GPCR/G-Protéine
Les inhibiteurs des GPCR/protéines G sont des composés qui ciblent les récepteurs couplés aux protéines G (GPCR) et les protéines G associées, qui jouent un rôle crucial dans la transmission des signaux de l'extérieur vers l'intérieur des cellules. Ces inhibiteurs sont essentiels pour étudier les voies de signalisation médiées par les GPCR, impliquées dans de nombreux processus physiologiques, y compris la perception sensorielle, la réponse immunitaire et la neurotransmission. Les inhibiteurs des GPCR sont également importants dans le développement de médicaments, car de nombreux agents thérapeutiques ciblent ces récepteurs. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de GPCR/protéines G de haute qualité pour soutenir vos recherches en pharmacologie, biologie cellulaire et domaines connexes.
Sous-catégories appartenant à la catégorie "GPCR/G-Protéine"
- récepteur 5-HT(1.025 produits)
- Récepteur d'adénosine(251 produits)
- Récepteur adrénergique(3.029 produits)
- Récepteur de la bombésine(35 produits)
- Récepteur de la bradykinine(61 produits)
- CXCR(158 produits)
- CaSR(34 produits)
- Récepteur cannabinoïde(218 produits)
- Cholécystokinine(1 produits)
- Récepteur de la dopamine(445 produits)
- Récepteur de l'endothéline(86 produits)
- Récepteur GNRH(84 produits)
- GPCR19(36 produits)
- GRK(33 produits)
- GTPase(23 produits)
- Récepteur du glucagon(195 produits)
- Hérisson/Smoothened(49 produits)
- Récepteur de l'histamine(385 produits)
- Récepteur LPA(21 produits)
- Récepteur de la mélatonine(26 produits)
- Récepteur OX(42 produits)
- Récepteur opioïde(327 produits)
- PAFR(14 produits)
- PKA(61 produits)
- Récepteur S1P(18 produits)
- SGLT(31 produits)
- Récepteur Sigma(46 produits)
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6013 produits trouvés pour "GPCR/G-Protéine"
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BMS-639623
CAS :BMS-639623 is a CCR3 antagonist with a picomolar inhibitory effect on eosinophilic chemotaxis and can be used in the treatment of asthma.Formule :C25H32FN7O2Couleur et forme :SolidMasse moléculaire :481.57BMS-194449
CAS :BMS-194449 is a full beta 3 agonist.Formule :C24H24F4N2O6SCouleur et forme :SolidMasse moléculaire :544.52Uridine 5'-diphosphate
CAS :Uridine 5'-diphosphate acts as a P2Y6 receptor agonist, exhibiting an EC50 value of 0.013 μM for the human P2Y6 receptor [1].Formule :C9H14N2O12P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :404.16SKF 81297 hydrobromide
CAS :SKF 81297 hydrobromide, a selective agonist of the dopamine D1-like receptor，exhibits central activity and is widely used to study the neuromodulatory effects.Formule :C16H17BrClNO2Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :370.67GLP-1R agonist 3
CAS :GLP-1R agonist 3 is a GLP-1R agonist, an imidazole derivative.GLP-1R agonist 3 can be used to study diabetes and obesity.Formule :C31H28FN5O4Degré de pureté :97.19%Couleur et forme :SolidMasse moléculaire :553.58CP-96021 hydrochloride
CAS :CP-96021 hydrochloride is a potent and orally active antagonist of leukotriene D4 (LTD4)/platelet activating factor receptor (Kis: 34 nM and 37 nM).Formule :C29H22ClFN4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :529.03Fosnetupitant chloride monohydrochloride
CAS :Fosnetupitant chloride monohydrochloride (Pro-netupitant chloride monohydrochloride) is a selective NK1 antagonist exhibiting high affinity for the human NK1Formule :C31H37Cl2F6N4O5PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :761.52EP2 receptor agonist 4
CAS :EP2 receptor agonist 4 selectively activates the EP2 receptor with an efficacy concentration (EC50) of 43 nM [1].Formule :C23H36O5Couleur et forme :SolidMasse moléculaire :392.53(2R,3S)-E1R
CAS :(2R,3S)-E1R, an enantiomer of E1R, is a sigma-1 receptor modulator for treating cognitive disorders.Formule :C13H16N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :232.285-HT2C agonist-3 free base
CAS :5-HT2C agonist-3 ((+)-19) free base, a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM), exhibits antipsychotic drug-like activity and inhibits Amphetamine-Formule :C19H22FNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :315.385-HT2 agonist-1 free base
CAS :Compound 24 (5-HT2 agonist-1 free base) is a potent agonist for 5-HT2A, 5-HT2B, and 5-HT2C receptors, exhibiting IC50 values of 10 nM, 8.3 nM, and 1.6 nM,Formule :C19H22N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :310.39Leukotriene B4-3-aminopropylamide
CAS :Leukotriene B4 (LTB4)-3-aminopropylamide is an analog of LTB4 that exhibits potent and selective binding to the BLT1 receptor with Ki values of 5.1 nM at BLT1 and 1,227 nM at BLT2, indicating its high affinity for BLT1 over BLT2. This compound's effects are mediated through interactions with two receptors, BLT1 and BLT2.Formule :C23H40N2O3Couleur et forme :SolidMasse moléculaire :392.6Pecavaptan
CAS :Pecavaptan is a vasopressin receptor antagonist.Formule :C22H19Cl2F3N6O3Couleur et forme :SolidMasse moléculaire :543.33BMS-960
CAS :BMS-960 is an S1P agonist with potential anti-tumour activity for cancer research.Formule :C26H23F3N4O5Degré de pureté :97.66% - 98.69%Couleur et forme :SolidMasse moléculaire :528.48mPGES1-IN-3
CAS :mPGES1-IN-3 is a potent and selective inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) .Formule :C24H16ClF5N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.85NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal)
CAS :Compound 39, an APJ receptor agonist, has a K i of 0.6 nM, activates Gαi1 (EC50 0.8 nM), recruits β-arrestin2 (EC50 31 nM), and affects heart function.Formule :C49H73N13O11Couleur et forme :SolidMasse moléculaire :1020.18SRX246
CAS :SRX246: potent CNS-penetrant V1a antagonist (Ki=0.3 nM), inactive at V1b/V2, negligible binding at 64 other receptor classes.Formule :C42H49N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :703.874-Amino-PPHT Hydrobromide
CAS :4-Amino-PPHT Hydrobromide is a precursor for fluorescent labeled Dopamine D2 receptors agonist.Formule :C21H28N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :324.4611-keto Fluprostenol
CAS :11-Keto Fluprostenol, a potent analog of prostaglandin F2α (PGF2α), primarily interacts with the FP receptor. It is a structurally modified derivative of prostaglandin D2 (PGD2) designed to enhance its potency and extend its half-life. The compound is produced by oxidizing fluprostenol at the C-11 position, which results in 11-keto fluprostenol. This modification allows 11-keto Fluprostenol to exhibit moderate affinity for the CRTH2/DP2 receptor, though it shows negligible activity at the DP1 receptor, distinguishing its action from that of PGD2.Formule :C23H27F3O6Couleur et forme :SolidMasse moléculaire :456.458S1P1 agonist 6 hemicalcium
CAS :Compound I (S1P1 agonist 6 hemicalcium) is an S1P1 agonist that diminishes autoimmune activity by inhibiting lymphocyte trafficking, and serves as anFormule :C25H26F3NO3CaDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :465.51PF-04634817
CAS :PF-0463481: safe, well-tolerated, dual CCR2/CCR5 antagonist for diabetic nephropathy; similar human/rodent CCR2 potency, less rodent CCR5 effect.Formule :C25H36F3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :511.584-Thiouridine 5′-triphosphate tetralithium
CAS :4-Thiouridine 5′-triphosphate tetralithium (4-Thio-UTP), a potent P2Y2 and P2Y4 receptor agonist, exhibits EC50 values of 35 nM for hP2Y2 and 350 nM for hP2Y4.Formule :C9H11Li4N2O14P3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.94CP-293019
CAS :CP-293019 is a potent, selective antagonist of dopamine D4 receptor.Formule :C19H22F2N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.4LY-368975
CAS :LY-368975 is a potent and selective inhibitor of the norepinephrine (NE) reuptake site. LY-368975 reduces food consumption in rodents.Formule :C17H21NOSCouleur et forme :SolidMasse moléculaire :287.42CI-949
CAS :CI-949 inhibits LTC4/D4, histamine, TXB2 release (IC50: 0.5, 11.4, 0.1 μM).Formule :C20H20N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.41Sulmazole
CAS :Sulmazole (AR-L 115-BS) is a small molecule Sulmazole is a small molecule cGMP-PDE inhibitor.Sulmazole is a competitive inhibitor of A1 adenosine receptors.Formule :C14H13N3O2SDegré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :287.34E-6123
CAS :E-6123 is an antagonist of platelet-activating factor (PAF) receptor.Formule :C23H22ClN5OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :451.97MNI-444
CAS :MNI-444 is a PET radiotracer for adenosine 2A receptors.Formule :C24H26FN9O2Couleur et forme :SolidMasse moléculaire :491.52Thromboxane A2
CAS :Thromboxane A2: unstable, leads to thromboxane B2, induces platelet aggregation, causes vasoconstriction.Formule :C20H32O5Couleur et forme :SolidMasse moléculaire :352.475-HT2C agonist-3
CAS :5-HT2C agonist-3 ((+)-19), a selective 5-HT2C agonist (EC 50: 24 nM, Ki: 78 nM), exhibits antipsychotic-like activity by blocking amphetamine-inducedFormule :C19H23ClFNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.84GSK494581A
CAS :GSK494581A is a GPR55 agonist and glycine transporter subtype 1 inhibitor.Formule :C27H28F2N2O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :514.58FR-181877
CAS :FR-181877: nonprostanoid PGI2 agonist, ADP-induced platelet aggregation inhibitor (IC50=0.081μM), orally bioavailable (56%), long half-life (4.3h) in rats.Formule :C30H28N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :480.55(S)-Bexicaserin
CAS :(S)-Bexcaserin (compound 2) serves as a 5-HT2C receptor agonist, presenting research possibilities in obesity and psychiatric disorders [1].Formule :C15H19F2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :295.33Facinicline hydrochloride
CAS :Facinicline hydrochloride (RG3487) is both a novel nicotinic alpha-7 receptor (alpha7nAChR) partial agonist (Ki = 6 nM) and an antagonist of 5-HT3(Ki = 1.2 nM).Formule :C15H19ClN4ODegré de pureté :98.70%Couleur et forme :SolidMasse moléculaire :306.79AC-099 hydrochloride
CAS :AC-099 hydrochloride is a full agonist of neuropeptide FF2 receptor NPFF2R and a partial agonist of neuropeptide FF1 receptor NPFF1R.Formule :C9H9Cl2F3N4Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :301.1Domesticine, (-)-
CAS :Domesticine, (-)- is an antagonist of alpha-1D-adrenoceptor.Formule :C19H19NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :325.36MRS2693 trisodium
CAS :MRS2693 trisodium, a selective P2Y6 agonist with an EC50 of 0.015 μM, demonstrates cytoprotective effects in a mouse hindlimb skeletal muscle ischemia-reperfusion injury model by reducing NF-kappaB activation and stimulating the ERK1/2 pathway [1] [2].Formule :C9H10IN2Na3O12P2Couleur et forme :SolidMasse moléculaire :596Hh-Ag1.5
CAS :Hh-Ag1.5 is a dual Hedgehog/Smo agonist (EC50/Ki: 0.5-2.3 nM), reprograms hepatic stem cells, and differentiates hiPSCs into neural/skin cells.Formule :C28H26ClF2N3OSDegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :526.04Ref: TM-T24754
1mg120,00€5mg289,00€1mL*10mM (DMSO)334,00€10mg447,00€25mg740,00€50mg1.044,00€100mg1.459,00€LX-1031
CAS :LX-1031 is an effective inhibitor of tryptophan 5-hydroxylase. LX-1031 decreases serotonin (5-HT) synthesis peripherally.Formule :C28H25F3N4O4Degré de pureté :97.123% - 98.97%Couleur et forme :SolidMasse moléculaire :538.52Ref: TM-T15796
1mg55,00€5mg120,00€1mL*10mM (DMSO)143,00€10mg187,00€25mg376,00€50mg597,00€100mg938,00€200mg1.264,00€LY108742
CAS :LY108742 is an antagonist of 5-HT2.Formule :C21H28N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.46Dihydrexidine
CAS :Dihydrexidine is a full efficacy D1-like dopamine receptor (D1/D5) agonist (IC50: 10 nM for D1 receptor). It also shows potent antiparkinsonian activity.Formule :C17H17NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :267.32SLIGRL-NH2 TFA
CAS :SLIGRL-NH2 TFA, also known as Protease-Activated Receptor-2 Activating Peptide TFA, is a Protease-Activated Receptor-2 (PAR-2) agonist [1].Formule :C31H57F3N10O9Couleur et forme :SolidMasse moléculaire :770.84GLP-1R agonist 10
CAS :GLP-1R agonist 10 is a GLP-1 agonist (EC50: 0.051 nM).Formule :C29H29ClFN5O4Couleur et forme :SolidMasse moléculaire :566.02Dothiepin
CAS :Dothiepin (Dosulepin; Dothep), an antidepressant with sedative/anxiolytic properties, preferentially inhibits noradrenaline over serotonin uptake, enhancingFormule :C19H21NSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :295.442-Thio-UTP tetrasodium
CAS :2-Thio-UTP tetrasodium, a potent agonist for P2Y2, P2Y4, and P2Y6 receptors, serves as a crucial compound in cancer research [1].Formule :C9H11N2Na4O14P3SCouleur et forme :SolidMasse moléculaire :588.13NGD9002
CAS :NGD9002 is a novel generation, topology 2 selective corticotropin releasing factor-1 (CRF-1) receptor antagonist agent.Formule :C20H31N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.49MLN-3897
CAS :MLN-3897 is an oral CCR1 antagonist, Ki 2.3 nM, blocks 125I-MIP-1α binding, and inhibits Akt signaling in MM cells.Formule :C30H31ClN2O4Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :519.03Befiradol
CAS :Befiradol (NLX-112) is an agonist of 5-HT1A receptor.Formule :C20H22ClF2N3OCouleur et forme :SolidMasse moléculaire :393.86TXNIP-IN-1
CAS :TXNIP-IN-1: TXNIP-TRX complex inhibitor, targets diabetes, cardiovascular, and inflammatory diseases.Formule :C12H12N2O4Degré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :248.23Ref: TM-T13230
1mg126,00€5mg260,00€1mL*10mM (DMSO)335,00€10mg394,00€25mg653,00€50mg888,00€100mg1.243,00€500mg2.493,00€β3-AR agonist 1
CAS :β3-AR agonist 1 is a highly selective, and orally available agonist of β3-adrenergic receptor (EC50: 18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/Formule :C22H28N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :444.55ACT 335827
CAS :ACT-335827: oral, brain-penetrant OXR1 selective antagonist; IC50: 6 nM (OXR1), 417 nM (OXR2); for neurological research.Formule :C31H38N2O5Couleur et forme :SolidMasse moléculaire :518.64CAY10508
CAS :CAY10508 is a potent and selective inverse agonist for the central cannabinoid (CB1) receptor with therapeutic potential for treating obesity and drug dependence, lacking psychotropic effects. It exhibits a Ki value of 243 nM and an EC50 of 195 nM. At a concentration of 10 µM, CAY10508 displaces [3H]-CP-55,940 with 100% efficacy at the CB1 receptor and 35% at the peripheral cannabinoid (CB2) receptor. Its inverse agonist activity at the CB1 receptor was confirmed through a [35S]-GTPγS binding assay.Formule :C21H14Br2N2O2Couleur et forme :SolidMasse moléculaire :486.2RG 14893
CAS :RG 14893 is a antagonist of high-affinity leukotriene B4 receptor.Formule :C29H27NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :453.53IPG7236
CAS :IPG7236, a selective CCR8 antagonist, demonstrates notable tumor suppression in a mouse xenograft model of human breast cancer and is applicable in cancerFormule :C23H31N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :429.58Prostaglandin F2α serinol amide
CAS :Prostaglandin F2α serinol amide, a serinolamide G protein-coupled receptor, elevates calcium levels in human non-small cell lung cancer cells. Additionally, Prostaglandin F2α functions as a luteinizing hormone in sheep and potentially serves as a nociceptive mediator in the spinal cord [1] [2] [3].Formule :C23H41NO6Couleur et forme :SolidMasse moléculaire :427.582BMS-764459
CAS :BMS-764459 is a potent antagonist of corticotropin-releasing factor/hormone receptor 1 (CRHR-1).Formule :C19H21F2N5O3Couleur et forme :SolidMasse moléculaire :405.4L 662025
CAS :L 662025 is a PAF receptor antagonist.Formule :C23H27N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :441.489-keto Fluprostenol isopropyl ester
CAS :9-Keto Fluprostenol Isopropyl Ester, an ester derivative of the FP receptor agonist fluprostenol, undergoes oxidation at carbon 9. This compound serves as a potential prodrug for 9-keto fluprostenol, which may function as an agonist at EP receptors. Additionally, it is considered a possible metabolite of fluprostenol isopropyl ester (travoprost), drawing parallels to the metabolism of latanoprost by 15-hydroxyprostaglandin dehydrogenase observed in monkey cornea. Furthermore, certain F-series prostaglandins, such as 6-keto prostaglandin F1α (PGF1α), undergo conversion to their E-series counterparts in isolated human platelets, highlighting a metabolic pathway of relevance.Formule :C26H33F3O6Couleur et forme :SolidMasse moléculaire :498.5L-796568 free base
CAS :L-796568 is a potent β3 agonist for obesity with 600x selectivity over β1/β2 receptors (EC50: 3.6 nM).Formule :C31H27F3N4O3S2Couleur et forme :SolidMasse moléculaire :624.7Robalzotan
CAS :Robalzotan is a selective 5-HT1A receptor antagonist.Formule :C18H23FN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :318.39LPA1 receptor antagonist 1
CAS :LPA1 receptor antagonist 1(LPA1 R antagonist 1) is a lysophosphatidic acid receptor antagonist for the study of idiopathic pulmonary fibrosis.Formule :C28H26N4O4Degré de pureté :99.46% - 99.56%Couleur et forme :SolidMasse moléculaire :482.53β3-AR agonist 2
CAS :β3-AR agonist 2 is a potent and selective agonist of β3-adrenergic receptor (β3-AR with an EC50 of 8 nM).Formule :C27H38N4O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :562.68EP4 receptor antagonist 1
CAS :EP4 antagonist 1: inhibits human/mouse EP4 receptors (IC50: 6.1/16.2 nM), selective over EP1-EP3 (>10 μM). For cancer immunotherapy.Formule :C23H21F3N4O3Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :458.43Gepirone
CAS :Gepirone is a 5-HT1A receptor agonist belonging to the buspirone family. Gepirone HCl possesses greater selectivity for the 5-HT1A receptor than SSRIs.Formule :C19H29N5O2Degré de pureté :99.35% - 99.89%Couleur et forme :SolidMasse moléculaire :359.47BU-E 75
CAS :BU-E 75 is an agonist of the histamine H2.Formule :C21H24F2N6Couleur et forme :SolidMasse moléculaire :398.45L-736380
CAS :L-736380, a CCK-B antagonist, reduces gastric acid (ID50: 0.064mg/kg) and blocks [(125)I]CCK-8S in mouse brains (ED50: 1.7mg/kg).Formule :C25H29N9O2Couleur et forme :SolidMasse moléculaire :487.56Omidenepag isopropyl
CAS :Omidenepag isopropyl (DE-117) is a prostaglandin EP2 receptor agonist used in the study of glaucoma and hypertension.Formule :C26H28N6O4SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :520.6NCGC00229600
CAS :NCGC00229600: Allosteric inverse TSHR agonist; blocks TSH and antibody TSHR activation; for Graves' disease research.Formule :C30H29N3O3Degré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :479.57Ref: TM-T12192
1mg60,00€5mg138,00€1mL*10mM (DMSO)144,00€10mg200,00€25mg353,00€50mg532,00€100mg773,00€Droxicam
CAS :Droxicam (Droxicamum) is a non-steroidal anti-inflammatory compound and can be used for research on the relief of inflammation and pain in musculoskeletalFormule :C16H11N3O5SDegré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :357.34TA-1887
CAS :TA-1887: Selective SGLT2 inhibitor, treats type 2 diabetes, lowers glucose in high-fat diet mice, boosts UGE, has good pharmacokinetics.Formule :C24H26FNO5Couleur et forme :SolidMasse moléculaire :427.47L 659837
CAS :L 659837 is an antagonist of ANC-2, lactam, and tackykinin.Formule :C40H52N8O7SCouleur et forme :SolidMasse moléculaire :788.96PD 160170
CAS :neuropeptide Y1 receptor antagonistFormule :C18H17N3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :371.41TC-SP 14
CAS :TC-SP 14 (compound 14) is a potent, orally available S1P1 agonist with EC50 of 0.042 μM; minimal S1P3 binding (EC50 3.47 μM); reduces blood lymphocytes.Formule :C25H20F2N2O2SCouleur et forme :SolidMasse moléculaire :450.5MK-0493
CAS :MK-0493 is an effective and selective agonist of the melanocortin receptor 4 (MC4R). It also demonstrated significant reductions in energy intake.Formule :C30H38ClF2N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :546.09Kisspeptin 234 TFA
CAS :Kisspeptin 234 TFA is a 10-amino acid peptide analog of Kisspeptin 10 [1] that functions as an antagonist to the kisspeptin receptor (KISS1, GPR54).Formule :C63H78N18O13·xC2HF3O2Couleur et forme :SolidMasse moléculaire :1409.43Prostaglandin E2 serinol amide
CAS :Prostaglandin E2 Serinol Amide acts as a weak inhibitor against the hydrolysis of [3H]2-oleoylglycerol, but it is non-hydrolyzable and cannot produce PGE2. Consequently, it is unable to inhibit leukotriene B4 biosynthesis, superoxide production, migration, and the release of antimicrobial peptides [1].Formule :C23H39NO6Couleur et forme :SolidMasse moléculaire :425.566Fazamorexant
CAS :Fazamorexant (YZJ-1139) is a powerful orexin receptor antagonist effective for insomnia research.Formule :C25H25FN4O2Couleur et forme :SolidMasse moléculaire :432.492-Linoleoyl Glycerol
CAS :2-Arachidonoyl glycerol (2-AG), a natural endocannabinoid ligand for the CB1 receptor, was isolated from porcine brain and characterized. Its congener, 2-linoleoyl glycerol (2-LG), which has a linoleoyl group instead of an arachidonoyl group, also exists alongside 2-AG in vivo. While 2-LG exhibits low intrinsic activity, it enhances the activity of 2-AG and other endocannabinoids through an "entourage" effect, attributed to the inhibition of breakdown and reuptake pathways that typically decrease endocannabinoid levels post-release.Formule :C21H38O4Couleur et forme :SolidMasse moléculaire :354.531RXFP1 receptor agonist-8
CAS :Example 2 (RXFP1 receptor agonist-8) is a potent RXFP1 receptor agonist that suppresses cAMP production in HEK293 cells expressing human RXFP1, exhibiting anFormule :C40H36F5N3O7Couleur et forme :SolidMasse moléculaire :765.72RXFP1 receptor agonist-1
CAS :RXFP1 receptor agonist-1 (Example 2), an agonist of the RXFP1 receptor, suppresses cAMP production in HEK293 cells that constitutively express the human RXFP1,Formule :C31H29F7N2O4Couleur et forme :SolidMasse moléculaire :626.56NAS181
CAS :rat 5-HT1B receptor antagonistFormule :C21H34N2O10S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.63Orvepitant maleate
CAS :Orvepitant maleate, a selective NK-1 receptor antagonist (pKi 10.2), may treat depression and CRC; crosses the blood-brain barrier.Formule :C35H39F7N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :744.7SB 258719
CAS :SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.Formule :C18H30N2O2SDegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :338.51Ref: TM-T12855
2mg34,00€5mg52,00€1mL*10mM (DMSO)58,00€10mg85,00€25mg155,00€50mg240,00€100mg355,00€200mg502,00€(Rac)-PF-4136309(1341224-83-6 Free base)
CAS :PF-4136309 (INCB8761, PF-04136309) is a highly effective and selective oral CCR2 antagonist with good bioavailability, with an IC50 value of 5.2 nM for humanFormule :C29H31F3N6O3Couleur et forme :SolidMasse moléculaire :568.59RXFP1 receptor agonist-5
CAS :RXFP1 receptor agonist-5 (Example 98) is an agonist that targets the RXFP1 receptor and demonstrates its bioactivity by inhibiting cAMP production in HEK293Formule :C30H23F6N3O7Couleur et forme :SolidMasse moléculaire :651.51Ro-24-0238
CAS :Ro-24-0238 blocks PAF, curbing thromboxane creation and inflammation caused by PAF release.Formule :C27H36N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.59Gentisein
CAS :Gentisein (NSC-329491), a primary metabolite of Mangiferin, exhibits significant inhibition of serotonin uptake, demonstrating potency with an IC50 value of 4.7Formule :C13H8O5Degré de pureté :96.89%Couleur et forme :SolidMasse moléculaire :244.2Bima SA
CAS :Bimatoprost Serinol Amide (Bima SA), a prostaglandin analog, shows research potential for glaucoma [1].Formule :C26H39NO6Couleur et forme :SolidMasse moléculaire :461.59Sigma-1 receptor antagonist 2
CAS :Sigma-1 receptor antagonist 2 is a more potent and selective antagonist of sigma 1 receptor (σ1 R, Ki = 3.88 nM) than σ2 receptor (Ki = 1288 nM).Formule :C20H26ClN3O2Degré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :375.89Ref: TM-T12911
1mg46,00€5mg96,00€1mL*10mM (DMSO)105,00€10mg161,00€25mg261,00€50mg371,00€100mg504,00€200mg675,00€TASP0412098
CAS :TASP0412098 is a potent, selective CRTH2 antagonist with oral activity.Formule :C27H23ClN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.94GR 125487 sulfamate
CAS :GR 125487 sulfamate is a 5-HT4 receptor antagonist.Formule :C19H29FN4O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :524.58Tedalinab
CAS :Tedalinab is an effective and selective cannabinoid receptor 2 agonist.Formule :C19H21F2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :345.39UCB-35440
CAS :UCB-35440, a 5-lipoxygenase inhibitor and a histamine H1 receptor antagonist, is used potentially for the treatment of dermatitis.Formule :C31H34ClN5O4Couleur et forme :SolidMasse moléculaire :576.09Osemozotan Free Base
CAS :Osemozotan Free Base is a 5-HT(1A) receptor agonist.Formule :C19H21NO5Couleur et forme :SolidMasse moléculaire :343.37OMDM-5
CAS :OMDM-5 is a potent vanilloid receptor type 1 (TRPV1, EC50 = 75 nM) agonist, showing weak ligand activity at cannabinoid type 1 receptor (CB1, Ki=4.9 μM).Formule :C26H44N2O3Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :432.64Ref: TM-T12306
1mg93,00€5mg177,00€1mL*10mM (DMSO)210,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.071,00€NK3R-IN-1
CAS :NK3R-IN-1 (compound 16x), an orally active imidazolepiperazine derivative, acts as a Neurokinin Receptor NK3R inhibitor and has been shown to reduce bloodFormule :C17H16FN5OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.41BLT2 probe 1
CAS :BLT2 Probe 1, based on CAY10583, is a fluorescent tool for studying BLT2 pharmacology, aiding research in diabetes and GI lesion treatment.Formule :C50H45N3O11SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :895.97Prostaglandin D3
CAS :Prostaglandin D3 (PGD3) functions as an inhibitor of platelet aggregation and modulates autonomic neurotransmission in humans [1].Formule :C20H30O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :350.45(±)-N-Methylcoclaurine
CAS :N-Methylcoclaurine (±) acts as a selective antagonist at the α2-adrenoceptor [1].Formule :C18H21NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :299.36BLT2 antagonist-1
CAS :BLT2 antagonist-1 (compound 15b) is a selective inhibitor of the BLT2 receptor, impeding the chemotaxis of CHO-BLT2 cells at an IC50 of 224 nM, while notFormule :C26H26FNO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :435.49AGN-191129
CAS :AGN-191129 (PGF2α-OMe) is a PGF2α analog with C-1 carboxyl replaced by O-methyl; it lowers eye pressure, but its receptors are unclear.Formule :C21H38O4Couleur et forme :SolidMasse moléculaire :354.52A1/A3 AR antagonist 3
CAS :A1/A3 AR Antagonist 3 is a dual A1R/A3R antagonist that demonstrates high affinity within the low-micromolar to nanomolar range, and is potentially useful inFormule :C22H19N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.42Foropafant
CAS :Foropafant (SR27417) is a highly potent and selective platelet-activating factor (PAF) receptor antagonist (Ki: 57 pM).Formule :C28H40N4SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :464.71AR-08
CAS :AR-08 is a potent α2-adrenergic receptor agonist for the study of ADHD and attention deficit.Formule :C12H12N6Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :240.26TG6-129
CAS :TG6-129 is an EP2 receptor antagonist, blocking PGE2 effects, reducing inflammatory markers with 1.6 µM IC50.Formule :C20H18FN5O3S3Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :491.58Ref: TM-T28958
1mg114,00€5mg227,00€1mL*10mM (DMSO)321,00€10mg404,00€25mg665,00€50mg888,00€100mg1.251,00€500mg2.538,00€KFM19
CAS :KFM19 is a potent and selective adenosine receptor (A1-receptor) antagonist (IC50 : 50 nM) for the study of neurological disorders.Formule :C16H22N4O3Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :318.37PW0464
CAS :PW0464 ((Rac)-Razpipadon) is a non-catechol D1R agonist and potent omplete G protein biased ligand with an EC50 (Gs-cAMP)=5.8 nM for neurological disorders.Formule :C19H17F2N3O4Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :389.35Ref: TM-T36946
1mg160,00€5mg386,00€1mL*10mM (DMSO)425,00€10mg635,00€25mg1.228,00€50mg1.839,00€100mg2.470,00€5-HT2A antagonist 1
CAS :5-HT2A antagonist 1, from US5728835A & JP 1007727, may treat gastrointestinal and circulatory issues.Formule :C26H28N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.53CB 65
CAS :CB 65 is a high affinity and selective CB2 receptor agonist with Ki values of 3.3 and > 1000 nM for CB2 and CB1 receptors respectively.Formule :C22H28ClN3O3Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :417.93SB 649915
CAS :SB 649915 is a serotonin reuptake inhibitor and 5-HT1A and 5-HT1B receptor antagonist.Formule :C26H29N3O3Couleur et forme :SolidMasse moléculaire :431.53NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)
CAS :Compound 40, a cyclic Ape13 analogue and potent APJ agonist (Ki 5.7 nM), shows Gα12-bias and longer half-life.Formule :C49H73N13O11Couleur et forme :SolidMasse moléculaire :1020.18DU-125530
CAS :DU-125530 is a 5-HT1A receptor antagonist.Formule :C23H26ClN3O5SCouleur et forme :SolidMasse moléculaire :491.99VKGILS-NH2 TFA
CAS :VKGILS-NH2 TFA, a non-impacting control peptide for PAR2 agonist SLIGKV-NH2, doesn't affect DNA synthesis.Formule :C30H55F3N8O9Couleur et forme :SolidMasse moléculaire :728.8Hemopressin(rat) TFA
CAS :Hemopressin(rat) TFA, a nonapeptide from hemoglobin α1-chain, selectively inhibits CB1 receptors and reduces inflammatory pain.Formule :C55H78F3N13O14Couleur et forme :SolidMasse moléculaire :1202.28L-796568 dihydrochloride
CAS :L-796568: potent β3 agonist (EC50 = 3.6 nM), >600-fold selectivity vs β1/β2, good oral bioavailability, long action.Formule :C31H29Cl2F3N4O3S2Couleur et forme :SolidMasse moléculaire :697.62Maropitant citrate anhydrous
CAS :Maropitant citrate anhydrous is a neurokinin (NK1) receptor antagonist.Formule :C38H48N2O8Couleur et forme :SolidMasse moléculaire :660.8Glycolithocholic acid 3-sulfate disodium
CAS :Glycolithocholic acid 3-sulfate (disodium) demonstrates inhibitory effects on in vitro HIV-1 replication and has potential applications in HIV infection andFormule :C26H41NNa2O7SCouleur et forme :SolidMasse moléculaire :557.65AGN 192836
CAS :AGN 192836 is a potent and selective α2 adrenergic agonist (EC50s: 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor).Formule :C12H13N3O2Couleur et forme :SolidMasse moléculaire :231.25Alclofenac
CAS :Alclofenac (W-7320) aids chronic rheumatism by affecting acute phase proteins and L-tryptophan binding.Formule :C11H11ClO3Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :226.66FAUC-312
CAS :FAUC-312 is a potent and selective agonist of the dopamine D4 receptor.Formule :C21H26N4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :334.46Butriptyline
CAS :Butriptyline (Butriptylene), a tricyclic antidepressant, is effective when administered orally [1].Formule :C21H27NCouleur et forme :SolidMasse moléculaire :293.45Sucrose octasulfate sodium
CAS :Sucrose octasulfate, a constituent of sulfoaluminum, promotes the release of somatostatin-like immunoreactivity (SLI) through direct interaction with D cellsFormule :C12H14Na8O35S8Couleur et forme :SolidMasse moléculaire :1158.66Prostaglandin D2-1-glyceryl ester
CAS :Prostaglandin D2-1-glyceryl ester (PGD2-G; PGD2 2-glyceryl ester) is a chemical compound known for its significance in various biological processes. This compound, commonly referred to by its abbreviations PGD2-G or PGD2 2-glyceryl ester, plays a crucial role in the mediation of physiological functions.Formule :C23H38O7Couleur et forme :SolidMasse moléculaire :426.55NBI-34041
CAS :NBI-34041: High-affinity CRF1 antagonist; reduces endocrine responses to CRF challenges.Formule :C22H26Cl2N4Couleur et forme :SolidMasse moléculaire :417.37Ebopiprant
CAS :Ebopiprant (OBE022) is a prostaglandin F2α (PGF2α) receptor antagonist that can be used to study obesity.Formule :C30H34FN3O5S2Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :599.74UNC9994 hydrochloride
CAS :UNC9994 hydrochloride is a selective β-arrestin-biased D2R agonist, Ki of 79 nM, that stimulates β-arrestin and modulates cAMP.Formule :C21H23Cl3N2OSCouleur et forme :SolidMasse moléculaire :457.84RS100329 hydrochloride
CAS :RS 100329 hydrochloride is an antagonist of α1A-adrenergic receptor.Formule :C20H26ClF3N4O3Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :462.89Carmoxirole hydrochloride
CAS :Carmoxirole hydrochloride (EMD 45609 hydrochloride) is a selective dopamine D2 receptor agonist with antihypertensive activity in vivo.Formule :C24H27ClN2O2Degré de pureté :99.37% - 99.62%Couleur et forme :SolidMasse moléculaire :410.94Ref: TM-T10683
1mg42,00€5mg86,00€1mL*10mM (DMSO)88,00€10mg123,00€25mg203,00€50mg299,00€100mg411,00€200mg553,00€O-2545 hydrochloride
CAS :O-2545 is a potent water-soluble central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptor agonist with Ki values of 1.5 and 0.32 nM, respectively. Typically, cannabinoid agonists are highly lipophilic and require solubilization through surfactant agents or binding to water miscible substances like albumin, Tween 80, or Emulphor for use. When dissolved in saline, O-2545 has shown high efficacy in mouse behavioral models, administered either intravenously or intracerebroventricularly.Formule :C26H36N2O2HClCouleur et forme :SolidMasse moléculaire :4458-iso-15(R)-Prostaglandin F2α
CAS :8-iso-15(R)-Prostaglandin F2α (8-iso-15(R) PGF2α) is a chemically distinct member within a broad group of prostaglandin-like eicosanoids, produced through the free radical peroxidation of arachidonic acid contained in membrane phospholipids. It represents the C-15 epimer of 8-isoPGF2α, distinguished as the sole isoprostane isomer extensively examined across numerous biological systems.Formule :C20H34O5Couleur et forme :SolidMasse moléculaire :354.52-O-Ethyl PAF C-16
CAS :2-O-Ethyl PAF C-16, a homolog of Platelet-activating Factor (PAF) and competitive ligand for the Platelet-activating Factor Receptor (PAFR), inhibits the binding of PAF antagonist WEB 2086 to PAFR with an IC50 of 21 nM [1].Formule :C26H56NO6PCouleur et forme :SolidMasse moléculaire :509.709T-0632
CAS :T-0632 is a potent and selective antagonist of CCKA receptor.Formule :C28H22FN3NaO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :522.488MDL-74156
CAS :MDL-74156 is an active metabolite of dolasetron and a 5-hydroxy-tryptamine3 (5-HT3) antagonist.Formule :C19H22N2O3Couleur et forme :SolidMasse moléculaire :326.39AL 8810 methyl ester
CAS :AL 8810 methyl ester, a prostaglandin F(2α) analog and receptor agonist, competitively antagonizes FP receptor agonist Fluprostenol effects. It lacks significant potency against TP, DP, EP(2), EP(4) receptor subtypes in cell lines [1].Formule :C25H33FO4Couleur et forme :SolidMasse moléculaire :416.53GLP-1R agonist 17
CAS :GLP-1R agonist 17 excels in stimulating GLP-1 receptors, useful for cardiovascular metabolic disease research.Formule :C28H26ClFN4O4SCouleur et forme :SolidMasse moléculaire :569.05GS-6201
CAS :GS-6201 (CVT-6883) is a selective antagonist of adenosine A2B receptor.Formule :C21H21F3N6O2Degré de pureté :99.78% - 99.94%Couleur et forme :SolidMasse moléculaire :446.43Ref: TM-T15418
1mg34,00€5mg71,00€1mL*10mM (DMSO)78,00€10mg114,00€25mg235,00€50mg380,00€100mg572,00€200mg805,00€Nemonapride
CAS :Nemonapride is a dopamine D2-like receptor antagonist.Formule :C21H26ClN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.9PF-02575799
CAS :PF-02575799 is an inhibitor of microsomal triglyceride transfer protein (MTP) (IC50: 0.77±0.29 nM).Formule :C42H37FN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :680.77RO5527239
CAS :RO5527239 is a potent, orally available GPBAR1 agonist agent.Formule :C28H31N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :457.56MRS5698
CAS :MRS5698, an A3 adenosine receptor agonist with Ki ~3 nM, blocks chronic pain, highly selective (>1000-fold over A1/A2A).Formule :C28H23ClF2N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :564.97GP3269
CAS :GP3269 is a selective, potent, orally active human adenosine kinase (AK) inhibitor (IC50: 11 nM) with anticonvulsant effects in rats.Formule :C23H21FN4O3Couleur et forme :SolidMasse moléculaire :420.445α-Pregnane-3α,20α-diol
CAS :5α-Pregnane-3α,20α-diol, an active metabolite of progesterone, is synthesized through intermediates 5α-pregnane-20α-ol-3-one and 5α-pregnane-3α-ol-20-one fromFormule :C21H36O2Couleur et forme :SolidMasse moléculaire :320.51Brilaroxazine
CAS :Brilaroxazine (RP5063): multimodal dopamine/5-HT modulator, partial agonist at D2/D3/D4, 5-HT1A/2A, and antagonist at 5-HT2B/7.Formule :C22H25Cl2N3O3Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :450.36Ref: TM-T14782
1mg100,00€5mg236,00€1mL*10mM (DMSO)268,00€10mg385,00€25mg663,00€50mg954,00€100mg1.305,00€200mg1.738,00€ST4206
CAS :ST4206 is an antagonist of adenosine A2A. For adenosine A2A receptor and adenosine A1 receptor, the Kis values are 12 nM and 197 nM , respectively.Formule :C12H14N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :286.29(R)-JNJ-31020028
CAS :(R)-JNJ-31020028: High-affinity, selective brain-penetrant Y2 receptor antagonist; pIC50: human 8.07, rat 8.22, mouse 8.21.Formule :C34H36FN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :565.68BAY-298
CAS :BAY-298: oral LH-R antagonist; IC50: 96nM (hLH), 23nM (rLH), 78nM (cLH); first to lower sex hormones in vivo.Formule :C27H21ClFN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.93Prostaglandin F2α 1,9-lactone
CAS :Prostaglandin F2α (PGF2α) 1,9-lactone, a lipid-soluble internal ester of PGF2α, demonstrates resistance to hydrolysis by human plasma esterases, maintaining its structure even after 20 hours of incubation under physiological conditions. Unlike PGF2α, this compound exhibits minimal antifertility and vasoactivity.Formule :C20H32O4Couleur et forme :SolidMasse moléculaire :336.5[D-Ala6]-LH-RH
CAS :[D-Ala6]-LH-RH, a Luteinizing-hormone-releasing hormone (LHRH) analogue, functions as a gonadotropin-releasing hormone (GnRH) receptor agonist [1].Formule :C56H77N17O13Couleur et forme :SolidMasse moléculaire :1196.32(1S)-CCR2 antagonist 1
CAS :(1S)-CCR2 antagonist 1, a left-handed chiral form of CCR2 antagonist 1, exhibits high affinity and a long residence time as a CCR2 antagonist, with an inhibition constant (K i) of 2.4 nM [1].Formule :C28H32BrF3N2OCouleur et forme :SolidMasse moléculaire :549.47ABO hydrochloride
CAS :ABO acts as an annexin A7 modulator, specifically binding to Thr286 to inhibit its phosphorylation on threonine (not on serine or tyrosine) residues within human umbilical vein endothelial cells (HUVECs). This compound furthers the annexin A7 interaction with the EF-hand protein GCA, leading to reduced GCA phosphorylation, lowered intracellular calcium levels, and enhanced autophagy in COS-7 cells. Moreover, ABO lessens phosphorylation of the microtubule-associated protein 1 light chain (LC3) in HUVECs and impedes the upregulation of phosphatidylcholine-specific phospholipase C (PC-PLC) due to oxidized low-density lipoprotein in vascular endothelial cells (VECs). In animal models, specifically apoE-/- mice on a Western diet, administration of ABO (50 or 100 mg/kg per day) has been shown to decrease PC-PLC expression, promote autophagy, and reduce apoptosis, lipid accumulation, and the extent of atherosclerotic plaques in the aortic endothelium.Formule :C9H12N2O2HClCouleur et forme :SolidMasse moléculaire :253.13SCH 206272
CAS :SCH 206272 is a potent, orally active antagonist of tachykinin NK(1), NK(2), and NK(3) receptor.Formule :C33H41Cl4N5O4Couleur et forme :SolidMasse moléculaire :713.52Cipralisant
CAS :Cipralisant: H3 receptor antagonist (in vivo), agonist (in vitro, pKi 9.9), Ki 0.47 nM in rats, may treat ADHD.Formule :C14H20N2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :216.32KUC-7322
CAS :Ritobegron is used as a selective β3-adrenoceptor agonist and the prodrug of the active compound, KUC-7322.Formule :C21H27NO5Couleur et forme :SolidMasse moléculaire :373.44S1R agonist 1 hydrochloride
CAS :S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstratedFormule :C20H26ClNODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :331.885-HT3-In-1
CAS :5-HT3-In-1 (compound example 8) exhabits with 5-HT3 inhibition activity.Formule :C16H21ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :352.8215(R)-Prostaglandin E2
CAS :15(R)-Prostaglandin E2, the C-15 epimer of the more physiologically abundant 15(S)-PGE2 (sc-201225) isomer, is produced mainly from arachidonic acid (sc-200770) via the action of COX and PGES enzymes. Present in nearly all cell types, PGE2 interacts with four distinct receptors, EP1 to EP4, leading to a wide range of biological effects. However, 15(R)-Prostaglandin E2 exhibits significantly lower efficacy in most biological assays compared to its 15(S) counterpart. Notably, acid catalyzed epimerization can transform 15(R)-Prostaglandin E2 into the more active 15(S)-Prostaglandin E2 form.Formule :C20H32O5Couleur et forme :SolidMasse moléculaire :352.471VU0652925
CAS :VU0652925 is a PAR4 antagonist. VU0652925 has a P-sel IC50 of 39.2 pM (-pIC50±SEM: 10.41±0.04) and a PAC1 IC50 of 43.0 pM (-pIC50±SEM: 10.4±0.04).Formule :C24H18N4O4S2Couleur et forme :SolidMasse moléculaire :490.55Bufuralol
CAS :Bufuralol (Ro 3-4787) is a 尾-adrenergic receptor blocker with a certain degree of sympathomimetic effects and can be used to study cardiovascular diseases.Formule :C16H23NO2Degré de pureté :98.26%Couleur et forme :SolidMasse moléculaire :261.36Prostaglandin E2 Ethanolamide
CAS :Prostaglandin E2 Ethanolamide (PGE 2 -EA), an analog of PGE2, is enzymatically synthesized through COX-2 oxygenation of endocannabinoids. It has the potential to modulate the production of the proinflammatory cytokine TNF-α in human blood and monocytic cells [1] [2].Formule :C22H37NO5Couleur et forme :SolidMasse moléculaire :395.54(Rac)-Modipafant
CAS :(Rac)-Modipafantis a PAFR antagonist that inhibits PAF-induced aggregation of washed platelets in rabbits.Formule :C34H29ClN6O3Degré de pureté :97.96% - 98.09%Couleur et forme :SolidMasse moléculaire :605.09Cipralisant maleate
CAS :Cipralisant maleate is a potent, selective Histamine H3 receptor antagonist.Formule :C18H24N2O4Couleur et forme :SolidMasse moléculaire :332.39Neladenoson dalanate
CAS :Neladenoson dalanate (BAY-1067197), an oral Adenosine A1 receptor partial agonist, is safe with good pharmacokinetics for chronic heart disease.Formule :C35H34ClN7O4S2Couleur et forme :SolidMasse moléculaire :716.27γ-Linolenoyl monoethanolamide
CAS :γ-Linolenoyl monoethanolamide, a fatty N-acyl ethanolamine, acts as an endocannabinoid [1] [2].Formule :C20H35NO2Couleur et forme :SolidMasse moléculaire :321.505Flesinoxan HCl
CAS :Flesinoxan HCl is the salt form of Flesinoxan, which is a selective 5-HT1A receptor agonist.Formule :C22H27ClFN3O4Couleur et forme :SolidMasse moléculaire :451.92MRS3558
CAS :MRS3558 is an agonist of A3 adenosine receptors.Formule :C20H20Cl2N6O3Couleur et forme :SolidMasse moléculaire :463.322,3-dinor Prostaglandin E1
CAS :Prostaglandin E1 (PGE1), though not predominantly found in nature, plays a significant role in clinical treatments, addressing conditions such as peripheral occlusive vascular disease, erectile dysfunction, and neonatal cardiology issues. The metabolism of PGE1 primarily begins with the oxidation at C-15, producing 13,14-dihydro-15-keto PGE1 as its major metabolite. Alternatively, inhibiting this pathway or overwhelming it with too much PGE1 could potentially enhance the production of 2,3-dinor metabolites, like 2,3-dinor PGE1, though their biological activities remain unreported. Cayman Chemical stands out as a prominent provider of prostaglandins and their metabolites, uniquely manufacturing 2,3-dinor PGE1.Formule :C18H30O5Couleur et forme :SolidMasse moléculaire :326.4LK 204-545
CAS :LK 204-545 is a highly selective antagonist of beta1-adrenoceptor.Formule :C25H32N4O6Couleur et forme :SolidMasse moléculaire :484.54Vatinoxan hydrochloride
CAS :Vatinoxan hydrochloride is an antagonist of the peripheral α2 adrenergic receptors.Formule :C20H27ClN4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :454.97SGC agonist 1
CAS :SGC agonist 1 is a potent soluble guanylate cyclase (SGC) agonist. SGC agonist 1 is able to increase solubility and has high cell permeability.Formule :C22H19F2N7OCouleur et forme :SolidMasse moléculaire :435.43L-772,405
CAS :L-772,405 is a highly selective agonists of h5-HT(1D) receptor.Formule :C26H31FN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.56Minocromil
CAS :Minocromil is a new agent of Anti-asthmatic.Formule :C18H16N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.332-Methyl-5-HT
CAS :2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.Formule :C11H14N2ODegré de pureté :97.18%Couleur et forme :SolidMasse moléculaire :190.24Ref: TM-T10075
5mg48,00€1mL*10mM (DMSO)50,00€10mg84,00€25mg177,00€50mg334,00€100mg500,00€500mg1.099,00€SDZ-216525
CAS :SDZ-216525, a 5-HT1A receptor antagonist, inhibits the tracheal contractions induced both by NKA (10 nM-3 microM) and 5-HT (10 nM-10 microM) (n=4-10).Formule :C25H28N4O5SCouleur et forme :SolidMasse moléculaire :496.58FK-1052
CAS :FK-1052 is a serotonin 3 & 4 dual receptor antagonist.Formule :C18H19N3OCouleur et forme :SolidMasse moléculaire :293.36CB2R-IN-1
CAS :CB2R-IN-1 is a potent inverse agonist of the cannabinoid CB2 receptor (Ki: 0.9 nM).Formule :C23H27F3N4O6S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :608.67(2S,3S)-E1R
CAS :(2R,3R)-E1R is a sigma-1 receptor modulator for cognitive/memory disorder treatment.Formule :C13H16N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :232.28CCG-63802
CAS :CCG-63802 is a reversible small-molecule inhibitor of regulator of G protein signaling (RGS) proteins.Formule :C26H18N4O2SDegré de pureté :90%Couleur et forme :SolidMasse moléculaire :450.51Timiperone
CAS :Timiperone exhibits a high affinity for cerebral dopamine D2 receptors, demonstrating antipsychotic activity as it mitigates stereotyped behavior.Formule :C22H24FN3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :397.51PD 128907
CAS :PD 128907 - potent, selective dopamine D2/D3 agonist for researching receptor roles in the brain.Formule :C14H19NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :249.31Lidamidine
CAS :Lidamidine (Lidamidinum) is an effective antidiarrheal agent that inhibits intestinal secretion, reduces intestinal transit, and inhibits smooth muscleFormule :C11H16N4ODegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :220.27Ref: TM-T25719
1mg115,00€2mg162,00€5mg249,00€10mg369,00€25mg562,00€50mg787,00€100mg1.054,00€200mg1.406,00€11(Z),14(Z)-Eicosadienoic Acid Ethanolamide
CAS :11(Z),14(Z)-Eicosadienoic acid ethanolamide is an ethanolamide derivative of 11(Z),14(Z)-eicosadienoic acid.Formule :C22H41NO2Couleur et forme :SolidMasse moléculaire :351.571-Carboxycyclohexaneacetic Acid
CAS :1-Carboxycyclohexaneacetic acid may be present as a potential impurity in commercial gabapentin, an antiepileptic drug. Furthermore, it serves as a precursor for synthesizing antagonists targeting the serotonin (5-HT) receptor subtype 5-HT2A.Formule :C9H14O4Couleur et forme :SolidMasse moléculaire :186.207SKI2496
CAS :SKI2496: potent, oral GnRH receptor antagonist, hGnRHR IC50=0.46nM, 84% LH inhibition at 12h, 76% at 24h, selective for humans over monkeys/rats.Formule :C35H36F7N5O5Couleur et forme :SolidMasse moléculaire :739.685-HT2A&5-HT2C agonist-1
CAS :5-HT2A&5-HT2C agonist-1 (Example 2) is a dual-acting agent targeting the 5-HT2A and 5-HT2C receptors with respective IC50 values of 196 nM and 0.9 nM.Formule :C14H20N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :232.32NVP-SAA164
CAS :NVP-SAA164 is a nonpeptide bradykinin B1 receptor antagonist agent.Formule :C36H45N5O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :659.84SKF 81297
CAS :SKF 81297 is a selective and potent agonist for the dopamine D1 receptor [1].Formule :C16H16ClNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :289.76Ro-70-0004
CAS :Ro-70-0004 is a selective antagonist of alpha1A-adrenoceptor.Formule :C20H24F4N4O3Couleur et forme :SolidMasse moléculaire :444.42TCS 2510
CAS :TCS 2510 (CAY10598) 是一种选择性 PGE2 和 EP4 受体激动剂，可增强细胞内 cAMP 浓度和活性 β-caten 的丰度。TCS 2510 抑制TNF-α 产生，可用于研究代谢紊乱带来的疾病。Formule :C21H29N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :383.49Δ17-6-keto Prostaglandin F1α
CAS :Δ17-6-keto Prostaglandin F1α (Δ17-6-keto PGF1α), a cyclooxygenase (COX) metabolite produced from eicosapentaenoic acid (EPA) in a variety of tissues including seminal vesicles, lungs, polymorphonuclear leukocytes, and ocular tissues, alongside other 3-series COX products from EPA such as PGF3α, PGE3, and thromboxane B3, is potentially linked to a lower occurrence of glaucoma in individuals consuming a marine-rich (EPA-rich) diet.Formule :C20H32O6Couleur et forme :SolidMasse moléculaire :368.47SORT-PGRN interaction inhibitor 2
CAS :SORT-PGRN Interaction Inhibitor 2 is a compound that downregulates SORT1 protein expression and enhances extracellular progranulin (PGRN) secretion in variousFormule :C19H31NOCouleur et forme :SolidMasse moléculaire :289.46SC 51322
CAS :SC 51322 is an EP1 prostanoid receptor antagonist.Formule :C22H20ClN3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :457.93Dibenamine hydrochloride
CAS :Dibenamine hydrochloride is a competitive and irreversible blocking agent of the β-adrenergic receptor.Formule :C16H19Cl2NDegré de pureté :96.43%Couleur et forme :Oily Liquid SolidMasse moléculaire :296.23DG-041
CAS :DG-041: EP3 receptor antagonist, high affinity (IC50: 4.6 & 8.1 nM), inhibits PGE2 in platelets, blood-brain barrier permeable.Formule :C23H15Cl4FN2O3S2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :592.32Ref: TM-T15108
1mg48,00€2mg63,00€5mg92,00€1mL*10mM (DMSO)104,00€10mg150,00€25mg284,00€50mg512,00€100mg737,00€500mg1.521,00€Fiduxosin
CAS :Fiduxosin is a selective and potent α1-adrenoceptor antagonist with inhibitory effects on α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, with KiFormule :C30H29N5O4SDegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :555.65TRAP-6-IN-1
CAS :TRAP-6-IN-1 inhibits collagen/TRAP-6, IC50: 17.12/11.88 μM, blocks platelet aggregation.Formule :C18H20O3Couleur et forme :SolidMasse moléculaire :284.35Flesinoxan
CAS :Flesinoxan is a hypotensive agent and is an effective, high affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).Formule :C22H26FN3O4Couleur et forme :SolidMasse moléculaire :415.46RU-SKI 43
CAS :RU-SKI 43: Potent, selective Hhat inhibitor, IC50 850 nM. Anticancer; potential lung adenocarcinoma treatment. Inhibits Gli-1, Akt, mTOR pathways.Formule :C22H30N2O2SDegré de pureté :99.85% - 99.92%Couleur et forme :SolidMasse moléculaire :386.55S1p receptor agonist 2
CAS :S1P5-selective agonist; less so for S1P1/S1P3; useful for CNS disorders.Formule :C24H23ClN2O4Couleur et forme :SolidMasse moléculaire :438.9Fiduxosin hydrochloride
CAS :Fiduxosin hydrochloride is an alpha 1a-adrenoceptor antagonist that may be useful in the treatment of Benign Prostatic Hyperplasia.Formule :C30H30ClN5O4SCouleur et forme :SolidMasse moléculaire :592.11PD 165929
CAS :PD 165929 is a selective antagonist of Bombesin BB1.Formule :C37H47N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :593.8
