Enzimi inibitori
Gli inibitori enzimatici sono composti che riducono o arrestano l'attività degli enzimi legandosi specificamente ad essi. Questi inibitori svolgono un ruolo cruciale nella regolazione dei processi biologici e sono ampiamente utilizzati nella ricerca medica e nello sviluppo di farmaci. Bloccando l'attività enzimatica, consentono di studiare la funzione degli enzimi e di sviluppare trattamenti per diverse malattie. Presso CymitQuimica, offriamo un'ampia gamma di inibitori enzimatici di alta qualità per supportare la vostra ricerca in biologia e farmacologia.
Trovati 123 prodotti di "Enzimi inibitori"
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Argatroban
CAS:Formula:C23H38N6O6SPurezza:(HPLC) ≥ 98%Colore e forma:White to off-white powderPeso molecolare:526.65IU1
CAS:Formula:C18H21FN2OPurezza:(TLC) ≥ 98%Colore e forma:Off-white to pale brown solidPeso molecolare:300.37Fumagillin
CAS:Formula:C26H34O7Purezza:≥ 95.0%Colore e forma:White, off-white or pale yellow to tan powderPeso molecolare:458.54Vildagliptin
CAS:Formula:C17H25N3O2Purezza:≥ 98.0%Colore e forma:White to off-white powderPeso molecolare:303.40Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride
CAS:Formula:C14H21ClN2O3S·HClPurezza:(HPLC) ≥ 98.0%Colore e forma:White powderPeso molecolare:369.31Nafamostat
CAS:Formula:C19H17N5O2Purezza:≥ 98.0%Colore e forma:White to off-white powderPeso molecolare:347.37Lactacystin
CAS:Formula:C15H24N2O7SPurezza:≥ 95.0%Colore e forma:White solid or powderPeso molecolare:376.43E-64 protease inhibitor
CAS:Formula:C15H27N5O5Purezza:(HPLC) ≥ 98.0%Colore e forma:White crystalline powderPeso molecolare:357.40Bestatin hydrochloride
CAS:Formula:C16H24N2O4·HClPurezza:≥ 98.0% (dried basis)Colore e forma:White to almost white powderPeso molecolare:344.87Bortezomib
CAS:Formula:C19H25BN4O4Purezza:≥ 98.0%Colore e forma:White to off-white powder or solidPeso molecolare:384.24Suramin sodium salt
CAS:Formula:C51H34N6Na6O23S6Purezza:≥ 98%Colore e forma:White to off-white powderPeso molecolare:1429.16Phosphoramidon disodium salt
CAS:Formula:C23H32N3Na2O10PPurezza:≥ 97.0%Colore e forma:Colourless, transparent crystals or white to light yellow crystalline powderPeso molecolare:587.47Nafamostat mesylate
CAS:Formula:C19H17N5O2Purezza:≥ 99.0%Colore e forma:White to off-white or beige crystalline powderPeso molecolare:347.37Z-Leu-Leu-Leu-al
CAS:Formula:C26H41N3O5Purezza:≥ 97.0%Colore e forma:White to off-white powder or solidPeso molecolare:475.63Carfilzomib
CAS:Formula:C40H57N5O7Purezza:(HPLC) ≥ 98.0%Colore e forma:White to off-white crystalline powder or crystalsPeso molecolare:719.91DAPT
CAS:Formula:C23H26F2N2O4Purezza:(NMR) ≥ 98.0%Colore e forma:White to off-white solidPeso molecolare:432.50N-p-Tosyl-L-phenylalanine chloromethyl ketone
CAS:Formula:C17H18ClNO3SPurezza:(TLC) ≥ 98.0%Colore e forma:White to off-white powderPeso molecolare:351.85Leupeptin hemisulfate
CAS:Formula:C20H38N6O4·5H2SO4Purezza:≥ 95%Colore e forma:White to off-white powderPeso molecolare:475.59Pepstatin A
CAS:Formula:C34H63N5O9Purezza:≥ 98.0%Colore e forma:White to off-white powderPeso molecolare:685.90E-64d protease inhibitor
CAS:Formula:C17H30N2O5Purezza:≥ 95.0%Colore e forma:White powderPeso molecolare:342.43Elastatinal microbial
CAS:Formula:C21H36N8O7Purezza:~0.64μg/ml (IC50, pH8.8, 37°C)Colore e forma:White to light-yellow or tan powderPeso molecolare:512.60Z-VAD-FMK, cell permeable
CAS:Formula:C22H30FN3O7Purezza:≥ 95.0%Colore e forma:White to off-white solidPeso molecolare:467.5AEBSF hydrochloride
CAS:Formula:C8H10FNO2S·HClPurezza:≥ 98.0%Colore e forma:White to off-white powder or solidPeso molecolare:239.69Apricoxib
CAS:Prodotto controllato<p>Applications Apricoxib, is an orally active, selective COX-2 inhibitor, used as as an analgesic and anti-inflammatory agent, and also has anticancer potential, since COX-2 inhibition can reduce tumor growth and augment therapy.<br>References Kirane, A, et al.: Clinical Cancer Res., 18, 5031 (2012); Rohatagi, Sh., et al.: British J. Clin. Pharmaco., 66, 60 (2008);<br></p>Formula:C19H20N2O3SColore e forma:NeatPeso molecolare:356.44Vitamin B12 e-Monocarboxylic Acid
CAS:<p>Stability Hygroscopic<br>Applications Vitamin B12 Monocarboxylic Acid is an impurity of Vitamin B12 (V676005) which is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood.<br>References Rickes, et al.: Science, 107, 396 (1948); Kirschbaum, J., et al.: Anal. Profiles Drug Subs., 10, 183 (1981); Grasbeck, R., et al.: Clin. Biochem., 17, 99 (1984)<br></p>Formula:C63H87CoN13O15PColore e forma:Dark Red SolidPeso molecolare:1356.35(3S,4S,3’S)-Ezetimibe
CAS:<p>Applications (3S,4S,3’S)-Ezetimbe is a 3-epimer impurity of Ezetimibe (E975000), a cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Formula:C24H21F2NO3Colore e forma:Off-WhitePeso molecolare:409.43(3S,5S)-Atorvastatin Calcium Salt
CAS:Prodotto controllato<p>Impurity Atorvastatin Related Compound E<br>Applications Impuritiy of Atorvaststin (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia. Atorvastatin Related Compound E<br>References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000),<br></p>Formula:C33H34FN2O5·CaColore e forma:NeatPeso molecolare:1155.34N-(2-Hydroxyethyl)-1-deoxy-L-altronojirimycin Hydrochloride Salt
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications α-Glycosidase inhibitor.<br>References Jefferies, I., et al.: Bioorg. Med. Chem. Lett., 7, 1171 (1997), Hassan, A., et al.: Carbohydr. Res., 339, 1565 (2004),<br></p>Formula:C8H18ClNO5Colore e forma:NeatPeso molecolare:243.68522,5-Dideoxy-2,5-imino-D-mannitol
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications A glucosidase inhibitor.<br>References Fellows, L.E.: Pestic. Sci., 17, 602 (1986)<br></p>Formula:C6H13NO4Colore e forma:Off White SolidPeso molecolare:163.17Nitromifene Citrate (E/Z mixture)
CAS:Prodotto controllato<p>Applications Nitromifene citrate is a non-steroidal estrogen antagonist. It is structurally similar to Tamoxifen (T006000) which is a selective estrogen response modifier (SERM).<br>References Rudick, C., et al.: Endorcrinol., 144, 179 (2003); Sutherland, R., et al.: Nature, 267, 434 (1977)<br></p>Formula:C33H36N2O11Colore e forma:Yellow To OrangePeso molecolare:636.65N-(2-Hydroxyethyl)-1-deoxy-L-idonojirimycin Hydrochloride
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications α-Glycosidase inhibitor.<br>References van de Water, F., et al.: Drug Metab. Rev., 37, 443 (2005), Koepsell, H., et al.: Pharm. Res., 24, 1227 (2007), Jappar, D., et al.: Pharm. Res., 26, 172 (2009),<br></p>Formula:C8H18ClNO5Colore e forma:NeatPeso molecolare:243.69Daidzein Diglucuronide
CAS:Prodotto controllatoFormula:C27H26O16Colore e forma:White To Off-WhitePeso molecolare:606.49Teneligliptin Hydrobromide (2:5)
CAS:Prodotto controllato<p>Applications Teneligliptin Hydrobromide (2:5) is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. It is eliminated via excretion, and has a half-life of 24.2 hours in the human body.<br>References Goda, M. & Kadowaki, T.: Drugs Today, 49, 615 (2013); Kishimoto, M.: Diabetes Metab. Syndr. Obes., 6, 187 (2012)<br></p>Formula:C22H32·5Br2·5N6OSColore e forma:NeatPeso molecolare:628.862-(Hydroxyamino)acetic Acid
CAS:Prodotto controllato<p>Applications 2-(Hydroxyamino)acetic Acid is a novel lactase inhibitor.<br>References Hattori, M., et al.: J. Insect Physiol., 51, 1359 (2005); Murao, S., et al.: Biosci. Biotech. Biochem., 56, 987 (1992)<br></p>Formula:C2H5NO3Colore e forma:NeatPeso molecolare:91.07Galacto-PUGNAc (>90%)
CAS:Prodotto controllato<p>Stability Moisture and Temperature Sensitive<br>Applications Galacto-PUGNAc is a highly selective inhibitor for β-hexosaminidases HEXA and HEXB is cell-permeable. Galacto-PUGNAc is able to modulate the activity of HEXA and HEXB in tissue culture, increasing ganglioside GM2 levels in neuroblastoma cells<br>References Stubbs, K.A. et al.: Angew. Chem. Int. Ed., 48, 1300 (2009);<br></p>Formula:C15H19N3O7Purezza:>90%Colore e forma:NeatPeso molecolare:353.33Aprotinin Hydrochloride
CAS:<p>Applications Aprotinin is used in cardiac surgery to minimize bleeding and reduce exposure to blood products.<br>References Mangano, D. et al.: New Eng. J. Med., 354, 353 (2006); Fergusson, D. et al.: New. Eng. J. Med., 358, 2319 (2008);<br></p>Formula:C284H432N84O79S7·x(ClH)Colore e forma:White SolidPeso molecolare:6511.51(free amine)tert-Butyl (2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-[(1,3-thiazolidin-3-yl)carbonyl]pyrrolidine-1-carboxylate
CAS:Prodotto controllato<p>Applications tert-Butyl (2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-[(1,3-thiazolidin-3-yl)carbonyl]pyrrolidine-1-carboxylate is an orally anti-diabetic agent as a inhibitors of dipeptidylpeptidase IV (DPP-4).<br>References Yoshida, T., et al.: Bioorg. Med. Chem., 20, 5705-5719 (2012);<br></p>Formula:C27H38N6O3SColore e forma:NeatPeso molecolare:526.69LCZ696
CAS:<p>Applications LCZ696 is a novel dual-acting inhibitor of angiotensin II receptor and neprilysin, which can be used for blood pressure reduction.<br>References Ruilope, L.M.; et al.: Lancet, 375, 1255 (2010)<br></p>Formula:C24H28NO5·C24H27N5O3·3Na·x(H2O)Colore e forma:MixturePeso molecolare:479.48 + (433.47) + x(18.02)Abamine
CAS:Prodotto controllato<p>Applications Abamine is an inhibitor of 9-Cis-Epoxycarotenoid dioxygenase (NCED), the key regulatory enzyme in the plant hormone abscisic acid (ABA) biosynthesis pathway.<br>References Kitahata, N., et al.: Bioorg. Med. Chem., 14, 5555 (2006); Han, S., et al.: Bioorg. Med. Chem. Lett., 14, 3033 (2004)<br></p>Formula:C21H24FNO4Colore e forma:NeatPeso molecolare:373.42CP-10447
CAS:<p>Applications CP-10447 is an inhibitor apolipoprotein B (apoB) and triglyceride secretion in human hepatoma cells (HepG2) by inhibiting MTP activity and stimulating the early ER degradation of apoB. It is useful tool for further study of the mechanisms of apoB secretion and triglyceride-rich lipoprotein assembly.<br>References Haghpassand, M. et al.: J. Lipid. Res., 37, 1468 (1996); Pan, M. et al.: J. Biol. chem., 275, 27399 (2000);<br></p>Formula:C16H13BrN2OColore e forma:NeatPeso molecolare:329.193'-Deoxyadenosine 5’-Diphosphate Triethylamine Salt (>90%)
CAS:<p>Stability Hygroscopic<br>Applications 3'-Deoxyadenosine 5’-Diphosphate Triethylamine Salt, is a nucleotide and was proposed to be a possible inhibitor of DNA synthesis.<br>References Frederiksen, Sune.: Biochimica et Biophysica Acta, 76(3), 366-71 (1963)<br></p>Formula:C10H15N5O9P2•xC6H15NPurezza:>90%Colore e forma:NeatPeso molecolare:411.20 + x(101.19)Bis(2-butoxyethyl) 2-(3-Hydroxybutoxy)ethyl Phosphate Triester
CAS:Prodotto controllato<p>Applications Bis(2-butoxyethyl) 2-(3-Hydroxybutoxy)ethyl Phosphate Triester is derived from 2-Butoxyethanol (B692895), which is a reagent in the synthesis of 4-butoxyethoxy-N-octadecyl-1,8-naphthalimide as a new fluorescent probe for the determination of proteins. Also used as a reagent in the synthesis of 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors.<br>References Sun, Y., et al.: Bioorg. Med. Chem. Lett., 21, 3798 (2011); Yi, W., et al.: Eur. J. Med. Chem., 45, 639 (2010)<br></p>Formula:C18H39O8PColore e forma:Colourless To Light YellowPeso molecolare:414.47Nicotelline
CAS:Prodotto controllato<p>Applications Nicotelline is a Nicotine (N412420) related metabolite with potential as an inhibitor of human cytochrome P-450 2A6.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Denton, T. et al.: Biochem. Pharm., 67, 751 (2004); Gorrod, J. et al.: Anal. Det. Nic. Rel. Comp. Metab., 69, (1999);<br></p>Formula:C15H11N3Colore e forma:NeatPeso molecolare:233.27Naringenin chalcone
CAS:Prodotto controllatoFormula:C15H12O5Colore e forma:NeatPeso molecolare:272.25N-(10-Aminodecyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride
CAS:Prodotto controllato<p>Applications Naphthalenesulfonamides derivatives are neoplasm inhibitors.<br>References Hidaka, H., et al.: Proc. Nat. Acad. Sci. USA, 78, 4354 (1981)<br></p>Formula:C20H29ClN2O2S·ClHColore e forma:NeatPeso molecolare:433.44Avelestat
CAS:Prodotto controllato<p>Applications Avelstat inhibits plasma neutrophil elastase (NE) activity in zymosan-stimulated whole blood, and also inhibits NE activity on the surface of stimulated polymorphonuclear cells and in the supernatant of primed, stimulated cells.<br>References Stevens, T., et al.: J. Pharmacol. Exp. Ther., 339, 313 (2011)<br></p>Formula:C25H22F3N5O4SColore e forma:NeatPeso molecolare:545.53Enviroxime
CAS:Prodotto controllato<p>Applications Enviroxime is a benzimidazole derivative that inhibits rhinovirus multiplication.<br>References De Long, D.C., et al.: J. Infect. Dis., 141, 87 (1980), Wikel, J.H., et al.: J. Med. Chem., 23, 368 (1980), Phillpotts, R.J., et al.: Lancet, 1, 1342 (1981), Haden, F.G., et al.: Antimicrob. Agents Chemother., 21, 892 (1982),<br></p>Formula:C17H18N4O3SColore e forma:NeatPeso molecolare:358.41Benzyl Methyl Carbonate
CAS:Prodotto controllato<p>Applications Benzyl Methyl Carbonate is used in designing of inhibitors for serine and thiol proteases.<br></p>Formula:C9H10O3Colore e forma:NeatPeso molecolare:166.174,5,6,7-Tetrabromo-1H-benzotriazole
CAS:Prodotto controllato<p>Applications TBB is one of the most selective protein kinase inhibitors known, and when tested against a panel of 33 serine/threonine and tyrosine protein kinases, only three exhibited moderate inhibition by TBB, with Ki values one to two orders of magnitude higher than that for CK2.<br>References Boehning, D., et al.: Neuron, 40, 129 (2993)<br></p>Formula:C6HBr4N3Colore e forma:NeatPeso molecolare:434.71Chelerythrine Chloride
CAS:<p>Stability Hygroscopic<br>Applications Chelerythrine Chloride is a cell permeable protein kinase C (PKC) inhibitor.<br>References Song, L., et. al.: Brain Res., 1564, 52 (2014)<br></p>Formula:C21H18NO4·ClColore e forma:YellowPeso molecolare:383.82(R)-Pinocembrin
CAS:Prodotto controllato<p>Applications (2R)-Pinocembrin is the (R)-enantiomer of Pinocembrin, a flavanoid with antioxidant activity found in damiana, honey, and propolis. (2R)-Pinocembrin is a potential inhibitor of PIM1 kinase, an oncogene that has been implicated in the development of leukemias, lymphomas, and prostate cancer.<br>References Zhao, J. et al.: J. Ethnopharmacol., 120, 387 (2008); Holder, S. et al.: Mol. Cancer Ther., 6, 163 (2007); Holder, S. et al.: Bioorg. Med. Chem., 15, 6463 (2007);<br></p>Formula:C15H12O4Colore e forma:WhitePeso molecolare:256.25O,O-Dimethyl Dithiophosphate
CAS:Prodotto controllatoFormula:C2H7O2PS2Colore e forma:ColourlessPeso molecolare:158.18Morusin
CAS:Prodotto controllato<p>Stability Light Sensitive<br>Applications Morusin is an inhibitor of human cervical cancer stem cell growth, attenuating NF-kB activity, and initiating apoptosis.<br>References Wang, L. et al.: Mol. Cell. Biochem., 379, 7 (2013);<br></p>Formula:C25H24O6Colore e forma:NeatPeso molecolare:420.45GDC 0152
CAS:Prodotto controllato<p>Applications GDC 0152 is a peptidomimetic small molecule antagonist of inhibitor of apoptosis (IAP) proteins with antitumor activity.<br>References Yue, Q., et. al.: Drug Metab. Dispos., 41, 508 (2013)<br></p>Formula:C25H34N6O3SColore e forma:NeatPeso molecolare:498.64Ipidacrine Hydrochloride Hydrate
CAS:Formula:C12H16N2·ClH·H2OColore e forma:NeatPeso molecolare:242.753a,6,7,7a-Tetrahydro-5-(hydroxymethyl)-2-methyl-(3aR,5R,6S,7R,7aR)-5H-pyrano[3,2-d]thiazole-6,7-diol
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications 3a,6,7,7a-Tetrahydro-5-(hydroxymethyl)-2-methyl-(3aR,5R,6S,7R,7aR)-5H-pyrano[3,2-d]thiazole-6,7-diol, can be used in the synthesis of Hexosaminidase inhibitors, which are the new drug candidates for the therapy of osteoarthritis.<br>References Liu, J. et al.: Chem. Bio., 8, 701 (2001);<br></p>Formula:C8H13NO4SColore e forma:White To Light BeigePeso molecolare:219.26Bisindolylmaleimide VIII Acetic Acid Salt
CAS:Prodotto controllato<p>Applications It is a potent inhibitor of protein kinase C (PKC) activity. Bisindolylmaleimide VIII (Bis VIII) has been previously shown to enhance Fas-mediated apoptosis through a protein kinase C-independent mechanism.<br>References Emery, J., et al.: J. Biol. Chem., 273, 14363 (1998), Wiley, S., et al.: Immunity, 3, 673 (1995), MacFarlane, M., et al.: Biochem. J., 348, 93 (2000),<br></p>Formula:C26H26N4O4Colore e forma:NeatPeso molecolare:458.511-(5-Isoquinolinesulfonyl)-2-methylpiperazine Dihydrochloride
CAS:Prodotto controllato<p>Applications A selective inhibitor of protein kinase C or cyclic-nucleotide-dependent protein kinases.<br>References Hidaka, H. and Kawamoto, S.: Biochem. and Biophys. Res. Comm., 125, 1, 258 (1984)<br></p>Formula:C14H17N3O2S·2ClHColore e forma:NeatPeso molecolare:364.29O,S-Diethyl Methylphosphonothioate
CAS:Prodotto controllato<p>Stability Moisture Sensitive<br>Applications An inhibitor of cholinesterase.<br>References Berman, H., et al.: J. Biol. Chem., 264, 3951 (1989), Millard, C., et al.: Biochemistry, 37, 237 (1998), Koellner, G., et al.: J. Mol. Biol., 296, 713 (2000),<br></p>Formula:C5H13O2PSColore e forma:NeatPeso molecolare:168.193-Acetyl-11-keto-β-boswellic Acid
CAS:Prodotto controllatoFormula:C32H48O5Colore e forma:WhitePeso molecolare:512.721-Propan-1,1,2,2,3,3,3-d7-amine
CAS:Prodotto controllatoFormula:C3H2D7NColore e forma:NeatPeso molecolare:66.15O-(2,4-Dinitrophenyl)hydroxylamine
CAS:<p>Applications O-(2,4-Dinitrophenyl)hydroxylamine is a rapid active-site-directed inhibitor of D-amino acid oxidase; modification results in specific incorporation of an amine group into an accessible nucleophilic residue with concomitant release of 2,4-dinitrophenol.<br>References D'Silva, C., et al.: Biochemi., 25, 5602 (1986),<br></p>Formula:C6H5N3O5Colore e forma:Brown SolidPeso molecolare:199.12N-Acetyl-Lys-Octreotide Trifluoroacetic Acid Salt
CAS:<p>Stability Hygroscopic<br>Applications N-Acetyl-Phe-Octreotide is used as reactant/reagent in inhibition of octreotide acylation inside PLGA microspheres by derivatization of amines of peptide with self-immolative protecting group.<br>References Shirangi, M., et al.: Bioconjugate Chem., 27, 576-585 (2016)<br></p>Formula:C51H68N10O11S2·xC2HF3O2Colore e forma:NeatPeso molecolare:1061.284Resolvin E1 Sodium Salt
CAS:Prodotto controllatoFormula:C20H29NaO5Colore e forma:NeatPeso molecolare:372.431(5E)-6-(4-Hydroxy-3-methoxyphenyl)-5-hexene-2,4-dione
CAS:Prodotto controllato<p>Applications Curcumin (C838500) and gingerdione derivative. A possible human glyoxalase I inhibitor. Flavor modifier.<br>References Yuan, M. et al.; Bioorg. Med. Chem. 19, 1189 (2011); Ley, J. et al.; J. Agr. Food Chem. 56, 6656 (2008)<br></p>Formula:C13H14O4Colore e forma:NeatPeso molecolare:234.25(±)-Procinolol Hydrochloride
CAS:Prodotto controllato<p>Applications (±)-Procinolol is a beta adrenergic receptor antagonist.<br>References Singh, K.: Indian J. Phsiol. Pharmacol., 27, 311 (1983)<br></p>Formula:C15H24ClNO2Colore e forma:NeatPeso molecolare:285.81Baohuoside I
CAS:Prodotto controllato<p>Applications Baohuoside I is an inhibitor of cell growth and also is a down-regulator of durvivin and cyclin D1 expression. Used in the treatment of esophageal cancer. Anti-cancer agent.<br>References Lifang, W. et al.: Oncology Rep., 26, 1149 (2011); Jin, X. et al.: Drug Dev. Ind. Pharm., 39, 1421 (2013);<br></p>Formula:C27H30O10Colore e forma:NeatPeso molecolare:514.52Raloxifene 4’-β-D-Glucuronide Lithium Salt
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications Raloxifene 4’-Glucuronide Lithium Salt is a metabolite of Raloxifene (R099995), a nonsteroidal estrogen receptor mixed agonist/antagonist.<br>References Dodge, J., et al.: Bioorg. Med. Chem. Lett., 7, 993 (1997); Jeong, E., et al.: Drug Metab. Dispos., 33, 785 (2005); Trontelj, J., et al.: Pharmacol. Res., 52, 334 (2005); Oswald, S., et al.: Clin. Pharmacol. Ther., 79 206 (2006)<br></p>Formula:C34H34LiNO10SColore e forma:NeatPeso molecolare:655.644-Amino-5-(bromomethyl)-2-methylpyrimidine Dihydrobromide
CAS:Prodotto controllato<p>Applications A pyrimidine derivative as G protein-coupled receptor kinase (GRK) inhibitor.<br>References Bigham, E., et al.: J. Med. Chem., 35, 1399 (1992), Jansen, M., et al.: Biochem. Pharmacol., 47, 1067 (1994), Hasbi, A., et al.: J. Neurochem., 70, 2129 (1998),<br></p>Formula:C17H17N3O2SColore e forma:NeatPeso molecolare:327.40N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
CAS:Prodotto controllato<p>Applications Found to have a potent inhibitory action against casein kinase 1 completely with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hidaka, H., et al.: J. of Biol. Chem., 264, 9, 4924 (1989)<br></p>Formula:C11H12ClN3O2S·2ClHColore e forma:NeatPeso molecolare:358.67Retorphan
CAS:Prodotto controllato<p>Applications Retorphan is a powerful and selective inhibitors of neprilysin and is being developed as a therapeutic agent. Retorphan behave as the prodrug of the enantiomers of Thiorphan (T369500).<br>References Monteil, T., et al.: Mini. Rev. Med. Chem., 2, 209 (2002); Roques, B.P., et al.: Nature, 288, 286 (1980); Tiraboschi, G., et al.: Protein Engineering, 12, 2, 141 (1999)<br></p>Formula:C21H23NO4SColore e forma:NeatPeso molecolare:385.48(1R,2R)-2-Fluorocyclopentanamine Hydrochloride
CAS:Prodotto controllato<p>Applications A cyclopentanamine used in the preparation of heterocyclic and aromatic ureas and amides as CEPT inhibitors.<br></p>Formula:C5H11ClFNColore e forma:NeatPeso molecolare:139.61-Deoxy-L-altronojirimycin Hydrochloride
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications α-Glycosidase inhibitor.<br>References Jefferies, I., et al.: Bioorg. Med. Chem. Lett., 7, 1171 (1997), Hassan, A., et al.: Carbohydr. Res., 339, 1565 (2004),<br></p>Formula:C6H13NO4·ClHPurezza:>90%Colore e forma:NeatPeso molecolare:199.634-Fluorobenzoic Acid-d4
CAS:Prodotto controllato<p>Applications 4-Fluorobenzoic Acid-d4 is used as a reagent in the synthesis of Flurofamide-d4 (F596687); the isotope labelled analog of Fluorofamide (F596685) which is a compound that acts as a urease inhibitor, useful in the treatment of gastritis and irregular urease activity in the urinary tract.<br>References Loes, A. et al.: Lett. App. Microbiol., 58, 31 (2014); Ohta, T.et al.: Biochem. Biophys, Res. Comm., 285, 728 (2001)<br></p>Formula:C7HD4FO2Colore e forma:NeatPeso molecolare:144.14tert-Butyl (3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-en-1-yl)carbamate
CAS:Prodotto controllatoFormula:C17H30BNO4Colore e forma:NeatPeso molecolare:323.24n-Pentyl-d11 chloroformate
CAS:Prodotto controllato<p>Applications n-Pentyl-d11 chloroformate is labelled n-Pentyl chloroformate which can be used to synthesize 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase.<br>References Kim, I., et al.: J. Med. Chem., 47, 2110 (2004); Hammock, B., et al.: PCT Int. Appl. (2006), WO 2006045119 A2 20060427.<br></p>Formula:C6D11ClO2Colore e forma:NeatPeso molecolare:161.674-Pyridin-2,3,5,6-d4-ol-d
CAS:Prodotto controllato<p>Applications 4-Pyridin-2,3,5,6-d4-ol-d is one of the azepanone derivatives studies as CGRP receptor antagonists.<br>References Liu, J.: PCT Int. Appl. (2010), WO 2010108103 A1 20100923.<br></p>Formula:C5D5NOColore e forma:NeatPeso molecolare:100.13n-Propyl-2,2,3,3,3-d5-amine Hydrochloride
CAS:Prodotto controllato<p>Applications n-Propyl-2,2,3,3,3-d5-amine Hydrochloride is the hydrochloride salt of 1-Propyl-d5-amine (P833702); the isotope labelled analog of 1-Propylamine (P833700) which is used in the synthesis of pyrimidine derivatives as novel and highly potent PDE4 inhibitors. It is also used in the preparation of fluorenone analogs with DNA topisomerase I inhibitors.<br>References Goto, T. et al.: Bioorg. Med. Chem., 21, 7025 (2013); Lee, C. et al.: Bioorg. Med. Chem. 21, 7125, (2013)<br></p>Formula:C3H5D5ClNColore e forma:NeatPeso molecolare:100.6tert-Butyl 4-Bromo-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoate
CAS:Prodotto controllatoFormula:C18H17BrN2O3Colore e forma:NeatPeso molecolare:389.24GW4869 TFA Salt (~90%, ~10% inorganics)
CAS:Prodotto controllato<p>Applications GW4869 is a selective inhibitor of N-SMase.<br>References Lallemand, T., et al.: Arterioscler. Thromb. Vasc. Biol., 38, 1479 (2018); Figuera-Losada, M., et al.: PLoS One, 10, 0124481 (2015)<br></p>Formula:C30H28N6O2·xC2HF3O2Colore e forma:NeatPeso molecolare:504.58 + x(114.02)N-Fmoc-glycine-d2
CAS:Prodotto controllato<p>Applications Isotope labelled N-Fmoc-glycine is an N-Fmoc-protected form of Glycine (G615990). Glycine is a nonessential amino acid that acts as an inhibitory neyrotransmitter in the vertebrate central nervous system. Glycine also posesses cytoprotective against oxidant damage in the kidney.<br>References Eulenberg, V., et al.: Trend. Biochem. Sci., 30, 325 (2005); Gundersen, R., et al.: Acta Anaesth. Scand., 49, 1108 (2005); Lockart, R. & Eagle, H.: Science, 129, 252 (1959); Sogabe, K., et al.: Kidn. Int., 50, 845 (1996)<br></p>Formula:C17H13D2NO4Colore e forma:NeatPeso molecolare:299.32Ethyl Palmitate-d31
CAS:Prodotto controllato<p>Applications A labelled fatty acid found in Amaranth oil; it shows inhibitory activity.<br>References Fidler, N., et al.: J. Lipid Res., 41, 1376 (2000), Yang, T., et al.: Food Chem., 80, 473 (2003), Gamel, T., et al.: J. Food Lipids, 14, 323 (2007),<br></p>Formula:C18H5D31O2Colore e forma:NeatPeso molecolare:315.671-Propyl-d5-amine
CAS:Prodotto controllato<p>Applications 1-Propyl-d5-amine is labelled 1-Propylamine (P833700) which is used in the synthesis of pyrimidine derivatives as novel and highly potent PDE4 inhibitors. It is also used in the preparation of fluorenone analogs with DNA topisomerase I inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C3H4D5NColore e forma:NeatPeso molecolare:64.14(3R,5S,6E)-7-(2-Cyclopropyl-4-phenyl-3-quinolinyl)-3,5-dihydroxy-6-heptenoic Acid Sodium Salt
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications (3R,5S,6E)-7-(2-cyclopropyl-4-phenyl-3-quinolinyl)-3,5-dihydroxy-6-heptenoic Acid Sodium Salt is an impurity of Pitavastatin (P531000), a HMG CoA reductase inhibitor and an antilipemic agent.<br>References Suzukim M., et al.: Bioorg. Med. Chem., 9, 2977 (1999); Yen, H., et al.: J. Clin. Invest., 98, 1253 (1996); Zou, Y., et al.: J. Biol. Chem., 274, 9760 (1999); Sun, X., et al.: Cancer Res., et al.: 61, 3382 (2001); Ladas, E.J., et al.: Clin. Oncol., 22, 517 (2004);<br></p>Formula:C25H24NNaO4Colore e forma:NeatPeso molecolare:425.45rac-1,2-Dioctanoyl-3-Chloropropanediol
CAS:Prodotto controllato<p>Stability Moisture Sensitive<br>Applications rac-1,2-Dioctanoyl-3-Chloropropanediol was studied for its ability to act as an inhibitor of protein kinase C.<br>References Briggs, Josie C., et al.: Carbohydrate Res., 234, 23-35 (1992)<br></p>Formula:C19H35ClO4Colore e forma:NeatPeso molecolare:362.93N-(n-Butyl)phosphoric Triamide
CAS:<p>Applications N-Alkyl phosphoric triamide useful as urease inhibitors.<br></p>Formula:C4H14N3OPColore e forma:White SolidPeso molecolare:151.153-Amino-N-(Tertbutylbenzenesulfonamide
CAS:Prodotto controllato<p>Applications 3-Amino-N-(Tert-Butyl)Benzenesulfonamide (cas# 608523-94-0) is a useful research chemical.<br></p>Formula:C10H16N2O2SColore e forma:NeatPeso molecolare:228.31(E)-a-Hydroxy Tamoxifen
CAS:Prodotto controllato<p>Applications A metabolite of the chemotherapeutic drug Tamoxifen (T006000). Exhibits a more potent estrogen agonist/antagonist activity than the parent drug. Also active as an intramembranous inhibitor of lipid peroxidation.<br>References Kupfer, D., et al.: Cancer Res., 54, 3140 (1994), Custodio, J.B.A., et al.: Biochem. Pharmacol., 47, 1989 (1994),<br></p>Formula:C26H29NO2Colore e forma:NeatPeso molecolare:387.51Valtrate
CAS:Prodotto controllato<p>Applications Valtrate is a Rev-transport inhibitor with anti-HIV activity from Valerianae Radix.<br>References Murakami, N., et al.: Bioorg. Med. Chem. Lett., 12, 2807 (2002); Watanabe, K., et al.: Drug Discoveries Ther., 5, 26 92011)<br></p>Formula:C22H30O8Colore e forma:Light Brown To Dark YellowPeso molecolare:422.47A 83-01
CAS:Prodotto controllato<p>Stability Moisture Sensitive<br>Applications A 83-01 is a selective inhibitor of TGF-β type I receptor. A 83-01 treatment increases tumor permeability.<br>References Minowa, T. et al.: British. J. Canc., 101, 1884 (2009)<br></p>Formula:C25H19N5SColore e forma:Off-WhitePeso molecolare:421.52
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