Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(6 prodotti)
- BCL(11 prodotti)
- Caspasi(125 prodotti)
- FOXO1(3 prodotti)
- IAP(66 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(125 prodotti)
- PDK(9 prodotti)
- PERK(25 prodotti)
- Chinasi di serina/treonina(15 prodotti)
- Survivin(13 prodotti)
- TNF(92 prodotti)
- c-RET(51 prodotti)
- p53(62 prodotti)
Mostrare 6 più sottocategorie
Trovati 5598 prodotti di "Apoptosi"
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KHKI-01215
<p>KHKI-01215 is a NUAK2 inhibitor with anticancer activity, inhibiting the proliferation of SW480 cancer cells and inducing apoptosis.</p>Formula:C24H26F3IN6OPurezza:98.19%Colore e forma:SolidPeso molecolare:598.4DA5-HTL
<p>DA5-HTL is a compound that combines dasatinib with the HaloTag system, effectively inhibiting the growth of tumor cells, with a GI50 of 1.923 nM.</p>Formula:C39H58Cl2N8O8SPeso molecolare:868.34754HFY-4A
CAS:<p>HFY-4A is a novel HDAC inhibitor.HFY-4A has antitumour activity and has shown antiproliferative activity in breast cancer cells.</p>Formula:C20H19N3O2Purezza:98.66% - 99.22%Colore e forma:SoildPeso molecolare:333.38Sandacanol
CAS:<p>Sandacanol (Sandranol) is an olfactory receptor (OR10H1) agonist.Sandacanol induces cell cycle arrest and partial apoptosis in bladder cancer cells.</p>Formula:C14H24OPurezza:99.59%Colore e forma:SolidPeso molecolare:208.34Moflerafusp alfa
CAS:<p>Moflerafusp alfa is a fusion protein that targets the human signal-regulatory protein alpha (SIRPα) variant V2 D1 domain and human programmed death-ligand 1 (PD-L1). It shows potential for research in various cancer treatments.</p>Colore e forma:LiquidRWJ-56110 dihydrochloride
CAS:<p>RWJ-56110 dihydrochloride is a potent PAR-1 inhibitor (IC50=0.44μM), blocking platelet aggregation, angiogenesis, and induces apoptosis. No PAR-2/3/4 effect.</p>Formula:C41H44Cl3F2N7O3Colore e forma:SolidPeso molecolare:827.2Δ8-Tetrahydrocannabinoquinone
CAS:<p>Δ8-Tetrahydrocannabinoquinone (HU-336) is a potent anti-angiogenic agent that inhibits angiogenesis by directly inducing apoptosis in vascular endothelial cells. It achieves this without altering the expression of pro-angiogenic and anti-angiogenic cytokines and receptors. Δ8-Tetrahydrocannabinoquinone also shows significant effectiveness against tumor xenografts in nude mice.</p>Formula:C21H28O3Colore e forma:SolidPeso molecolare:328.45Cathepsin B
CAS:<p>Cathepsin B, a cysteine protease located within the subcellular endosomes and lysosomal compartments, mediates apoptosis and can be used in cancer research.</p>Colore e forma:SolidNMC-001
<p>NMC-001 is a human IgG1 monoclonal antibody (mAb) that targets MDM2. It is useful for pancreatic cancer research. The recommended isotype control is HumanIgG1kappa, Isotype Control.</p>Colore e forma:Odour LiquidAntitumor agent-170
<p>Antitumor agent-170 (Compound C6) inhibits PD-1/PD-L1 interaction and PARP7 with IC50 values of 0.342 μM and 7.05 nM, respectively. It shows high affinity for human PD-L1, with a Ki of 9.31 nM, and can restore T cell function while increasing IFN-γ secretion. In mouse models, Antitumor agent-170 exhibits antitumor effects against melanoma and demonstrates favorable pharmacokinetic properties.</p>Formula:C59H69ClF3N11O9Peso molecolare:1167.49204c-JUN peptide
CAS:<p>Peptide from c-Jun (33-57) blocks JNK binding, inhibits phosphorylation, upregulates p21, and induces HeLa cell apoptosis.</p>Formula:C121H210N36O34SPurezza:98%Colore e forma:SolidPeso molecolare:2743.55TRBP-IN-1
<p>TRBP-IN-1 (Compound 13j) is an orally active inhibitor of TAR RNA-binding protein 2 (TRBP) with an IC50 of 12.72 μM. It exhibits significant anti-hepatocellular carcinoma (HCC) activity, effectively suppressing proliferation and metastasis of HCC cells [HCCLM3 cells (IC50: 18.96 μM) and SK-Hep-1 cells (IC50: 16.45 μM)]. TRBP-IN-1 modulates miRNA biosynthesis by targeting TRBP, inhibiting the expression of oncogenic miRNAs. It induces apoptosis and pyroptosis in HCC cells by decreasing miRNA levels. TRBP-IN-1 is suitable for research on targeted HCC therapy.</p>Formula:C25H23F3N2O5SColore e forma:SolidPeso molecolare:520.12798ChoKα inhibitor-5
<p>ChoKα Inhibitor-5, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoKα1 with an IC50 value of 0.64 μM and induces apoptosis.</p>Formula:C54H68Br2N4S4Colore e forma:SolidPeso molecolare:1061.21PERK-IN-6
CAS:<p>PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).</p>Formula:C23H22N6OPurezza:99.62% - 99.92%Colore e forma:SolidPeso molecolare:398.46BK60106
<p>BK60106 is a selective and direct inhibitor of the transmembrane protein CD99, which causes cell death in Ewing Sarcoma cells.</p>Formula:C15H15FN6O3Purezza:99.30% - >99.99%Colore e forma:SolidPeso molecolare:346.32GPLGIAGQ acetate
<p>GPLGIAGQ acetate: MMP2-cleavable peptide; stimulus-sensitive linker for MMP2-targeted liposomal/micellar carriers in photodynamic therapy.</p>Formula:C33H57N9O12Purezza:97.85%Colore e forma:SolidPeso molecolare:771.86Necrosis inhibitor 2 (hydrocholide)
<p>Necrosis inhibitor 2 hydrochloride (Compound B19) is an agent that inhibits cellular necrosis. It is useful for researching diseases associated with necrotic pathways, including inflammation, cancer, metabolic disorders, and neurodegenerative diseases.</p>Formula:C24H26ClN5O5Peso molecolare:499.162254-N-Nonyloxyphenol
CAS:<p>4-N-Nonyloxyphenol, kaolinite nanotube photosensitizer, degrades phenolic pesticides, and disrupts endocrine.</p>Formula:C15H24O2Purezza:99.94%Colore e forma:SoildPeso molecolare:236.35PQ401
CAS:<p>PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).</p>Formula:C18H16ClN3O2Purezza:99.77%Colore e forma:SolidPeso molecolare:341.79WEE1-IN-7
<p>WEE1-IN-7 (compound 12h) is a potent, orally active WEE1 inhibitor with an IC50 value of 2.1 nM. This compound induces apoptosis and causes cell cycle arrest in the S phase, demonstrating antitumor activity.</p>FLT3/HDAC-IN-1
<p>FLT3/HDAC-IN-1 is a dual inhibitor targeting FLT3 and HDAC, with IC50 values of 30.4 nM for FLT3 and 52.4, 14.7 nM for HDAC1/3, respectively. It induces apoptosis in MV-4-11 cells and exhibits antiproliferative effects against BaF3 cells transformed by FLT3 mutations. FLT3/HDAC-IN-1 is useful for research on refractory solid tumors and hematological malignancies.</p>Colore e forma:Odour SolidHDAC6 degrader-5
<p>HDAC6degrader-5 (Compound 6) exhibits inhibitory and degradative activity against HDAC6, with an IC50 of 4.95 nM and a DC50 of 0.96 nM. It suppresses the release of TNF-α, IL-1β, and IL-6, and prevents apoptosis in liver cells. Additionally, HDAC6degrader-5 demonstrates anti-inflammatory properties in a mouse model of APAP-induced liver injury.</p>Formula:C21H22N4O3Colore e forma:SolidPeso molecolare:378.424Fuscin
CAS:<p>Fuscin, a quinonoid from O. fuscum, inhibits ADP/ATP translocase, depletes glutathione, disrupts NADH oxidation, and blocks MIP-1α/CCR5 binding (IC50: 21µM).</p>Formula:C15H16O5Colore e forma:SolidPeso molecolare:276.288Ara-SH
<p>Ara-SH, a derivative of Cytarabine with a mercaptopropionic acid substitution, serves as the initiator for the self-assembly of a smart, co-loaded Cytarabine</p>Formula:C12H17N3O6SPurezza:98%Colore e forma:SolidPeso molecolare:331.34VEGFR-2-IN-53
<p>VEGFR-2-IN-53 (Compound 15w) is an inhibitor of VEGFR-2 with an IC50 value of 4.34 μM. It induces cell apoptosis (Apoptosis) and inhibits angiogenesis by blocking VEGFR-2 activity and preventing cell migration. Additionally, it shows an IC50 of 3.87 μM in inhibiting the growth of MCF-7 cells, making it pertinent for research in cancer therapeutics.</p>Colore e forma:Odour SolidRIPK1-IN-22
<p>RIPK1-IN-13 (compound 28) is a selective inhibitor of receptor-interacting serine/threonine-protein kinase 1 (RIPK1), showing a pKi of 7.66 as measured by the ADP-Glo kinase assay. It exhibits inhibitory effects in human leukemia U937 cells with a pIC50 of 7.2.</p>Formula:C22H22N4O3SPeso molecolare:422.14126LZFPN-90
LZFPN-90 (LZ90) is a dual-target compound aimed at NAMPT and PD-L1. It inhibits the interaction between PD-1/PD-L1 and NAMPT activity. LZFPN-90 suppresses cell growth in a NAMPT-dependent manner, blocking the cell cycle and subsequently inducing apoptosis. Additionally, LZFPN-90 exhibits target-dependent antitumor activity, impacting metabolic processes and the immune system.Formula:C33H36N8O2SPeso molecolare:608.26819WK369
<p>WK369 is an innovative small molecule inhibitor of BCL6, demonstrating remarkable bioactivity against ovarian cancer by inducing cell cycle arrest and triggering apoptosis. It binds directly to the BCL6-BTB domain, obstructing the interaction between BCL6 and SMRT, which results in the reactivation of p53, ATR, and CDKN1A.</p>Formula:C19H20FN5O2Peso molecolare:369.1601PROTAC EGFR degrader 9
CAS:<p>PROTACEGFRdegrader 9 (Compound C6) is an orally active, CRBN-based PROTAC EGFR degrader. It has a DC50 of 10.2 nM and a Kd of 240.2 nM against EGFRL858R/T790M/C797S. PROTACEGFRdegrader 9 demonstrates effective degradation activity against various EGFR mutants while not affecting EGFRWT.</p>Formula:C45H48F3N9O6SPeso molecolare:899.98NAE-IN-1
<p>NAE-IN-1 (compound X-10) is a potent inhibitor of NAE1. It induces apoptosis and causes cell cycle arrest in the G2/M phase. Furthermore, NAE-IN-1 increases ROS levels and inhibits cell migration, demonstrating antiproliferative activity.</p>Formula:C29H30N4O2SPeso molecolare:498.20895MX106-4C
<p>MX106-4C is a survivin inhibitor that selectively targets ABCB1-positive colorectal cancer cells. It can work synergistically with Doxorubicin for enhanced anticancer effects or restore Doxorubicin sensitivity in drug-resistant ABCB1 cells.</p>Formula:C23H25BrN2O2Peso molecolare:440.10994Bornyl acetate
CAS:Bornyl acetate (Isobornyl acetate) has an anti-inflammatory effect. It is the volatile ingredient in some Chinese traditional herbs and numerous conifer oils.Formula:C12H20O2Purezza:99.19%Colore e forma:LiquidPeso molecolare:196.29p53 (17-26)
CAS:<p>Peptide is p53's amino acids 17-26, contacts Mdm-2 binding domain, also called p53N.</p>Formula:C60H90N12O17Purezza:98%Colore e forma:SolidPeso molecolare:1251.43DHFR-IN-23
<p>DHFR-IN-23 (compound 5) is a dual inhibitor of DNA binders/DHFR, exhibiting an IC50 value of 0.08 μM against hDHFR. It serves as an apoptosis inducer and is applicable in research on ER+ breast cancer.</p>Colore e forma:Odour SolidYX-02-030
CAS:<p>YX-02-030M is a PROTACMDM2 degrader. It inhibits the binding of MDM2 to p53 and VHL to HIF1α, with IC50 values of 63 nM and 1.35 μM, respectively. YX-02-030M binds to MDM2 and recruits the VHL E3 ubiquitin ligase to initiate MDM2 degradation, effectively killing p53 mutant or deficient triple-negative breast cancer (TNBC) cells.</p>Formula:C66H85Cl2N9O10SPeso molecolare:1267.41Anti-Mouse TNF α Antibody (TN3-19.12)
<p>Anti-Mouse TNF alpha Antibody is a rat-derived IgG inhibitor targeting mouse TNF alpha.</p>Purezza:95% - ＞10mg/mlColore e forma:Odour LiquidThalidomide-O-C8-NH2
CAS:<p>Thalidomide-O-C8-NH2 is a synthetic cereblon ligand & PROTAC linker, serving as an E3 ligase ligand-linker.</p>Formula:C21H27N3O5Colore e forma:SolidPeso molecolare:401.463SB 699551
CAS:<p>SB 699551 is a selective 5-HT5A antagonist (Ki=6.31 nM) that enhances 5-HT neuronal function. It inhibits SERT (Ki=25.12 nM),inhibit breast cancer.</p>Formula:C34H45N3OPurezza:99.83%Peso molecolare:511.74(±)-Enterodiol
CAS:<p>"(±)-Enterodiol, the racemate of Enterodiol, is metabolized from lignans found in whole-grain cereals, nuts, legumes, flaxseed, and vegetables by human intestinal bacteria. This compound exhibits apoptotic effects in colorectal cancer (CRC) cells and has been identified to possess anti-cancer activities [1] [2]."</p>Formula:C18H22O4Colore e forma:SolidPeso molecolare:302.36Oligomycin B
CAS:<p>Oligomycin B is an antibiotic isolated from marine Streptomyces, is an eukaryotic ATP synthase inhibitor, induces apoptosis.</p>Formula:C45H72O12Purezza:98%Colore e forma:SolidPeso molecolare:805.05Ferroptosis inducer-6
CAS:<p>Ferroptosisinducer 6 (6d) is an inducer of ferroptosis (ferroptosis) that exhibits potent potential for Type I/II photodynamic therapy by inducing ROS production, oxidative stress, and mitochondrial damage. Additionally, it demonstrates antitumor activity.</p>Formula:C69H78F12N12P2RuColore e forma:SolidPeso molecolare:1466.44MS78
<p>MS78, an acetylation targeting chimera (AceTAC), specifically acetylates the p53Y220C mutant by recruiting the histone acetyltransferase p300/CBP.</p>Formula:C57H66FN9O6SColore e forma:SolidPeso molecolare:1024.25PD-1/PD-L1-IN-39
<p>PD-1/PD-L1-IN-39 (X 14) is an orally active PD-1/PD-L1 inhibitor with an IC50 value of 15.73 nM. It exhibits strong binding affinity to human and mouse PD-L1, with KD values of 14.62 and 392 nM, respectively. PD-1/PD-L1-IN-39 also demonstrates antitumor activity.</p>Formula:C23H20ClFN2O3Peso molecolare:426.11465PD0166285 dihydrochloride
CAS:<p>PD-166285 is an effective and broadly active inhibitor of protein tyrosine kinase.</p>Formula:C26H29Cl4N5O2Colore e forma:SolidPeso molecolare:585.35Garivulimab
CAS:<p>Garivulimab (BGB-A333), a humanized IgG1 monoclonal antibody, binds to PD-L1, blocking PD-1 interaction and exhibiting antitumor activity.</p>Colore e forma:LiquidLIB3S0280
<p>LIB3S0280 is a potent inhibitor of TBK1, with an IC50 of 493.9 nM. It suppresses TBK1 downstream signaling by reducing the phosphorylation of IκBα and AKT. LIB3S0280 causes G2/M phase arrest and induces apoptosis in pancreatic cancer cells. Notably, it exhibits significant inhibitory effects on pancreatic cancer cell lines with high TBK1 expression, with a 96-hour IC50 value ranging from 6.64-10.98 μM. LIB3S0280 shows potential for research in pancreatic ductal adenocarcinoma (PDAC).</p>Colore e forma:Odour SolidABBV-167
CAS:<p>ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax.</p>Formula:C46H53ClN7O11PSColore e forma:SolidPeso molecolare:978.45Ferumoxytol
CAS:<p>Ferumoxytol is an iron oxide nanoparticle with anti-leukemia properties, specifically against acute myeloid leukemia (AML) cells with low ferroportin (FPN) expression. By increasing intracellular iron levels, Ferumoxytol induces the Fenton reaction to produce reactive oxygen species (ROS), resulting in oxidative stress and ferroptosis. It selectively kills leukemia cells with low FPN expression while sparing normal cells, making it useful for studying leukemia targeting iron metabolism abnormalities.</p>Colore e forma:SolidFLT3-IN-29
<p>FLT3-IN-29 (Compound MY-10) is an FLT3 inhibitor with IC50 values of 6.5 nM and 10.3 nM for FLT3-ITD and FLT3-D835Y mutants, respectively. It induces cell cycle arrest at the G0/G1 phase and effectively triggers apoptosis (Apoptosis). Additionally, FLT3-IN-29 reduces reactive oxygen species (ROS) and mitochondrial membrane potential (MMP), displaying anti-leukemic properties.</p>Formula:C25H30N6O2Colore e forma:SolidPeso molecolare:446.545PROTAC GPX4 degrader-4
CAS:<p>PROTACGPX4 degrader-4 is a GPX4 PROTAC degrader with a DC50 of 5.32 nM. It inhibits the activity of cancer cell lines RT4, T24, and J82 with IC50 values of 0.09, 2.97, and 7.58 μM, respectively. This compound elevates lipid ROS levels and induces ferroptosis in T24 and RT4 cells. In T24 tumor-bearing BALB/c nude mouse models, PROTACGPX4 degrader-4 demonstrates antitumor activity. It is applicable to bladder cancer research.</p>Formula:C43H58N2O13Colore e forma:SolidPeso molecolare:810.93KRAS inhibitor-40
CAS:<p>KRAS inhibitor-40 (Compound 41) is an inhibitor of KRAS, disrupting the KRAS G12C-BRAF complex and suppressing the phosphorylation of the downstream ERK signaling pathway. This compound also inhibits the proliferation of tumor cells with various KRAS mutations, exhibiting antitumor activity.</p>Formula:C53H66ClF4N9O8SColore e forma:SolidPeso molecolare:1100.66DB2313
CAS:<p>DB2313 is a potent PU.1 inhibitor (IC50=14 nM) that disrupts gene binding, induces AML cell apoptosis, and has anticancer properties.</p>Formula:C42H41FN8O2Purezza:98.63% - 99.29%Colore e forma:SolidPeso molecolare:708.83PROTAC Mcl1 degrader-1
CAS:<p>PROTAC Mcl1 degrader-1 is a Cereblon ligand-based targeted chimeric protein degrader (PROTAC) and an Mcl-1 inhibitor, useful in cancer research.</p>Formula:C45H45BrN6O8SPurezza:98.74%Colore e forma:SolidPeso molecolare:909.84FR900359
CAS:<p>FR900359 is a macrocyclic Gq protein inhibitor that inhibits melanoma cell proliferation and can be used to study asthma, inflammation and cancer.</p>Formula:C49H75N7O15Purezza:98%Colore e forma:SolidPeso molecolare:1002.16USP7-IN-9
<p>USP7-IN-9 is a potent USP7 inhibitor (IC50 = 40.8 nM), induces apoptosis, arrests RS4;11 cells, and modulates key oncoproteins.</p>Formula:C32H33ClF6N6O8Colore e forma:SolidPeso molecolare:779.08C-Peptide 1 (rat)
CAS:<p>C-Peptide 1 (rat) is a polypeptide isolated from proinsulin. C-Peptide acts as a β-catenin/GSK-3β activator, influences Na/K-ATPase, regulates apoptosis.</p>Formula:C140H228N38O51Purezza:99.788%Colore e forma:SolidPeso molecolare:3259.58Pro-GA
CAS:<p>Pro-GA is a cell-permeable γ-glutamylcyclotransferase (γ-GGCT) inhibitor that inhibit proliferation in multiple bladder cancer cell lines. antitumour.</p>Formula:C12H19NO7Colore e forma:SolidPeso molecolare:289.28d-(KLAKLAK)2, Proapoptotic Peptide
CAS:<p>d-(KLAKLAK)2 is an antimicrobial and antitumor peptide, notable within the group of antimicrobial peptides, and exhibits strong anticancer properties. It kills bacteria by disrupting their cell membranes, causing leakage of cell contents. Additionally, d-(KLAKLAK)2 inhibits tumor cell proliferation by inducing apoptosis through mitochondrial swelling and membrane damage.</p>Formula:C72H139N21O14Colore e forma:SolidPeso molecolare:1523.01Obexelimab
CAS:<p>ACBI3 is a pan-KRAS degrader with anticancer activity, degrading oncogenic KRAS.</p>Purezza:98% (SDS-PAGE); 100% (SEC-HPLC) - 98% (SDS-PAGE); 100% (SEC-HPLC)Colore e forma:LiquidEGFR/COX-2-IN-1
<p>EGFR/COX-2-IN-1 is an EGFR/COX-2 inhibitor that effectively targets EGFRWT, EGFRT790M, COX-1, and COX-2 with IC50 values of 0.12, 0.076, 20.1, and 1.52 μM, respectively. It inhibits MCF-7, HT-29, and A-549 cells with IC50 values of 1.20, 5.14, and 14.81 μM, respectively. The compound induces apoptosis by upregulating Bax protein and downregulating Bcl-2 protein levels. Additionally, EGFR/COX-2-IN-1 significantly increases the proportion of cells in the G2/M phase in MCF-7 cells, demonstrating a broad-spectrum antitumor effect.</p>Formula:C20H17FN6O2S2Colore e forma:SolidPeso molecolare:456.52Thalidomide-O-PEG4-NHS ester
CAS:<p>Thalidomide-O-PEG4-NHS ester is a polyethylene glycol (PEG)-based linker, commonly employed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].</p>Formula:C28H33N3O13Purezza:98%Colore e forma:SolidPeso molecolare:619.57IDH1/2-IN-1
<p>IDH1/2-IN-1 (Compound 6b) is a dual inhibitor of IDH1(R132H)/IDH2(R140Q) with IC50 values of 0.22 μM and 1.6 μM, respectively. This compound effectively inhibits tumor growth by suppressing tumor cell proliferation and activating antioxidative enzymes to enhance host defense. Additionally, IDH1/2-IN-1 reduces inflammation and promotes apoptosis, demonstrating significant anti-tumor activity. It is also utilized in leukemia research.</p>Colore e forma:Odour SolidFurazolidone
CAS:<p>Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.</p>Formula:C8H7N3O5Purezza:99.96%Colore e forma:Yellow Crystals From Dmf (N N-Dimethylformamide) SolidPeso molecolare:225.16Pantinin-1
CAS:<p>Pantinin-1 is an antimicrobial peptide found in the venom of the emperor scorpion (Pandinus imperator). This compound exhibits strong antibacterial activity against Gram-positive bacteria and fungi, but has weaker effects on Gram-negative bacteria. Additionally, Pantinin-1 demonstrates very low hemolytic activity on human red blood cells and possesses anticancer properties, specifically inducing apoptosis in tumor cells.</p>Formula:C75H119N17O18Colore e forma:SolidPeso molecolare:1546.85MKC-1
CAS:<p>MKC-1 (Ro-31-7453) is an oral bisindolylmaleimide inhibitor that disrupts tubulin polymerization, potentially halting cancer cell division.</p>Formula:C22H16N4O4Purezza:99.63% - 99.85%Colore e forma:SolidPeso molecolare:400.39Ac-FEID-CMK
<p>Ac-FEID-CMK: Potent inhibitor for zebrafish GSDMEb, reduces pyroptosis, and lessens septic AKI.</p>Formula:C27H37ClN4O9Colore e forma:SolidPeso molecolare:597.06Azalamellarin N
CAS:<p>Azalamellarin N is a pyroptosis inhibitor that exhibits varying inhibitory effects on different pyroptosis inducers. It functions by targeting molecules upstream of NLRP3 inflammasome activation, instead of directly affecting the components of the NLRP3 inflammasome. Its inhibitory potency against various inducers is ranked as follows: Nigericin > R837 [1].</p>Formula:C28H22N2O7Colore e forma:SolidPeso molecolare:498.48p53 and MDM2 proteins-interaction-inhibitor dihydrochloride
<p>p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is a interaction inhibitor between p53 and MDM2 proteins.</p>Formula:C40H51Cl4N5O4Purezza:98%Colore e forma:SolidPeso molecolare:807.68BWA-522
<p>BWA-522 is a small molecule, orally available protein-targeting chimera (PROTAC) that potentates the degradation of both full-length androgen receptor (AR-FL)</p>Formula:C43H51ClN4O7Purezza:98%Colore e forma:SolidPeso molecolare:771.34Apoptosis inducer 33
<p>Apoptosisinducer 33 (compound H2) is a hydrazone derivative. It exhibits antioxidant and antimicrobial properties, capable of inhibiting the growth of Staphylococcus aureus, Escherichia coli, and Candida albicans. Additionally, Apoptosisinducer 33 can suppress tumor cell proliferation and induce apoptosis (apoptosis), making it useful for tumor research.</p>Formula:C16H13N3O2Colore e forma:SolidPeso molecolare:279.293Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride
CAS:<p>Thalidomide-based E3 ligase ligand with PEG2-C2 linker; used as an immunomodulatory cancer treatment.</p>Formula:C21H27ClN4O8Purezza:98.09%Colore e forma:SolidPeso molecolare:498.914S-Adenosyl-L-methionine
CAS:<p>S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.</p>Formula:C15H22N6O5SPurezza:99.08%Colore e forma:SolidPeso molecolare:398.44Thrombospondin-1 (1016-1023) (human, bovine, mouse)
CAS:<p>Thrombospondin-1 (1016-1023) (human, bovine, mouse) is part of Thrombospondin-1 (TSP-1), a peptide with CD47 agonism.</p>Formula:C56H81N13O10SPurezza:99.23%Colore e forma:SolidPeso molecolare:1128.39Bcl-2-IN-22
<p>Bcl-2-IN-22 (compound 1), a gold (I) NHC complex, exhibits anticancer activity. It induces cell death (apoptosis) via the mitochondrial pathway with an IC50 value of 0.014 μM. Additionally, Bcl-2-IN-22 targets members of the BCL-2 family, promoting apoptosis and sensitization in multidrug-resistant leukemia cells overexpressing BCL-2.</p>Colore e forma:Odour SolidCV-4-26
<p>CV-4-26 (Compound 22) acts as a covalent inhibitor of TEAD. By inhibiting YAP/TEAD-driven transcription, it diminishes the expression of CTGF and CYR61. Furthermore, CV-4-26 impedes colony formation in Huh7 and HepG2 cells, inducing cell cycle arrest and apoptosis (apoptosis). This compound demonstrates anti-tumoral activity against hepatocellular carcinoma (HCC) and hepatoblastoma (HB).</p>Colore e forma:Odour SolidEGFR T790M/L858R-IN-2
<p>EGFRT790M/L858R-IN-2: selective inhibitor, IC50: 3.5 nM (mutant), 1290 nM (WT); reduces p-EGFR/AKT/ERK1/2, triggers apoptosis, G1 arrest, anti-cancer.</p>Formula:C28H28FN7OColore e forma:SolidPeso molecolare:497.57Ropeginterferon alfa-2b
CAS:<p>Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft), a monopegylated interferon-alpha (IFN-α), is utilized in the study of myeloproliferative neoplasms [1].</p>Colore e forma:LiquidPBE-AMF
<p>PBE-AMF is a prodrug that activates H2O2 and exhibits anticancer activity. It impedes tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing cell death (apoptosis), and blocking the cell cycle. PBE-AMF effectively and selectively inhibits the proliferation of MDA-MB-231 cells (IC50=6.4 μM) while sparing non-cancerous MCF-10A cells.</p>Colore e forma:Odour SolidKinamycin C
CAS:<p>Kinamycin C is a bacterial metabolite used as an anticancer agent.</p>Formula:C24H20N2O10Colore e forma:SolidPeso molecolare:496.428Pomalidomide-C5-Dovitinib
CAS:<p>Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC that links Pomalidomide and Dovitinib via a CRBN connector, exhibiting potent antiproliferative activity in</p>Formula:C39H38FN9O6Purezza:98%Colore e forma:SolidPeso molecolare:747.77TNF-α (31-45), human
CAS:<p>TNF-α (31-45), human is a peptide of tumor necrosis factor-α.</p>Formula:C69H122N26O22Purezza:98%Colore e forma:SolidPeso molecolare:1667.895Antagonist G
CAS:<p>Antagonist G is an anticancer peptide and is also a broad spectrum neuropeptide growth factor antagonist.</p>Formula:C49H66N12O6SPurezza:98%Colore e forma:SolidPeso molecolare:951.19KRN 5500
CAS:<p>KRN 5500, a derivative of the nucleoside antibiotic spicamycin, has a wide range of antitumor activity against human cancer cell lines.</p>Formula:C28H43N7O7Purezza:98%Colore e forma:SolidPeso molecolare:589.68Volrustomig
CAS:<p>Volrustomig is a bi-engineered fragment crystallizable (Fc) domain, a monovalent bispecific IgG1 monoclonal antibody targeting the key immune checkpoint receptors PD-1 and CTLA-4. It boosts T-cell activation and antitumor immunity, making it a promising immunotherapy for various cancers. Molecular weight: 146.77 kDa.</p>Colore e forma:LiquidCRM1-IN-2
<p>CRM1-IN-2 (Compound KL2) is a noncovalent inhibitor that targets CRM1, localizing it to the nuclear periphery, depleting its nuclear presence, and inhibiting</p>Formula:C29H48N2O5Purezza:98%Colore e forma:SolidPeso molecolare:504.7PB28
CAS:<p>PB28: A potent σ2 agonist (Ki 0.68 nM), σ1 antagonist (Ki 0.38 nM), with anti-tumor properties and inhibits SARS-CoV-2 interactions.</p>Formula:C24H38N2OColore e forma:SolidPeso molecolare:370.581Antiproliferative agent-25
<p>Antiproliferative Agent-25 (Compound 3s4) is a selective PRMT5 inhibitor displaying an IC50 of 0.11 μM.</p>Formula:C20H21BrN2O2Purezza:98%Colore e forma:SolidPeso molecolare:401.3AZD5582 TFA
<p>AZD5582 TFA is a potent IAP antagonist that binds to the BIR3 domain of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15 nM, respectively.AZD5582 TFA</p>Formula:C60H79F3N8O10Purezza:99.89%Colore e forma:SoildPeso molecolare:1129.31Thalidomide-O-amide-C5-NH2
CAS:<p>Thalidomide-O-amide-C5-NH2 is a synthetic E3 ligase linker combining cereblon ligand and PROTAC linker.</p>Formula:C20H24N4O6Colore e forma:SolidPeso molecolare:416.43Apoptosis inducer 37
<p>Apoptosis inducer37 (Derivative 10) is an agent that induces apoptosis and exhibits anticancer properties by causing cell cycle arrest at the S-G2/M phase and promoting cell apoptosis. It significantly inhibits HCT116, SKOV3, and HepG2 cancer cells with IC50 values of 24.98 μM, 26.15 μM, and 23.09 μM, respectively. Apoptosis inducer37 demonstrates antitumor activity and can be utilized in ovarian cancer research.</p>Formula:C27H37BrN2O4SColore e forma:SolidPeso molecolare:564.16574Thalidomide 4'-oxyacetamide-alkyl-C2-amine HCl
CAS:<p>Thalidomide 4'-oxyacetamide-alkyl-C2-amine HCl is an E3 ligase ligand-linker conjugate containing the E3 ubiquitin ligase cereblon (CRBN) and linker.</p>Formula:C17H19ClN4O6Purezza:99.78%Colore e forma:SolidPeso molecolare:410.817-Methoxy-1-tetralone
CAS:<p>7-Methoxy-1-tetralone may have insecticidal activity.</p>Formula:C11H12O2Purezza:99.85% - 99.89%Colore e forma:White CrystalPeso molecolare:176.21Boc-AEVD-CHO
CAS:<p>Boc-AEVD-CHO, a selective Caspase 8 inhibitor, facilitates apoptosis research and the investigation of immune and inflammatory diseases [1] [2].</p>Formula:C22H36N4O10Purezza:98%Colore e forma:SolidPeso molecolare:516.54Nrf2 activator-9
<p>Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-density</p>Formula:C26H27N5O4Colore e forma:SolidPeso molecolare:473.52(-)-Irofulven
CAS:<p>Irofulven is an agent of DNA-damaging and antitumor. It is used for the treatment of advanced solid tumors, including prostate, ovarian, and pancreatic cancers.</p>Formula:C15H18O3Colore e forma:SolidPeso molecolare:246.30Sincalide ammonium
CAS:<p>Sincalide ammonium, a CCK analog, stimulates bile release, gallbladder contraction, and sphincter relaxation, aiding in diagnoses.</p>Formula:C49H65N11O16S3Purezza:98.46%Colore e forma:SolidPeso molecolare:1160.3Akt/NF-κB/MAPK-IN-1
<p>Akt/NF-κB/MAPK-IN-1 (compound 2m) serves as a potent, orally active inhibitor targeting NO with an IC50 of 7.70 μM and demonstrates low toxicity.</p>Formula:C38H56N2O4Purezza:98%Colore e forma:SolidPeso molecolare:604.86RIPK1-IN-17
CAS:<p>RIPK1-IN-17 is a dual inhibitor of RIPK1 and RIPK3 inhibits necrosis by inhibiting phosphorylation of RIPK1, RIPK3 and MLKL,in a tnf-induced inflammation model.</p>Formula:C26H19F4N3O3SPurezza:95.22%Colore e forma:SolidPeso molecolare:529.51Tubulin/AKT1-IN-1
<p>Tubulin/AKT1-IN-1 (Compound D1-1) serves as an inhibitor of both tubulin polymerization and AKT pathway activation, effectively suppressing proliferation and</p>Formula:C38H34ClNO11Purezza:98%Colore e forma:SolidPeso molecolare:716.138-Aminoadenosine
CAS:<p>8-Aminoadenosine reduces ATP, blocks mRNA synthesis, and Akt/mTOR signaling, triggering autophagy and apoptosis independently of p53, with antitumor effects.</p>Formula:C10H14N6O4Colore e forma:SolidPeso molecolare:282.26
