GPCR/G-Protéine
Les inhibiteurs des GPCR/protéines G sont des composés qui ciblent les récepteurs couplés aux protéines G (GPCR) et les protéines G associées, qui jouent un rôle crucial dans la transmission des signaux de l'extérieur vers l'intérieur des cellules. Ces inhibiteurs sont essentiels pour étudier les voies de signalisation médiées par les GPCR, impliquées dans de nombreux processus physiologiques, y compris la perception sensorielle, la réponse immunitaire et la neurotransmission. Les inhibiteurs des GPCR sont également importants dans le développement de médicaments, car de nombreux agents thérapeutiques ciblent ces récepteurs. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de GPCR/protéines G de haute qualité pour soutenir vos recherches en pharmacologie, biologie cellulaire et domaines connexes.
Sous-catégories appartenant à la catégorie "GPCR/G-Protéine"
- récepteur 5-HT(1.025 produits)
- Récepteur d'adénosine(249 produits)
- Récepteur adrénergique(3.030 produits)
- Récepteur de la bombésine(35 produits)
- Récepteur de la bradykinine(61 produits)
- CXCR(159 produits)
- CaSR(34 produits)
- Récepteur cannabinoïde(217 produits)
- Cholécystokinine(1 produits)
- Récepteur de la dopamine(445 produits)
- Récepteur de l'endothéline(86 produits)
- Récepteur GNRH(84 produits)
- GPCR19(33 produits)
- GRK(33 produits)
- GTPase(22 produits)
- Récepteur du glucagon(196 produits)
- Hérisson/Smoothened(49 produits)
- Récepteur de l'histamine(385 produits)
- Récepteur LPA(21 produits)
- Récepteur de la mélatonine(26 produits)
- Récepteur OX(42 produits)
- Récepteur opioïde(325 produits)
- PAFR(14 produits)
- PKA(55 produits)
- Récepteur S1P(17 produits)
- SGLT(31 produits)
- Récepteur Sigma(46 produits)
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5985 produits trouvés pour "GPCR/G-Protéine"
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(+)-15-epi Cloprostenol
CAS :(+)-15-epi Cloprostenol is a synthetic analogue of prostaglandin F2α (PGF2α) and functions as a potent FP receptor agonist. The compound (+)-15-epi Cloprostenol is the 15(S) or 15β-hydroxy enantiomer of (+)-(+)-15-epi Cloprostenol. Compared to the 15(R)-(+)-15-epi Cloprostenol, this epimer exhibits significantly lower activity as an FP receptor ligand. However, the specific activity of this isomer remains inadequately studied.Formule :C22H29ClO6Masse moléculaire :424.92Aplaviroc hydrochloride
CAS :Aplaviroc, a potent CCR5 inhibitor, binds selectively, blocking HIV entry and specific monoclonal antibody attachment in vitro.Formule :C33H44ClN3O6Couleur et forme :SolidMasse moléculaire :614.17L-365260 hemihydrate
L-365260 hemihydrate: selective oral CCK-B/gastrin blocker, Ki=1.9/2.0 nM, competes with guinea pig receptors.Formule :C24H24N4O3Couleur et forme :SolidMasse moléculaire :407.47Nedocromil sodium
CAS :Nedocromil sodium is a pharmacologic stabilizer of mast cells, has been shown to normalize cytokine levels and attenuate cardiac remodeling.Formule :C19H17NNaO7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.335GLP-1 receptor agonist 15
CAS :GLP-1 receptor agonist 15 (Example 4) is a GLP receptor agonist with an EC50 of 0.74 nM. It exhibits an IC50 of 10.1 μM against the hERG potassium ion channel. This compound is applicable for research in the diabetes field.Formule :C32H31ClFN3O5Couleur et forme :SolidMasse moléculaire :592.057Apafant
CAS :Apafant (WEB 2086) is a PAF antagonist that blocks eosinophil activation and can be used to study experimental allergic conjunctivitis in guinea pigs.Formule :C22H22ClN5O2SDegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :455.96LRH-1 modulator-1
CAS :LRH-1 modulator-1: potent agonist, boosts IL-10, reduces IL-1b/TNFa, anti-inflammatory in gut.Formule :C28H36N2O2SCouleur et forme :SolidMasse moléculaire :464.66Zafirlukast metabolite M1
CAS :Zafirlukast metabolite M1 (compound 15) is an inhibitor used in the treatment of asthma and other allergic pulmonary conditions, effectively antagonizing leukotriene activity.Formule :C25H25N3O4SCouleur et forme :SolidMasse moléculaire :463.54916(R)-Iloprost
CAS :Iloprost, a potent prostacyclin analog, binds IP & EP1 receptors (Ki 11 nM), contains 16(S/R) isomers, and inhibits platelets (IC50 65 nM).Formule :C22H32O4Couleur et forme :SolidMasse moléculaire :360.49Enprostil
CAS :Enprostil: synthetic PGE2 analog, reduces gastric acid, protects mucosa, lowers post-meal gastrin, treats ulcers effectively and safely.Formule :C23H28O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :400.46GLP-1R agonist 33
CAS :GLP-1R agonist 33 (Compound 224) is a GLP-1 receptor agonist with potential applications in research related to diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD).Formule :C30H27FN6O4Couleur et forme :SolidMasse moléculaire :554.57BIBO3304 diTFA
CAS :BIBO3304 (diTFA), a selective neuropeptide Y (NPY) Y1 receptor antagonist, demonstrates oral efficacy. It exhibits high affinity for Y1 receptors in both humans and rats, with IC50 values of 0.38 nM and 0.72 nM, respectively. Additionally, BIBO3304 (diTFA) enhances bone-tendon healing via the Wnt/β-catenin signaling pathway [1] [2] [3].Formule :C33H37F6N7O7Couleur et forme :SolidMasse moléculaire :757.68BI 703704
CAS :BI 703704, a soluble guanylate cyclase (sGC) activator, inhibits the progression of diabetic nephropathy in the ZSF1 rat [1].Formule :C32H37N3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :559.725-HT2A receptor agonist-8
CAS :5-HT2A receptor agonist-8 (compound 8) is a potent 5-HT2A receptor agonist with an EC50 of 0.6784 nM. It is suitable for research related to depression and bipolar disorder.Formule :C22H27N3OCouleur et forme :SolidMasse moléculaire :349.47PGDM
CAS :PGD2 is involved in allergy, asthma, sleep, temperature regulation, inhibits clotting, and relaxes blood vessels; PGDM, its metabolite, is a biomarker.Formule :C16H24O7Couleur et forme :SolidMasse moléculaire :328.36Sulprostone
CAS :EP3 and EP1 receptor agonistFormule :C23H31NO7SDegré de pureté :98%Couleur et forme :White To Off-White SolidMasse moléculaire :465.56P2Y14R antagonist 4
CAS :Compound 25l, also known as P2Y14R antagonist 4, is an orally active antagonist of the P2Y14R receptor with an IC50 of 5.6 nM. It exhibits higher binding affinity for P2Y14R compared to other PPTN receptors. P2Y14R antagonist 4 also possesses anti-inflammatory properties, reducing the release of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) induced by LPS.Formule :C27H27F3N2O4SCouleur et forme :SolidMasse moléculaire :532.574SR 142948-C3-NHMe
CAS :<p>SR 142948-C3-NHMe is the methylated form of SR 142948.</p>Formule :C42H58N6O6Couleur et forme :SolidMasse moléculaire :742.946GLP-1R agonist 8
CAS :GLP-1R agonist 8 is a potent agonist of GLP-1R (EC50 < 2 nM).Formule :C33H32N4O5Couleur et forme :SolidMasse moléculaire :564.63L-657926
CAS :L-657926 is a stereoselective antagonist of the thromboxane A2 (TxA2) receptor, composed of (-)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid and (+)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid. The IC50 values for the (-) and (+) configurations against TxA2 are 0.27 nM and 124 nM, respectively.Formule :C21H19ClFNO2Couleur et forme :SolidMasse moléculaire :371.832EP-3945
CAS :EP-3945 is an agonist of Mas-related G protein-coupled receptors (MRGPR), exhibiting greater potency than the small molecule agonist β-Alanine targeting MRGPRD. MRGPRs play a crucial role in inflammatory itch and pain perception. These receptors interact with Gq (MRGPRX2, MRGPRX4, and MRGPRX1 are coupled with Gq; MRGPRX2 and MRGPRD couple with Gi), with EP-3945 having an EC50 value of 211.6 nM for Gq.Formule :C24H26N4O3Couleur et forme :SolidMasse moléculaire :418.488CP-865569
CAS :CP-865569 is a CCR1 antagonist useful in the research of inflammatory and autoimmune diseases, including conditions such as rheumatoid arthritis and multiple sclerosis.Formule :C22H26ClFN2O5SCouleur et forme :SolidMasse moléculaire :484.969(E/Z)-Ozagrel sodium
CAS :(E/Z)-Ozagrel (sodium) [(E/Z)-OKY-046 (sodium)] is a mixture of the EZ isomers of Ozagrel (sodium). It acts as a thromboxane A2 (TXA2) synthase inhibitor. As an antiplatelet agent, Ozagrel (sodium) selectively inhibits human platelet aggregation, with an IC50 of 53.12 μM.Formule :C13H11N2NaO2Couleur et forme :SolidMasse moléculaire :250.228Bzo-poxizid
CAS :Bzo-poxizid is a synthetic cannabinoid and a psychoactive substance.Formule :C20H21N3O2Couleur et forme :SolidMasse moléculaire :335.40Atumelnant
CAS :Atumelnant (CRN04894) is an MC2R antagonist used in the study of congenital adrenocortical hyperplasia (CAH) and Cushing's disease (CD).Formule :C33H42F3N5O3Degré de pureté :98.41%Couleur et forme :SolidMasse moléculaire :613.71NMDAR antagonist 5
CAS :NMDAR antagonist 5 (Compound A17) is a multi-target antagonist that acts on NMDAR and monoamine transporters (SERT, DAT, and NET). It demonstrates strong NMDAR antagonistic efficacy (IC50= 0.3 μM) and effective activity on monoamine transporters (SERT IC50= 1.1 μM, DAT IC50= 0.7 μM, NET IC50= 2.7 μM). NMDAR antagonist 5 exhibits high safety with low toxicity (hepatic and renal toxicity IC50> 100 μM; cardiac toxicity IC50= 24.5 μM). It has antidepressant properties and is useful for depression research.Formule :C17H21N3Couleur et forme :SolidMasse moléculaire :267.369Befiradol hydrochloride
CAS :<p>Befiradol HCl (NLX-112) is a selective 5-HT1A receptor agonist with anxiolytic effects and prevents ATXN3 aggregation.</p>Formule :C20H23Cl2F2N3ODegré de pureté :99.1%Couleur et forme :SolidMasse moléculaire :430.32SSTR5 antagonist 2 hydrochloride
SSTR5 antagonist 2 hydrochloride: potent, oral SSTR5 blocker with potential in type 2 diabetes research.Formule :C32H36ClFN2O5Couleur et forme :SolidMasse moléculaire :583.09LK 11
CAS :LK-11, an alkaloid derivative, inhibits the passive uptake of norepinephrine (NA) by synaptic vesicles in the thalamus, similarly to cocaine.Formule :C15H26N2O3Couleur et forme :SolidMasse moléculaire :282.38L-796778 acetate
CAS :L-796778 acetate is a selective sst3 receptor agonist. In CHO-K1 cells expressing hsst3 receptors, it acts as a partial agonist that inhibits Forskolin-induced cAMP production, with an IC50 value of 18 nM. Additionally, L-796778 acetate exhibits anticonvulsant properties.Formule :C31H44N6O9Couleur et forme :SolidMasse moléculaire :644.716VA012
CAS :VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.Formule :C21H19N3Couleur et forme :SolidMasse moléculaire :313.40UTPγS trisodium salt
CAS :P2Y2 and P2Y4 receptor agonistFormule :C9H12N2Na3O14P3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :566.15Beloxepin
CAS :Beloxepin is an oral dual selective inhibitor of serotonin and norepinephrine uptake.Formule :C19H21NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :295.38GRPR antagonist-2
GRPR antagonist-2 blocks GRPR, kills some cancer cells, effective on HGC-27 (IC50: 0.77 μM) & Pan02 (IC50: 2.5 μM).Formule :C28H32F3N5O4Couleur et forme :SolidMasse moléculaire :559.58AL 8810
CAS :AL-8810 is an 11β-fluoro analog of PGF 2α with selective antagonist effects at the PGF 2α receptor (FP receptor) [1].Formule :C24H31FO4Couleur et forme :SolidMasse moléculaire :402.5ZK118182 isopropyl ester
CAS :ZK118182 isopropyl ester is a PG analog with potent DP-agonist activity (EC50 = 16.5 nM) and high affinity for the DP receptor (Ki = 74 nM).Formule :C23H37ClO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.99D4R antagonis-2
Potent D4R antagonist-2: selective, IC50=6.52 μM, good in vitro PK and brain penetration, potential for Parkinson's research.Formule :C21H23ClF2N2O2Couleur et forme :SolidMasse moléculaire :408.87Avitriptan
CAS :Avitriptan is a 5-HT1B/1D receptor agonist with pKi values of 7.44 for 5-HT1Brat, 7.68 for 5-HT1Bhuman, and 8.36 for 5-HT1Dhuman. It can induce contraction in isolated coronary arteries and is used for the treatment of migraines.Formule :C22H30N6O3SMasse moléculaire :458.577N-methyl Leukotriene C4
CAS :N-methyl LTC4 is a stable synthetic analog of LTC4 and a selective CysLT2 agonist, useful in studying leukotriene pharmacology.Formule :C31H49N3O9SCouleur et forme :SolidMasse moléculaire :639.85-HT1A modulator 4
CAS :5-HT1A modulator 4 (Compound 1) is a ligand for the 5-HT receptor, with Ki values of 2.18 μM for 5-HT1A and 19.7 μM for 5-HT2A.Formule :C9H14N4Couleur et forme :SolidMasse moléculaire :178.234NCATS-SM4420
CAS :NCATS-SM4420 (Compound A35) is an orally effective ligand for the thyroid-stimulating hormone receptor (TSHR) that inhibits the proliferation of MDA-T32 and MDA-T85 cells both in vitro and in vivo, with IC50 values of 0.71 μM and 0.38 μM, respectively. Additionally, it suppresses the metastasis of MDA-T85F1 in mice. NCATS-SM4420 holds potential for research in the field of thyroid cancer.Formule :C31H27N3O5Couleur et forme :SolidMasse moléculaire :521.56ASN-1377642
CAS :ASN-1377642 is an NK1 receptor antagonist with a Ki value of 251 nM. It demonstrates antitumor activity in breast cancer cells with high expression of NK1R-Tr.Formule :C21H16ClN5OSCouleur et forme :SolidMasse moléculaire :421.90CCR4 antagonist 2
CAS :CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits TregFormule :C26H28Cl2N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :511.45Abarelix acetate
CAS :Abarelix acetate: synthetic GnRHR antagonist, spikes histamine, lowers LH and testosterone temporarily, used in advanced prostate cancer.Formule :C72H95ClN14O14·xC2H4O2Couleur et forme :SolidMasse moléculaire :1476.14TAK-637
CAS :TAK-637 is a tachykinin 1 (NK1) receptor antagonist.Formule :C30H25F6N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :573.53CCR5 antagonist 1
CAS :CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.Formule :C39H46ClF2N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :738.33APJ receptor agonist 8
CAS :<p>APJ receptor agonist 8 is a small molecule agonist of the APJ receptor, enhancing load-independent cardiac contractility in isolated perfused rat hearts.</p>Formule :C24H27N7O5SDegré de pureté :98.31% - 99.60%Couleur et forme :SolidMasse moléculaire :525.58SB 224289
CAS :SB 224289: selective 5-HT1B antagonist, pKi 8.2, 60x selectivity, effective orally.Formule :C32H32N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :520.62CGRP antagonist 7
CAS :CGRP antagonist 7 is a potent calcitonin gene-related peptide receptor (CGRP) antagonist with a Ki value of 0.029 nM. It effectively inhibits CGRP receptor-mediated cyclic adenosine monophosphate (cAMP) production, with an IC50 value of 1.5 nM. This compound is useful in migraine research.Formule :C30H32FN5O3Couleur et forme :SolidMasse moléculaire :529.61Lp(a)-IN-8
CAS :LPA2 antagonist 3 (compound 15) serves as an Lp(a) antagonist. Lp(a) is a pathogenic risk factor for atherosclerotic cardiovascular disease (ASCVD).Formule :C21H40Cl2N4O5Couleur et forme :SolidMasse moléculaire :499.472Spns2-IN-3
CAS :Spns2-IN-3 (compound 510) is an SPNS2 inhibitor with an IC50 value of 1.2 μM for hSPNS2. It is applicable in research on autoimmune diseases such as multiple sclerosis (MS) and inflammatory bowel disease (IBD), as well as fibrosis, muscle atrophy, metastasis, acute lung injury, rheumatoid arthritis, colitis, Alzheimer's disease, and other conditions linked to SPNS2 activity.Formule :C25H25F5N4O3Couleur et forme :SolidMasse moléculaire :524.485-HT6/5-HT2AR antagonist-1
Potent 5-HT6/5-HT2A receptors dual antagonist with K i of 11 nM & 39 nM.Formule :C21H26N6SCouleur et forme :SolidMasse moléculaire :394.54BD-1047
CAS :BD-1047 is a selective functional antagonist of sigma receptors. It can alleviate climbing behavior induced by Apomorphine and head twitching caused by Phencyclidine.Formule :C13H20Cl2N2Couleur et forme :SolidMasse moléculaire :275.217GLP-1 receptor agonist 12
CAS :Compound 20A, known as GLP-1 receptor agonist 12, acts as an agonist of the GLP receptor. It is utilized in researching diseases like diabetes [1].Formule :C31H31FN6O4Masse moléculaire :570.61AA 497 (Free Base)
CAS :AA 497, a beta-2 agonist, causes relaxation and suppresses Ca spike frequency.Formule :C14H21NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :251.32BAY-3153
CAS :BAY-3153 is a selective CCR1 ( C-C motif chemokine receptor 1 ) antagonist (human IC 50 =3 nM ; rat IC 50 =11 nM ; mice IC 50 =81 nM) .Formule :C25H29Cl2N3O4Couleur et forme :SolidMasse moléculaire :506.42(2R,3S)-Azelaprag
CAS :(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide is an Apelin receptor agonistFormule :C25H29N7O4SDegré de pureté :97.47% - >99.99%Couleur et forme :SoildMasse moléculaire :523.61PD 135158
CAS :PD 135158 is a CCK2 receptor antagonist.Formule :C42H61N5O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :811.96Burapitant
CAS :<p>Burapitant (SSR 240600) is a novel non-peptide tachykinin neurokinin 1 (NK) receptor antagonist with anti-coke oven and antidepressant activity.</p>Formule :C31H35Cl2F6N3O3Degré de pureté :>99.99% - >99.99%Couleur et forme :SolidMasse moléculaire :682.52MRGPRX2 modulator-3
CAS :MRGPRX2 modulator-3 (Compound 4-400) is a quinoline derivative and an MRGPRX2 regulator. It is utilized in the investigation of MRGPRX2-related conditions, including allergies, itching, pain, inflammation, and autoimmune diseases.Formule :C21H21ClF3N5OCouleur et forme :SolidMasse moléculaire :451.87SJPYT-310
CAS :SJPYT-310 is a selective PXR antagonist, exhibiting no noticeable cytotoxicity.Formule :C27H36N4O3Couleur et forme :SolidMasse moléculaire :464.6GPR183 inverse agonist-1
CAS :GPR183 inverse agonist-1 (Compound 78) is an inverse agonist of GPR183. It inhibits GPR183-mediated Gi activation and β-arrestin2 recruitment while blocking PBMC migration. This compound is utilized in research concerning inflammation, autoimmune, and cancer-related diseases.Formule :C20H20BrN5O2Couleur et forme :SolidMasse moléculaire :442.31MSX-3
CAS :MSX-3 is an antagonist of the A2A adenosine receptor and a prodrug of MSX-2.Formule :C21H23N4Na2O7PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :520.389Ac-Atovaquone
CAS :Ac-Atovaquone, an ester-acetylated derivative of atovaquone, acts as a potent inhibitor of cytochrome bc1 (cytochrome bc1). This compound shows potential for use in malaria research.Formule :C24H21ClO4Couleur et forme :SolidMasse moléculaire :408.87Ici D1542
CAS :Ici D1542: potent TXS inhibitor & TXA2 receptor antagonist, effective thromboxane blocker in vitro.Formule :C25H30N2O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :470.51LK-732
CAS :LK-732 is a thrombin inhibitor with antithrombotic activity. It exhibits dose-dependent inhibition in models of hypercoagulability, with an IC50 value of 1.3 mg/kg. LK-732 is used in cardiovascular and cerebrovascular research.Formule :C25H29N5O3SCouleur et forme :SolidMasse moléculaire :479.59YGZ-331
CAS :YGZ-331, a sedative hypnotic, acts by elevating GABA levels as a derivative of the adenosine nucleoside NGBA. It functions through activating A1R and A2aR, and inhibiting the phosphorylation of CaMKII (pCaMKII), thereby exerting its calming effects. Additionally, YGZ-331 reduces spontaneous motor activity in mice.Formule :C19H23N5O4Couleur et forme :SolidMasse moléculaire :385.42LPA2 antagonist 6
CAS :LPA2 antagonist 6 (example 2) acts as an antagonist of Lp(a). It inhibits the formation of Lp(a) with an IC50 value of 2.33 nM, making it useful for cardiovascular disease research.Formule :C26H34Cl2N2O6Couleur et forme :SolidMasse moléculaire :541.464OX2R agonist 1
CAS :OX2R agonist 1 is an OX2R activator with an EC50 of less than 100 nM. It is utilized in research related to narcolepsy and cataplexy.Formule :C21H28F2N2O5SCouleur et forme :SolidMasse moléculaire :458.52SSR 146977 hydrochloride
CAS :SSR 146977 hydrochloride is a potent, selective antagonist of the tachykinin NK 3 receptor, and it can be utilized in research on psychiatric disorders and airway inflammation [1].Formule :C35H43Cl3N4O2Masse moléculaire :658.1CP-481715
CAS :CP 481715 is an effective selective CCR1 antagonist with potential therapeutic significance for inflammatory diseases.Formule :C26H31FN4O4Couleur et forme :SolidMasse moléculaire :482.55YM-31636 free base
CAS :YM-31636 (free base) is an orally active, potent, and selective agonist of the 5-HT3 receptor with a pKi value of 9.67. This compound induces contraction in isolated guinea pig distal colon and provokes tachycardia in isolated guinea pig right atrium, demonstrating a relative intrinsic activity of about 0.23. YM-31636 (free base) holds potential for research in constipation management.Formule :C14H11N3SCouleur et forme :SolidMasse moléculaire :253.32R-96544 hydrochloride
CAS :5-HT2 receptor antagonistFormule :C22H29NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.47Ophiobolin C
CAS :inhibitor of human CCR5 binding to HIV-1 gp120Formule :C25H38O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :386.57Protease-Activated Receptor-1 antagonist 1
Compound 13 is a PAR-1 antagonist with a 3 nM IC50, useful for thrombosis and heart disease research.Formule :C25H24F2N2O3Couleur et forme :SolidMasse moléculaire :438.47Sitamaquine hydrochloride
CAS :Sitamaquine hydrochloride (WR 6026) is an orally active 8-aminoquinoline analog with antileishmanial activity. This compound inhibits mitochondrial complex II (succinate dehydrogenase) and is characterized by its lipophilic weak base properties. It rapidly accumulates in the acidic compartments of Leishmania parasites, predominantly localizing within the acidocalcisomes.Formule :C21H35Cl2N3OCouleur et forme :SolidMasse moléculaire :416.43SphK2-IN-1
CAS :SphK2-IN-1 is an SphK2 inhibitor with an IC50 value of 0.359 μM. SphK2-IN-1 can be used to study cancer, inflammation, neurological and cardiovascular diseases.Formule :C23H22ClF3N8OCouleur et forme :SolidMasse moléculaire :518.92YM-49598 iodide
CAS :YM-49598 iodide is a tachykinin NK-1 receptor antagonist. It inhibits drug-induced bladder contractions in rats with an IC50 of 11 μg/kg.Formule :C36H45Cl2IN2O2Couleur et forme :SolidMasse moléculaire :735.57CM699
CAS :CM699 is an effective dual inhibitor of the dopamine transporter (DAT) and Sigma receptor (σR), with IC50 values of 311 nM and 14.1 nM, respectively.Formule :C24H29N3O2Couleur et forme :SolidMasse moléculaire :391.51ChemR23-IN-3
ChemR23-IN-3 is a potent thiazole-based ChemR23 inhibitor with an IC 80 value of 12 nM.Formule :C31H33N5O5S2Couleur et forme :SolidMasse moléculaire :619.75Osanetant HCl
CAS :Osanetant HCl is the (R)-enantiomer; neurokinin-3 receptor antagonistFormule :C35H42Cl3N3O2Couleur et forme :SolidMasse moléculaire :643.09ATL444
CAS :ATL444 is an adenosine receptor antagonist with affinity (Ki values) for rA1AR, rA2AAR, rA2BAR, and rA3AR of 7.0, 2.5, 61.8, and >1000 nM, respectively.Formule :C17H19N5OCouleur et forme :SolidMasse moléculaire :309.37PF-00446687
CAS :PF-00446687 is a selective agonist of melanocortin-4 receptor (MC4R) (EC50 of 12 ± 1 nM).Formule :C28H36F2N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :470.59AAZ-A 154 mesylate
CAS :AAZ-A 154 mesylate mesylate is a selective, competitive, and non-hallucinogenic antagonist of 5-HT2AR. It enhances neuronal growth in rodents and produces enduring beneficial behavioral effects.Formule :C15H24N2O4SCouleur et forme :SolidMasse moléculaire :328.43AB-FUBINACA 3-fluorobenzyl isomer
CAS :AB-FUBINACA 3-fluorobenzyl isomer is a synthetic cannabinoid and an indazole derivative, exhibiting high affinity for central CB1 receptors (Ki= 0.9 nM) and possessing anticonvulsant activity.Formule :C20H21FN4O2Couleur et forme :SolidMasse moléculaire :368.41MRS4833
CAS :MRS4833 (compound 15) is an orally active, potent, competitive antagonist of P2Y14R, exhibiting IC50 values of 5.92 nM for hP2Y14R and 4.8 nM for mP2Y14R. It reduces airway eosinophilia in protease-mediated asthma models and reverses chronic neuropathic pain in mouse CCI models.Formule :C30H24F3NO3Couleur et forme :SolidMasse moléculaire :503.51SAR-150640
CAS :SAR-150640, a selective β3-adrenergic receptor agonist, prevents an increase in MMP activity and production observed after LPS stimulation or in cases of chorioamnionitis.Formule :C25H35ClN2O7SCouleur et forme :SolidMasse moléculaire :543.07ADORA2A/PDE4D-IN-1
CAS :ADORA2A/PDE4D-IN-1 (Compound 9) is a dual inhibitor of the adenosine A2a receptor (ADORA2A) and phosphodiesterase 4D (PDE4D). This compound is applicable for research in bronchial asthma.Formule :C14H11N5Couleur et forme :SolidMasse moléculaire :249.271BMS-741672
CAS :BMS-741672 is a potent, selective CCR2 antagonist for the treatment of neuropathic pain.Formule :C25H33F3N6O2Couleur et forme :SolidMasse moléculaire :506.56Quinagolide Free Base
CAS :Quinagolide Free Base is a non-ergot dopamine D(2)-agonist.Formule :C20H33N3O3SCouleur et forme :SolidMasse moléculaire :395.5614,15-dehydro Leukotriene B4
CAS :LTB4 is a leukocyte-activating fatty acid via 5-lipoxygenase. Two receptors, BLT1 and BLT2, bind it. 14,15-dehydro LTB4 is a stronger BLT1 antagonist.Formule :C20H30O4Couleur et forme :SolidMasse moléculaire :334.45SAR-114137
CAS :SAR-114137 is a histone sphingomyelin kinase inhibitor used in the study of molluscum arteriosum and peripheral neuropathic pain.Formule :C25H34N4O7SDegré de pureté :99.09% - 99.91%Couleur et forme :SolidMasse moléculaire :534.63Leukotriene B4 dimethyl amide
CAS :LTB4 dimethyl amide: inhibits human neutrophil degranulation and rat lysozyme release; antagonizes LTB4 receptor on guinea pig lung membranes (Ki = 130 nM).Formule :C22H37NO3Couleur et forme :SolidMasse moléculaire :363.53Fosrolapitant
CAS :Fosrolapitant is an antagonist of the neurokinin 1 (NK1) receptor.Formule :C27H29F6N2O8PCouleur et forme :SolidMasse moléculaire :654.49Dopamine D3 receptor antagonist-1
Dopamine D3 receptor antagonist-1 is a dopamine D3 receptor selective or multi-targeting ligand with a Ki value of 1.58 nM that has demonstrated therapeuticFormule :C31H35Cl2N3O3Couleur et forme :SolidMasse moléculaire :568.53SS-RJW100
SS-RJW100 is an enantiomer of RJW100 targeting LRH-1, SF-1, enhances Tif2 interaction, and disrupts LRH-1 networks with lowered stability.Formule :C28H34OCouleur et forme :SolidMasse moléculaire :386.57Mesulergine hydrochloride
CAS :5-HT2A and 2C receptor antagonistFormule :C18H27ClN4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.95Tonapofylline
CAS :Tonapofylline, orally active, selectively blocks A1 adenosine receptor (Ki: 7.4 nM), used in heart failure research.Formule :C22H32N4O4Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :416.51Tixanox sodium
CAS :Tixanox sodium effectively blocks histamine release in the lungs triggered by anti-IgE. It has also been demonstrated that when administered orally, Tixanox sodium can successfully counteract exercise-induced asthma.Formule :C15H9NaO5SCouleur et forme :SolidMasse moléculaire :324.28Nocloprost
CAS :Nocloprost (SH 475) is a prostaglandin E2 (PGE2) analog, an EP1 and EP3 receptor agonist with local gastric protection and ulcer healing effects.Formule :C22H37ClO4Couleur et forme :SolidMasse moléculaire :400.98GLP-1 receptor agonist 11
CAS :GLP-1 Receptor Agonist 11 (compound 3) acts as an effective agonist for the GLP Receptor, finding use in research related to conditions like diabetes and non-alc. fatty liver disease [1].Formule :C31H31ClFN3O4Couleur et forme :SolidMasse moléculaire :564.05L-654284
CAS :L-654284 is an α2-adrenergic receptor antagonist characterized by its notable selectivity. It competes with 3H-clonidine and 3H-rauwolscine for binding in vitro, exhibiting Ki values of 0.8 nM and 1.1 nM, respectively. L-654284 effectively blocks the pre-ejaculatory effects of clonidine in isolated rat vas deferens, with a pA2 value of 9.1. The compound demonstrates significant selectivity for α2 over α1 adrenergic receptors, with a Ki value of 110 nM against 3H-prazosin binding. In vivo, L-654284 significantly increases the turnover of norepinephrine in the rat cerebral cortex, indicating its activity in blocking α2-adrenergic receptors within the central nervous system.Formule :C18H24N2O4SCouleur et forme :SolidMasse moléculaire :364.46(R)-MrgprX2 antagonist-3
CAS :(R)-MrgprX2 antagonist-3 is an antagonist of MrgprX2. It is applicable in the study of inflammatory skin diseases. For more detailed information, please refer to compound E118 in patent document WO2021092240A1.Formule :C16H20FN3O2SMasse moléculaire :337.41Monlunabant
CAS :Monlunabant ((S)-MRI-1891), a solid dispersion compound, functions as an inhibitor of the cannabinoid CB1 receptor [1].Formule :C26H22ClF3N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :591.00NPRA agonist-11
CAS :NPRA agonist-11 (Example 161) is an NPRA (NPR1) agonist with AC50 values of 1.681 μM and 0.989 μM for human and monkey, respectively. It is applicable in research on cardiovascular and other diseases.Formule :C37H52FN7O2Couleur et forme :SolidMasse moléculaire :645.85Methacycline
CAS :<p>Methacycline, a tetracycline antibiotic, inhibits bacterial protein synthesis and effectively suppresses epithelial-mesenchymal transition (EMT). It blocks EMT in vitro and inhibits fibrogenesis in vivo without directly affecting the TGF-β1Smad signaling pathway. As an antimicrobial agent, Methacycline holds potential for research in pulmonary fibrosis.</p>Formule :C22H22N2O8Couleur et forme :SolidMasse moléculaire :442.42SSR-241586
CAS :SSR-241586: Neurokinin antagonist, treats depression, schizophrenia, urinary issues, emesis, IBS.Formule :C32H42Cl2N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :601.61AFP-07
CAS :AFP-07 is a highly selective and potent agonist. It was used for the prostacyclin receptor.Formule :C22H29F2NaO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.45CP-608039
CAS :CP-608039 is a selective adenosine A3 receptor agonist for both human A3 and human A1 receptors.Formule :C23H25ClN8O5Couleur et forme :SolidMasse moléculaire :528.95BW A868C
CAS :BW A868C is a potent, selective PGD2 antagonist and a BW245C analogue, inert to other prostaglandin receptors.Formule :C25H37N3O5Couleur et forme :SolidMasse moléculaire :459.58RGS10 modulator-1
CAS :RGS10 modulator-1 (compound 15) is an effective regulator of RGS10. It significantly reverses IFNγ-induced expression of both RGS10 protein and mRNA, as well as COX-2 mRNA and iNOS expression triggered by IFNγ.Formule :C16H15BrN2O3S2Couleur et forme :SolidMasse moléculaire :427.336Histamine H3 antagonist-1
CAS :<p>Compound 10o, a histamine H3 antagonist-1, functions as both a histamine H3 antagonist and a serotonin reuptake inhibitor, making it useful for research in depression [1].</p>Formule :C24H28F3N3O2Couleur et forme :SolidMasse moléculaire :447.49Diosuxentan
CAS :Diosuxentan is an inhibitor of ETA and is utilized in research pertaining to cardiovascular, renal, and neuronal inflammatory diseases.Formule :C20H21BrN6O7SCouleur et forme :SolidMasse moléculaire :569.39Anti-MRSA agent 19
CAS :Anti-MRSA agent 19 (Compound 1) is an antibiotic that exhibits activity against Staphylococcus aureus. It is active against 40 clinical isolates from the CDC, representing diverse bacterial species with various resistance factors, including resistance to vancomycin, aminoglycoside/tetracycline, and oxazolidinone (median MIC=4 μg/mL).Formule :C15H10Cl3NO4Couleur et forme :SolidMasse moléculaire :374.6SB-423557
CAS :SB-423557 is an orally active antagonist of calcium-sensing receptor (CaR) with IC50 of 520 nMFormule :C28H36N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.60CVT-5440
CAS :CVT-5440 is a selective, high-affinity (2B) adenosine receptor antagonist with good selectivity.Formule :C27H28N6O5Couleur et forme :SolidMasse moléculaire :516.55AChE-IN-5
AChE-IN-5: oral, crosses blood-brain barrier, targets AChE/5-HT1A/SERT, potent with 2.29 nM IC50.Formule :C38H45N5OCouleur et forme :SolidMasse moléculaire :587.8Tezosentan
CAS :Tezosentan is an antagonist of the endothelin receptor (pA2s: 9.5, 7.7 for ETA and ETB receptors, respectively).Formule :C27H27N9O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :605.63Y1 receptor antagonist 1
CAS :Y1 receptor antagonist 1 is an antagonist of neuropeptide Y1 receptor.Formule :C28H33N5O3Degré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :487.59Terguride
CAS :Terguride: treats hyperprolactinemia, blocks 5-HT2A/B, activates dopamine receptors, studied for PAH.Formule :C20H28N4OCouleur et forme :SolidMasse moléculaire :340.46Fasitibant
CAS :Fasitibant is a potent and selective nonpeptide kinin B2 receptor antagonist.Formule :C36H49Cl2N6O6SCouleur et forme :SolidMasse moléculaire :764.78O-1269
CAS :O-1269 acts as a partial agonist for the cannabinoid receptor 1 (CB1R), with a binding affinity (Ki) of 32 nM. Additionally, it exhibits analgesic properties.Formule :C22H22Cl3N3OCouleur et forme :SolidMasse moléculaire :450.79U75302
CAS :U75302 is an antagonist of thymosin beta-4 (TB4) receptor with a Ki value of 159 nM on guinea pig lung membranes.Formule :C22H35NO3Degré de pureté :98%Couleur et forme :Light Yellow OilMasse moléculaire :361.52(Rac)-BI 703704
CAS :(Rac)-BI 703704 is a potent activator of soluble guanylyl cyclase (sGC).Formule :C32H37N3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :559.72Merigolix
CAS :Merigolix is a potent gonadotrophin releasing hormone (GnRH) antagonist .Formule :C36H35F7N4O6Couleur et forme :SolidMasse moléculaire :752.68ONO-9780307
CAS :ONO-9780307 is a specific antagonist of LPA1 (lysophosphatidic acid receptor 1) (IC50: 2.7 nM).Formule :C30H35NO7Couleur et forme :SolidMasse moléculaire :521.6AMG-369
CAS :AMG-369 (AMG 247) is an S1P1/S1P5 dual agonist that delays the development of experimental autoimmune encephalomyelitis in rats.Formule :C26H22FN3O2SDegré de pureté :98.04% - 98.92%Couleur et forme :SolidMasse moléculaire :459.54Kendomycin
CAS :Kendomycin is a proteasome inhibitor and endothelin receptor antagonist. It induces apoptosis in lymphoma.Formule :C29H42O6Couleur et forme :SolidMasse moléculaire :486.64(R)-BAY-899
(R)-BAY-899: R-isomer, selective LH-R antagonist, effective on hLH (IC50: 185 nM) and rLH (IC50: 46 nM), orally active.Formule :C25H19F2N5O2Couleur et forme :SolidMasse moléculaire :459.45U92016A hydrochloride
CAS :U92016A hydrochloride: potent, orally active 5-HT1A agonist, metabolically stable, high intrinsic activity, Ki=0.2 nM.Formule :C19H26ClN3Couleur et forme :SolidMasse moléculaire :331.89AFP-07 free acid
CAS :AFP 07 free acid is a 7,7-difluoroprostacyclin derivative. It also acts as a selective and highly potent agonist for the IP receptor.Formule :C22H30F2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :412.47AM9405
AM9405: peripheral CB1/5-HT3 agonist, suppresses gut motility, relieves GI disorder symptoms in mice.Formule :C24H33BrN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.44CI-624
CAS :CI-624 reduces the secretion and output of hydrogen ions, sodium ions, potassium ions, and pepsin. This compound may be utilized in research focusing on cancer and autoimmune diseases.Formule :C8H8N2SCouleur et forme :SolidMasse moléculaire :164.228Tiprenolol hydrochloride
CAS :Tiprenolol hydrochloride is a β-adrenoceptor (β-adrenoceptor) antagonist. This compound is effective in eliminating ventricular arrhythmias in dogs caused by intravenous administration of adrenaline, following inhalation of halothane.Formule :C13H22ClNO2SCouleur et forme :SolidMasse moléculaire :291.84Leukotriene F4
CAS :LTF4, made in vitro from LTE4 with enzymes, contracts vascular muscle weakly; potency is LTD4 > LTC4 > LTE4 >> LTF4.Formule :C28H44N2O8SCouleur et forme :SolidMasse moléculaire :568.72BAY 38-7271
CAS :BAY 38-7271: potent neuroprotective, selective CB1/CB2 agonist, Ki of 1.85 nM (CB1) & 5.96 nM (CB2).Formule :C20H21F3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.44MK-3207 Hydrochloride
CAS :MK-3207 Hydrochloride (MK-3207 HCl) is a potent CGRP receptor antagonist with IC50 and Kiof 0.12 nM and 0.022 nM, highly selective versus human AM1, AM2, CTR, and AMY3. Phase 2.Formule :C31H30ClF2N5O3Degré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :594.05Thielavin B
CAS :Thielavin B, from Thielavia terricola, inhibits prostaglandin E2 synthesis and reduces rat oedema.Formule :C31H34O10Couleur et forme :SolidMasse moléculaire :566.6SphK1-IN-1
SphK1-IN-1: SphK1 ATPase inhibitor, IC50=2.48 μM, potential for cancer research.Formule :C22H22N6O2Couleur et forme :SolidMasse moléculaire :402.45LPA5 antagonist 2
LPA5 antagonist 2, compound 65, water-soluble, reduces nociception, for inflammatory/neuropathic pain study.Formule :C26H25FN2O4SCouleur et forme :SolidMasse moléculaire :480.55BER-5
CAS :BER-5 is a potent MrgX2 antagonist, demonstrating broad-spectrum antagonistic activity against various MrgX2 agonists. It can inhibit Substance P(SP)-induced degranulation in LAD2 cells and alleviate SP-induced allergic reactions in mice. BER-5 is useful for researching mechanisms related to allergic reactions.Formule :C20H16O4Couleur et forme :SolidMasse moléculaire :320.34Setomagpran
CAS :Setomagpran is an antagonist of the mas-related G protein-coupled receptor (MRGPR) and possesses anti-inflammatory properties.Formule :C22H19Cl2F6N5OCouleur et forme :SolidMasse moléculaire :554.316PAR4 antagonist 3
CAS :PAR4 antagonist3 (Compound 36) is a selective antagonist of protease-activated receptor 4 (PAR4). It exhibits antiplatelet activity with an IC50 of 26.1 nM and enhances metabolic stability in human liver microsomes, with a half-life (T1/2) of 97.6 minutes.Formule :C22H16FN3O5SMasse moléculaire :453.44Substituted piperidines-1
CAS :Substituted piperidines-1 can promote the release of growth hormone in humans and animals.Formule :C29H39N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.67Taranabant
CAS :Taranabant: potent CB1 receptor inverse agonist; inhibits agonists with 0.13 nM Ki in vitro.Formule :C27H25ClF3N3O2Degré de pureté :99.06% - 99.06%Couleur et forme :SolidMasse moléculaire :515.96LX2761
CAS :LX2761 is a stable inhibitor for SGLT1/2 with IC50s of 2.2/2.7 nM; it targets SGLT1 in the GI tract.Formule :C32H47N3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :601.80GAT564
GAT564, an allosteric CB1R modulator, shows EC50s of 87 nM (cAMP) & 320 nM (β-arrestin2) and lowers IOP effectively in glaucoma mice.Formule :C20H16N2O2SCouleur et forme :SolidMasse moléculaire :348.42LAS195319
CAS :LAS195319 is a potent and selective inhaled PI3Kδ Inhibitor (IC50 = 0.5 nM) for the Treatment of Respiratory Diseases.Formule :C29H26N10O3SCouleur et forme :SolidMasse moléculaire :594.65Rodatristat
CAS :Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively).Formule :C27H27ClF3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :561.98Inupadenant HCl
CAS :Inupadenant (EOS-850) is a selective A2a receptor antagonist, targeting immunosuppression in tumors.Formule :C25H27ClF2N8O4S2Couleur et forme :SolidMasse moléculaire :641.11MDA77
CAS :MDA77 is a CB2 agonist with an EC50 value of 5.82 nM and exhibits no activity towards CB1.Formule :C21H23N3O3Couleur et forme :SolidMasse moléculaire :365.43Rimegepant sulfate hydrate
CAS :Rimegepant (BMS-927711/BHV-3000): oral CGRP blocker for migraines, effective without vasoconstriction, beats placebo, well-tolerated.Formule :C56H64F4N12O13SCouleur et forme :SolidMasse moléculaire :1221.2526Macitentan (n-butyl analogue)
CAS :Macitentan n-butyl analogue, an oral ETA/ETB receptor blocker, may treat IPF and PAH.Formule :C20H21Br2N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :587.29GPR27 agonist-1
CAS :GPR27 agonist-1 (compound I) is a selective agonist for GPR27 with a pEC50 value of 6.34.Formule :C19H14Cl2N2O3SCouleur et forme :SolidMasse moléculaire :421.30A1/A3 AR antagonist 1
<p>Compound 10 is a potent dual A1/A3 AR antagonist, with Ki values of 37.6 nM (hA1), 25.4 nM (hA3), and 1.47 nM (rA1), studied in renal, lung, and Alzheimer's.</p>Formule :C24H18N2O3SCouleur et forme :SolidMasse moléculaire :414.485-HT7R antagonist 1
5-HT7R antagonist 1 is a G protein-biased antagonist with Ki of 6.5 nM for 5-HT 7R.Formule :C14H18Cl2N4Couleur et forme :SolidMasse moléculaire :313.23YNT-3708
CAS :YNT-3708 is an orexin receptor (OXR) agonist, exhibiting EC50 values of 14.6 nM for OX1R and 277 nM for OX2R.Formule :C35H36N4O6SCouleur et forme :SolidMasse moléculaire :640.749(Rac)-Nebivolol
CAS :(Rac)-Nebivolol, a racemic β1-adrenergic blocker (IC50=0.8 nM), has vasodilatory properties and mitigates ethanol-induced cardiac harm.Formule :C22H25F2NO4Couleur et forme :SolidMasse moléculaire :405.43A1AR antagonist 1
Compound 18g, a potent A1AR blocker with Ki: 2.08 nM (hA1), 6.91 nM (hA2A), 31.2 nM (hA2B).Formule :C18H14N4OCouleur et forme :SolidMasse moléculaire :302.33BAY-899
CAS :BAY-899, oral LH-R antagonist, IC50: 185 nM (hLH), 46 nM (rLH), lowers sex hormones in vivo.Formule :C25H19F2N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :459.45GRPR antagonist-1
GRPR antagonist-1 targets GRPR, kills specific cancer cells (e.g., PC3, Pan02, HGC-27), and promotes apoptosis by modulating Bcl-2 and Bax.Formule :C29H33F3N4O4Couleur et forme :SolidMasse moléculaire :558.59CI-988
CAS :CCK2 (CCK-B) receptor antagonistFormule :C35H42N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :614.73SSR 146977
CAS :NK3 receptor antagonistFormule :C35H42Cl2N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :621.64GPBAR1-IN-3
CAS :GPBAR1-IN-3 (Compound 14) is both a selective agonist for GPBAR1, with an EC50 value of 0.17 μM, and an antagonist for CysLT1R [1].Formule :C21H23NO2Couleur et forme :SolidMasse moléculaire :321.41Cendifensine
CAS :Cendifensine functions as a monoamine reuptake inhibitor, targeting the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT).Formule :C14H17Cl2NOCouleur et forme :SolidMasse moléculaire :286.197CCR3 antagonist 2
CAS :CCR3 antagonist2 (example 66) is a CCR3 antagonist useful for researching inflammatory or allergic diseases, particularly those affecting the respiratory tract, such as inflammatory or obstructive airway conditions.Formule :C21H28ClN5O3Couleur et forme :SolidMasse moléculaire :433.93S1PR1 agonist 1
CAS :<p>S1PR1 agonist 1 is a potent agonist of S1PR1. S1PR1 agonist 1 has potential in autoimmune diseases.</p>Formule :C29H30N4O4Couleur et forme :SolidMasse moléculaire :498.57DM-4111
CAS :DM-4111, one of the primary monohydroxy metabolites of Tolvaptan, is an effective vasopressin V2 receptor (vasopressin V2 receptor) inhibitor. By inhibiting water reabsorption in renal tubules, it facilitates the excretion of electrolyte-free water. DM-4111 holds potential for research in cardiovascular diseases.Formule :C26H25ClN2O4Couleur et forme :SolidMasse moléculaire :464.94AAZ-A 154
CAS :AAZ-A 154 is a selective, competitive, and non-hallucinogenic antagonist of the 5-HT2AR. It promotes neuronal growth in rodents and results in lasting beneficial behavioral effects.Formule :C14H20N2OCouleur et forme :SolidMasse moléculaire :232.32LY 215840
CAS :5-HT2/5-HT7 receptor antagonistFormule :C24H33N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.54H-Glu-Thr-OH
CAS :H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide composed of two amino acids—glutamic acid (Glu) and threonine (Thr)—linked by a peptide bond and functions as an agonist of the extracellular calcium-sensing receptor (CaSR).Formule :C9H16N2O6Couleur et forme :SolidMasse moléculaire :248.23FDU-PB-22
CAS :FDU-PB-22, a novel synthetic cannabinoid, undergoes rapid metabolism in human liver microsomes (HLM) with a half-life of 12.4 minutes.Formule :C26H18FNO2Couleur et forme :SolidMasse moléculaire :395.43Tofogliflozin
CAS :Tofogliflozin specifically inhibits SGLT2; IC50s are 2.9 nM (human), 14.9 nM (rat), 6.4 nM (mouse).Formule :C22H26O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :386.44AAZ-A 154 benzoate
CAS :AAZ-A 154 benzoate is a selective, competitive, and non-hallucinogenic 5-HT2AR antagonist. This compound facilitates neuronal growth in rodents and produces lasting beneficial behavioral effects.Formule :C21H26N2O3Couleur et forme :SolidMasse moléculaire :354.44Protease-Activated Receptor-1 antagonist 3
PAR-1 antagonist 3: potent (IC50: 7 nM), binds hERG K+ channels (IC50: 9 μM).Formule :C30H34N4O3Couleur et forme :SolidMasse moléculaire :498.62(S)-Praziquantel
CAS :(S)-Praziquantel is the inactive isomer of R-praziquantel.Formule :C19H24N2O2Couleur et forme :SolidMasse moléculaire :312.406CCR1 antagonist 11 hydrochloride
Oral CCR1 antagonist A1B1 targets h/m/rCCR1 (IC50: 0.03/0.58/0.32 μM), potential for treating inflammatory diseases.Couleur et forme :SolidA3AR antagonist 5
CAS :A3AR antagonist 5 (Compound 16) acts as a selective antagonist for the human adenosine A3 receptor (human adenosine A3 receptor), with an affinity expressed as a pC value of 4.542 μM.Formule :C18H16N2O2SCouleur et forme :SolidMasse moléculaire :324.40ATX inhibitor 27
CAS :ATX inhibitor 27 (Compound 31) is an ATX inhibitor. It demonstrates IC50 values of 13 nM against human autotaxin (hATX) and 23 nM against lysophosphatidylcholine (LPC). By inhibiting the ATX enzyme, ATX inhibitor 27 reduces LPA levels in the body. This compound is applicable in research related to ATX-LPA-associated conditions such as inflammation, neurodegenerative disorders, and cancer.Formule :C26H26ClN5O3Couleur et forme :SolidMasse moléculaire :491.972,3-dinor-11β-Prostaglandin F2α
CAS :2,3-dinor-11β-Prostaglandin F2α (2,3-dinor-11β-PGF2α) was recovered from the urine of both normal monkeys and humans when infused with radiolabeled PGD2, whereFormule :C18H30O5Couleur et forme :SolidMasse moléculaire :326.43Sigma-2 Radioligand 2
CAS :Sigma-2 Radioligand 2 (compound 4) exhibits low nanomolar affinity for the σ2 receptor (Ki=2.30 nM) and high subtype selectivity (Ki(σ1)/Ki(σ2) > 1500).Formule :C23H28FN3O3Couleur et forme :SolidMasse moléculaire :413.49MRS2179 tetrasodium hydrate
MRS2179 blocks turkey P2Y1 receptor (Kb 102 nM, pA2 6.99), affects platelet aggregation, and has varying IC50s on P2 receptors.Formule :C11H15N5Na4O10P2Couleur et forme :SolidMasse moléculaire :576.21Ro-24-4736
CAS :Ro 24-4736 is an effective and selective platelet-activating factor antagonist.Formule :C31H20ClN5OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :546.04PSB 36
CAS :A1 adenosine receptor antagonistFormule :C21H30N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :386.49CP-199330
CAS :CP-199330: non-toxic alternative to Zafirlukast & Pranlukast, blocks cysteyl LT1 receptors.Formule :C28H24ClF3N2O6SCouleur et forme :SolidMasse moléculaire :609.01Hoe 892
CAS :Hoe 892 is a stable thia-thimo-analogue of prostacyclin and acts as a platelet aggregation inhibitor.Formule :C20H33NO4SCouleur et forme :SolidMasse moléculaire :383.55Cicaprost
CAS :Cicaprost (ZK 96480) is an IP agonist with artery relaxing effects; EC50 is 5.8 nM.Formule :C22H30O5Couleur et forme :SolidMasse moléculaire :374.47MK-3207
CAS :MK-3207 is a potent, oral CGRP receptor antagonist with high selectivity for human and monkey receptors, inhibiting blood flow in vivo.Formule :C31H29F2N5O3Couleur et forme :SolidMasse moléculaire :557.59NK-1 Antagonist 1
CAS :NK-1 Antagonist 1 is a NK-1 receptor antagonist.Formule :C25H23F6N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :539.475-HT6R/MAO-B modulator 1
5-HT6R/MAO-B modulator 1 blocks 5-HT6R and permanently inhibits MAO-B, protects glial cells, and reverses memory loss.Formule :C33H38N4O3SCouleur et forme :SolidMasse moléculaire :570.74UNC10099984A
CAS :UNC10099984A (Compound 6) is a functionally selective ligand for the dopamine D2 receptor, exhibiting a Ki value of 4.6 nM and an EC50 of 6.2 nM for β-arrestin. This compound is useful for research into central nervous system diseases related to the D2 receptor.Formule :C24H29Cl2N3O2Couleur et forme :SolidMasse moléculaire :462.41TAK-661
CAS :TAK-661 is an inhibitor of eosinophil chemotaxis (eosinophil chemotaxis) that significantly alleviates late-phase bronchoconstriction while inhibiting the proliferation of eosinophils in bronchoalveolar lavage (BAL) and their infiltration into the airway walls.Formule :C13H21N5O3SCouleur et forme :SolidMasse moléculaire :327.40Revexepride
CAS :Revexepride, a 5-HT4 agonist, may boost CYP3A4, used for treating GERD.Formule :C21H32ClN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.95CB1/2 agonist 1
Potent CB1/2 agonist 1; crosses blood-brain barrier; anti-inflammatory, analgesic; for multiple sclerosis research.Formule :C21H24BrFN2O2Couleur et forme :SolidMasse moléculaire :435.33Alixorexton
CAS :Alixorexton is an agonist of the orexin-2 receptor (orexin-2 receptor) and is utilized in obesity research.Formule :C21H30N2O5SCouleur et forme :SolidMasse moléculaire :422.538RF9 hydrochloride
RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist that acts on hNPFF1R (Ki: 58 nM) and hNPFF2R (Ki: 7 nM).Formule :C26H39ClN6O3Couleur et forme :SolidMasse moléculaire :519.08DA-302168S
CAS :DA-302168S is an orally active, selective GLP-1R agonist with an EC50 value of 1.32 nM. It promotes insulin secretion and has a hypoglycemic effect. Additionally, DA-302168S reduces food intake. It primarily activates GLP-1R in humans and monkeys, with minimal effect on GLP-1R in rats, mice, and dogs. DA-302168S can be used for research in type 2 diabetes and obesity.Formule :C33H24ClF2N3O5Couleur et forme :SolidMasse moléculaire :616.011LJ-4517
LJ-4517 is an effective A2AAR antagonist (Ki=18.3 nM). LJ-4517 can effectively replace the binding of [3H] ZM241385 at WT A2AAR.Formule :C19H21N5O3SCouleur et forme :SolidMasse moléculaire :399.471'-Naphthoyl-2-methylindole
CAS :1'-Naphthoyl-2-methylindole (Compound 88) acts as a cannabinoid mimic and an inhibitor of Win 55212-2, displaying a 34% inhibition of [3H]Win 55212-2 binding to cannabinoid receptors at a concentration of 3 μM.Formule :C20H15NOCouleur et forme :SolidMasse moléculaire :285.34Delmadinone acetate
CAS :Delmadinone acetate is an orally active compound used to control estrus and ovulation in both female and male pets. It induces adrenal suppression by inhibiting the pituitary release of ACTH.Formule :C23H27ClO4Couleur et forme :SolidMasse moléculaire :402.911
