Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(6 prodotti)
- BCL(11 prodotti)
- Caspasi(127 prodotti)
- FOXO1(3 prodotti)
- IAP(65 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(126 prodotti)
- PDK(9 prodotti)
- PERK(24 prodotti)
- Chinasi di serina/treonina(15 prodotti)
- Survivin(13 prodotti)
- TNF(91 prodotti)
- c-RET(51 prodotti)
- p53(62 prodotti)
Mostrare 6 più sottocategorie
Trovati 5622 prodotti di "Apoptosi"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
WF 10129
CAS:<p>WF 10129 is a new angiotensin converting enzyme inhibitor generated by a fungus, Doratomyces putredinis.</p>Formula:C20H28N2O8Purezza:98%Colore e forma:SolidPeso molecolare:424.45Balstilimab
CAS:<p>Balstilimab (AGEN2034) is a fully human monoclonal IgG4 antibody against PD-1 [1] .</p>Colore e forma:LiquidPacmilimab
CAS:<p>Pacmilimab (CX-072) is a Probody immune checkpoint inhibitor targeting programmed death ligand 1 (PD-L1) with anti-tumor activity for the study of solid tumors.</p>Purezza:98.8% (SDS-PAGE); 96.3% (SEC-HPLC) - 98.8% (SDS-PAGE); 96.3% (SEC-HPLC)Colore e forma:LiquidMetronidazole hydrochloride
CAS:<p>Oral nitroimidazole antibiotic; treats anaerobic infections; may cause inflammation and muscle contractions with long-term use.</p>Formula:C6H10ClN3O3Colore e forma:SolidPeso molecolare:207.62Pidilizumab
CAS:<p>Pidilizumab (CT-011), a humanized IgG1κ anti-PD-1 monoclonal antibody, serves as a DLL1 antagonist with potential applications in researching hematologic</p>Purezza:98%Colore e forma:LiquidSB 699551
CAS:<p>SB 699551 is a selective 5-HT5A antagonist (Ki=6.31 nM) that enhances 5-HT neuronal function. It inhibits SERT (Ki=25.12 nM),inhibit breast cancer.</p>Formula:C34H45N3OPurezza:99.83%Peso molecolare:511.74Echitamine chloride
CAS:<p>Echitamine chloride, an alkaloid in Alstonia scholaris, has anti-cancer properties and inhibits pancreatic lipase (IC50: 10.92 µM).</p>Formula:C22H29ClN2O4Colore e forma:SolidPeso molecolare:420.93Chlopynostat
<p>Chlopynostat (Compound 6c) is an HDAC1 inhibitor with an IC50 value of 67 nM. It induces apoptosis by inhibiting HDAC1, thereby reversing STAT4/p66Shc defects.</p>Formula:C22H17ClN4O2Peso molecolare:404.104Aromatase-IN-5
<p>Aromatase-IN-5 (Compound 10) is a potent inhibitor of aromatase with an IC50 value of 0.06 μM. It effectively blocks estrogen production and inhibits the proliferation of breast cancer cell lines such as MCF-7, arresting the cell cycle in the G1 phase and inducing apoptosis. Aromatase-IN-5 shows promise for breast cancer research.</p>Colore e forma:Odour SolidP1D-34
<p>P1D-34 is a Pin1 PROTAC degrader with a DC50 value of 177 nM. It downregulates Pin1 substrate proteins, including Cyclin D1, Rb, Mcl-1, Akt, and c-Myc. Additionally, P1D-34 exhibits antiproliferative activity across various acute myeloid leukemia (AML) cell lines and induces DNA damage and apoptosis by generating reactive oxygen species (ROS).</p>Colore e forma:Odour SolidMEK/PI3K-IN-2
CAS:<p>MEK/PI3K-IN-2 is a potent dual inhibitor (MEK1 IC50: 352 nM, PI3Kα: 107 nM, PI3Kδ: 137 nM) that reduces pAKT, pERK1/2, and hinders tumor cell growth.</p>Formula:C38H41F5IN9O7Colore e forma:SolidPeso molecolare:957.68HPOB
CAS:<p>HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.</p>Formula:C17H18N2O4Purezza:99.91%Colore e forma:SolidPeso molecolare:314.34AZD5582 TFA
<p>AZD5582 TFA is a potent IAP antagonist that binds to the BIR3 domain of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15 nM, respectively.AZD5582 TFA</p>Formula:C60H79F3N8O10Purezza:99.89%Colore e forma:SoildPeso molecolare:1129.31PARP1-IN-15
<p>PARP1-IN-15 (Compound 6) is a PARP1 inhibitor that also inhibits tankyrase (TNKS) and promotes DNA double-strand breaks, leading to tumor cell apoptosis.</p>Formula:C16H12N2O2Purezza:98%Colore e forma:SolidPeso molecolare:264.28JGB1741
CAS:<p>JGB1741, a SIRT1 inhibitor (IC50=15µM), modulates apoptosis markers and p53 acetylation in breast cancer research.</p>Formula:C27H24N2O2SPurezza:99.86%Colore e forma:SolidPeso molecolare:440.56Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA
CAS:Arg-Gly-Asp-D-Phe-Val (TFA) has anti-tumor activity and is an inhibitor of integrin αvβ3.Formula:C28H39F3N8O9Purezza:98%Colore e forma:SolidPeso molecolare:688.662Moflerafusp alfa
CAS:<p>Moflerafusp alfa is a fusion protein that targets the human signal-regulatory protein alpha (SIRPα) variant V2 D1 domain and human programmed death-ligand 1 (PD-L1). It shows potential for research in various cancer treatments.</p>Colore e forma:LiquidBOC-D-FMK
CAS:<p>Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).</p>Formula:C11H18FNO5Purezza:97.02%Colore e forma:SolidPeso molecolare:263.26Thalidomide-O-amido-C3-PEG3-C1-NH2
CAS:<p>Thalidomide-based E3 ligase linker for PROTACs with a 3-unit PEG chain.</p>Formula:C27H35F3N4O11Colore e forma:SolidPeso molecolare:648.589Spexin
CAS:<p>Potent GAL2/GAL3 agonist (EC50 = 45.7, 112.2 nM), inactive at GAL1. Reduces appetite, fatty acid uptake in adipocytes, and LH in goldfish; anxiolytic in vivo.</p>Formula:C74H114N20O19SPurezza:98%Colore e forma:SolidPeso molecolare:1619.9Hellebrin
CAS:<p>Cytotoxic and antiproliferative effects of Hellebrin on breast and lung cancer cells.</p>Formula:C36H52O15Colore e forma:SolidPeso molecolare:724.79Vorsetuzumab
CAS:<p>Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) is a monoclonal antibody targeting the CD70 antibody.</p>Purezza:SDS-PAGE:95% SEC-HPLC:99.29%Colore e forma:LiquidPeso molecolare:146.1 kDaCSF1R-IN-26
<p>CSF1R-IN-26 (Compound III-1) is an inhibitor of CSF-1R with an IC50 of 20.07 nM. It promotes the polarization of M2 macrophages to M1 macrophages, inducing apoptosis in MC-38 cancer cells. CSF1R-IN-26 inhibits the activation of the AKT/ERK/STAT3 signaling pathways, remodels the tumor immune microenvironment, and exhibits antitumor activity in mouse models. In SD rats, CSF1R-IN-26 demonstrates favorable pharmacokinetic properties, with a half-life of 1.86 hours and an oral bioavailability of 79.22%.</p>Colore e forma:Odour SolidNauclefine
CAS:<p>Nauclefine, a plant alkaloid, triggers cancer cell death through PDE3A-SLFN12, binding but not inhibiting PDE3A.</p>Formula:C18H13N3OPurezza:99.92%Colore e forma:SolidPeso molecolare:287.32Thalidomide-NH-C8-NH2
CAS:<p>Thalidomide-NH-C8-NH2 is a synthetic E3 ligase ligand-linker for PROTAC, combining cereblon ligand and a specific linker.</p>Formula:C21H28N4O4Colore e forma:SolidPeso molecolare:400.4792-Chloronaphthalene
CAS:<p>2-Chloronaphthalene is an organochlorine chemical compound and is a chlorinated derivative of naphthalene. The compound is an isomer for 1-chloronaphthalene.</p>Formula:C10H7ClPurezza:98%Colore e forma:SolidPeso molecolare:162.62Ianalumab
CAS:<p>Ianalumab (VAY-736) is a decarboxylated humanized antibody against BAFF-R.</p>Purezza:100% (SEC-HPLC) - > 95%Colore e forma:LiquidPeso molecolare:146.44 kDaLambertianic acid
CAS:<p>Lambertianic acid is a bioactive chemical that has anti-allergic and antibacterial effects.</p>Formula:C20H28O3Purezza:98%Colore e forma:SolidPeso molecolare:316.441Fludioxonil
CAS:<p>Fludioxonil (CGA 173506), a phenylpyrrole fungicide, inhibits the growth of B. cinerea from strawberry and blackberry crops.</p>Formula:C12H6F2N2O2Purezza:99.971%Colore e forma:SolidPeso molecolare:248.18Aspochalasin D
CAS:<p>Aspochalasin D, isolated from A. microcysticus, shows antibacterial properties and cytotoxicity affecting Ba/F3-V12 cells, with IC50s of 0.49 and 1.9 μg/ml.</p>Formula:C24H35NO4Colore e forma:SolidPeso molecolare:401.54Taltirelin acetate
CAS:<p>Taltirelin acetate (TA-0910 acetate) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R)(IC50 of 910 nM and EC50 of 36 nM for stimulating an</p>Formula:C19H27N7O7Purezza:99.21%Colore e forma:SolidPeso molecolare:465.46RET-IN-28
CAS:RET-IN-28 (Compound 16) is an inhibitor of RET (a transmembrane receptor tyrosine kinase). It specifically inhibits the activity of a mutant RET enzyme (RET-V804M) and is utilized in cancer research.Formula:C26H29N9Colore e forma:SolidPeso molecolare:467.57Verdinexor
CAS:<p>Verdinexor (KPT-335) (KPT-335), a specific XPO1/CRM1 inhibitor, are orally bioavailable.</p>Formula:C18H12F6N6OPurezza:98% - 99.68%Colore e forma:SolidPeso molecolare:442.32HTR2A antagonist 1
<p>HTR2A antagonist 1 (Compound 15f) is an HTR2A antagonist with an IC50 of 42.79 nM. It induces sub-G1 cell cycle arrest and apoptosis in colorectal cancer cells by activating the p53/p21/caspase 3 signaling pathway. HTR2A antagonist 1 exhibits good liver microsomal stability and is useful for colorectal cancer research.</p>Formula:C35H43Cl2F2N5O4Colore e forma:SolidPeso molecolare:706.65Thrombospondin-1 (1016-1023) (human, bovine, mouse)
CAS:<p>Thrombospondin-1 (1016-1023) (human, bovine, mouse) is part of Thrombospondin-1 (TSP-1), a peptide with CD47 agonism.</p>Formula:C56H81N13O10SPurezza:99.23%Colore e forma:SolidPeso molecolare:1128.39Methyl-4-oxoretinoate
CAS:<p>Methyl-4-oxoretinoate is a synthetic retinoid with anticancer properties, used for skin conditions and potential ocular treatments.</p>Formula:C21H28O3Purezza:98.07%Colore e forma:SolidPeso molecolare:328.45(E/Z)-Squalene
CAS:<p>(E/Z)-Squalene modulates ROS, triggers apoptosis/necrosis, reduces liver cholesterol and triglycerides.</p>Formula:C30H50Purezza:99.28%Colore e forma:SolidPeso molecolare:410.72MNK8
CAS:MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.Formula:C15H12N2O2Purezza:99.74%Colore e forma:SolidPeso molecolare:252.27STAT3-D11-PROTAC-VHL
<p>STAT3-D11-PROTAC-VHL (Compound D11-PROTAC) is a PROTAC degrader targeting signal transducer and activator of transcription 3 (STAT3). It demonstrates anti-tumor activity with IC50 values of 1335 nM in HeLa cells and 1973 nM in MCF-7 cells. The compound binds to the DNA binding domain of STAT3, recruits the E3 ligase VHL to form a ternary complex, leading to ubiquitination and subsequent proteasomal degradation of STAT3. Additionally, STAT3-D11-PROTAC-VHL inhibits tumor cell growth, induces cell cycle arrest and apoptosis (apoptosis), and suppresses tumor immune evasion.</p>Colore e forma:Odour SolidZYH-23
<p>ZYH-23 is a potent inhibitor of necroptosis. It targets HSP90 to inhibit the phosphorylation of RIPK1, RIPK3, and MLKL, effectively blocking programmed cell necrosis.</p>Formula:C41H50N4O3Colore e forma:SolidPeso molecolare:646.38829Anticancer agent 273
<p>Anticanceragent 273 (Compound 9q) is an effective anticancer compound identified from matrine. It inhibits cancer cell proliferation, with an IC50 of 4.48 μM against HeLa cells. Anticanceragent 273 exerts its anticancer effects by modulating PI3K/AKT expression and activating activating transcription factor 4 (ATF4), which induces endoplasmic reticulum stress and triggers apoptosis. It holds potential for cancer research, including cervical cancer.</p>Colore e forma:Odour SolidPamrevlumab
CAS:<p>FG-3019 (Pamrevlumab), a human antibody, targets CTGF, potentially treating idiopathic pulmonary fibrosis.</p>Purezza:100% (SEC-HPLC) - 95%Colore e forma:LiquidPARP1-IN-27
PARP1-IN-27 (Compound 9B) serves as an inhibitor of both PARP1 and PARP2, exhibiting IC 50 values of 2.53 nM and 6.45 nM, respectively, in SUM149PT cells. This compound effectively suppresses the proliferation of BRCA-mutated cancer cell lines such as SUM149PT, HCC1937, and Capan-1, with respective IC 50 values of 0.62, 1.91, and 4.26 μM. Additionally, PARP1-IN-27 exacerbates DNA double-strand breaks, enhances ROS production, causes G2/M phase cell cycle arrest, and triggers apoptosis in SUM149PT cells.Formula:C17H12FNO4Colore e forma:SolidPeso molecolare:313.28c-Met-IN-24
<p>c-Met-IN-24 (compound 3g) serves as a dual-target inhibitor for STAT-3 (=4.7 μM) and c-MET (=12.67 μM), exhibiting anticancer properties. It arrests the G2/M cell cycle and induces apoptosis in SNB-75 cells, making it applicable in the research of central nervous system cancers.</p>Formula:C20H15ClN4O4SColore e forma:SolidPeso molecolare:442.88Ub4ix
CAS:<p>Ub4ix, a DUB/26S proteasome inhibitor, safeguards K48-linked Ub chains against cleavage by deubiquitinating enzymes (DUBs) and inhibits the proteasomal degradation of Ub-tagged proteins. Additionally, it diminishes the viability of Hela cells and triggers apoptosis, exhibiting an IC 50 value of 1.6 μM.</p>Formula:C84H106N18O23SColore e forma:SolidPeso molecolare:1767.91ROS inducer 4
<p>Compound TE3, also known as ROS inducer 4, serves as a mitochondrial inhibitor. This compound induces a variety of mitochondria-related physiological alterations in tumors, including mitochondrial fragmentation, intense generation and accumulation of ROS, reduced mitochondrial membrane potential, and lower ATP content. Additionally, it activates ROS-mediated apoptotic signaling within mitochondria.</p>Formula:C49H62BrO4PColore e forma:SolidPeso molecolare:825.89HDAC-IN-77
HDAC-IN-77 (HL-5s), an HDAC inhibitor, has the capability to induce ferroptosis and suppress the Nrf2/HO-1 signaling pathway. This compound is utilized in cancer research.Formula:C22H26N4O2SColore e forma:SolidPeso molecolare:410.53TOFA-Plasmalogen
<p>TOFA-Plasmalogen (compound 1), a derivative of glyceraldehyde, exhibits ferroptosis-inducing properties. This compound promotes lipid peroxidation in cell membranes, leading to cytotoxic effects with an inhibition concentration (IC 50 = 32.87 μM).</p>Formula:C33H62NO7PColore e forma:SolidPeso molecolare:615.82BTK-IN-37
<p>BTK-IN-37 (compound 8d), a BTK inhibitor, demonstrates potent apoptotic effects on cancer cells by targeting BTK with K_i and IC_50 values of 5.07 nM and 3.6 nM, respectively. Additionally, this compound selectively promotes the enrichment of genes associated with necroptosis and pyroptosis.</p>Formula:C29H29N9O4SColore e forma:SolidPeso molecolare:599.66Cholesteryl Hemisuccinate Tris Salt
CAS:<p>Cholesteryl Hemisuccinate Tris Salt is a cholesteryl ester with anticancer activity.Cholesteryl hemisuccinate has antitumor activity and inhibits tumor growth.</p>Formula:C35H61NO7Purezza:≥98%Colore e forma:SolidPeso molecolare:607.86hCAIX/XII-IN-13
<p>hCAIX/XII-IN-13 functions as an inhibitor targeting specific human carbonic anhydrases (hCA) IX and XII, crucial in tumor-related processes. Demonstrating efficacy, this compound offers inhibitory K i values of 0.08 µM for IX and 0.06 µM for XII. Additionally, under hypoxic conditions, hCAIX/XII-IN-13 enhances the effectiveness of Doxorubicin on MCF-7 cells by promoting G2/M phase cell cycle arrest and increasing apoptosis.</p>Formula:C25H16N6O6SColore e forma:SolidPeso molecolare:528.5AEG 3482
CAS:<p>AEG 3482 blocks JNK, induces HSP70, binds HSP90, and boosts HSP25 expression, preventing cell death.</p>Formula:C10H8N4O2S2Purezza:99.76%Colore e forma:SolidPeso molecolare:280.33TS-24
CAS:<p>TS-24 is a cysteine protease histone S (CTSS) inhibitor that promotes BRCA1-mediated apoptosis.</p>Formula:C20H15NO2Purezza:99.41%Colore e forma:SoildPeso molecolare:301.34GSPT1 degrader-1
<p>GSPT1 Degrader-1 (Compound 9q) effectively facilitates the degradation of G1 to S phase transition 1 (GSPT1) through the ubiquitin-proteasome system and induces</p>Formula:C28H33ClN4O5Purezza:98%Colore e forma:SolidPeso molecolare:541.04TAT-BH4 (Bcl-xL) (TFA)
<p>"TAT-BH4 (Bcl-xL) TFA, primarily localized at the mitochondria, inhibits apoptotic cell death.</p>Formula:C159H268N58O45·xC2HF3O2Purezza:98%Colore e forma:SolidPeso molecolare:3712.19 (free acid)Varlilumab
CAS:<p>Varlilumab (CDX-1127) is a novel human IgG1 anti-CD27 monoclonal antibody. Varlilumab has antitumor activity and can be used to study advanced solid tumors.</p>Purezza:SDS-PAGE:95% SEC-HPLC:98.65%Colore e forma:LiquidPeso molecolare:146 kDaAnti-inflammatory agent 35
CAS:<p>Anti-inflammatory agent 35 is a potent anti-inflammatory agent.</p>Formula:C27H29NO8Purezza:99.98%Colore e forma:SoildPeso molecolare:495.52PI3K-AKT-mTOR Compound Library
<p>A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with</p>Colore e forma:Odour SolidAntitumor agent-113
<p>Antitumor Agent-113 exhibits cytotoxicity in A549 cells, with an IC50 of 46.60 μM, and induces apoptosis, making it applicable for research in non-small cell</p>Formula:C21H22ClN5O2SPurezza:98%Colore e forma:SolidPeso molecolare:443.95EGFR/VEGFR2-IN-1
<p>EGFR/VEGFR2-IN-1 (Compound 10e) serves as an inhibitor for VEGFR-2 and EGFR, with respective IC50 values of 0.26 and 0.14 μM. It inhibits microtubule protein polymerization with an IC50 of 40.9 μM and induces cell apoptosis (Apoptosis). EGFR/VEGFR2-IN-1 is applicable in research related to anti-leukemia and anti-lymphoma treatments.</p>Colore e forma:Odour SolidVEGFR-2-IN-53
<p>VEGFR-2-IN-53 (Compound 15w) is an inhibitor of VEGFR-2 with an IC50 value of 4.34 μM. It induces cell apoptosis (Apoptosis) and inhibits angiogenesis by blocking VEGFR-2 activity and preventing cell migration. Additionally, it shows an IC50 of 3.87 μM in inhibiting the growth of MCF-7 cells, making it pertinent for research in cancer therapeutics.</p>Colore e forma:Odour SolidApoptosis inducer 28
<p>Apoptosisinducer 28 (Compound X1) is an apoptosis inducer with demonstrated in vitro anticancer activity. It arrests the cell cycle at the G1 phase, promoting cell death and inducing apoptosis by disrupting the mitochondrial membrane potential.</p>Colore e forma:Odour SolidAnti-Mouse TNF α Antibody (TN3-19.12)
<p>Anti-Mouse TNF alpha Antibody is a rat-derived IgG inhibitor targeting mouse TNF alpha.</p>Purezza:95% - ＞10mg/mlColore e forma:Odour LiquidTP4 (Nile tilapia piscidin)
CAS:<p>TP4 (Nile tilapia piscidin) is an orally active piscidin-like antimicrobial peptide that exhibits inhibition of various gram-positive and negative bacterial</p>Formula:C135H226N50O27Purezza:98%Colore e forma:SolidPeso molecolare:2981.56TAT-NEP1-40 TFA
<p>TAT-NEP1-40 TFA, a blood-brain barrier-permeable peptide, safeguards PC12 cells against oxygen and glucose deprivation (OGD) and fosters neurite outgrowth.</p>Formula:C268H438N88O77·xC2HF3O2Purezza:98%Colore e forma:SolidPeso molecolare:6124.89 (free base)Antitumor agent-112
<p>Antitumor agent-112 (compound 3a) is a potent antitumor agent that induces apoptosis and exhibits cytotoxic activity on A549 cells, with an IC50 value of 91.35</p>Formula:C18H17ClN4O2SPurezza:98%Colore e forma:SolidPeso molecolare:388.87EGFR-IN-151
<p>EGFR-IN-151 (Compound 10) inhibits EGFR and its downstream signaling pathways ERK/STAT3. It effectively suppresses the proliferation of various lung cancer cells, with IC50 values of 11.7, 5.19, 7.32, and 1.53 μM for NCI-H1781, HCC827, NCI-H3255, and NCI-H1975, respectively. Additionally, EGFR-IN-151 hinders colony formation and cell migration in H1975, induces G1 phase cell cycle arrest, and triggers apoptosis in H1975 cells.</p>Colore e forma:Odour SolidUSP7-IN-9
<p>USP7-IN-9 is a potent USP7 inhibitor (IC50 = 40.8 nM), induces apoptosis, arrests RS4;11 cells, and modulates key oncoproteins.</p>Formula:C32H33ClF6N6O8Colore e forma:SolidPeso molecolare:779.08eIF4E-IN-3
CAS:<p>eIF4E-IN-3: potent eIF4e inhibitor with promise for cancer study.</p>Formula:C34H30ClF3N6O4SColore e forma:SolidPeso molecolare:711.16CDK-IN-14
<p>CDK-IN-14 (B34) is a CDK2 inhibitor (IC50=0.097 μM) that exhibits anti-hepatocellular carcinoma activity. It inhibits the cell cycle in HepG-2 cancer cells and induces apoptosis (apoptosis) through a caspase-mediated mechanism.</p>Colore e forma:Odour SolidCDK/HDAC-IN-4
<p>CDK/HDAC-IN-4 is a highly selective dual inhibitor of cyclin-dependent kinase (CDK) and histone deacetylase (HDAC), with IC50 values of 88.4 nM and 168.9 nM, respectively. This compound exhibits antiproliferative effects in both hematologic and solid tumor cells. Additionally, CDK/HDAC-IN-4 induces apoptosis and S-phase cell cycle arrest in MV-4-11 cells. It has also demonstrated significant antitumor efficacy in an MV-4-11 xenograft model.</p>Colore e forma:Odour SolidTNF-α (31-45), human
CAS:<p>TNF-α (31-45), human is a peptide of tumor necrosis factor-α.</p>Formula:C69H122N26O22Purezza:98%Colore e forma:SolidPeso molecolare:1667.895Pyridinium bisretinoid A2E TFA
CAS:<p>Pyridinium bisretinoid A2E (A2E) TFA, a fluorophore derived from retinal pigment epithelium (RPE) lipofuscin, initiates blue-light-induced apoptosis, mediates</p>Formula:C44H58F3NO3Purezza:98%Colore e forma:SolidPeso molecolare:705.93(-)-Irofulven
CAS:<p>Irofulven is an agent of DNA-damaging and antitumor. It is used for the treatment of advanced solid tumors, including prostate, ovarian, and pancreatic cancers.</p>Formula:C15H18O3Colore e forma:SolidPeso molecolare:246.30Sincalide ammonium
CAS:<p>Sincalide ammonium, a CCK analog, stimulates bile release, gallbladder contraction, and sphincter relaxation, aiding in diagnoses.</p>Formula:C49H65N11O16S3Purezza:98.46%Colore e forma:SolidPeso molecolare:1160.3Akt/NF-κB/MAPK-IN-1
<p>Akt/NF-κB/MAPK-IN-1 (compound 2m) serves as a potent, orally active inhibitor targeting NO with an IC50 of 7.70 μM and demonstrates low toxicity.</p>Formula:C38H56N2O4Purezza:98%Colore e forma:SolidPeso molecolare:604.86TAT-BH4 (Bcl-xL)
<p>TAT-BH4 (Bcl-xL), primarily localized at the mitochondria, inhibits apoptotic cell death.</p>Formula:C159H268N58O45Purezza:98%Colore e forma:SolidPeso molecolare:3712.19NA-Ir
CAS:<p>NA-Ir is a ferroptosis (Ferroptosis) inducer that targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to stimulate ferritin autophagy (). It also induces the production of reactive oxygen species (ROS) through photodynamic therapy (PDT), depletes glutathione (GSH), and downregulates glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and ferroptosis. NA-Ir exhibits enhanced anticancer activity under light exposure and selectively inhibits cancer cells with high H2S content.</p>Formula:C49H36F6IrN8O4PColore e forma:SolidPeso molecolare:1138.04ZMF-24
<p>ZMF-24 is an anti-triple-negative breast cancer (TNBC) agent that exhibits IC50 values of 0.22 μM and 0.44 μM against BT-549 and MDA-MB-231 TNBC cell proliferation, respectively. It targets the eukaryotic translation initiation factor 3 subunit D (EIF3D), disrupting TNBC's energy supply by inhibiting glycolysis. Additionally, ZMF-24 induces TNBC cell apoptosis (apoptosis) by stimulating sustained endoplasmic reticulum stress.</p>Colore e forma:Odour SolidHDAC-IN-79
<p>HDAC-IN-79 (compound 4) is an orally active dual inhibitor of xanthine oxidase and HDAC, exhibiting potent anti-hyperuricemia and antitumor activities in vivo (Xanthine oxidase: IC50=6.6 nM; HDAC1: IC50=134 nM; HDAC2: IC50=284 nM; HDAC3: IC50=173 nM; HDAC6: IC50=1.32 nM). Among leukemia cells, it is most effective in inhibiting the growth of HL60 cells (IC50=0.706 μM) and induces both apoptosis and autophagy. HDAC-IN-79 also modulates the expression levels of biomarkers associated with intracellular HDAC inhibition.</p>Colore e forma:Odour SolidProdigiosin hydrochloride
CAS:<p>Prodigiosin hydrochloride is a bioactive red pigment from bacteria with antibacterial, antifungal, anticancer properties, and inhibits Wnt/β-catenin.</p>Formula:C20H26ClN3OColore e forma:SolidPeso molecolare:359.9Anticancer agent 272
<p>Anticanceragent 272 (Compound 2) is an anticancer agent demonstrating significant activity against bladder cancer cells (T-24) with an IC50 of 2.81 μM. It depletes glutathione (GSH) through a Fenton-like reaction, generating reactive oxygen species (ROS) and hydroxyl radicals (•OH), thereby inducing apoptosis and ferroptosis. Anticanceragent 272 enhances chemodynamic therapy (CDT) and promotes tumor cell death through mitochondrial dysfunction and autophagy. It holds potential for further research in bladder cancer.</p>Formula:C26H34Br2Cl4Cu2N8Colore e forma:SolidPeso molecolare:881.86192GPX4-IN-6
CAS:GPX4-IN-6 is a GPX4 inhibitor with antitumor activity.GPX4-IN-6 induces iron death and is used for the treatment and prevention of triple-negative breast cancerFormula:C18H17BrFNO5Purezza:99.54%Colore e forma:SoildPeso molecolare:426.23Flaccidoside II
CAS:<p>Flaccidoside II, an active triterpenoid saponin from Anemone flaccida rhizome, both inhibits proliferation and induces apoptosis in Malignant Peripheral Nerve</p>Formula:C59H96O25Purezza:98%Colore e forma:SolidPeso molecolare:1205.38Antitumor agent-96
<p>"Antitumor agent-96 (Compound D34) is a potent MRE11 inhibitor that down-regulates the homologous recombination (HR) pathway by binding to and suppressing the</p>Formula:C27H32N2O2Purezza:98%Colore e forma:SolidPeso molecolare:416.56TG101209 analog 1
<p>TG101209 analog 1 (Compound 8h) serves as an inhibitor of BUB1B, exhibiting an IC50 of 10.36 μM. It also possesses cytotoxic properties, demonstrated by an IC50 of 1.347 μM against Caki-1 cells, and can induce necrosis and apoptosis.</p>Formula:C24H31N5O5SColore e forma:SolidPeso molecolare:501.598CAY10726
CAS:<p>CAY10726, an arylurea fatty acid, cuts ATP by 28% and promotes apoptosis in breast cancer cells by depleting mitochondrial lipids.</p>Formula:C24H36ClF3N2O3Colore e forma:SolidPeso molecolare:493Violacein
CAS:<p>Violacein, a purple antibacterial and antiprotozoal compound from C. violaceum, effective against Gram-positive bacteria and P. falciparum.</p>Formula:C20H13N3O3Colore e forma:SolidPeso molecolare:343.34Asparanin A
CAS:<p>Asparanin A, an apoptosis inducer with anticancer properties, arrests the cell cycle in the G0/G1 phase via the mitochondria and PI3K/AKT signaling pathways.</p>Formula:C39H64O13Purezza:98%Colore e forma:SolidPeso molecolare:740.92Anticancer agent 130
<p>Anticancer agent 130 (compound 8d) significantly induces apoptosis in A549 cells [1].</p>Formula:C38H46FN5O5Purezza:98%Colore e forma:SolidPeso molecolare:671.8Mcl-1 antagonist 1
CAS:Mcl-1 antagonist 1 is a Mcl-1 protein antagonist.Formula:C41H54ClF2N5O8SPurezza:98%Colore e forma:SolidPeso molecolare:850.42VEGFR-2-IN-64
<p>VEGFR-2-IN-64 (Compound 28) is an inhibitor of VEGFR2 with an IC50 of 27.8 nM. It suppresses the proliferation of cancer cells A549, T-47D, and Caco-2, exhibits anti-migration and anti-colony formation activities in T-47D cells, and induces apoptosis in T-47D cells.</p>Formula:C72H123N9O6Colore e forma:SolidPeso molecolare:1210.8anti-TNBC agent-1
CAS:anti-TNBC agent-1 targets TNBC effectively, with IC50 of 0.20-0.27 μM, inducing apoptosis and G1 arrest in SUM-159 cells.Formula:C26H30O7Colore e forma:SolidPeso molecolare:454.51Δ8-Tetrahydrocannabinoquinone
CAS:<p>Δ8-Tetrahydrocannabinoquinone (HU-336) is a potent anti-angiogenic agent that inhibits angiogenesis by directly inducing apoptosis in vascular endothelial cells. It achieves this without altering the expression of pro-angiogenic and anti-angiogenic cytokines and receptors. Δ8-Tetrahydrocannabinoquinone also shows significant effectiveness against tumor xenografts in nude mice.</p>Formula:C21H28O3Colore e forma:SolidPeso molecolare:328.45Calphostin C
CAS:Calphostin C is a protein kinase C inhibitor.Formula:C44H38O14Purezza:98%Colore e forma:Red To Brown PowderPeso molecolare:790.76Ac-LEHD-AMC
CAS:<p>Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.</p>Formula:C33H41N7O11Colore e forma:SolidPeso molecolare:711.729TQB-2858
<p>TQB-2858 is a bifunctional fusion protein composed of an anti-PD-L1 monoclonal antibody fused with the extracellular domain of the TGF-β receptor. It exhibits high affinity for PD-L1, TGF-β1, and TGF-β3, and demonstrates a high target occupancy rate for PD-L1. TQB-2858 can be used in research on osteosarcoma and alveolar soft part sarcoma (ASPS).</p>Colore e forma:Odour LiquidBM-962
CAS:<p>BM-962 (Compound 31) is a potent small-molecule inhibitor with an IC50 value of 4 nM (Ki=0.8 nM) for Bcl-2 and an IC50 of 3.9 nM (Ki<1 nM) for Bcl-xL. It inhibits H1417 and H146 cell lines with IC50 values of 9 and 13 nM, respectively, and shows potential for use in cancer research.</p>Formula:C53H58ClF3N6O7S3Colore e forma:SolidPeso molecolare:1079.7184-B10
CAS:<p>84-B10 provides protection in cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors.</p>Formula:C25H22F3NO5Purezza:99.76%Colore e forma:SolidPeso molecolare:473.44Gemcitabine monophosphate sodium salt hydrate
CAS:<p>Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine.</p>Formula:C9H12F2N3Na2O8PPurezza:98%Colore e forma:SolidPeso molecolare:405.16
