Toxicologie

<p>Stability Hygroscopic<br>Applications 2,3,4,5,6-Pentachlorobenzeneamine-13C6,is the labeled analogue of 2,3,4,5,6-Pentachlorobenzeneamine (P237925), which is a chemical in pesticides used to protect crops from various fungus and bacterium.<br>References Gartrell, M. et al.: J. Aossoc. Off. Anal. Chem., 68, 1163 (1985); Renner, G. et al.: App. Env. Microbio. 46, 765 (1983);<br></p>

<p>Applications Erythritol a sugar alcohol used as a food additive.<br>References Leisso, R., et al.: J. Agr. Food. Chem., 61, 1373 (2013); Hillmann, H., et al.: J. Agr. Food. Chem., 60, 9974 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications Deethylterbutryne is a pollutant. It is photocatalytic degradation product of herbicide Irgarol (I764100), which is photosynthesis inhibitor.<br>References Konstantinou, I., et al.: Environ. Sci. Technol., 35, 398 (2001); Thomas, K., et al.: Sci. Total Environ., 293, 117 (2002); Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009);<br></p>

<p>Applications 2-chloro-N-(2-ethyl-6-methylphenyl)acetamide (cas# 32428-71-0) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications Bensulide, is an organophosphate acetylcholinesterase inhibitor used as an herbicide (1) in the protection of crops through pesticides (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Lisker, E. et al.: Bull. Environ. Contam. Toxicol. 2011 Oct;87(4):355-60.2. Pinkerton, T. et al.: Methods Mol. Biol. 2012;847:11-23.<br></p>

<p>Applications Used to stimulate root formation of plant clippings. Suitable for plant cell culture tested.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Handa, A., et al.: Plant Physiol., 69, 514 (1982), Polanco, C., et al.: Plant Sci., 162, 817 (2002), Rzepka-Plevnes, D., et al.: J. Food Agric. Environ., 5, 194 (2007),<br></p>

<p>Applications A metabolite of Estradiol.<br>References Bucala, R., et al.: J. Clin. Endocrinol. Metab., 60, 841 (1985), Telang, N., et al.: Anticancer Res., et al.: 11, 1021 (1991), Seeger, H., et al.: Med. Sci. Res., 26, 481 (1998), Bolton, J., et al.: Chem. Res. Toxicol., 13, 135 (2000),<br></p>

<p>Applications An aryloxyphenoxypropionate (AOPP) post-emergence herbicide that shows an exclusive whole plant safety to rice with a high control efficacy to annual grass weeds, especially barnyardgrass.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Doroh, M.C. et al.: Weed Technol., 26, 97 (2011); Zeng, Z. et al.: Nongyao, 43, 327 (2004); Kim, T.J. et al.: Cong. Proc. BCPC Int. Cong. Crop Sci. Technol., 2, 833 (2003);<br></p>

<p>Applications Procaine Penicillin G is a composed of the β-lactam antibiotic of Penicillin G and the sodium channel blocker Procaine. As an antibiotic, Penicillin G is noted to posses effectiveness mainly against gram-positive organisms. Procaine Penicillin G is used a growth stimulant for poultry.<br>References Galal, E.E. et al.: J Drug Res., 3, 179 (1971); Coates, M.E. et al.: J. Sci. Food Agric., 20, 182 (1969);<br></p>

<p>Applications Herbicide used to control the spread of weedgrass.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Haith, D., et al.: Environ. Sci. Technol., 44, 6496 (2010), Jabran, K., et al.: Int. J. Agric. Biol., 12, 335 (2010), Rahaman, S., et al.: Environ. Ecol., 28, 1 (2010),<br></p>

<p>Applications Synthetic androgen epimeric with Bolasterone (B674970). Has been used in treatment of breast cancer. Controlled substance (anabolic steroid).<br>References Horn, H., et al.: Br. J. Cancer, 33, 336 (1976), Zumoff, B., et al.: J. Clin. Endocrinol. Metab., 44(6), 1203 (1977),<br></p>

<p>Applications Labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.<br>References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>

<p>Applications Eltenac is a nonsteroidal anti-inflammatory drug.<br>References Allen, A., et al.: Gut, 21, 249 (1980), Tobin, T., et al.: J. Vet. Pharmacol. Therap., 9, 1 (1986),<br></p>

<p>Applications Labelled Talinolol. Selective β1-adrenergic blocker structurally related to Practolol. Antihypertensive; antiarrhythmic.<br>References Assmann, I., et al.: Curr. Med. Res. Opin., 13, 325 (1995), Trausch, B., et al.: Biopharm. Drug Dispos., 16, 403 (1995),<br></p>

<p>Applications Diuretic; antihypertensive. A subunit-specific inhibitor of GABAC receptors.<br>References Wentling, C.D., et al.: Anal. Profiles Drug Subs., 1, 65 (1972), Dingledine, R., et al.: Pharmacol. Rev., 51, 7 (1999), Qian, H., et al.: J. Neurobiol., 40, 67 (1999), Qian, H., et al.: Mol. Pharmacol., 67, 470 (2005), Hadley, S., et al.: J. Physiol., 581, 1001 ( 2007),<br></p>

<p>Applications Iron Saccharate has been used to treat iron deficiency and iron deficiency anemia associated with different chronic diseases.<br>References Stein, J., et al.: Curr. Med. Res. Opinion, 28, 241 (2012),<br></p>

<p>Applications Zinc Dimethyldithiocarbamate is a member of a class of dithiocarbamates, and has been used in agriculture as a fungicide (1) and in the rubber industry as a vulcanization accelerator. It is a neurotoxin which is associated with parkinson’s disease (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Ema, M. et al.: Bull Environ Contam Toxicol. 1994 Dec;53(6):930-6.2. Lulla, A. et al.: Environ Health Perspect. 2016 Nov;124(11):1766-1775.<br></p>

<p>Applications Labelled Abiraterone (A108490). A steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.<br>References Denis, L., et al.: Cancer, 72, 3888 (1993), Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995), Denmeade, S., et al.: Nat. Rev., 2, 389(2002), Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005),<br></p>

<p>Applications Nitrendipine-d5 is the isotope labelled analogue of Nitrendipine (N490150), a dihydropyridine calcium channel blocker. Nitrendipine is used in the treatment of primary (essential) hypertension to decrease blood pressure. Antihypertensive.<br>References Ventura, H.O., et al.: Am. J. Cardiol., 51, 783 (1983),<br></p>

<p>Applications Possible Progesterone metabolite.<br>References Meng, L., et al.: J. Hepatol., 27, 346 (1997), Ho, C., et al.: Biochem., 45, 5695 (2006),<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Amisulpride (A633250). Amisulpride is a neuroleptic agent, an analogue of Sulpiride (S689145). Amisulpride is used as an antipsychotic. Amisulpride is a dopamine receptor antagonist.<br>References Protais, P., et al.: Neuropharmacol., 24, 861 (1985), Perrault, G., et al.: J. Pharmacol. Exp. Ther., 280, 73 (1997),<br></p>

<p>Applications 2,6-Difluorobenzamide (CAS# 18063-03-1) is a useful building block used in the synthesis of (E)-3-methyleneisoindolin-1-ones via oxidative annulation acrylates.<br>References Laha, J. K.; et al.: J. Org. Chem., 82, 7346 (2017).<br></p>

<p>Applications Labelled Nizatidine. Histamine H2-receptor antagonist related to Ranitidine (R120000). Antiulcerative.<br>References Callaghan, J.T., et al.: Clin. Pharmacol. Ther., 37, 162 (1985), Secor, J.W., et al.: Br. J. Clin. Pharmacol., 20, 710 (1985), Knadler, M.P., et al.: Drug Metab. Dispos., 14, 175 (1986), Wozniak, T.J., et al.: Anal. Profiles Drug Subs., 19, 397(1990)<br></p>

<p>Applications Hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action.<br>References Barchas, et al.: Nature, 214, 919 (1967), Glass, J.D., et al.: Science, 214, 821 (1981),<br></p>

<p>Applications A isothiazolidin-3-one derivative as antimicrobial. It was tested for inhibition of PCAF activity. 5-Chloroisothiazolinones showed the most potent inhibition of PCAF.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sadhale, P.P., et al.: J. Biol. Chem., 279, 33716 (2004), Thomsen, R., et al.: J. Med. Chem., 49, 3315 (2006),<br></p>

<p>Applications 3-Hydroxystearoylcarnitine Hydrochloride is found in overweight patients.<br>References Rodriguez-Gutierrez, R., et. al.: J. Int. Society Sports Nutrition, 9, 22, (2012)<br></p>

<p>Applications Ketorolac is an analgesic; anti-inflammatory.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Etman, M., et al.: Pharm. Technol., 32, 58 (2008), Chelladurai, S., et al.: Chem. Pharm. Bull., 56, 1596 (2008), Sanderson, H., et al.: Toxicol. Lett., 187, 84 (2009),<br></p>

<p>Applications Labelled trichloroethylene metabolite<br>References Werner, M., et al.: Chem. Res. Toxicol., 9, 41 (1996), Bruning, T., et al.: Toxicol. Sci., 41, 157 (1998), Newman, D., et al.: Drug Metab. Disposition, 35, 43 (2007),<br></p>

<p>Applications Methyclothiazid, is derivative of Hydrochlorothiazide (H714560), which is a diuretic used in the hospital or for personal use to promote excess fluid associated with congestive heart failure. It is also used as an antihypertensive.<br>References Piala, J.J., et al.: J. Pharmacol. Exp. Ther., 134, 273 (1961), Deppeler, H.P., et al.: Anal. Profiles Drug Subs., 10, 405 (1981),<br></p>

<p>Applications 1,4-Dihydro-1-methyl-4-oxo-3-pyridinecarboxamide-d3 is the isotope labelled analog of 1,4-Dihydro-1-methyl-4-oxo-3-pyridinecarboxamide (D453415); a compound that has been shown to be one of the potential novel biomarkers of peroxisome proliferation in the rat.<br>References Ringeissen, S., Biomarkers, 8, 240 (2003); Shibata, K., et al.: Biosci. Biotech. and Biochem., 77, 2105 (2013)<br></p>

<p>Applications A fluorimetric substrate for cytochrome P450 IAI. Inhibits vasorelaxant responses to acetylcholine.<br>References Donato, M.T., et al.: Anal. Biochem., 213, 29 (1993), Oyekan, A.O., et al.: J. Pharmacol. Exp. Ther., 268, 262 (1994)<br></p>

<p>Applications N-Octanoyl-d15-glycine is labelled N-Octanoylglycine (O239735) which is a derivative of Glycine (G615990) and is an amphiphilic lipoamino acid commonly used in cosmetics for its antibacterial properties. N-Octanoylglycine is the active ingredient in products designed to treat seborrheic dermatitis on the scalp and acne prone skin.<br>References Georgalas, A.: Cosmet. Toiletries, 127, 96 (2012); Nakamura, S.: Frag. J., 39, 36 (2011)<br></p>

<p>Applications Methoxyphenone is a pesticidal compound, and it is used in preparation of Nitrones as herbicides.<br>References Campbell, Matthew J., et al:. PCT Int. Appl., (2018); Garizi, N., et al:.U.S. Pat. Appl. Publ., (2014);<br></p>

<p>Applications (R)-10-Monohydroxy-10,11-dihydro Carbamazepine-d3 is labelled (R)-10-Monohydroxy-10,11-dihydro Carbamazepine which is the metabolite of Oxcarbazepine (OXC) and Eslicarbazepine acetate, (BIA 2-093, ESL), novel central nervous system drugs.<br>References Duncan, J., et al.: Br. J. Clin. Pharmacol., 53, 123 (2002), Almeida, L., et al.: J. Clin. Pharmacol., 45, 1062 (2005), Coppola, G., et al.: CNS Drugs, 18, 133 (2004),<br></p>

<p>Applications Cephalosporin Antibiotic.<br>References Murata, H., et al.: J. Hepatol., 38, 573 (2003), Osawa, M., et al.: Legal Med., 10, 143 (2008), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009),<br></p>

<p>Applications A synthetic progestin largely used in hormone therapy, on the central nervous system by studying two markers of the neuroendocrine function: the neurosteroid allopregnanolone and the opioid .beta.-endorphin. Progestogen.<br>References Bernardi, F., et al.: Eur. J. Endocrinol., 138, 316 (1998), Rupprecht, R., et al.: Steroids, 64, 83 (1999), Uzunova, V., et al.: Brain Res., 976, 1 (2003), Pluchino, N., et al.: J. Steroid Biochem. Mol. Biol., 102, 205 (2006),<br></p>

<p>Applications Eszopiclone is the active stereoizomer of Zopiclone and belongs to the class of drug known as cyclopyrrones. It is a nonbenzodiazepine hypnotic agent used as a treatment for insomnia.This is a controlled substance (depressant) in the US but not in Canada.<br>References Gottesmann, C., et al.: Eur. J. Neurosci., 10, 409 (1998), Yoshimoto, M., et al.: Eur. Neuropsychopharmacol., 9, 29 (1999),<br></p>

<p>Applications Labelled Tryptamine (T894600). Occurs in plants.<br></p>

<p>Applications Tripamide is a diuretic.<br>References Ogihara, T., et al.: Hypert. Res., 32, 163 (2009)<br></p>

<p>Applications Zolmitriptan is a serotonin 5HTID-receptor agonist and used to treat migraine (1,2,3).<br>References (1) Glen, R.C., et al.: J. Med. Chem., 38, 3566 (1995)(2) Seaber, E., et al.: Brit. J. Clin. Pharmacol., 41, 141 (1996)(3) Tepper, S.J., et al.: Curr. Med. Res. Opin., 15, 254 (1999)<br></p>

<p>Applications Antilipemic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Metz, G., et al.: Arzneim.-Forsch., 27, 1173 (1977), Hassan, A.M., et al.: Anal. Profiles Drug Subs., 11, 197 (1982),<br></p>

<p>Applications Phentermine is an appeitie suppressant used in the treatment of obesity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ryan D.H., et. al.: Obesity Research, 7, 313 (1999); Wadden, T.A., et. al.: Oesity Research, 5, 218 (1997)<br></p>

<p>Applications 2,4,5-Trichlorophenol is used as a broad range pesticide against insects, fungi, vegetation and bacteria. It has become a common environmental contaminant and probable human carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Amer, S. et al.: Cytologia, 39, 633 (1974); Xu, X. wt l.: Occup. Environ. Med., 68, 557 (2011); Sinclair, C.J. et al.: Environ. Sci. Technol., 37, 4617 (2003);<br></p>

<p>Applications Isotope labelled Pyraclostrobin is a fungicide for use in seed grass and food crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gyldenkaerne, S., et al.: Pestic Sci., 55, 1210 (1999), Pennington, D., et al.: Environ. Sci. Technol., 39, 1119 (2005), Wang, S., et al.: Food Control., 18, 731 (2007),<br></p>