GPCR/G-Protéine
Les inhibiteurs des GPCR/protéines G sont des composés qui ciblent les récepteurs couplés aux protéines G (GPCR) et les protéines G associées, qui jouent un rôle crucial dans la transmission des signaux de l'extérieur vers l'intérieur des cellules. Ces inhibiteurs sont essentiels pour étudier les voies de signalisation médiées par les GPCR, impliquées dans de nombreux processus physiologiques, y compris la perception sensorielle, la réponse immunitaire et la neurotransmission. Les inhibiteurs des GPCR sont également importants dans le développement de médicaments, car de nombreux agents thérapeutiques ciblent ces récepteurs. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de GPCR/protéines G de haute qualité pour soutenir vos recherches en pharmacologie, biologie cellulaire et domaines connexes.
Sous-catégories appartenant à la catégorie "GPCR/G-Protéine"
- récepteur 5-HT(1.025 produits)
- Récepteur d'adénosine(249 produits)
- Récepteur adrénergique(3.030 produits)
- Récepteur de la bombésine(35 produits)
- Récepteur de la bradykinine(61 produits)
- CXCR(159 produits)
- CaSR(34 produits)
- Récepteur cannabinoïde(217 produits)
- Cholécystokinine(1 produits)
- Récepteur de la dopamine(445 produits)
- Récepteur de l'endothéline(86 produits)
- Récepteur GNRH(84 produits)
- GPCR19(33 produits)
- GRK(33 produits)
- GTPase(22 produits)
- Récepteur du glucagon(196 produits)
- Hérisson/Smoothened(49 produits)
- Récepteur de l'histamine(385 produits)
- Récepteur LPA(21 produits)
- Récepteur de la mélatonine(26 produits)
- Récepteur OX(42 produits)
- Récepteur opioïde(325 produits)
- PAFR(14 produits)
- PKA(55 produits)
- Récepteur S1P(17 produits)
- SGLT(31 produits)
- Récepteur Sigma(46 produits)
Affichez 19 plus de sous-catégories
5985 produits trouvés pour "GPCR/G-Protéine"
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CP-122288
CAS :CP-122288: potent, selective 5-HT1B/D/F agonist; inhibits plasma protein extravasation, neurogenic inflammation.Formule :C16H23N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :321.44BMS-960
CAS :BMS-960 is an S1P agonist with potential anti-tumour activity for cancer research.Formule :C26H23F3N4O5Degré de pureté :97.66% - 98.69%Couleur et forme :SolidMasse moléculaire :528.48S1R agonist 1 hydrochloride
CAS :S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstratedFormule :C20H26ClNODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :331.88Frovatriptan
CAS :Frovatriptan, potent 5-HT 1B/D agonist, shows high cerebroselectivity and efficacy for migraine with aura.Formule :C14H17N3OCouleur et forme :SolidMasse moléculaire :243.3CB-25
CAS :CB-25 is a partial agonist ligand of CB1 cannabinoid receptors, augmenting Forskolin-induced cAMP formation in cancer cells, though not affecting hCB1-CHO cellsFormule :C25H41NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :403.6L-796568 free base
CAS :L-796568 is a potent β3 agonist for obesity with 600x selectivity over β1/β2 receptors (EC50: 3.6 nM).Formule :C31H27F3N4O3S2Couleur et forme :SolidMasse moléculaire :624.7Crisdesalazine
CAS :Crisdesalazine (AAD 2004) is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1).Formule :C16H14F3NO3Degré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :325.28LBT 999
CAS :LBT 999 is used as a dopamine reuptake inhibitor.Formule :C20H26FNO2Couleur et forme :SolidMasse moléculaire :331.42Capeserod HCl
CAS :Capeserod HCl, a 5-hydroxytriptamine 4 (5-HT4) receptor agonist, is used potentially for the treatment of Alzheimer's disease.Formule :C23H26Cl2N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :493.38Droxicam
CAS :Droxicam (Droxicamum) is a non-steroidal anti-inflammatory compound and can be used for research on the relief of inflammation and pain in musculoskeletalFormule :C16H11N3O5SDegré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :357.34Ono-RS 347
CAS :Ono-RS 347 is a leukotriene antagonists with the activity of SRS-A antagonist.Formule :C26H25N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.51GP3269
CAS :GP3269 is a selective, potent, orally active human adenosine kinase (AK) inhibitor (IC50: 11 nM) with anticonvulsant effects in rats.Formule :C23H21FN4O3Couleur et forme :SolidMasse moléculaire :420.44CCR3 antagonist 1
CAS :CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.Formule :C19H21Cl2N3O4S2Degré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :490.42Ref: TM-T10156
1mg92,00€5mg188,00€10mg305,00€25mg489,00€50mg655,00€100mg883,00€1mL*10mM (DMSO)224,00€Enerisant
CAS :Enerisant (TS-091) is a histamine H3 receptor antagonist that promotes pro-cognitive effects and reverses scopolamine-induced cognitive deficits.Formule :C22H30N4O3Degré de pureté :99.7%Couleur et forme :SoildMasse moléculaire :398.50Ref: TM-T67828
1mg52,00€2mg71,00€5mg107,00€10mg170,00€25mg359,00€50mg462,00€100mg645,00€200mg873,00€1mL*10mM (DMSO)117,00€OPC-28326
CAS :OPC-28326: an α2-adrenergic blocker; dilates blood vessels; inhibits α2A/B/C receptors with Ki 2040/285/55 nM.Formule :C26H35N3O2Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :421.58Ref: TM-T13804
1mg187,00€5mg455,00€10mg620,00€25mg940,00€50mg1.264,00€100mg1.663,00€200mg2.252,00€1mL*10mM (DMSO)567,00€Adomeglivant
CAS :Adomeglivant (LY2409021) is a potent and selective glucagon receptor antagonist. Which is used in clinical trial for type 2 diabetes mellitus.Formule :C32H36F3NO4Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :555.63Ertugliflozin L-pyroglutamic acid
CAS :Ertugliflozin is a potent oral hSGLT2 inhibitor (IC50: 0.877 nM) for type 2 diabetes treatment studies.Formule :C27H32ClNO10Degré de pureté :99.88% - 99.94%Couleur et forme :SolidMasse moléculaire :566Ref: TM-T15244
5mg47,00€10mg60,00€25mg89,00€50mg96,00€100mg140,00€200mg198,00€500mg340,00€1mL*10mM (DMSO)52,00€ST-1006
CAS :ST-1006: histamine H4 agonist, pKi 7.94, anti-inflammatory, anti-pruritic, promotes basophil migration.Formule :C16H20Cl2N6Degré de pureté :99.96% - 99.98%Couleur et forme :SolidMasse moléculaire :367.28Ref: TM-T34709
1mg90,00€5mg198,00€10mg316,00€25mg513,00€50mg633,00€100mg785,00€200mg1.045,00€1mL*10mM (DMSO)197,00€GI 181771
CAS :GI 181771 is an agonist of the cholecystokinin 1 receptor. GI 181771 can be used in studies about obesity.Formule :C34H31N5O6Degré de pureté :95.02%Couleur et forme :SolidMasse moléculaire :605.64K777
CAS :K777: Oral cysteine protease inhibitor, CYP3A4 blocker (IC50=60 nM), CCR4 antagonist, anti-Trypanosoma cruzi, antiviral, halts EBOV/SARS-CoV entry (IC50<1 nM).Formule :C32H38N4O4SDegré de pureté :98.43% - 99.14%Couleur et forme :SolidMasse moléculaire :574.730990CL
CAS :0990CL is an effective heterotrimer Gαi subunit specific inhibitor, which can interact with purified Go± in GDP-bound state, and can block α2AR mediated cAMPFormule :C21H21N5Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :343.42Ref: TM-T13983
1mg202,00€5mg512,00€10mg740,00€25mg1.121,00€50mg1.539,00€100mg2.072,00€1mL*10mM (DMSO)535,00€AS2717638
CAS :AS2717638: oral LPA5 antagonist, IC50 38 nM, reduces PGF2α/PGE2/AMPA allodynia.Formule :C25H25N3O5Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :447.48Ref: TM-T10381
1mg59,00€5mg125,00€10mg200,00€25mg399,00€50mg645,00€100mg1.017,00€200mg1.378,00€1mL*10mM (DMSO)138,00€TAK-441
CAS :TAK-441: oral Hedgehog signal blocker, potent anticancer, IC50=4.4 nM, reduces Gli1 mRNA & tumor growth.Formule :C28H31F3N4O6Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :576.56AY 77
CAS :<p>AY 77: Potent, selective PAR2 agonist, favors Ca2+ (ec50=40nM) & ERK1/2 (ec50=2μM), boosts breast cancer cell migration.</p>Formule :C21H32N4O4Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :404.5SB 216641 hydrochloride
CAS :SB 216641 hydrochloride (SB-216641A) is a 5-HT1B/D receptor antagonist with anxiolytic properties.Formule :C28H31ClN4O4Degré de pureté :98.06% - 99.23%Couleur et forme :SolidMasse moléculaire :523.02PSB-603
CAS :<p>PSB-603 is a selective antagonist of Adenosine A2B receptor(Ki = 0.553 nM) with anti-inflammatory effects.</p>Formule :C24H25ClN6O4SDegré de pureté :97.13%Couleur et forme :SolidMasse moléculaire :529.01GW 833972A
CAS :<p>GW 833972A: selective CB2 agonist; reduces neural depolarization and citric acid cough in animals.</p>Formule :C18H14Cl2F3N5ODegré de pureté :99.93%Couleur et forme :SoildMasse moléculaire :444.24GV150013
CAS :GV150013 is an antagonist of cholecystokinin-2 (CCK2) receptor.Formule :C33H34N4O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :534.65Ref: TM-T27503
1mg187,00€5mg455,00€10mg620,00€25mg940,00€50mg1.264,00€100mg1.663,00€200mg2.252,00€1mL*10mM (DMSO)645,00€Selatogrel
CAS :Selatogrel (ACT-246475) is a P2Y12 receptor antagonist with antithrombotic activity and inhibits platelet aggregation.Formule :C28H39N6O8PDegré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :618.62LGD-6972
CAS :<p>LGD-6972 is an antagonist of glucagon receptor.</p>Formule :C43H46N2O5SDegré de pureté :98.8% - 99.62%Couleur et forme :SolidMasse moléculaire :702.9Vidupiprant
CAS :Vidupiprant (AMG 853) is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of 8 nM and 35 nM in human plasma.Formule :C28H27Cl2FN2O6SDegré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :609.49Ref: TM-T17232
1mg66,00€5mg144,00€10mg217,00€25mg396,00€50mg590,00€100mg840,00€500mg1.691,00€1mL*10mM (DMSO)188,00€Deriglidole
CAS :Deriglidole (SL 86-0715), an alpha2 receptor inhibitor, blocks colistin/Idazoxan but not prazosin/α2-adrenergic receptors.Formule :C16H21N3Degré de pureté :98.12% - 99.03%Couleur et forme :SolidMasse moléculaire :255.36Azelaprag
CAS :Azelaprag (Example 263.0) is a candidate active molecule (EC50= 0.32 nM) for an apelin receptor agonist. treat nervous system diseases. High-Quality, Low-Cost!Formule :C25H29N7O4SDegré de pureté :98.04% - >99.99%Couleur et forme :SolidMasse moléculaire :523.61Didesmethyl cariprazine
CAS :Didesmethyl cariprazine, Cariprazine's active metabolite, treats schizophrenia/bipolar with D3/D2 affinity; half-life 1-3 weeks.Formule :C19H28Cl2N4ODegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :399.36(±)-Prenalterol
CAS :(±)-Prenalterol (H 80/62) is an agonist of beta-2- and beta-1-adrenergic receptors and is used to study chronic congestive heart failure.Formule :C12H19NO3Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :225.28NMI 8739
CAS :<p>NMI 8739 (n-docosahexaenoyl dopamine) is an agonist of D2 autoreceptor.</p>Formule :C30H41NO3Degré de pureté :98.51%Couleur et forme :SolidMasse moléculaire :463.65CGP-20712
CAS :CGP-20712 is a selective β 1-adrenoceptor antagonist with an IC50 of 0.7 nM.Formule :C23H25F3N4O5Degré de pureté :99.40% - 99.58%Couleur et forme :SolidMasse moléculaire :494.46Ref: TM-T30846
1mg315,00€5mg745,00€10mg1.018,00€25mg1.431,00€50mg1.783,00€100mg2.250,00€500mg4.410,00€Clazosentan
CAS :Clazosentan (Ro 61-1790) is a selective ET_A receptor antagonist that inhibits ET-1 vasoconstriction and prevents cerebral vasospasm.Formule :C25H23N9O6SDegré de pureté :95.39% - >99.99%Couleur et forme :SolidMasse moléculaire :577.57Ref: TM-T64084
1mg79,00€5mg178,00€10mg279,00€25mg628,00€50mg1.017,00€100mg1.311,00€200mg1.768,00€1mL*10mM (DMSO)230,00€Osemozotan HCl
CAS :Osemozotan is a 5-HT1A receptor agonist potentially for the treatment of generalized anxiety disorder.Formule :C19H22ClNO5Degré de pureté :98.87% - 99.63%Couleur et forme :SolidMasse moléculaire :379.84INT-777
CAS :INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM.Formule :C27H46O5Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :450.65Ref: TM-T11662L
1mg130,00€5mg313,00€10mg447,00€25mg715,00€50mg999,00€100mg1.395,00€1mL*10mM (DMSO)343,00€Calindol hydrochloride
CAS :Calindol (hydrochloride) is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM.Formule :C21H21ClN2Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :336.86Lotiglipron
CAS :<p>Lotiglipron (PF-07081532) is a GLP-1R agonist that lowers blood glucose and may be used in the study of type 2 diabetes mellitus (T2DM) and excess obesity.</p>Formule :C31H31ClN4O5Degré de pureté :98.3%Couleur et forme :SolidMasse moléculaire :575.05Selvigaltin
CAS :Selvigaltin (GB1211) is a Gal-3 inhibitor with potential anticancer activity. Selvigaltin is used in the study of cirrhosis and cancer.Formule :C19H16BrF3N4O4SDegré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :533.32Ref: TM-T63751
1mg264,00€5mg655,00€10mg1.121,00€25mg2.262,00€50mg3.753,00€100mg5.663,00€1mL*10mM (DMSO)À demanderα1 adrenoceptor-MO-1
CAS :α1 adrenoceptor-MO-1 (S enantiomer) has affinity at alpha 1 adrenergic receptor with alphalytic activity and analgesic action.Formule :C20H24ClN5ODegré de pureté :99.20% - 99.29%Couleur et forme :SolidMasse moléculaire :385.89Ref: TM-T10003
1mg198,00€5mg393,00€10mg542,00€25mg785,00€50mg1.074,00€100mg1.454,00€200mg1.967,00€1mL*10mM (DMSO)467,00€Talibegron hydrochloride
CAS :Talibegron hydrochloride: β3 adrenoceptor agonist, pD2 3.72, relaxes rat arteries, reduces leptin in mice.Formule :C18H22ClNO4Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :351.83PAOPA
CAS :dopamine D2 receptor modulatorFormule :C11H18N4O3Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :254.29A2B receptor antagonist 1
CAS :A2B receptor antagonist 1 (EXAMPLE 9B) is a potent A2B adenosine receptor antagonist.Formule :C21H24N6O2Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :392.45Ref: TM-T10058
1mg369,00€5mg735,00€10mg938,00€25mg1.473,00€50mg1.882,00€100mg2.670,00€1mL*10mM (DMSO)843,00€SAG 21k
CAS :SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration.Formule :C29H28ClF2N3O2SDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :556.07WAY-607695
CAS :WAY-607695 is a potential 5-HT1A receptor agonist.Formule :C13H12FNO2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :233.24WAY-639889
CAS :WAY-639889 is a small molecule compound with selective and potent inhibitory effects on neuropeptide Y-5 receptors.Formule :C25H27N5ODegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :413.51SR 142948
CAS :SR 142948 is a neurotensin (NT) receptor antagonist.Formule :C39H51N5O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :685.85Lumateperone
CAS :<p>Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).</p>Formule :C24H28FN3ODegré de pureté :99.68% - 99.91%Couleur et forme :SolidMasse moléculaire :393.5SB-616234-A
CAS :SB-616234-A is a selective and orally bioavailable antagonist of 5-HT1B receptor, with anxiolytic and antidepressant activity.Formule :C32H36ClN5O3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :574.11PSB 1115
CAS :PSB 1115 is an A2B receptor antagonist and can counteract the inhibitory effect of NECA.Formule :C14H14N4O5SDegré de pureté :98.69% - >99.99%Couleur et forme :SolidMasse moléculaire :350.35INCB3344
CAS :INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8Formule :C29H34F3N3O6Degré de pureté :98% - 98.2%Couleur et forme :SolidMasse moléculaire :577.59Ref: TM-TQ0103
1mg66,00€5mg144,00€10mg230,00€25mg358,00€50mg512,00€100mg707,00€200mg973,00€1mL*10mM (DMSO)178,00€Nocloprost
CAS :Nocloprost (SH 475) is a prostaglandin E2 (PGE2) analog, an EP1 and EP3 receptor agonist with local gastric protection and ulcer healing effects.Formule :C22H37ClO4Couleur et forme :SolidMasse moléculaire :400.98(±)-Penbutolol
CAS :(±)-Penbutolol ((Rac)-Penbutolol) is the racemic form of Penbutolol. It acts as an orally active β-adrenergic receptor antagonist. (±)-Penbutolol mitigates the tachycardia induced by exercise, reduces the increase in peak expiratory flow rate (PEFR) caused by physical activity, and decreases plasma renin activity (PRA) at rest. The peak plasma concentration of this compound is achieved one hour after oral administration, with a half-life of 4.5 hours, and it is metabolized into active metabolites in the body. This compound is utilized in research related to cardiovascular diseases.Formule :C18H29NO2Couleur et forme :SolidMasse moléculaire :291.43Spns2-IN-3
CAS :Spns2-IN-3 (compound 510) is an SPNS2 inhibitor with an IC50 value of 1.2 μM for hSPNS2. It is applicable in research on autoimmune diseases such as multiple sclerosis (MS) and inflammatory bowel disease (IBD), as well as fibrosis, muscle atrophy, metastasis, acute lung injury, rheumatoid arthritis, colitis, Alzheimer's disease, and other conditions linked to SPNS2 activity.Formule :C25H25F5N4O3Couleur et forme :SolidMasse moléculaire :524.48Disulergine
CAS :Disulergine is a dopamine receptor agonist. It also prolactin release-inhibiting 8 alpha-amino-ergoline.Formule :C17H24N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.46Opipramol dihydrochloride
CAS :Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) primarily functioning as a sigma (σ) receptor agonist. It interacts effectively with sigma recognition sites, having a Ki value of 50 nM. Opipramol is applicable in the study of generalized anxiety disorder (GAD).Formule :C23H31Cl2N3OCouleur et forme :SolidMasse moléculaire :436.418Ophiobolin C
CAS :inhibitor of human CCR5 binding to HIV-1 gp120Formule :C25H38O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :386.57YNT-3708
CAS :YNT-3708 is an orexin receptor (OXR) agonist, exhibiting EC50 values of 14.6 nM for OX1R and 277 nM for OX2R.Formule :C35H36N4O6SCouleur et forme :SolidMasse moléculaire :640.7495-HT2A receptor agonist-8
CAS :5-HT2A receptor agonist-8 (compound 8) is a potent 5-HT2A receptor agonist with an EC50 of 0.6784 nM. It is suitable for research related to depression and bipolar disorder.Formule :C22H27N3OCouleur et forme :SolidMasse moléculaire :349.47CP-199330
CAS :CP-199330: non-toxic alternative to Zafirlukast & Pranlukast, blocks cysteyl LT1 receptors.Formule :C28H24ClF3N2O6SCouleur et forme :SolidMasse moléculaire :609.01Befiradol hydrochloride
CAS :<p>Befiradol HCl (NLX-112) is a selective 5-HT1A receptor agonist with anxiolytic effects and prevents ATXN3 aggregation.</p>Formule :C20H23Cl2F2N3ODegré de pureté :99.1%Couleur et forme :SolidMasse moléculaire :430.32Iralukast (CGP 45715A)
CAS :Iralukast is a cysteinyl-leukotriene antagonist (CysLT) with a pKi of 7.8 for CysLT1.Formule :C38H37F3O8SCouleur et forme :SolidMasse moléculaire :710.76AM8936
AM8936: potent CB1 agonist, EC50 rCB1=8.6nM/hCB1=1.4nM, Ki rat CB1=0.55nM; potential for CNS, metabolic, pain, glaucoma research.Formule :C25H33NO3Couleur et forme :SolidMasse moléculaire :395.53Cicaprost
CAS :Cicaprost (ZK 96480) is an IP agonist with artery relaxing effects; EC50 is 5.8 nM.Formule :C22H30O5Couleur et forme :SolidMasse moléculaire :374.47SSTR5 antagonist 2 hydrochloride
SSTR5 antagonist 2 hydrochloride: potent, oral SSTR5 blocker with potential in type 2 diabetes research.Formule :C32H36ClFN2O5Couleur et forme :SolidMasse moléculaire :583.09OP-2507
CAS :OP-2507, a prostacyclin agonist, is used potentially for the treatment of hepatic insufficiency and hypertension.Formule :C25H41NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :419.6DSP-1053 benzenesulfonate
CAS :DSP-1053: Benzylpiperidine-based, potent SERT inhibitor (Ki=1.02nM), partial 5-HT1A receptor agonist (Ki=5.05nM), antidepressant.Formule :C32H38BrNO7SCouleur et forme :SolidMasse moléculaire :660.62RGS10 modulator-1
CAS :RGS10 modulator-1 (compound 15) is an effective regulator of RGS10. It significantly reverses IFNγ-induced expression of both RGS10 protein and mRNA, as well as COX-2 mRNA and iNOS expression triggered by IFNγ.Formule :C16H15BrN2O3S2Couleur et forme :SolidMasse moléculaire :427.336SphK1-IN-1
SphK1-IN-1: SphK1 ATPase inhibitor, IC50=2.48 μM, potential for cancer research.Formule :C22H22N6O2Couleur et forme :SolidMasse moléculaire :402.45Setomagpran
CAS :Setomagpran is an antagonist of the mas-related G protein-coupled receptor (MRGPR) and possesses anti-inflammatory properties.Formule :C22H19Cl2F6N5OCouleur et forme :SolidMasse moléculaire :554.316LX2761
CAS :LX2761 is a stable inhibitor for SGLT1/2 with IC50s of 2.2/2.7 nM; it targets SGLT1 in the GI tract.Formule :C32H47N3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :601.80SLF1081851 hydrochloride
CAS :SLF1081851 (hydrochloride), a Spns2 inhibitor, effectively inhibits S1P release with an IC50 value of 1.93 μM. This compound is instrumental in the development and functioning of the immune system [1].Formule :C21H34ClN3OCouleur et forme :SolidMasse moléculaire :379.97RXFP1 receptor agonist-9
CAS :RXFP1 receptor agonist-9 is a potent RXFP1 agonist with an EC50 value of 2.5 μM and a Ymax of 65%. This compound exhibits significant microsomal stability, desirable pharmacokinetic properties, and pharmacodynamic activity. RXFP1 receptor agonist-9 is useful in the study of heart failure.Formule :C37H34F5N3O7Couleur et forme :SolidMasse moléculaire :727.67GPBAR1-IN-3
CAS :GPBAR1-IN-3 (Compound 14) is both a selective agonist for GPBAR1, with an EC50 value of 0.17 μM, and an antagonist for CysLT1R [1].Formule :C21H23NO2Couleur et forme :SolidMasse moléculaire :321.412,3-dinor-11β-Prostaglandin F2α
CAS :2,3-dinor-11β-Prostaglandin F2α (2,3-dinor-11β-PGF2α) was recovered from the urine of both normal monkeys and humans when infused with radiolabeled PGD2, whereFormule :C18H30O5Couleur et forme :SolidMasse moléculaire :326.43MRS2179 tetrasodium hydrate
MRS2179 blocks turkey P2Y1 receptor (Kb 102 nM, pA2 6.99), affects platelet aggregation, and has varying IC50s on P2 receptors.Formule :C11H15N5Na4O10P2Couleur et forme :SolidMasse moléculaire :576.21DA-302168S
CAS :DA-302168S is an orally active, selective GLP-1R agonist with an EC50 value of 1.32 nM. It promotes insulin secretion and has a hypoglycemic effect. Additionally, DA-302168S reduces food intake. It primarily activates GLP-1R in humans and monkeys, with minimal effect on GLP-1R in rats, mice, and dogs. DA-302168S can be used for research in type 2 diabetes and obesity.Formule :C33H24ClF2N3O5Couleur et forme :SolidMasse moléculaire :616.011Nolpitantium besilate
CAS :Nolpitantium besilate is a neurokinin-1 receptor antagonist.Formule :C43H50Cl2N2O5SCouleur et forme :SolidMasse moléculaire :777.84Sp-UTP-α-S
CAS :Sp-UTP-α-S serves as an activator of P2Y2 and P2Y4 receptors and is applicable in cancer research.Formule :C9H15N2O14P3SMasse moléculaire :500.21COX-2-IN-6
CAS :COX-2-IN-6: Potent, selective COX-2 inhibitor; oral; IC50 0.84μM, Ki 69nM; blocks PGE2 synthesis; prevents colorectal cancer.Formule :C20H27NO6SDegré de pureté :99.29% - 99.32%Couleur et forme :SoildMasse moléculaire :409.5GLP-1R agonist 33
CAS :GLP-1R agonist 33 (Compound 224) is a GLP-1 receptor agonist with potential applications in research related to diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD).Formule :C30H27FN6O4Couleur et forme :SolidMasse moléculaire :554.57Histamine H3 antagonist-1
CAS :<p>Compound 10o, a histamine H3 antagonist-1, functions as both a histamine H3 antagonist and a serotonin reuptake inhibitor, making it useful for research in depression [1].</p>Formule :C24H28F3N3O2Couleur et forme :SolidMasse moléculaire :447.49SPL-IN-1
CAS :SPL-IN-1 (compound C17) acts as a dual species inhibitor of sphingosine-1-phosphate lyase [1].Formule :C31H42N2O6S2Couleur et forme :SolidMasse moléculaire :602.8CCR1 antagonist 13
CAS :CCR1 antagonist13 is a selective small molecule antagonist of CCR1.Formule :C25H27ClFN3O4Couleur et forme :SolidMasse moléculaire :487.95LJ-4517
LJ-4517 is an effective A2AAR antagonist (Ki=18.3 nM). LJ-4517 can effectively replace the binding of [3H] ZM241385 at WT A2AAR.Formule :C19H21N5O3SCouleur et forme :SolidMasse moléculaire :399.47EP4 receptor antagonist 2
CAS :EP4 receptor antagonist 2 (compound 2-13) is a potent agonist of the EP4 receptor (IC50: 7.8 nM) and has antitumour effects.Formule :C27H29N3O5Couleur et forme :SolidMasse moléculaire :475.54CVN766
CAS :CVN766 is an orally active orexin 1 receptor antagonist with blood-brain permeability, demonstrating IC50 values of 8 nM for OX1R and >10 μM for OX2R. CVN766 can be used to study schizophrenia [1].Formule :C20H21F3N8OCouleur et forme :SolidMasse moléculaire :446.43AMG-369
CAS :AMG-369 (AMG 247) is an S1P1/S1P5 dual agonist that delays the development of experimental autoimmune encephalomyelitis in rats.Formule :C26H22FN3O2SDegré de pureté :98.04% - 98.92%Couleur et forme :SolidMasse moléculaire :459.54Sigma-1 receptor antagonist 6
CAS :Sigma-1 receptor antagonist 6 (Compound 12), a σ1R antagonist, demonstrates significant antiallodynic effects by targeting the Sigma-1 receptor (σ1R). This compound is effective in animal models for neuropathic pain, particularly for reducing mechanical allodynia caused by paclitaxel.Formule :C32H34N6Couleur et forme :SolidMasse moléculaire :502.65YM-31636 free base
CAS :YM-31636 (free base) is an orally active, potent, and selective agonist of the 5-HT3 receptor with a pKi value of 9.67. This compound induces contraction in isolated guinea pig distal colon and provokes tachycardia in isolated guinea pig right atrium, demonstrating a relative intrinsic activity of about 0.23. YM-31636 (free base) holds potential for research in constipation management.Formule :C14H11N3SCouleur et forme :SolidMasse moléculaire :253.32RS 12254
CAS :RS 12254 is a dopamine agonist and antihypertensive agent.Formule :C28H40N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.63Pareptide monohydrochloride
CAS :Pareptide monohydrochloride is a metabolically stable analog of melatonin inhibitor (MIF).Formule :C14H27ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :334.84ASP-2205
CAS :ASP-2205, a 5-HT2C receptor agonist (human 5-HT2C receptor, EC50=0.85 nM; rat 5-HT2C receptor, EC50=2.5 nM), enhances the urethral closure reflex mediated by the genital nerve, thereby preventing urinary incontinence.Formule :C19H28N2OCouleur et forme :SolidMasse moléculaire :300.44LRH-1 modulator-1
CAS :LRH-1 modulator-1: potent agonist, boosts IL-10, reduces IL-1b/TNFa, anti-inflammatory in gut.Formule :C28H36N2O2SCouleur et forme :SolidMasse moléculaire :464.66AB-FUBINACA 3-fluorobenzyl isomer
CAS :AB-FUBINACA 3-fluorobenzyl isomer is a synthetic cannabinoid and an indazole derivative, exhibiting high affinity for central CB1 receptors (Ki= 0.9 nM) and possessing anticonvulsant activity.Formule :C20H21FN4O2Couleur et forme :SolidMasse moléculaire :368.41Butopamine hydrochloride
CAS :Butopamine hydrochloride is an orally active inotropic compound that is more effective at increasing heart rate compared to Dobutamine.Formule :C18H24ClNO3Couleur et forme :SolidMasse moléculaire :337.84AChE-IN-5
AChE-IN-5: oral, crosses blood-brain barrier, targets AChE/5-HT1A/SERT, potent with 2.29 nM IC50.Formule :C38H45N5OCouleur et forme :SolidMasse moléculaire :587.8DNA crosslinker 6
CAS :DNA crosslinker 6 (compound 1) is an anti-mitotic agent known for its strong binding affinity to AT-DNA and inhibition of AT-hook 1 binding to DNA (IC50=0.03 µM). Additionally, it exhibits anti-protozoal activity, effectively inhibiting T. brucei with an EC50 of 0.83 µM.Formule :C19H21N7OCouleur et forme :SolidMasse moléculaire :363.42AM11638
CAS :AM11638 is an endogenous cannabinoid analogue that targets cannabinoid receptors (CB1 and CB2 receptors), exhibiting analgesic properties. It shows potential for research in neurological disorders and inflammation-related diseases.Formule :C27H41NO2Couleur et forme :SolidMasse moléculaire :411.62AChE/BChE-IN-21
CAS :AChE/BChE-IN-21 is an antagonist of the histamine H3 receptor, a calcium channel blocker, and an acetylcholinesterase inhibitor. It exhibits neuroprotective activities against H2O2 and Aβ1-40, and can restore cognitive functions in AD mice.Formule :C38H54N4O4Couleur et forme :SolidMasse moléculaire :630.86(+)-15-epi Cloprostenol
CAS :(+)-15-epi Cloprostenol is a synthetic analogue of prostaglandin F2α (PGF2α) and functions as a potent FP receptor agonist. The compound (+)-15-epi Cloprostenol is the 15(S) or 15β-hydroxy enantiomer of (+)-(+)-15-epi Cloprostenol. Compared to the 15(R)-(+)-15-epi Cloprostenol, this epimer exhibits significantly lower activity as an FP receptor ligand. However, the specific activity of this isomer remains inadequately studied.Formule :C22H29ClO6Masse moléculaire :424.92PDE4B/7A-IN-1
CAS :5-HT1A antagonist; Ki=8nM, Kb=0.04nM. PDE4B IC50=80.4μM; PDE7A IC50=151.3μM. Good biofilm penetration, stable, anticognitive, antidepressant.Formule :C25H35N3O3Couleur et forme :SolidMasse moléculaire :425.56Toladryl
CAS :Toladryl is a derivative of Diphenhydramine that can cross the blood-brain barrier and exhibits oral activity, with antihistamine and anticholinergic properties. Its anticholinergic effects are approximately a tenth of those seen with Diphenhydramine, yet it offers 2-4 times the protection against lethal doses of histamine in guinea pigs. The side effects of Toladryl are fewer and milder compared to Diphenhydramine; however, at higher doses, it may cause symptoms such as insomnia, agitation, and disorientation related to the central nervous system. Toladryl is utilized in the research of allergic diseases.Formule :C18H23NOCouleur et forme :SolidMasse moléculaire :269.38Tixanox sodium
CAS :Tixanox sodium effectively blocks histamine release in the lungs triggered by anti-IgE. It has also been demonstrated that when administered orally, Tixanox sodium can successfully counteract exercise-induced asthma.Formule :C15H9NaO5SCouleur et forme :SolidMasse moléculaire :324.288 Hydroxy PIPAT oxalate
CAS :8 Hydroxy PIPAT oxalate is a selective 5-HT1A receptor agonist that enhances the spontaneous release of histamine by promoting the degranulation of mast cells in guinea pig and human intestinal preparations. By activating the serotonin signaling pathway, this compound demonstrates potential in regulating gastrointestinal functions and offers insight into the management and suppression of functional gastrointestinal disorders such as irritable bowel syndrome. Its effects in increasing histamine release could play a crucial role in gastrointestinal regulation.Formule :C18H24INO5Couleur et forme :SolidMasse moléculaire :461.29L 156903
CAS :L 156903 is a bioactive chemical. It also inhibits the binding of neurotensin to brain tissue.Formule :C35H41N7O5SCouleur et forme :SolidMasse moléculaire :671.81BI 639667
CAS :BI 639667, an azaindazole-class compound, potently inhibits CCR1 (IC50=1.8 nM in calcium flux assays).Formule :C22H18FN5O3SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :451.47CCR5 antagonist 1
CAS :CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.Formule :C39H46ClF2N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :738.33Quinagolide Free Base
CAS :Quinagolide Free Base is a non-ergot dopamine D(2)-agonist.Formule :C20H33N3O3SCouleur et forme :SolidMasse moléculaire :395.56SAR-114137
CAS :SAR-114137 is a histone sphingomyelin kinase inhibitor used in the study of molluscum arteriosum and peripheral neuropathic pain.Formule :C25H34N4O7SDegré de pureté :99.09% - 99.91%Couleur et forme :SolidMasse moléculaire :534.6314,15-dehydro Leukotriene B4
CAS :LTB4 is a leukocyte-activating fatty acid via 5-lipoxygenase. Two receptors, BLT1 and BLT2, bind it. 14,15-dehydro LTB4 is a stronger BLT1 antagonist.Formule :C20H30O4Couleur et forme :SolidMasse moléculaire :334.45NPRA agonist-11
CAS :NPRA agonist-11 (Example 161) is an NPRA (NPR1) agonist with AC50 values of 1.681 μM and 0.989 μM for human and monkey, respectively. It is applicable in research on cardiovascular and other diseases.Formule :C37H52FN7O2Couleur et forme :SolidMasse moléculaire :645.85BAY 38-7271
CAS :BAY 38-7271: potent neuroprotective, selective CB1/CB2 agonist, Ki of 1.85 nM (CB1) & 5.96 nM (CB2).Formule :C20H21F3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.44GnRH antagonist 2
CAS :GnRH antagonist 2 is a GnRH receptor antagonist, useful for studying endocrine diseases.Formule :C28H27F2N9O5Degré de pureté :98.08%Couleur et forme :SolidMasse moléculaire :607.57LAS195319
CAS :LAS195319 is a potent and selective inhaled PI3Kδ Inhibitor (IC50 = 0.5 nM) for the Treatment of Respiratory Diseases.Formule :C29H26N10O3SCouleur et forme :SolidMasse moléculaire :594.65Udifitimod
CAS :Udifitimod (BMS-986166) is a potent, selective, and orally active modulator of the S1P1R receptor, showing potential for research in autoimmune diseases.Formule :C25H33NO2Couleur et forme :SolidMasse moléculaire :379.54MRT-92
CAS :MRT-92 is an antagonist of Smoothened (Smo) with anti-cancer activity, featuring a binding affinity (Ki) of 0.7 nM. It inhibits the Hedgehog signaling pathway by obstructing the overlapping binding sites within the transmembrane domain of the Smoothened receptor and suppresses the proliferation of cerebellar granule cells in rodents (IC50=0.4 nM). MRT-92 is utilized for research into cerebellar gliomas.Formule :C33H34N4O5Couleur et forme :SolidMasse moléculaire :566.65Thielavin B
CAS :Thielavin B, from Thielavia terricola, inhibits prostaglandin E2 synthesis and reduces rat oedema.Formule :C31H34O10Couleur et forme :SolidMasse moléculaire :566.6LB-102
CAS :LB-102 is an orally active inhibitor of dopamine D2, D3, and serotonin 5-HT7 receptors, utilized in the study of schizophrenia and other psychiatric disorders.Formule :C18H29N3O4SCouleur et forme :SolidMasse moléculaire :383.51D4R antagonist-1
Potent, selective D4R antagonist; IC50 = 6.87 µM; potential in Parkinson’s disease research.Formule :C21H25F2NO2Couleur et forme :SolidMasse moléculaire :361.43Nedemelteon
CAS :Nedemelteon is an agonist of the melatonin receptor (melatonin receptor).Formule :C15H18N2O2Couleur et forme :SolidMasse moléculaire :258.32O-1269
CAS :O-1269 acts as a partial agonist for the cannabinoid receptor 1 (CB1R), with a binding affinity (Ki) of 32 nM. Additionally, it exhibits analgesic properties.Formule :C22H22Cl3N3OCouleur et forme :SolidMasse moléculaire :450.79H-Glu-Thr-OH
CAS :H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide composed of two amino acids—glutamic acid (Glu) and threonine (Thr)—linked by a peptide bond and functions as an agonist of the extracellular calcium-sensing receptor (CaSR).Formule :C9H16N2O6Couleur et forme :SolidMasse moléculaire :248.23(R)-MrgprX2 antagonist-3
CAS :(R)-MrgprX2 antagonist-3 is an antagonist of MrgprX2. It is applicable in the study of inflammatory skin diseases. For more detailed information, please refer to compound E118 in patent document WO2021092240A1.Formule :C16H20FN3O2SMasse moléculaire :337.41CBR Agonist-1
CBR Agonist-1 targets CB1R and CB2R with Ki of 0.18 μM and 1.22 μM, useful for studying cannabinoid-related diseases.Formule :C27H27FN4OCouleur et forme :SolidMasse moléculaire :442.53AAZ-A 154 hydrobromide
CAS :AAZ-A 154 hydrobromide is a selective, competitive, non-hallucinogenic 5-HT2AR antagonist. It promotes neuronal growth in rodents and yields enduring beneficial behavioral effects.Formule :C14H21BrN2OCouleur et forme :SolidMasse moléculaire :313.23RBM10-8
CAS :RBM10-8 irreversibly inhibits human sphingosine-1- phosphate lyase (hS1PL) while behaving also as an enzyme substrate.Formule :C17H36NO5PCouleur et forme :SolidMasse moléculaire :365.45YM158 free base
CAS :YM158 free base is a potent and selective antagonist of TXA2 and LTD4 receptor (pA2s: about 8.81 and 8.87).Formule :C32H33ClN6O5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :681.225-HT6R/MAO-B modulator 1
5-HT6R/MAO-B modulator 1 blocks 5-HT6R and permanently inhibits MAO-B, protects glial cells, and reverses memory loss.Formule :C33H38N4O3SCouleur et forme :SolidMasse moléculaire :570.74ZD6021
CAS :ZD6021 is an antagonist of neurokinin 1 receptor.Formule :C35H35Cl2N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :632.64Teoprolol
CAS :Teoprolol is a blocker of β-adrenergic receptor.Formule :C23H30N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :454.52PAR-2-IN-2
CAS :PAR-2-IN-2 (compound P-596) is an inhibitor of protease-activated receptor 2 (PAR-2), with an IC50 of 10.79 μM for SLIGKV and an IC50 greater than 200 μM for trypsin.Formule :C25H20F3N5O2Couleur et forme :SolidMasse moléculaire :479.454PF-4693627
CAS :PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM).Formule :C26H29Cl2N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :502.43Burapitant
CAS :<p>Burapitant (SSR 240600) is a novel non-peptide tachykinin neurokinin 1 (NK) receptor antagonist with anti-coke oven and antidepressant activity.</p>Formule :C31H35Cl2F6N3O3Degré de pureté :>99.99% - >99.99%Couleur et forme :SolidMasse moléculaire :682.52S1PR1 agonist 2
CAS :S1PR1 agonist 2 is potent for autoimmune research (from WO2021175225A1).Formule :C25H25N5O4Couleur et forme :SolidMasse moléculaire :459.50BI-685509
CAS :BI-685509: potent, oral sGC activator, boosts cGMP, enhances NO pathways, for CKD/DKD research.Formule :C34H38N4O5Couleur et forme :SolidMasse moléculaire :582.69JKC 302
CAS :JKC 302 is an ET-A receptor antagonist that partially inhibits the contraction of tracheal rings in asthmatic rats induced by ET-1.Formule :C30H42N6O6Couleur et forme :SolidMasse moléculaire :582.69NK1 receptor antagonist 2
CAS :NK1 Receptor Antagonist 2, a compound targeting the NK1 receptor, holds potential for tinnitus and hearing loss research.Formule :C31H35F7N4O2Couleur et forme :SolidMasse moléculaire :628.628-iso Prostaglandin F3α
CAS :8-iso PGF3α is an isoprostane produced from the free-radical peroxidation of EPA.Formule :C20H32O5Couleur et forme :SolidMasse moléculaire :352.47GLP-1 receptor agonist 16
CAS :GLP-1 receptoragonist 16 (Example 53) is a GLP-1 agonist applicable for research in diabetes, obesity, or diseases related to non-alcoholic steatohepatitis.Formule :C33H31ClFN3O4Couleur et forme :SolidMasse moléculaire :588.068CB2 receptor antagonist 1
CAS :Compound 29 is a potent, CB2-selective antagonist/reverse agonist. Derivatives 23 & 24 offer antinociception; 24 activates cannabinoid/TRPV1 receptors.Formule :C28H47NO3Couleur et forme :SolidMasse moléculaire :445.68ONO-8809
CAS :ONO-8809: Thromboxane A2 antagonist, reduces airway hyperresponse, macrophage accumulation, and MMP-9 in SHRSP brains.Formule :C30H46BrNO4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :596.669-Methyl-β-carboline
CAS :9-Methyl-β-carboline is a cognitive enhancer with neuroprotective, neurorestorative, and anti-inflammatory properties. Its behavioral effects may be linked to hippocampal dopamine levels and the stimulation of dendritic and synaptic proliferation.Formule :C12H10N2Couleur et forme :SolidMasse moléculaire :182.221M1069
M1069 is an oral A2A/A2B receptor antagonist, 100x more selective over A1/A3, with antitumor properties by blocking adenosine's immunosuppressive effects.Formule :C25H30N4O8SCouleur et forme :SolidMasse moléculaire :546.59PSB 36
CAS :A1 adenosine receptor antagonistFormule :C21H30N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :386.49H3R antagonist 2
Compound 23: H3R antagonist with 170 nM Ki; inhibits AChE, BChE, hMAO B; IC50s: 180, 880, 775 nM; anti-pain, memory boost; crosses BBB. [1]Formule :C24H29NO3Couleur et forme :SolidMasse moléculaire :379.49ADORA2A/PDE4D-IN-1
CAS :ADORA2A/PDE4D-IN-1 (Compound 9) is a dual inhibitor of the adenosine A2a receptor (ADORA2A) and phosphodiesterase 4D (PDE4D). This compound is applicable for research in bronchial asthma.Formule :C14H11N5Couleur et forme :SolidMasse moléculaire :249.271BMS-986120
CAS :BMS-986120: Oral, reversible PAR4 antagonist. IC50: 9.5 nM (human), 2.1 nM (monkey). Potent, selective antiplatelet.Formule :C23H23N5O5S2Couleur et forme :SolidMasse moléculaire :513.59BIIE-0246 HCl
CAS :BIIE-0246: A potent, non-peptide Y2 receptor antagonist; >650-fold more selective than Y1, Y4, Y5.Formule :C49H59Cl2N11O6Couleur et forme :SolidMasse moléculaire :968.97MF-592
CAS :MF-592: EP4 receptor antagonist, hEP4 IC50 3 nM, hWB IC50 78 nM, great oral PK, rat arthritis ED50 0.1 mg/kg/day, promising for development.Formule :C34H33Cl2N3O6SCouleur et forme :SolidMasse moléculaire :682.61LY 245769
CAS :LY 245769 is an inhibitor of leukotriene E4 (LTE4).Formule :C25H33F3N8OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :550.64LP 12 hydrochloride hydrate
LP 12 hydrochloride hydrate: potent, selective 5-HT7 agonist (Ki: 0.13 nM); less affinity for D2, 5-HT1A/2A receptors.Formule :C32H39N3O·HCl·xH2OCouleur et forme :SolidMRS2279
CAS :Selective, high affinity competitive antagonist of the P2Y1 receptorFormule :C13H18ClN5O8P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.71AM9405
AM9405: peripheral CB1/5-HT3 agonist, suppresses gut motility, relieves GI disorder symptoms in mice.Formule :C24H33BrN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.44Rivenprost
CAS :Rivenprost, selective EP4 agonist (Ki: 0.7 nM), promotes bone growth, osteoblast differentiation, and aids wound healing.Formule :C24H34O6SCouleur et forme :SolidMasse moléculaire :450.59SSR 146977
CAS :NK3 receptor antagonistFormule :C35H42Cl2N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :621.64GnRH-R antagonist 1
CAS :Compound 21a: Oral GnRH-R antagonist, IC50=0.57 nM, potent against prostate cancer/prevents LH surges.Formule :C31H28F5N7O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :721.65Apafant
CAS :Apafant (WEB 2086) is a PAF antagonist that blocks eosinophil activation and can be used to study experimental allergic conjunctivitis in guinea pigs.Formule :C22H22ClN5O2SDegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :455.96RF9 hydrochloride
RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist that acts on hNPFF1R (Ki: 58 nM) and hNPFF2R (Ki: 7 nM).Formule :C26H39ClN6O3Couleur et forme :SolidMasse moléculaire :519.0816(S)-Iloprost
CAS :Iloprost, a potent prostacyclin analog, binds to human IP & EP1 receptors with high affinity; inhibits platelet aggregation effectively.Formule :C22H32O4Couleur et forme :SolidMasse moléculaire :360.49CB1/2 agonist 1
Potent CB1/2 agonist 1; crosses blood-brain barrier; anti-inflammatory, analgesic; for multiple sclerosis research.Formule :C21H24BrFN2O2Couleur et forme :SolidMasse moléculaire :435.33NK-1 Antagonist 1
CAS :NK-1 Antagonist 1 is a NK-1 receptor antagonist.Formule :C25H23F6N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :539.47VU0514009
CAS :VU0514009 is a competitive antagonist of chemokine-like receptor 1 (CMKLR1) with an EC50 of 2 nM. It effectively inhibits chemerin-9-induced arrestin recruitment and receptor internalization, significantly reducing Ca2+ flux responses in HEK293 cells. This compound shows potential for research in inflammatory diseases and metabolic syndrome.Formule :C21H20ClN3O5S2Couleur et forme :SolidMasse moléculaire :493.98WIN 66306
CAS :WIN 66306: Cyclic heptapeptide, blocks NK1/NK2 receptors, inhibits substance P-triggered contractions in guinea pig ileum.Formule :C41H52N8O9Couleur et forme :SolidMasse moléculaire :800.9NPR-C activator 1
CAS :NPR-C activator 1 is an activator of the natriuretic peptide receptor C (NPR-C), which can be used to study cardiovascular diseases.Formule :C18H24N6O3Degré de pureté :98.74%Couleur et forme :SolidMasse moléculaire :372.42Monlunabant
CAS :Monlunabant ((S)-MRI-1891), a solid dispersion compound, functions as an inhibitor of the cannabinoid CB1 receptor [1].Formule :C26H22ClF3N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :591.00(Rac)-Nebivolol
CAS :(Rac)-Nebivolol, a racemic β1-adrenergic blocker (IC50=0.8 nM), has vasodilatory properties and mitigates ethanol-induced cardiac harm.Formule :C22H25F2NO4Couleur et forme :SolidMasse moléculaire :405.43Ici D1542
CAS :Ici D1542: potent TXS inhibitor & TXA2 receptor antagonist, effective thromboxane blocker in vitro.Formule :C25H30N2O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :470.515-HT7R antagonist 1
5-HT7R antagonist 1 is a G protein-biased antagonist with Ki of 6.5 nM for 5-HT 7R.Formule :C14H18Cl2N4Couleur et forme :SolidMasse moléculaire :313.23Macitentan (n-butyl analogue)
CAS :Macitentan n-butyl analogue, an oral ETA/ETB receptor blocker, may treat IPF and PAH.Formule :C20H21Br2N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :587.29Orvepitant
CAS :Orvepitant is a potent and selective NK1 antagonist, which may be potentially useful for patients with major depressive disorder (MDD), anxiety and insomnia.Formule :C31H35F7N4O2Couleur et forme :SolidMasse moléculaire :628.62U92016A hydrochloride
CAS :U92016A hydrochloride: potent, orally active 5-HT1A agonist, metabolically stable, high intrinsic activity, Ki=0.2 nM.Formule :C19H26ClN3Couleur et forme :SolidMasse moléculaire :331.89ONO-9780307
CAS :ONO-9780307 is a specific antagonist of LPA1 (lysophosphatidic acid receptor 1) (IC50: 2.7 nM).Formule :C30H35NO7Couleur et forme :SolidMasse moléculaire :521.6Terguride
CAS :Terguride: treats hyperprolactinemia, blocks 5-HT2A/B, activates dopamine receptors, studied for PAH.Formule :C20H28N4OCouleur et forme :SolidMasse moléculaire :340.46Fasitibant
CAS :Fasitibant is a potent and selective nonpeptide kinin B2 receptor antagonist.Formule :C36H49Cl2N6O6SCouleur et forme :SolidMasse moléculaire :764.78CP-608039
CAS :CP-608039 is a selective adenosine A3 receptor agonist for both human A3 and human A1 receptors.Formule :C23H25ClN8O5Couleur et forme :SolidMasse moléculaire :528.95GLP-1R agonist 8
CAS :GLP-1R agonist 8 is a potent agonist of GLP-1R (EC50 < 2 nM).Formule :C33H32N4O5Couleur et forme :SolidMasse moléculaire :564.63S1PR1 agonist 1
CAS :<p>S1PR1 agonist 1 is a potent agonist of S1PR1. S1PR1 agonist 1 has potential in autoimmune diseases.</p>Formule :C29H30N4O4Couleur et forme :SolidMasse moléculaire :498.57Taranabant
CAS :Taranabant: potent CB1 receptor inverse agonist; inhibits agonists with 0.13 nM Ki in vitro.Formule :C27H25ClF3N3O2Degré de pureté :99.06% - 99.06%Couleur et forme :SolidMasse moléculaire :515.96NMDAR antagonist 5
CAS :NMDAR antagonist 5 (Compound A17) is a multi-target antagonist that acts on NMDAR and monoamine transporters (SERT, DAT, and NET). It demonstrates strong NMDAR antagonistic efficacy (IC50= 0.3 μM) and effective activity on monoamine transporters (SERT IC50= 1.1 μM, DAT IC50= 0.7 μM, NET IC50= 2.7 μM). NMDAR antagonist 5 exhibits high safety with low toxicity (hepatic and renal toxicity IC50> 100 μM; cardiac toxicity IC50= 24.5 μM). It has antidepressant properties and is useful for depression research.Formule :C17H21N3Couleur et forme :SolidMasse moléculaire :267.369A1AR antagonist 1
Compound 18g, a potent A1AR blocker with Ki: 2.08 nM (hA1), 6.91 nM (hA2A), 31.2 nM (hA2B).Formule :C18H14N4OCouleur et forme :SolidMasse moléculaire :302.33AL 8810
CAS :AL-8810 is an 11β-fluoro analog of PGF 2α with selective antagonist effects at the PGF 2α receptor (FP receptor) [1].Formule :C24H31FO4Couleur et forme :SolidMasse moléculaire :402.5Mesulergine hydrochloride
CAS :5-HT2A and 2C receptor antagonistFormule :C18H27ClN4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.95ZK118182 isopropyl ester
CAS :ZK118182 isopropyl ester is a PG analog with potent DP-agonist activity (EC50 = 16.5 nM) and high affinity for the DP receptor (Ki = 74 nM).Formule :C23H37ClO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.99CCR1 antagonist 11 hydrochloride
Oral CCR1 antagonist A1B1 targets h/m/rCCR1 (IC50: 0.03/0.58/0.32 μM), potential for treating inflammatory diseases.Couleur et forme :SolidProtease-Activated Receptor-1 antagonist 2
Selective, orally active PAR-1 antagonist with an IC50 of 7 nM, potential for cardiovascular disease studies.Couleur et forme :SolidRG-15
CAS :RG-15 is an orally active dopamine receptor antagonist with high affinity for the human D2 receptor (pKi of 8.23) and human D3 receptor (pKi of 10.49). It inhibits dopamine-stimulated [35S]GTPγS binding with IC50 values of 21.2 nM in rat striatal membranes, 36.7 nM in mouse A9 cells expressing human D2L receptors, and 7.2 nM in CHO cells expressing human D3 receptors. RG-15 enhances dopamine turnover and synthesis in the striatum and olfactory bulb of mice, exhibiting antipsychotic activity.Formule :C25H32Cl2F3N5O2SCouleur et forme :SolidMasse moléculaire :594.52Leukotriene B4 dimethyl amide
CAS :LTB4 dimethyl amide: inhibits human neutrophil degranulation and rat lysozyme release; antagonizes LTB4 receptor on guinea pig lung membranes (Ki = 130 nM).Formule :C22H37NO3Couleur et forme :SolidMasse moléculaire :363.53D4R antagonis-2
Potent D4R antagonist-2: selective, IC50=6.52 μM, good in vitro PK and brain penetration, potential for Parkinson's research.Formule :C21H23ClF2N2O2Couleur et forme :SolidMasse moléculaire :408.87A2A receptor antagonist 2
A2A receptor antagonist 2 is a highly selective and potent antagonist of the adenosine A2Areceptor (IC50: 8.3 nM).Formule :C25H28FN7O3Couleur et forme :SolidMasse moléculaire :493.53Abarelix acetate
CAS :Abarelix acetate: synthetic GnRHR antagonist, spikes histamine, lowers LH and testosterone temporarily, used in advanced prostate cancer.Formule :C72H95ClN14O14·xC2H4O2Couleur et forme :SolidMasse moléculaire :1476.14U75302
CAS :U75302 is an antagonist of thymosin beta-4 (TB4) receptor with a Ki value of 159 nM on guinea pig lung membranes.Formule :C22H35NO3Degré de pureté :98%Couleur et forme :Light Yellow OilMasse moléculaire :361.52MCTR1
CAS :MCTR1, a pro-resolving mediator derived from DHA, promotes tissue repair and reduces inflammation by enhancing phagocytosis and decreasing eicosanoids.Formule :C32H47N3O9SCouleur et forme :SolidMasse moléculaire :649.8CI-936
CAS :CI-936 (MRS-3310) is an orally active A2 agonist with a binding affinity of 25 nM. In preclinical studies, it has demonstrated potent and selective effects, indicating potential antipsychotic efficacy. Additionally, CI-936 inhibits exploratory behavior in mice.Formule :C24H25N5O4Couleur et forme :SolidMasse moléculaire :447.49CI-624
CAS :CI-624 reduces the secretion and output of hydrogen ions, sodium ions, potassium ions, and pepsin. This compound may be utilized in research focusing on cancer and autoimmune diseases.Formule :C8H8N2SCouleur et forme :SolidMasse moléculaire :164.228AFP-07 free acid
CAS :AFP 07 free acid is a 7,7-difluoroprostacyclin derivative. It also acts as a selective and highly potent agonist for the IP receptor.Formule :C22H30F2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :412.47
