Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(6 prodotti)
- BCL(11 prodotti)
- Caspasi(125 prodotti)
- FOXO1(3 prodotti)
- IAP(66 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(125 prodotti)
- PDK(9 prodotti)
- PERK(25 prodotti)
- Chinasi di serina/treonina(15 prodotti)
- Survivin(13 prodotti)
- TNF(92 prodotti)
- c-RET(51 prodotti)
- p53(62 prodotti)
Mostrare 6 più sottocategorie
Trovati 5593 prodotti di "Apoptosi"
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sEH inhibitor-19
<p>sEH inhibitor-19 (Compound (R)-14i) is an orally active soluble epoxide hydrolase (sEH) inhibitor with an IC50 of 1.2 nM. This compound suppresses the expression of TNF-α and IL-6 and exhibits anti-inflammatory effects in mouse models of acute pancreatitis and Carrageenan-induced edema.</p>Formula:C28H28F3N3O4Colore e forma:SolidPeso molecolare:527.535CDK4/6/HDAC-IN-1
<p>CDK4/6/HDAC-IN-1 (Compound N14) is a dual-target inhibitor of CDK4/6 and HDAC, with IC50 values of 7.23 nM for CDK4, 13.20 nM for CDK6, 55.66 nM for HDAC1, and 48.38 nM for HDAC6. It induces apoptosis and G0/G1 phase arrest through the HDAC-p21-CDK signaling pathway and can inhibit hepatocellular carcinoma.</p>Formula:C35H39N9O5Colore e forma:SolidPeso molecolare:665.742(+)-Mcl-1 inhibitor 21
CAS:<p>(+)-Mcl-1 inhibitor 21 (Example 1-37) is a chemical compound that acts as an Mcl-1 inhibitor with an IC50 value of 172 nM. It demonstrates pro-apoptotic and antiproliferative activities in SUDHL5 and SUDHL10 cell lines, making it useful for cancer research.</p>Formula:C32H33N3O4Colore e forma:SolidPeso molecolare:523.622TTQ-SA
<p>TTQ-SA is a near-infrared spiraling aggregation-induced emitter capable of converting near-infrared light (NIR) into thermal energy, resulting in thermal damage and death of tumor cells. In cancer cells MF-7, TTQ-SA shows cell uptake and targeting capabilities. TTQ-SA binds with DNAzyme to inhibit the expression of the survivin gene, enhancing the sensitivity of tumor cells to photothermal therapy.</p>Formula:C78H53N7SColore e forma:SolidPeso molecolare:1120.37Milademetan tosylate hydrate
CAS:<p>Milademetan tosylate hydrate, an oral MDM2 inhibitor targeting AML and solid tumors, induces G1 arrest and apoptosis.</p>Formula:C37H44Cl2FN5O8SColore e forma:SolidPeso molecolare:808.74Chloranthalactone B
CAS:<p>Chloranthalactone B, a sesquiterpenoid from Sarcandra glabra, inhibits inflammation via AP-1 & p38 MAPK.</p>Formula:C15H16O3Colore e forma:SolidPeso molecolare:244.29DP-15
CAS:<p>DP-15 acts as a degrader of GSPT1 and BRD4, with DC50 values of 5.25 nM and 0.48 nM, respectively. This compound exhibits antiproliferative activity in AML and NHL cells, showing IC50 values in the nanomolar range, induces G1 phase cell cycle arrest, and triggers apoptosis in MOLM13 cells. Additionally, DP-15 demonstrates anti-leukemic properties in the MOLM-13 xenograft mouse model. [Pink: ligand for target protein JQ-1 carboxylic acid; Black: linker; Blue: ligand for E3 ligaseCereblonThalidomide-5-OH]</p>Formula:C42H44ClN9O5SColore e forma:SolidPeso molecolare:822.374PROTAC XPO1 degrader-1
<p>PROTAC XPO1 degrader-1 (Compound 2c) is an XPO1 degrader. It exhibits anti-proliferative effects, induces apoptosis, inhibits NF-κB activity, and causes cell cycle arrest at the G1 phase. PROTAC XPO1 degrader-1 is applicable to research on hematological malignancies.</p>Formula:C33H35ClF3N7O7Colore e forma:SolidPeso molecolare:734.122STEP-IN-1
<p>STEP-IN-1 (Compound 14b) is a potent and selective inhibitor of STEP, with an IC50 of 5.27 μM. It offers neuroprotective effects by safeguarding neuronal cells from glutamate-induced toxicity, reducing intracellular reactive oxygen species (ROS) accumulation, and inhibiting apoptosis. STEP-IN-1 is applicable in research related to neurodegenerative diseases.</p>Formula:C21H10ClNO7Colore e forma:SolidPeso molecolare:423.76AMPK-IN-6
<p>AMPK-IN-6 (compound 13a) is a potent AMPK inhibitor with an IC50 value of 0.093 µM. It induces apoptosis and suppresses autophagy. Additionally, AMPK-IN-6 exhibits antiproliferative activity and holds potential for research into pulmonary arterial hypertension.</p>Formula:C18H20FN5OColore e forma:SolidPeso molecolare:341.383JAK-IN-40
<p>JAK-IN-40 (Compound 46) is an inhibitor of JAK, effectively targeting JAK1, JAK2, and JAK3 with IC50 values of 0.022, 0.759, and 1.601 μM, respectively. It reduces the phosphorylation of STAT3 and inhibits the proliferation of cancer cells Ba/F3 and JAK1-TEL Ba/F3 with GI50 values of 0.614 μM and 0.193 μM. JAK-IN-40 arrests cell cycle progression at the G2/M phase in H1975 and H2087 cells, leading to apoptosis. Additionally, JAK-IN-40 exhibits a synergistic anti-tumor effect when used in combination with Osimertinib.</p>Formula:C26H32N8O3SColore e forma:SolidPeso molecolare:536.65Antitumor agent-196
CAS:<p>Antitumor agent-196 (Compound 6a (β, β, β)) is an artemisinin-based oligomer with anticancer properties, exhibiting an IC50 of 90 nM against MCF-7 breast cancer cells. This compound induces apoptosis by modulating the Bax-caspase 3 signaling pathway and triggers ferroptosis by regulating key signaling molecules (including GPX4). Antitumor agent-196 shows potential for cancer research applications.</p>Formula:C51H81NO15Colore e forma:SolidPeso molecolare:948.187Apoptosis inducer 31
<p>Apoptosisinducer 31 (compound 19) triggers caspase-dependent apoptosis (cell death). It plays a crucial role in cancer research.</p>Formula:C14H10N4O3Colore e forma:SolidPeso molecolare:282.254Anagrelide hydrochloride monohydrate
CAS:<p>Anagrelide HCl monohydrate is a platelet-reducing imidazoquinazoline for ET and PV research.</p>Formula:C10H10Cl3N3O2Colore e forma:SolidPeso molecolare:310.56Ganglioside GD3 disodium salt
CAS:<p>Ganglioside GD3 disodium salt is a melanoma-associated antigen often targeted in immune therapy for melanomas.</p>Formula:C70H123N3Na2O29Colore e forma:SolidPeso molecolare:1516.71STAT3-IN-40
CAS:<p>STAT3-IN-40 (Compound 8b) is an anticancer agent. It initiates immune responses in CD4+ and CD8+ T lymphocytes by inhibiting the expression and phosphorylation of STAT3, and induces ferroptosis and apoptosis in tumor cells. STAT3-IN-40 is valuable for research into cancer chemoimmunotherapy drugs.</p>Formula:C34H40ClN3O10PtColore e forma:SolidPeso molecolare:881.232TopoII/tubulin-IN-1
<p>TopoII/tubulin-IN-1 (Compound 1B8) is an inhibitor of TopoII/tubulin. It effectively suppresses the proliferation of tumor cells and reduces ROS levels, while inducing apoptosis and cell cycle arrest, without showing significant cytotoxicity to normal cells. TopoII/tubulin-IN-1 exhibits antitumor activity.</p>Formula:C21H18ClN5O3Colore e forma:SolidPeso molecolare:423.85ERK-IN-6
<p>ERK-IN-6, a potent agent, inhibits ESCC growth and induces apoptosis through the ERK pathway.</p>Formula:C19H18BrN3O3SColore e forma:SolidPeso molecolare:448.33Thalidomide-NH-PEG2-COOH
CAS:<p>Thalidomide-NH-PEG2-COOH: a synthesized E3 ligase ligand-linker with cereblon ligand and PROTAC linker.</p>Formula:C20H23N3O8Colore e forma:SolidPeso molecolare:433.417(Rac)-BIO8898
CAS:<p>(Rac)-BIO8898 is a chemical compound that serves as an inhibitor of the co-stimulatory interaction between CD40 and CD154.</p>Formula:C53H64N8O6Colore e forma:SolidPeso molecolare:909.13Lenercept
CAS:<p>Lenercept (Ro 45-2081) is a recombinant fusion protein combining the soluble TNF-receptor (p55) with the Fc portion of human IgG1 [1].</p>Colore e forma:LiquidAnticancer agent 104
<p>Anticancer agent 104 has anticancer activity, and induces cancer cell apoptosis [1] .</p>Formula:C34H47F3N2O2S2Colore e forma:SolidPeso molecolare:636.87TAS-117
CAS:<p>TAS-117, a PKB/Akt inhibitor, is used potentially for the treatment of solid tumors.</p>Formula:C26H24N4O2Colore e forma:SolidPeso molecolare:424.49Cardanol (C15:1)
CAS:<p>Cardanol (C15:1), found in cashew nut shell liquid, induces mitochondria-associated apoptosis in human melanoma cells.</p>Formula:C21H34OPurezza:98.48% - 99.77%Colore e forma:SolidPeso molecolare:302.49Odoroside A
CAS:<p>Odoroside A, from Nerium oleander leaves, induces cancer cell death via ROS/p53, causing apoptosis and cell cycle arrest.</p>Formula:C30H46O7Colore e forma:SolidPeso molecolare:518.68Xylopine
CAS:<p>Xylopine: an aporphine alkaloid, cytotoxic to cancer cells, induces oxidative stress, G2/M arrest, and apoptosis.</p>Formula:C18H17NO3Colore e forma:SolidPeso molecolare:295.33Thalidomide-O-C4-COOH
CAS:<p>Thalidomide-O-C4-COOH is a synthetic E3 ligase linker derived from Thalidomide for PROTAC tech.</p>Formula:C18H18N2O7Colore e forma:SolidPeso molecolare:374.3447Tripchlorolide
<p>Tripchlorolide is a useful organic compound for research related to life sciences and the catalog number is T126047.</p>Formula:C20H25ClO6Colore e forma:SolidPeso molecolare:396.86Bromoiodoacetamide
CAS:<p>Bromoiodoacetamide (I-HAcAm): cytotoxic, induces ROS & apoptosis in HepG-2 cells.</p>Formula:C2H3BrINOColore e forma:SolidPeso molecolare:263.86H-20
CAS:<p>H-20 is a PD-1 agonist that reduces the required dosage of morphine for analgesia. It can be used in studies related to chronic pain.</p>Formula:C44H64N10O15Colore e forma:SolidPeso molecolare:973.037KP1019
CAS:<p>KP1019 is now discontinued.</p>Formula:C21H19Cl4N6RuColore e forma:SolidPeso molecolare:598.30eIF4A3-IN-7
CAS:<p>eIF4A3-IN-7: Potent eIF4A3 inhibitor, potential cancer/dysproliferation research (WO2019161345A1, Compound 8).</p>Formula:C26H25NO7Colore e forma:SolidPeso molecolare:463.486Pimivalimab
CAS:<p>Pimivalimab (JTX-4014), a PD-1 inhibitor, is utilized in solid tumor research [1].</p>Colore e forma:Liquid(Iso)-Z-VAD(OMe)-FMK
CAS:<p>(Iso)-Z-VAD(OMe)-FMK is an isomer of Z-VAD(OMe)-FMK, which is a pan-caspase inhibitor with irreversible properties. Z-VAD(OMe)-FMK is also an inhibitor UCHL1.</p>Formula:C22H30FN3O7Purezza:97.10%Colore e forma:SoildPeso molecolare:467.49cis-Clovamide
CAS:<p>cis-Clovamide is a naturally occurring phenolic compound with noteworthy antioxidant, anti-inflammatory, and antiapoptotic properties.</p>Formula:C18H17NO7Colore e forma:SolidPeso molecolare:359.334TRP-601
CAS:<p>TRP-601 is a caspase inhibitor.</p>Formula:C40H48F2N6O11Purezza:98%Colore e forma:SolidPeso molecolare:826.852LZ-07
<p>LZ-07 is an IRAK4 PROTAC degrader (DC50 = 1.14 nM), that, upon degradation of IRAK4, significantly inhibits the expression of cytokines such as IL-6, IL-1β, TNF-α, and IL-10. It is applicable in research related to autoimmune diseases.</p>Colore e forma:Odour SolidZ-LEHD-fmk
CAS:<p>Z-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis.Z-LEHD-FMK exhibits antitumor and</p>Formula:C32H43FN6O10Purezza:96.13%Colore e forma:SolidPeso molecolare:690.72Lorigerlimab
CAS:<p>Lorigerlimab (MGD019) is a bispecific IgG4 DART that blocks PD-1/CTLA-4, enhancing T-cells for mCRPC research.</p>Colore e forma:Liquid(D)-PPA 1 TFA
<p>(D)-PPA 1 TFA is a hydrolysis-resistant D-peptide antagonist and a potent PD-1/PD-L1 inhibitor, exhibiting an affinity for PD-1 of 0.51 μM and demonstrating</p>Formula:C72H99F3N20O23Purezza:98%Colore e forma:SolidPeso molecolare:1669.67SSE1806
<p>SSE1806, a podophyllotoxin derivative (a natural antimitotic agent), functions as a microtubule/tubulin inhibitor, exhibiting potent anticancer and</p>Formula:C21H18N2O5Colore e forma:SolidPeso molecolare:378.38hCAIX-IN-13
CAS:<p>hCAIX-IN-13 (Pt2) inhibits CAIX with 6.57 μM IC50, curbs cancer cell growth, and induces apoptosis for cancer research.</p>Formula:C37H33F3N6O7PtS2Colore e forma:SolidPeso molecolare:989.9ARI-1
<p>ARI-1 is a receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitor that binds to ROR1's extracellular Frizzled domain, effectively inhibiting aberrant</p>Colore e forma:Odour SolidTNF-α-IN-11
<p>TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.</p>Formula:C24H26N2O5Colore e forma:SolidPeso molecolare:422.47Petromurin C
CAS:<p>Petromurin C, a bis-indolyl benzenoid from P. muricatus, is cytotoxic to NS-1 cells (IC50=33μg/ml) and active against T. foetus (IC50=100μg/ml).</p>Formula:C26H24N2O5Colore e forma:SolidPeso molecolare:444.487Cytostatin
CAS:<p>Cytostatin: Natural antitumor, inhibits cell adhesion, blocks B16 melanoma, induces apoptosis, selectively targets PP2A (IC50 = 29 nM).</p>Formula:C21H33O7PColore e forma:SolidPeso molecolare:428.462Giloralimab
CAS:<p>Giloralimab (ABBV-927) is a antibody targeting CD40 with anticancer activity for the study of triple-negative breast cancer and non-small cell lung cancer.</p>Purezza:95.6% (SDS-PAGE); 95.1% (SEC-HPLC) - 95.6% (SDS-PAGE); 95.1% (SEC-HPLC)Colore e forma:LiquidSpexin
CAS:<p>Potent GAL2/GAL3 agonist (EC50 = 45.7, 112.2 nM), inactive at GAL1. Reduces appetite, fatty acid uptake in adipocytes, and LH in goldfish; anxiolytic in vivo.</p>Formula:C74H114N20O19SPurezza:98%Colore e forma:SolidPeso molecolare:1619.9Z-DQMD-FMK
CAS:<p>Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.</p>Formula:C29H40FN5O11SPurezza:98%Colore e forma:SolidPeso molecolare:685.72Chloranil
CAS:<p>Chloranil (tetrachloro-p-benzoquinone) induces inflammation and neurological dysfunction and can be used to model inflammation in mice.</p>Formula:C6Cl4O2Purezza:99.38%Colore e forma:SolidPeso molecolare:245.88Pipermethystine
<p>Pipermethystine is a useful organic compound for research related to life sciences and the catalog number is T124340.</p>Formula:C16H17NO4Colore e forma:SolidPeso molecolare:287.315Beclin1-Bcl-2 interaction inhibitor 1
<p>Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].</p>Colore e forma:Odour SolidUrelumab
CAS:<p>"Urelumab (BMS-66513), a humanized IgG4 mAb CD137 agonist, boosts T-cell/NK cell-mediated cytotoxicity and anti-tumor activity."</p>Purezza:97.70%Colore e forma:LiquidPeso molecolare:145.90 kDaHKB99
CAS:<p>HKB99 suppresses NSCLC growth, metastasis, and overcomes erlotinib resistance.</p>Formula:C23H18N2O6SPurezza:97.35% - 97.35%Colore e forma:SolidPeso molecolare:450.46Anticancer agent 39
CAS:<p>Compound B12, a JOA derivative, collapses MMP to induce apoptosis, inhibits cloning/migration, and has an IC50 of 0.39 μM against HGC-27 cells.</p>Formula:C50H65N5O10Colore e forma:SolidPeso molecolare:896.08Mcl-1 inhibitor 15
<p>Mcl-1 Inhibitor 15 (Compound (Ra)-15), with a K i of 0.02 nM, is utilized in cancer research [1].</p>Formula:C40H42ClFN6O4SColore e forma:SolidPeso molecolare:757.32Syringolin A
CAS:<p>Syringolin A is a useful organic compound for research related to life sciences. The catalog number is T125354 and the CAS number is 212115-96-3.</p>Formula:C24H39N5O6Colore e forma:SolidPeso molecolare:493.605BLU-222
CAS:<p>BLU-222 is a potent, selective and orally active CDK2 inhibitor. BLU-222 shows robust antitumor activity.</p>Formula:C15H17F2N7O2Purezza:99.17% - 99.92%Colore e forma:SoildPeso molecolare:365.34S-Adenosyl-L-methionine iodide
CAS:<p>S-(5'-Adenosyl)-L-methionine iodide, also known as S-Adenosyl-L-methionine iodide, is a vital methyl donor present in all living organisms [1].</p>Formula:C15H23IN6O5SColore e forma:SolidPeso molecolare:526.355α-dihydro Levonorgestrel
CAS:<p>5α-dihydro Levonorgestrel is a metabolite of the synthetic progestin levonorgestrel .</p>Formula:C21H30O2Colore e forma:SolidPeso molecolare:314.469HSP70-IN-6
<p>HSP70-IN-6 (Compound JL-15) acts as an inhibitor of the Hsp70-Bim protein-protein interactions (PPI) with an IC50 value of 70 nM. It induces apoptosis in chronic myeloid leukemia (CML) cells with EC50 values of 0.43 μM (BV173), 0.88 μM (K562), and 0.19 μM (K562-R3).</p>Colore e forma:Odour SolidTralokinumab
CAS:<p>Tralokinumab: human IgG4 monoclonal antibody, blocks IL-13, may treat atopic dermatitis.</p>Purezza:SDS-PAGE:95% SEC-HPLC:99.99%Colore e forma:LiquidPeso molecolare:144.14 kDaBcI-2/BcI-xI ligand 1
CAS:<p>BcI-2/BcI-xI ligand 1, functioning as a BcI-2/BcI-xI ligand, is utilized in the synthesis of PROTAC BcI-2/BcI-xI Degrader-1 .</p>Formula:C53H64ClF3N6O8S3Colore e forma:SolidPeso molecolare:1101.75Necroptosis-IN-4
<p>Necroptosis-IN-4 is an effective inhibitor of necroptosis, specifically targeting RIP kinase 1 (RIPK1) without inhibitory activity against RIPK3. It exhibits weak inhibitory effects on VEGFR1/2 and PDGFR-α.</p>Colore e forma:Odour Solid5-Fluorouracil-13C,15N2
CAS:<p>5-Fluorouracil-13C,15N2 is a standard for quantifying 5-fluorouracil via GC/LC-MS and blocks DNA synthesis, causing cell apoptosis.</p>Formula:C4H3FN2O2Colore e forma:SolidPeso molecolare:133.057Avotaciclib hydrochloride
<p>Avotaciclib hydrochloride, a CDK1 inhibitor, is the hydrochloride salt of Avotaciclib and exhibits potential therapeutic use in specific malignancies, including</p>Formula:C13H12ClN7OPurezza:98%Colore e forma:SolidPeso molecolare:317.73Annonacin
CAS:<p>Annonacin is a cytotoxic acetogenin in Graviola leaf extract; it blocks mitochondrial complex and inhibits NKA/SERCA ATPase pumps.</p>Formula:C35H64O7Purezza:98%Colore e forma:SolidPeso molecolare:596.88RET Ligand-Linker Conjugate-1
<p>RET Ligand-Linker Conjugate-1 consists of a complex formed by a RET ligand and a linker, which can be utilized in the synthesis of QZ2135.</p>Formula:C40H44N10OColore e forma:SolidPeso molecolare:680.84Necroptosis-IN-5
<p>Necroptosis-IN-5 (Compound 26) is an orally active inhibitor of necroptotic cell death (necroptosis). This compound also exhibits potent inhibitory activity against receptor-interacting protein kinase 1 (RIPK1). It can be utilized in research related to inflammatory diseases, neurodegenerative disorders, and cancer associated with necroptosis.</p>Colore e forma:Odour SolidCDC20-IN-2
<p>CDC20-IN-2 (14c) is an inhibitor of Cdc20 with a KD of 7.65 μM, inducing G2/M phase arrest, promoting DNA damage accumulation, and stabilizing key substrates such as Cyclin B1 and Bim. This leads to enhanced apoptosis, as well as inhibition of tumor cell proliferation and migration.</p>Colore e forma:Odour SolidEmavusertib hydrochloride
CAS:<p>Emavusertib (CA-4948) hydrochloride, a selective and potent IRAK4/FLT3 inhibitor, is designed for oral administration. It achieves an IC 50 of 57 nM against IRAK4 in a FRET kinase assay and demonstrates anti-tumor activity [1] [2] [3].</p>Formula:C24H26ClN7O5Colore e forma:SolidPeso molecolare:527.96Leucettamol A
CAS:<p>Leucettamol A, from Leucetta microraphis, blocks LTB4 receptor and prevents Ubc13-Uev1A complex formation.</p>Formula:C30H52N2O2Purezza:98%Colore e forma:SolidPeso molecolare:472.758Zamzetoclax
CAS:<p>Zamzetoclax (compound 1) acts as a potential inhibitor of Mcl-1.</p>Formula:C38H46ClN5O6SColore e forma:SolidPeso molecolare:736.32TPP-1 TFA
<p>TPP-1 TFA is a high-affinity PD-L1 inhibitor (KD=95nM) that boosts T-cell function to curb tumor growth.</p>Formula:C109H151F3N34O34S2Colore e forma:SolidPeso molecolare:2602.69Antagonist G TFA
<p>Potent vasopressin blocker, Antagonist G TFA also mildly inhibits GRP & Bradykinin, triggers AP-1, enhances chemo response.</p>Formula:C51H67F3N12O8SColore e forma:SolidPeso molecolare:1065.21(E/Z)-Eltrombopag 13C4
CAS:<p>(E/Z)-Eltrombopag 13C4 is a mix of E/Z isotopologues, both 13C-labeled TPO receptor agonists for thrombocytopenia.</p>Formula:C25H22N4O4Colore e forma:SolidPeso molecolare:446.444Solasodine hydrochloride
CAS:<p>Solasodine hydrochloride (90 μM; 2 days) treatment induced significant budding in P19 cells. This compound strongly stimulated the expression of various neuronal markers, including βIII-tubulin, synaptophysin, MAP2, ChAT, and the neural progenitor marker doublecortin. Predominantly, Solasodine hydrochloride directed the differentiation of P19 cells towards neuronal pathways.</p>Formula:C27H44ClNO2Colore e forma:SolidPeso molecolare:450.1XIAP BIR2/BIR2-3 inhibitor-3
CAS:<p>XIAP BIR2/BIR2-3 Inhibitor-3 functions as a dual inhibitor targeting both BIR2 and BIR2-3 domains, exhibiting potent activity with IC50 values below 1 nM. This compound is utilized in cancer research [1].</p>Formula:C86H106N18O16S2Colore e forma:SolidPeso molecolare:1712GSK-1070916
CAS:<p>GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM.</p>Formula:C30H33N7OPurezza:99.73%Colore e forma:SolidPeso molecolare:507.634-Nitrothalidomide
CAS:<p>4-Nitrothalidomide is a modified form of thalidomide that inhibits the growth and proliferation of HUVEC cells and is commonly used in the synthesis of pomalidomide, which has anticancer potential.</p>Formula:C13H9N3O6Purezza:99.94%Colore e forma:SolidPeso molecolare:303.23MMRi62
CAS:<p>MMRi62, a MDM2-MDM4 inhibitor, induces ferroptosis and autophagy in PDAC, degrades FTH1 and mutant p53, and inhibits KRAS/TP53 mutant PDAC in mice.</p>Formula:C21H15Cl2N3OPurezza:99.87%Colore e forma:SoildPeso molecolare:396.27IRF1-IN-2
CAS:<p>IRF1-IN-2 is a small molecule IRF1 inhibitor that suppresses pyroptosis, protecting against radiation-induced skin damage.</p>Formula:C18H20N2O4SPurezza:99.85%Colore e forma:SolidPeso molecolare:360.43Reproxalap
CAS:<p>Reproxalap (NS-2) is a dry eye treatment that neutralizes aldehydes like malondialdehyde.</p>Formula:C12H13ClN2OPurezza:99.4% - 99.97%Colore e forma:SolidPeso molecolare:236.7Oxatomide
CAS:<p>Oxatomide: Dual H1/P2X7 antagonist, antihistamine, anti-allergic, treats immune diseases, IC50: 0.95 μM (P2X7), 0.43 μM (5-HT).</p>Formula:C27H30N4OPurezza:98.82% - 99.72%Colore e forma:White PowderPeso molecolare:426.55FL118
CAS:<p>FL118 is a novel survivin inhibitor that inhibits cancer stem cell-like properties.FL118 is a novel camptothecin analog with anticancer activity that inhibits</p>Formula:C21H16N2O6Purezza:98.99%Colore e forma:SoildPeso molecolare:392.36CDK2-IN-45
<p>CDK2-IN-45 is a CDK2 inhibitor with an IC50 value of 0.64 μM. It effectively inhibits the proliferation of DU-145 and PC-3 cell lines, with IC50 values of 2.20 μM and 4.17 μM, respectively. Additionally, CDK2-IN-45 induces G0/G1 phase cell cycle arrest and apoptosis. It is utilized in prostate cancer research.</p>Formula:C25H16ClN5SColore e forma:SolidPeso molecolare:453.95YX0798
<p>YX0798 is a selective, orally active CDK9 inhibitor (Kd: 0.28 nM). It downregulates the oncogenic protein c-MYC and the pro-survival protein MCL-1. YX0798 disrupts the cell cycle and causes transcriptome reprogramming, ultimately leading to apoptosis. The compound exhibits antitumor activity.</p>Formula:C21H19ClF3N5O2Colore e forma:SolidPeso molecolare:465.86Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2
<p>Thalidomide-PEG conjugate for E3 ligase in PROTACs; has cereblon ligand and 3-unit PEG linker.</p>Formula:C27H35F3N4O11Purezza:98%Colore e forma:SolidPeso molecolare:648.58Cot inhibitor-1 hydrochloride
<p>Cot inhibitor-1 hydrochloride blocks TPL-2 kinase (IC50=28nM) and TNF-α synthesis (IC50=5.7nM) in human blood.</p>Formula:C27H28Cl3FN8Purezza:98.26%Colore e forma:SoildPeso molecolare:589.92TNF-α Antagonist
CAS:<p>TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with</p>Formula:C58H71N11O15S2Colore e forma:SolidPeso molecolare:1226.39Pep19-2.5
CAS:<p>Pep19-2.5: Synthetic antitoxin peptide inhibits LP/LPS signals via PRRs, preventing inflammation and pyroptosis.</p>Formula:C135H187N37O22SColore e forma:SolidPeso molecolare:2712.23Boc-Asp(OBzl)-CMK
CAS:<p>Boc-Asp(OBzl)-CMK, an inhibitor of IL-1 converting enzyme (ICE, caspase1), prevents the death of CHP100 neuroblastoma cells and inhibits IL-1β release induced by the viral coat protein [1].</p>Formula:C17H22ClNO5Colore e forma:SolidPeso molecolare:355.81WKYMVM
CAS:<p>WKYMVM is a N-formyl peptide receptor (FPR1) agonist.</p>Formula:C41H61N9O7S2Purezza:98%Colore e forma:SolidPeso molecolare:856.11Trilexium
CAS:<p>Trilexium (TRX-E-009-1), a third-generation benzopyran structurally related to TRX-E-002-1, increases p21 protein expression, induces apoptosis, depolymerizes microtubules, and demonstrates broad anti-cancer activity [1] [2].</p>Formula:C24H23FO6Colore e forma:SolidPeso molecolare:426.43Azalamellarin N
CAS:<p>Azalamellarin N is a pyroptosis inhibitor that exhibits varying inhibitory effects on different pyroptosis inducers. It functions by targeting molecules upstream of NLRP3 inflammasome activation, instead of directly affecting the components of the NLRP3 inflammasome. Its inhibitory potency against various inducers is ranked as follows: Nigericin > R837 [1].</p>Formula:C28H22N2O7Colore e forma:SolidPeso molecolare:498.48Ac-FEID-CMK
<p>Ac-FEID-CMK: Potent inhibitor for zebrafish GSDMEb, reduces pyroptosis, and lessens septic AKI.</p>Formula:C27H37ClN4O9Colore e forma:SolidPeso molecolare:597.06Volrustomig
CAS:<p>Volrustomig is a bi-engineered fragment crystallizable (Fc) domain, a monovalent bispecific IgG1 monoclonal antibody targeting the key immune checkpoint receptors PD-1 and CTLA-4. It boosts T-cell activation and antitumor immunity, making it a promising immunotherapy for various cancers. Molecular weight: 146.77 kDa.</p>Colore e forma:LiquidUNC10245380
<p>UNC10245380 is a CIB1 inhibitor with an IC50 of 8 μM. It also inhibits the phosphorylation of AKT and ERK while upregulating the expression of TRAIL-R1/D5. UNC10245380 specifically kills cancer cells that are dependent on CIB1, demonstrating its potential value in the development of CIB1 probes and cancer research.</p>Colore e forma:Odour SolidBIIB023
<p>BIIB023 is a human monoclonal antibody (mAb) that targets TNFRSF12A/TWEAKR/CD266. It is applicable for research in lupus nephritis and rheumatoid arthritis.</p>Colore e forma:Odour LiquidKB03-SLF
CAS:<p>KB03-SLF is a protease with the capability to target specific proteins and regulate intracellular protein levels by inducing protein degradation. This mechanism renders KB03-SLF potentially valuable in the suppression of related diseases.</p>Formula:C50H63ClF3N5O12Colore e forma:SolidPeso molecolare:1018.51
