CAS: 477575-56-7 - (3Z)-5-[(2,6-dichlorobenzyl)sulfonyl]-3-[(3,5-dimethyl-4-{[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one

Formula: C₃₂H₃₄Cl₂N₄O₄S

InChI: InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1

InChI key: InChIKey=OYONTEXKYJZFHA-SSHUPFPWSA-N

SMILES: O=C1NC2=CC=C(C=C2C1=CC=3NC(=C(C(=O)N4CCCC4CN5CCCC5)C3C)C)S(=O)(=O)CC=6C(Cl)=CC=CC6Cl

Sinonimi:

• (2R)-1-[[5-[(z)-[5-[[(2,6-dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3h-indol-3-ylidene]methyl]-2,4-dimethyl-1h-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine
• (3Z)-5-[(2,6-Dichlorobenzyl)sulfonyl]-3-[(3,5-dimethyl-4-{[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
• (3Z)-5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[(2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one
• 2H-Indol-2-one, 5-[[(2,6-dichlorophenyl)methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[(2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-1H-pyrrol-2-yl]methylene]-1,3-dihydro-, (3Z)-
• Pha 665752
• Pha665752
• Pyrrolidine, 1-[[5-[(Z)-[5-[[(2,6-dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)-, (2R)-
• Tcmdc-125885

PHA-665752

CAS: 477575-56-7

• Formula: C₃₂H₃₄Cl₂N₄O₄S
• Purezza: 98%
• Colore e forma: Solid
• Peso molecolare: 641.6078

PHA-665752 hydrate

CAS: 477575-56-7

• Formula: C₃₂H₃₄Cl₂N₄O₄S·xH₂O
• Peso molecolare: 641.61 (anhydrous)

PHA-665752

CAS: 477575-56-7

PHA-665752 is an effective, specific and ATP-competitive c-Met inhibitor (IC50: 9 nM), >50-fold selectivity for …

• Formula: C₃₂H₃₄Cl₂N₄O₄S
• Purezza: 99.35%
• Colore e forma: Solid
• Peso molecolare: 641.61

PHA-665752 Hydrate

CAS: 477575-56-7

• Formula: C₃₂H₃₄Cl₂N₄O₄S•xH₂O
• Peso molecolare: 641.608

PHA-665752-d8 Hydrate

CAS: 477575-56-7

• Formula: C₃₂H₂₆D₈Cl₂N₄O₄S•xHO
• Peso molecolare: 667.68

PHA 665752

CAS: 477575-56-7

Inhibitor of c-Met tyrosine kinase

• Formula: C₃₂H₃₄Cl₂N₄O₄S
• Purezza: Min. 95%
• Peso molecolare: 641.61 g/mol