C31H33N5O5S2Couleur et forme :SolidMasse moléculaire :619.75D4R antagonis-2
Potent D4R antagonist-2: selective, IC50=6.52 μM, good in vitro PK and brain penetration, potential for Parkinson's research.Formule :C21H23ClF2N2O2Couleur et forme :SolidMasse moléculaire :408.87PF-06372222
CAS :PF-06372222: a small-molecule that modulates GCGR and antagonizes GLP-1R, affecting insulin and glucagon.Formule :C26H28F3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.53L 668750
CAS :L 668750 is an inhibitor of platelet-activating factor.Formule :C25H34O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :510.6AM9405
AM9405: peripheral CB1/5-HT3 agonist, suppresses gut motility, relieves GI disorder symptoms in mice.Formule :C24H33BrN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.44MDMB-FUBICA
CAS :MDMB-FUBICA is a potent agonist of the cannabinoid receptors and exhibits psychoactive properties. It can be utilized in e-cigarettes.Formule :C23H25FN2O3Couleur et forme :SolidMasse moléculaire :396.455SphK2-IN-2
SphK2-IN-2 (21g) is a potent and selective inhibitor of SphK2 (IC50: 0.23 μM).Formule :C21H25ClN10OCouleur et forme :SolidMasse moléculaire :468.94Methacycline
CAS :Methacycline, a tetracycline antibiotic, inhibits bacterial protein synthesis and effectively suppresses epithelial-mesenchymal transition (EMT). It blocks EMT in vitro and inhibits fibrogenesis in vivo without directly affecting the TGF-β1Smad signaling pathway. As an antimicrobial agent, Methacycline holds potential for research in pulmonary fibrosis.Formule :C22H22N2O8Couleur et forme :SolidMasse moléculaire :442.42RS 61756-007
CAS :RS 61756-007 is a selective thromboxane receptor (TP) agonist.Formule :C23H28O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :384.47MRGPRX1 agonist 3
Compound 1f, a potent MRGPRX1 agonist, has an EC50 of 0.22 μM, useful for neuropathic pain studies.Formule :C14H11FN2OSCouleur et forme :SolidMasse moléculaire :274.31TAK-637
CAS :TAK-637 is a tachykinin 1 (NK1) receptor antagonist.Formule :C30H25F6N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :573.53CP-481715
CAS :CP 481715 is an effective selective CCR1 antagonist with potential therapeutic significance for inflammatory diseases.Formule :C26H31FN4O4Couleur et forme :SolidMasse moléculaire :482.55SGLT inhibitor-1
CAS :SGLT inhibitor-1 is a potentsodium glucose co-transporter proteins (SGLTs) dual inhibitor(hSGLT1 and hSGLT2 with IC50s of 43 nM and 9 nM, respectively).Formule :C24H27FO8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.46RBM10-8
CAS :RBM10-8 irreversibly inhibits human sphingosine-1- phosphate lyase (hS1PL) while behaving also as an enzyme substrate.Formule :C17H36NO5PCouleur et forme :SolidMasse moléculaire :365.45L-657926
CAS :L-657926 is a stereoselective antagonist of the thromboxane A2 (TxA2) receptor, composed of (-)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid and (+)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid. The IC50 values for the (-) and (+) configurations against TxA2 are 0.27 nM and 124 nM, respectively.Formule :C21H19ClFNO2Couleur et forme :SolidMasse moléculaire :371.832BMS-986104 HCl
CAS :BMS-986104 is a potent and selective S1P1 receptor modulator.Formule :C22H36ClNODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.98Protease-Activated Receptor-1 antagonist 1
Compound 13 is a PAR-1 antagonist with a 3 nM IC50, useful for thrombosis and heart disease research.Formule :C25H24F2N2O3Couleur et forme :SolidMasse moléculaire :438.47LPA receptor antagonist-1
CAS :LPA receptor antagonist-1 (example 52) serves as an antagonist for the lysophosphatidic acid (LPA) receptor and is applicable in various types of studies [1].Formule :C30H26ClNO5SCouleur et forme :SolidMasse moléculaire :548.05Enprostil
CAS :Enprostil: synthetic PGE2 analog, reduces gastric acid, protects mucosa, lowers post-meal gastrin, treats ulcers effectively and safely.Formule :C23H28O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :400.46GLP-1 receptor agonist 15
CAS :GLP-1 receptor agonist 15 (Example 4) is a GLP receptor agonist with an EC50 of 0.74 nM. It exhibits an IC50 of 10.1 μM against the hERG potassium ion channel. This compound is applicable for research in the diabetes field.Formule :C32H31ClFN3O5Couleur et forme :SolidMasse moléculaire :592.057L-654284
CAS :L-654284 is an α2-adrenergic receptor antagonist characterized by its notable selectivity. It competes with 3H-clonidine and 3H-rauwolscine for binding in vitro, exhibiting Ki values of 0.8 nM and 1.1 nM, respectively. L-654284 effectively blocks the pre-ejaculatory effects of clonidine in isolated rat vas deferens, with a pA2 value of 9.1. The compound demonstrates significant selectivity for α2 over α1 adrenergic receptors, with a Ki value of 110 nM against 3H-prazosin binding. In vivo, L-654284 significantly increases the turnover of norepinephrine in the rat cerebral cortex, indicating its activity in blocking α2-adrenergic receptors within the central nervous system.Formule :C18H24N2O4SCouleur et forme :SolidMasse moléculaire :364.46
