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Signalisation PI3K/Akt/mTOR

Signalisation PI3K/Akt/mTOR

Les inhibiteurs de la signalisation PI3K/Akt/mTOR sont des composés qui ciblent les voies de la phosphoinositide 3-kinase (PI3K), de la kinase Akt et de la cible de la rapamycine chez les mammifères (mTOR). Ces voies sont des régulateurs critiques de la croissance cellulaire, de la survie, du métabolisme et de l'autophagie, ce qui en fait des cibles clés dans la recherche sur le cancer et les troubles métaboliques. Inhiber ces voies peut aider à contrôler la croissance et la prolifération tumorales, offrant ainsi des stratégies thérapeutiques potentielles pour divers cancers et autres maladies caractérisées par une signalisation cellulaire dysrégulée. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de haute qualité de PI3K/Akt/mTOR pour soutenir vos recherches en oncologie, signalisation cellulaire et maladies métaboliques.

Sous-catégories appartenant à la catégorie "Signalisation PI3K/Akt/mTOR"

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1038 produits trouvés pour "Signalisation PI3K/Akt/mTOR"

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  • PI3K-IN-26
    Targetmol
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    PI3K-IN-26

    CAS :
    <p>PI3K-IN-26 is an effective PI3K inhibitor. PI3K-IN-26 inhibits the proliferation of SU-DHL-6 cells, IC50= 36 nM.</p>
    Formule :C21H18N6OS
    Couleur et forme :Solid
    Masse moléculaire :402.47

    Ref: TM-T61966

  • EGFR-IN-133
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    EGFR-IN-133

    CAS :
    <p>EGFR-IN-133 (Compound 24) serves as an inhibitor targeting various mutations of the EGFR, including the wild type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with respective IC50 values of 0.1, 0.044, 0.036, 0.04, and 0.054 nM. The compound exhibits favorable pharmacokinetic properties and high oral bioavailability.</p>
    Formule :C27H29F2N7O3
    Couleur et forme :Solid
    Masse moléculaire :537.56

    Ref: TM-T201790

  • EGFR-IN-132
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    EGFR-IN-132

    CAS :
    <p>EGFR-IN-132 (Compound 23) is an EGFR inhibitor effective against various EGFR mutations including the wild-type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with IC50 values of 1.6, 0.025, 0.019, 0.022, and 0.029 nM, respectively. This compound demonstrates favorable pharmacokinetics with high oral bioavailability.</p>
    Formule :C27H31N7O3
    Couleur et forme :Solid
    Masse moléculaire :501.58

    Ref: TM-T201638

  • EGFR-IN-139
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    EGFR-IN-139

    CAS :
    <p>EGFR-IN-139 (compound PD 18) is an EGFR inhibitor with IC50 values of 12.88 nM (wild type), 10.84 nM (L858R/T790M), and 42.68 nM (L858R/T790M/C797S). It demonstrates significant anticancer activity against the A549 and H1975 cancer cell lines, which express high levels of EGFR. EGFR-IN-139 exhibits strong selectivity for cancer cells and can be utilized in research on non-small cell lung cancer (NSCLC).</p>
    Formule :C27H25ClN2O4
    Couleur et forme :Solid
    Masse moléculaire :476.951

    Ref: TM-T204772

  • Tarloxotinib bromide
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    Tarloxotinib bromide

    CAS :
    <p>Tarloxotinib bromide (TH-4000) is an irreversible inhibitor of EGFR/HER2.</p>
    Formule :C24H24Br2ClN9O3
    Degré de pureté :99.52%
    Couleur et forme :Solid
    Masse moléculaire :681.77

    Ref: TM-T13088

  • Le logo de CymitQuimica
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    Vps34-IN-3

    <p>Vps34-IN-3 is a potent, selective, and orally bioavailable inhibitor of VPS34 kinase .</p>
    Formule :C14H20N4O2
    Couleur et forme :Solid
    Masse moléculaire :276.33

    Ref: TM-T60506

  • Le logo de CymitQuimica
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    EGFR-IN-18

    <p>EGFR-IN-18 strongly inhibits L858R/T790M/C797S mutant EGFR (4.9 nM) and also targets wild-type EGFR (47 nM).</p>
    Formule :C33H28N6O3S
    Couleur et forme :Solid
    Masse moléculaire :588.68

    Ref: TM-T64170

  • PI3kδ inhibitor 1
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    PI3kδ inhibitor 1

    CAS :
    <p>PI3kδ inhibitor 1 is a selective inhibitor of PI3Kδ (IC50 of 3.8 nM).</p>
    Formule :C28H33FN6O2
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :504.60

    Ref: TM-T12463

  • PI4KIIIbeta-IN-11
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    PI4KIIIbeta-IN-11

    CAS :
    <p>PI4KIIIbeta-IN-11 is a PI4KIIIβ inhibitor (mean pIC50=9.1) that can be used to study diseases caused by RNA viruses and Plasmodium falciparum.</p>
    Formule :C33H39N7O3
    Couleur et forme :Solid
    Masse moléculaire :581.71

    Ref: TM-T64106

  • SST0116CL1
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    SST0116CL1

    CAS :
    <p>SST0116CL1 is an HSP90 inhibitor (IC50: 0.21 μM) that targets the ATP-binding pocket of Hsp90, disrupting its chaperone function and leading to the degradation of client proteins (EGFR, CDK4, and AKT). It induces the degradation of Her2 in BT-474 cells (IC50: 0.2 μM) and exhibits antiproliferative activity, inhibiting tumor growth.</p>
    Formule :C22H31ClN4O6
    Couleur et forme :Solid
    Masse moléculaire :482.96

    Ref: TM-T200022

  • EGFR-IN-149
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    EGFR-IN-149

    CAS :
    <p>EGFR-IN-149 (Compound 3-OH) is an EGFR inhibitor with an IC50 value of 0.42 nM.</p>
    Formule :C16H15N3OS
    Couleur et forme :Solid
    Masse moléculaire :297.375

    Ref: TM-T205658

  • NS-062
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    NS-062

    CAS :
    <p>NS-062 is an orally effective, irreversible covalent inhibitor targeting EGFR, demonstrating antiproliferative activity in the resistant double mutant H1975 cells with an IC50 of 0.19 μM. It also exhibits antitumor activity in a murine H1975 xenograft model.</p>
    Formule :C28H30Cl2F2N6O4
    Couleur et forme :Solid
    Masse moléculaire :623.48

    Ref: TM-T201773

  • PF-5177624
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    PF-5177624

    CAS :
    <p>PF-5177624 is a selective and potent PDK1 inhibitor inducing anti-tumor activity in breast cancer cells.</p>
    Formule :C25H25FN8O2
    Couleur et forme :Solid
    Masse moléculaire :488.52

    Ref: TM-T70911

  • GSK-3β inhibitor 25
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    GSK-3β inhibitor 25

    CAS :
    <p>GSK-3β inhibitor25 (Compound 6h) exhibits weak inhibitory activity against GSK-3β with an IC50 greater than 100 μM.</p>
    Formule :C16H15NOS
    Couleur et forme :Solid
    Masse moléculaire :269.361

    Ref: TM-T204501

  • EGFR-IN-159
    Targetmol
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    EGFR-IN-159

    CAS :
    <p>EGFR-IN-159 (compound 12) is a dihydropyrimidine and a potent EGFR inhibitor with an IC50 of 29.00 nM. It exhibits dose-dependent inhibition of EGFR and HER2. The compound shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC50 values of 16.07 μg/mL and 35.98 μg/mL, respectively. EGFR-IN-159 does not cross the blood-brain barrier (BBB) and demonstrates significant anticancer activity.</p>
    Formule :C21H23N3O5
    Couleur et forme :Solid
    Masse moléculaire :397.424

    Ref: TM-T206989

  • 4-FPBUA
    Targetmol
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    4-FPBUA

    CAS :
    <p>4-FPBUA, a semi-synthetic analog of lichen acid, enhances the functionality of cell-based blood-brain barriers (BBB) and increases the transport of β-amyloid (Aβ) in monolayer cells. Additionally, it acts as an inhibitor of mTOR, enhancing cellular autophagy (Autophagy) which can reverse BBB disruption in vivo, making it relevant for research in Alzheimer's disease.</p>
    Formule :C31H23FO7
    Couleur et forme :Solid
    Masse moléculaire :526.51

    Ref: TM-T89888

  • DNA-PK-IN-2
    Targetmol
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    DNA-PK-IN-2

    CAS :
    <p>DNA-PK-IN-2 is an inhibitor of the DNA-PK enzyme complex, useful in cancer research.</p>
    Formule :C20H23N5O3
    Couleur et forme :Solid
    Masse moléculaire :381.43

    Ref: TM-T61633

  • HER2-IN-8
    Targetmol
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    HER2-IN-8

    CAS :
    <p>HER2-IN-8 is an inhibitor of HER-2 that can be used in the study of cancer and inflammation-related diseases.</p>
    Formule :C26H25F2N9O3
    Couleur et forme :Solid
    Masse moléculaire :549.53

    Ref: TM-T63881

  • NSC381467
    Targetmol
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    NSC381467

    CAS :
    <p>NSC381467: Potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.</p>
    Formule :C20H16O7
    Couleur et forme :Solid
    Masse moléculaire :368.34

    Ref: TM-T61441

  • PD-M6
    Targetmol
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    PD-M6

    CAS :
    <p>PD-M6 is an mTOR PROTAC degrader with a DC50 of 4.8 μM, which facilitates the ubiquitination and degradation of mTOR. It inhibits the proliferation of cancer cell lines HeLa, MCF-7, and HepG2 with IC50 values of 11.3, 2.58, and 3.23 μM, respectively, and induces autophagy. Additionally, PD-M6 specifically targets the degradation of the key protein LAMTOR1 in the mTOR signaling pathway.</p>
    Formule :C30H39N9O6
    Couleur et forme :Solid
    Masse moléculaire :621.69

    Ref: TM-T207406