Signalisation PI3K/Akt/mTOR
Les inhibiteurs de la signalisation PI3K/Akt/mTOR sont des composés qui ciblent les voies de la phosphoinositide 3-kinase (PI3K), de la kinase Akt et de la cible de la rapamycine chez les mammifères (mTOR). Ces voies sont des régulateurs critiques de la croissance cellulaire, de la survie, du métabolisme et de l'autophagie, ce qui en fait des cibles clés dans la recherche sur le cancer et les troubles métaboliques. Inhiber ces voies peut aider à contrôler la croissance et la prolifération tumorales, offrant ainsi des stratégies thérapeutiques potentielles pour divers cancers et autres maladies caractérisées par une signalisation cellulaire dysrégulée. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de haute qualité de PI3K/Akt/mTOR pour soutenir vos recherches en oncologie, signalisation cellulaire et maladies métaboliques.
Sous-catégories appartenant à la catégorie "Signalisation PI3K/Akt/mTOR"
- AMPK(158 produits)
- ATM/ATR(71 produits)
- ADN-PK(51 produits)
- EGFR(572 produits)
- MELK(7 produits)
- PDK(9 produits)
- PI3K(242 produits)
- S6 Kinase(9 produits)
- gsk-3(112 produits)
- mTOR(144 produits)
Affichez 2 plus de sous-catégories
1038 produits trouvés pour "Signalisation PI3K/Akt/mTOR"
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Lapatinib
CAS :<p>Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity.</p>Formule :C29H26ClFN4O4SDegré de pureté :99.00% - 99.81%Couleur et forme :PowderMasse moléculaire :581.06Petosemtamab
CAS :<p>Petosemtamab (MCLA 158), a dual-action monoclonal antibody targets EGFR & LGR5, used in solid tumor research like HNSCC & CRC.</p>Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :145.97 kDaLCH-7749944
CAS :<p>LCH-7749944 suppresses human gastric cancer cell growth, induces apoptosis, and inhibits PAK4 with IC50 of 14.93 μM.</p>Formule :C20H22N4O2Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :350.41Khellin
CAS :<p>Khellin (Methafrone) is a vasodilator that also has bronchodilatory action.</p>Formule :C14H12O5Degré de pureté :99.89% - 99.95%Couleur et forme :Light Yellow CrystallineMasse moléculaire :260.24Epertinib hydrochloride
CAS :<p>Epertinib hydrochloride (S-22611 hydrochloride) shows potent antitumor activity.</p>Formule :C30H28Cl2FN5O3Degré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :596.48NV-5138
CAS :<p>NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects.Cost-effective and quality-assured.</p>Formule :C7H13F2NO2Degré de pureté :98% - ≥98%Couleur et forme :SolidMasse moléculaire :181.18BRD0705
CAS :<p>BRD0705: potent, selective GSK3α inhibitor, oral, IC50: 66 nM, 8x more selective than GSK3β.</p>Formule :C20H23N3ODegré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :321.42Cromolyn sodium
CAS :<p>Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.</p>Formule :C23H14Na2O11Degré de pureté :99.4% - 99.95%Couleur et forme :Colorless Crystals From Ethanol + Ether White Crystalline PowderMasse moléculaire :512.33PI4KIIIbeta-IN-9
CAS :<p>PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .</p>Formule :C23H25N3O5S2Degré de pureté :97.18%Couleur et forme :SolidMasse moléculaire :487.59Mevastatin
CAS :<p>Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.</p>Formule :C23H34O5Degré de pureté :99.12%Couleur et forme :White-Yellowish To Yellow Powder Solid PowderMasse moléculaire :390.51Pyrotinib dimaleate
CAS :<p>Pyrotinib dimaleate is a selective EGFR/HER2 dual inhibitor, respectively, for the treatment of HER2-positive breast cancer.Cost-effective and quality-assured.</p>Formule :C40H39ClN6O11Degré de pureté :97.27% - 99.52%Couleur et forme :SolidMasse moléculaire :815.22Panitumumab
CAS :<p>Panitumumab is a fully human IgG2 monoclonal antibody targeting the epidermal growth factor receptor EGFR).</p>Degré de pureté :95% - 98.1% (SDS-PAGE); 99.4% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :147 kDaSafingol hydrochloride
CAS :<p>Safingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) is a PKC-specific inhibitor that inhibits PKC and PI3k and induces cancer cell death.</p>Formule :C18H40ClNO2Degré de pureté :99.39% - 99.71%Couleur et forme :SoildMasse moléculaire :337.969PI4KIIIbeta-IN-10
CAS :<p>PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).</p>Formule :C22H25N3O5S2Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :475.58Indazole
CAS :<p>Indazole, a heterocyclic compound, offers diverse biological activities.</p>Formule :C7H6N2Degré de pureté :99.59% - 99.85%Couleur et forme :White Or Beige Crystalline PowderMasse moléculaire :118.14Margetuximab
CAS :<p>Margetuximab (MGAH-22) is a second generation anti-HER2 monoclonal antibody with anti-tumor activity.</p>Degré de pureté :95.3% (SDS-PAGE); 99.3% (SEC-HPLC) - 95.3% (SDS-PAGE); 99.3% (SEC-HPLC)Couleur et forme :LiquidGefitinib
CAS :<p>Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations.</p>Formule :C22H24ClFN4O3Degré de pureté :99.92% - >99.99%Couleur et forme :Light-Yellow Crystalline PowderMasse moléculaire :446.9PT-1
CAS :<p>PT-1 is an AMPKα1 activator that dose-dependently activates AMPK α1394, α1335, and α2398 and enhances AMPK phosphorylation.</p>Formule :C23H16ClN3O6SDegré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :497.91Barecetamab
CAS :<p>Barecetamab (ISU-104) is a humanized monoclonal antibody against tyrosine protein kinase ErbB3 with anticancer activity.</p>Degré de pureté :97.1% (SDS-PAGE); 96.4% (SEC-HPLC) - 97.1% (SDS-PAGE); 96.4% (SEC-HPLC)Couleur et forme :LiquidLosatuxizumab
CAS :<p>Losatuxizumab (ABT-806) is an anti-EGFR monoclonal antibody with potential anti-tumor activity for the study of advanced malignant solid tumors.</p>Degré de pureté :97.3% (SDS-PAGE); 95.1% (SEC-HPLC) - 97.3% (SDS-PAGE); 95.1% (SEC-HPLC)Couleur et forme :LiquidSTL127705
CAS :<p>STL127705 inhibits Ku 70/80 protein & DNA-PKCS kinase, IC50s: 3.5 μM & 2.5 μM.</p>Formule :C22H20FN5O4Degré de pureté :99.53% - 99.81%Couleur et forme :SolidMasse moléculaire :437.42SN32976
CAS :<p>SN32976 is a pan PI3K inhibitor. SN32976 potently inhibited PI3K isoforms and mTOR, displaying preferential activity for PI3Kα and sparing of PI3Kδ.</p>Formule :C24H33F2N9O4SDegré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :581.64P110δ-IN-1
CAS :<p>P110δ-IN-1 (PWT-143) is an effective and selective inhibitor of P110δ (IC50: 8.4 nM).</p>Formule :C31H40N8O3SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :604.77Rociletinib
CAS :<p>Rociletinib (CNX-419) is an orally available small molecule, irreversible inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic</p>Formule :C27H28F3N7O3Degré de pureté :98.52% - 99.25%Couleur et forme :SolidMasse moléculaire :555.55Erlotinib hydrochloride
CAS :<p>Erlotinib hydrochloride (NSC 718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.</p>Formule :C22H23N3O4·HClDegré de pureté :99.78% - 99.85%Couleur et forme :White Or Off-White PowderMasse moléculaire :429.99-ING-41
CAS :<p>9-ING-41 is a glycogen synthase kinase-3 inhibitor.</p>Formule :C22H13FN2O5Degré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :404.35IPI-3063
CAS :<p>IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).</p>Formule :C25H25N7O2Degré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :455.51AZ7550 hydrochloride
CAS :<p>AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Formule :C27H32ClN7O2Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :522.04Mutated EGFR-IN-1
CAS :<p>Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating</p>Formule :C25H31N7ODegré de pureté :98.91%Couleur et forme :SolidMasse moléculaire :445.56MK8722
CAS :<p>MK8722 is an effective and systemic activator of pan-AMPK.</p>Formule :C24H20ClN3O4Degré de pureté :98.08% - 99.8800%Couleur et forme :SolidMasse moléculaire :449.89Tenalisib
CAS :<p>Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)</p>Formule :C23H18FN5O2Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :415.42AV-412
CAS :<p>AV-412 (MP412) is an EGFR inhibitor (EGFR, EGFR T790M, EGFR L858R, EGFR L858R/T790M and ErbB2 with IC50s of 0.75, 0.79, 0.5, 2.3, 19 nM).</p>Formule :C41H44ClFN6O7S2Degré de pureté :99.85% - 99.92%Couleur et forme :SolidMasse moléculaire :851.41Gancotamab
CAS :<p>Gancotamab (MM-302) is a polyethylene glycolated liposome targeting HER2 with antitumor activity for the study of advanced HER2-positive breast cancer.</p>Degré de pureté :96.7% (SDS-PAGE); 98.4% (SEC-HPLC) - 96.7% (SDS-PAGE); 98.4% (SEC-HPLC)Couleur et forme :LiquidParsaclisib
CAS :<p>Parsaclisib (INCB050465) is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)</p>Formule :C20H22ClFN6O2Degré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :432.88Cyanoacetohydrazide
CAS :<p>Cyanoacetohydrazide (Cyanoacetic hydrazide) is an anti-TB drug. It has also been used to derive compounds that may have antitumor properties.</p>Formule :C3H5N3ODegré de pureté :99.78%Couleur et forme :Stout Prisms From Alcohol Slightly Brown PowderMasse moléculaire :99.09Rilzabrutinib
CAS :<p>Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).</p>Formule :C36H40FN9O3Degré de pureté :98.28% - 99.76%Couleur et forme :SolidMasse moléculaire :665.76Lapatinib ditosylate monohydrate
CAS :<p>Lapatinib ditosylate monohydrate: a drug for advanced breast cancer; may cause liver issues.</p>Formule :C29H26ClFN4O4S·2(C7H8O3S)·H2ODegré de pureté :98% - 99.41%Couleur et forme :Colourless To Light-Yellow CrystalMasse moléculaire :943.47Allitinib
CAS :<p>Allitinib (AST-1306) (AST-1306) has anti-cancer activity，and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]</p>Formule :C24H18ClFN4O2Degré de pureté :99.89% - 99.91%Couleur et forme :SolidMasse moléculaire :448.88MELK-IN-1
CAS :<p>MELK-IN-1 (MELK inhibitor 17) is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK),(IC50:3nm;Ki:0.39 nM).</p>Formule :C31H33N5O4Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :539.62Lapatinib Ditosylate
CAS :<p>Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).</p>Formule :C29H26ClFN4O4S·2C7H8O3SDegré de pureté :99.41%Couleur et forme :Yellow SolidMasse moléculaire :925.46SAR405 R enantiomer
CAS :<p>SAR405 R enantiomer is the less active enantiomer of SAR405. SAR405 is an inhibitor of PIK3C3/Vps34.</p>Formule :C19H21ClF3N5O2Degré de pureté :98.04%Couleur et forme :SolidMasse moléculaire :443.85Intetumumab
CAS :<p>Intetumumab (CNTO 95) is a fully humanized anti-α(v)-integrin monoclonal antibody that is a radiosensitizer for xenograft tumor-bearing mice.</p>Degré de pureté :97.6% (SDS-PAGE); 97.1% (SEC-HPLC) - 97.6% (SDS-PAGE); 97.1% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.6 (kDa)O-Desmethyl gefitinib
CAS :<p>O-Desmethyl gefitinib is an active EGFR inhibitor (IC50: 36 nM), a metabolite of Gefitinib, formed by CYP2D6.</p>Formule :C21H22ClFN4O3Degré de pureté :97.17%Couleur et forme :SolidMasse moléculaire :432.88GSK-3 inhibitor 4
CAS :<p>Orally active GSK-3 inhibitor 4 targets GSK-3α/β, CDK2/5 (IC50: 0.45-0.68 μM) and may aid in Alzheimer's research by lowering Tau protein.</p>Formule :C22H15F2N5ODegré de pureté :99.41%Couleur et forme :SoildMasse moléculaire :403.38ICSN3250 HCl
CAS :<p>ICSN3250 HCl is an mTOR inhibitor that specifically targets cancer cells, preventing mTOR activation and leading to cytotoxicity.</p>Formule :C31H41ClN4O8Degré de pureté :98.46% - 99.60%Couleur et forme :SoildMasse moléculaire :633.13NSC781406
CAS :<p>NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).</p>Formule :C29H27F2N5O5S2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :627.68LTURM34
CAS :<p>LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM.</p>Formule :C24H18N2O3SDegré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :414.48Erlotinib
CAS :<p>Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.</p>Formule :C22H23N3O4Degré de pureté :98.19% - 99.98%Couleur et forme :White To Off-White PowderMasse moléculaire :393.44ALKBH1-IN-3
<p>ALKBH1-IN-3 is an effective inhibitor of the DNA N6-methyladenosine (6mA) demethylase ALKBH1. This compound enhances the abundance of 6mA in gastric cancer cell lines HGC27 and AGS, simultaneously inhibiting cell viability and upregulating the AMP-activated protein kinase (AMPK) signaling pathway. ALKBH1-IN-3 holds potential for use in cancer research, including studies on gastric cancer.</p>Couleur et forme :Odour SolidMulti-target kinase inhibitor 4
<p>Multi-target kinase inhibitor 4 (Compound 2) is a PI3K/DNA-PK inhibitor and a potent chemosensitizer that enhances the number of DNA double-strand breaks induced by Doxorubicin. It serves as an effective multidrug resistance (MDR) inhibitor, demonstrating inhibitory activity against P-glycoprotein (P-gp) mediated drug efflux. Multi-target kinase inhibitor 4 can be encapsulated in PEG-coated lipid nanoparticles.</p>Couleur et forme :Odour Solid
