Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(1 prodotti)
- Caspasi(154 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(134 prodotti)
- PDK(9 prodotti)
- PERK(23 prodotti)
- Chinasi di serina/treonina(17 prodotti)
- Survivin(14 prodotti)
- TNF(93 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6222 prodotti di "Apoptosi"
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Chol-CTPP
Chol-CTPP targets the BBB and glioma cells; when combined with Chol-TPP, forms Lip-CTPP, enhancing anti-glioma drug efficacy.Formula:C144H263N3O53Colore e forma:SolidPeso molecolare:2884.62CSN5-IN-2
CSN5-IN-2 (Compound 31) is a CSN5 inhibitor with an IC50 of 0.36 μM. It increases Cullin 1 neddylation levels in cancer cells and downregulates the expression of RAD51 and PD-L1. CSN5-IN-2 exhibits antitumor activity, which is enhanced when used in combination with Talazoparib.Colore e forma:Odour SolidNecrosis inhibitor 2 (hydrocholide)
Necrosis inhibitor 2 hydrochloride (Compound B19) is an agent that inhibits cellular necrosis. It is useful for researching diseases associated with necrotic pathways, including inflammation, cancer, metabolic disorders, and neurodegenerative diseases.Formula:C24H26ClN5O5Peso molecolare:499.16225PTD-p65-P1 Peptide TFA
Ptd-p65-p1 Peptide TFA inhibits NF-kappaB, has a cell-penetrating antennapedia sequence, and selectively blocks NF-kappaB activation.Formula:C170H276F3N57O46SPurezza:98%Colore e forma:SolidPeso molecolare:3943.52Apoptosis inducer 27
Apoptosisinducer 27 (compound 1c) is a potent inhibitor of MDA-MB-231 breast cancer cells, demonstrating an IC50 of 12.8 μM and inducing early apoptosis in these cells. Additionally, it can bind to DNA molecules as well as Bax and Bcl-2 proteins, thereby inducing DNA damage.Formula:C29H37BrN2Colore e forma:SolidPeso molecolare:493.52JC2-11
CAS:JC2-11 is an anti-inflammatory agent blocking NLRC 4, AIM 2, ROS production, caspase-1 activity, and reducing GSDMD, IL-1β, and LDH in vesicles.
Formula:C17H15FO4Purezza:98.6%Colore e forma:SoildPeso molecolare:302.3PUMA BH3
PUMA BH3 activates Bak, binds Bcl-2; triggers apoptosis via cytochrome C release; Kd 26 nM.Formula:C128H202N42O43SPurezza:98%Colore e forma:SolidPeso molecolare:3049.3Ecdysone
CAS:Ecdysone is a major steroid hormone in insects and herbs.Formula:C27H44O6Purezza:99.22%Colore e forma:PowderPeso molecolare:464.63Photosensitizer-5
Photosensitizer-5, a photodynamic agent, exhibits cytotoxicity towards HeLa and HepG2 cells, with IC50 values of 10.4 nM and 6.9 nM, respectively. It induces cell death through lipid peroxidation via an iron-independent ferroptosis pathway. Additionally, Photosensitizer-5 displays antitumor activity in HeLa-tumor-bearing mice.Formula:C35H26BF2IN4O2Colore e forma:SolidPeso molecolare:710.32PROTAC Bcl-xL ligand-1
PROTAC Bcl-xL ligand-1 serves as a ligand targeting Bcl-xL, essential in synthesizing PROTACs [1].Formula:C32H29IN4O4S2Colore e forma:SolidPeso molecolare:724.63Nauclefine
CAS:Nauclefine, a plant alkaloid, triggers cancer cell death through PDE3A-SLFN12, binding but not inhibiting PDE3A.Formula:C18H13N3OPurezza:99.92%Colore e forma:SolidPeso molecolare:287.32Ref: TM-TN6120
25mgPrezzo su richiesta50mgPrezzo su richiesta1mg110,00€2mg166,00€5mg241,00€10mg355,00€JPS014 TFA
JPS014 TFA, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDACFormula:C48H60F3N7O9SPurezza:98%Colore e forma:SolidPeso molecolare:968.09Arisostatin A
CAS:Arisostatin A is a secondary metabolite produced by microorganisms, recognized as an antibiotic (antibiotic) with activity against Gram-positive bacteria. This compound also exhibits potent antitumor properties. It induces apoptosis (apoptosis) by activating caspase-3 and generating reactive oxygen species (ROS) in AMC-HN-4 cells.Formula:C69H100N2O24Colore e forma:SolidPeso molecolare:1341.53RWJ-56110 dihydrochloride
CAS:RWJ-56110 dihydrochloride is a potent PAR-1 inhibitor (IC50=0.44μM), blocking platelet aggregation, angiogenesis, and induces apoptosis. No PAR-2/3/4 effect.Formula:C41H44Cl3F2N7O3Colore e forma:SolidPeso molecolare:827.2HSP90-IN-18
HSP90-IN-18 inhibits Hsp90 with 0.39 μM IC50, useful for viral, neurodegenerative, and inflammatory research.Formula:C25H33FO3Colore e forma:SolidPeso molecolare:400.53MALT1-IN-13
MALT1-IN-13 (compound 10m) is an inhibitor of the mucosa-associated lymphoid tissue lymphoma translocation protein (MALT1), forming a covalent and irreversible bond with the MALT1 protease, thereby inhibiting its activity with an IC50 of 1.7 μM. It suppresses the proliferation of ABC-DLBCL and induces apoptosis in ABC-DLBCL HBL1 cells. Additionally, MALT1-IN-13 regulates the mTOR and PI3K-Akt pathways.Formula:C20H15BrClN3O3S2Peso molecolare:522.94267c-JUN peptide
CAS:Peptide from c-Jun (33-57) blocks JNK binding, inhibits phosphorylation, upregulates p21, and induces HeLa cell apoptosis.
Formula:C121H210N36O34SPurezza:98%Colore e forma:SolidPeso molecolare:2743.55Canfosfamide
CAS:Canfosfamide, a prodrug activated by GSTP1-1, induces apoptosis and inhibits DNA-PK, producing an alkylating agent for cancer research.Formula:C26H40Cl4N5O10PSColore e forma:SolidPeso molecolare:787.47EGFR/BRAFV600E-IN-3
EGFR/BRAFV600E-IN-3 is an inhibitor targeting EGFR, BRAFV600E, and EGFRT790M with IC50 values of 57 nM, 68 nM, and 9.70 nM, respectively.Formula:C25H18N4O3Purezza:98%Colore e forma:SolidPeso molecolare:422.44MDMX/MDM2-IN-2
MDMX/MDM2-IN-2 is a potent dual inhibitor of p53-MDM2/MDMX, demonstrating dissociation constants (Kis) of 0.23 μM for MDM2 and 2.45 μM for MDMX.Formula:C28H25Cl3FN3O3Colore e forma:SolidPeso molecolare:576.87Zapalog
CAS:Zapalog: photocleavable dimerizer controlling instant protein interactions.Formula:C58H73N7O15Purezza:98%Colore e forma:SolidPeso molecolare:1108.24PI3K-AKT-mTOR Compound Library
A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved withColore e forma:Odour SolidRef: TM-L1300
1mgPrezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaPoly (I:C):Kanamycin (1:1)
Poly (I:C):Kanamycin (1:1) is an equimolar mixture of Poly(I:C) and kanamycin. TLR3 agonist commonly used as a vaccine adjuvant; enhanced Poly(I:C) stability.
Colore e forma:SolidRET-IN-4
CAS:RET-IN-4: Oral RET inhibitor, IC50 ~1 nM for variants. Selective over JAK2/FLT3. Potent anticancer use.Formula:C27H31FN10O2Colore e forma:SolidPeso molecolare:546.611PARP1-IN-15
PARP1-IN-15 (Compound 6) is a PARP1 inhibitor that also inhibits tankyrase (TNKS) and promotes DNA double-strand breaks, leading to tumor cell apoptosis.Formula:C16H12N2O2Purezza:98%Colore e forma:SolidPeso molecolare:264.28CXCR4-IN-2
CXCR4-IN-2 (compound A1), a potent bifunctional fluorinated small molecule, inhibits CXCR4 and exhibits anticancer properties by exerting cytotoxicity (IC 50:Formula:C21H20F6N4SPurezza:98%Colore e forma:SolidPeso molecolare:474.47Galloflavin Potassium
CAS:Galloflavin Potassium is an inhibitor of lactate dehydrogenase.Formula:C12H5KO8Colore e forma:SolidPeso molecolare:316.26EGFR-IN-144
EGFR-IN-144 (Compound 4B) inhibits EGFR (IC50=0.639 µg/mL) and tubulin polymerization (IC50=7.339 µg/mL). It exhibits cytotoxicity in various cancer cells with a GI50 at the nanomolar level. EGFR-IN-144 reduces the expression of mTOR, TNF-α, and IL-6, causes G1/S phase cell cycle arrest, and induces apoptosis.Formula:C20H17Cl2N3O3Colore e forma:SolidPeso molecolare:418.273ERK-IN-6
ERK-IN-6, a potent agent, inhibits ESCC growth and induces apoptosis through the ERK pathway.Formula:C19H18BrN3O3SColore e forma:SolidPeso molecolare:448.33Ac-YVAD-CHO acetate
Ac-YVAD-CHO acetate, potent reversible ICE and caspase-1 inhibitor; K_i: 3.0 nM (mouse), 0.76 nM (human); blocks IL-lβ production.Formula:C25H36N4O10Colore e forma:SolidPeso molecolare:552.57Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine
CAS:Cereblon ligand for PROTAC R&D; has E3 ligase, alkylC1-PEG3-alkylC3 linker, terminal amine. Part of Arvinas-licensed tool molecules.Formula:C25H35ClN4O9Colore e forma:SolidPeso molecolare:571.02AZT triphosphate TEA
AZT triphosphate TFA, a Zidovudine metabolite, inhibits HIV & HBV replication and triggers mitochondrial apoptosis.Colore e forma:SolidFeladilimab
CAS:Feladilimab (GSK3359609) is an IgG4 monoclonal antibody that is an ICOS agonist.
Purezza:SDS-PAGE:95% SEC-HPLC:98%Colore e forma:LiquidPeso molecolare:145.24 kDaGolimumab
CAS:Golimumab (CNTO-148), an anti-TNFα IgG1κ monoclonal antibody with anti-inflammatory and anti-cancer activity, can be used to prevent inflammation and cartilage.Colore e forma:LiquidPeso molecolare:146.93 kDaAnticancer agent 273
Anticanceragent 273 (Compound 9q) is an effective anticancer compound identified from matrine. It inhibits cancer cell proliferation, with an IC50 of 4.48 μM against HeLa cells. Anticanceragent 273 exerts its anticancer effects by modulating PI3K/AKT expression and activating activating transcription factor 4 (ATF4), which induces endoplasmic reticulum stress and triggers apoptosis. It holds potential for cancer research, including cervical cancer.Colore e forma:Odour SolidRIPK2-IN-2
CAS:RIPK2-IN-2, a RIP2 kinase PROTAC inhibitor, blocks proinflammatory signaling in autoinflammatory diseases.Formula:C53H65FN14O7S2Colore e forma:SolidPeso molecolare:1093.3CAY10726
CAS:CAY10726, an arylurea fatty acid, cuts ATP by 28% and promotes apoptosis in breast cancer cells by depleting mitochondrial lipids.Formula:C24H36ClF3N2O3Colore e forma:SolidPeso molecolare:493CYP51/PD-L1-IN-2
CYP51/PD-L1-IN-2 (compound L20), a quinazoline with antifungal properties, is a potent dual inhibitor targeting both CYP51 (IC50: 0.263 μM) and PD-L1 (IC50: 0.Formula:C25H23N7O3Colore e forma:SolidPeso molecolare:469.5PROTAC EGFR degrader 6
CAS:PROTAC EGFR degrader 6 effectively degrades EGFR Del19 in HCC827 cells (DC50=45.2 nM) and induces apoptosis and G1 arrest.Formula:C49H57FN12O5Colore e forma:SolidPeso molecolare:913.05Acetyl coenzyme A
CAS:Acetyl coenzyme A (Acetyl-CoA) is a pivotal molecule connecting multiple cellular metabolic pathways in the tricarboxylic acid cycle, fatty acid synthesisFormula:C23H38N7O17P3SPurezza:91.68%Colore e forma:SolidPeso molecolare:809.57Pipernonaline
CAS:Pipernonaline is a useful organic compound for research related to life sciences. The catalog number is T124000 and the CAS number is 88660-10-0.Formula:C21H27NO3Colore e forma:SolidPeso molecolare:341.451eIF4E-IN-2
CAS:eIF4E-IN-2 effectively inhibits eIF4e, crucial for research on diseases like cancer.Formula:C37H33ClF2N8O4S2Colore e forma:SolidPeso molecolare:791.29DB2115 tertahydrochloride
CAS:DB2115 (tertahydrochloride) inhibits PU.1, key in leukemia; potential for cancer research.
Formula:C32H34Cl4N8O2Colore e forma:SolidPeso molecolare:704.48Indinavir
CAS:Indinavir is an HIV protease inhibitor,HAART. inhibits the activation of MMP-2 in endothelial cells and exhibits affinity for α7-nAchR and SARS-CoV-2 Mpro.Formula:C36H47N5O4Colore e forma:SolidPeso molecolare:613.79Violacein
CAS:Violacein, a purple antibacterial and antiprotozoal compound from C. violaceum, effective against Gram-positive bacteria and P. falciparum.
Formula:C20H13N3O3Colore e forma:SolidPeso molecolare:343.34Flavopiridol
CAS:Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; also inhibits EGFR, PKA. In Phase 1/2 trials.Formula:C21H20ClNO5Purezza:97.74% - 99.99%Colore e forma:SolidPeso molecolare:401.84p38α inhibitor 6
p38α inhibitor6 (compound 19) is a p38α inhibitor with an IC50 value of 0.68 μM. It induces apoptosis, arrests the cell cycle in the G0 and G2/M phases, reduces TNF-α concentration, upregulates the expression of the tumor suppressor gene p53, increases the Bax/BCL-2 ratio, and activates caspase3/7.Colore e forma:Odour SolidGLP-2(rat)
CAS:intestinal epithelium-specific growth factorFormula:C166H256N44O56SPurezza:98%Colore e forma:SolidPeso molecolare:3796.17Kdo2-Lipid A ammonium
CAS:Kdo2-Lipid A ammonium (KLA) is a selective and potent TLR4 agonist, a lipopolysaccharide.Kdo2-Lipid A ammonium induces the release of TNF and PGE2.Formula:C110H214N6O39P2Purezza:98%Colore e forma:SolidPeso molecolare:2306.84UM4118
CAS:UM4118 (N-quinolin-8-ylpyridine-2-carboxamide) is a copper ion carrier used in the study of acute myeloid leukemia.Formula:C15H11N3OPurezza:99.76%Colore e forma:SolidPeso molecolare:249.27Hexapeptide-11
CAS:Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.Formula:C36H48N6O7Purezza:98%Colore e forma:SolidPeso molecolare:676.8MPP hydrochloride
MPP hydrochloride is a selective estrogen receptor (ERR) modulator.Formula:C29H32ClN3O3Purezza:99.75% - 99.90%Colore e forma:SolidPeso molecolare:506.04Ref: TM-T21897L
1mg50,00€5mg99,00€1mL*10mM (DMSO)110,00€10mg160,00€25mg313,00€50mg528,00€100mg707,00€200mg973,00€Carbonic anhydrase inhibitor 33
Carbonic anhydrase inhibitor33 (11D) is a dual inhibitor that targets both CA (carbonic anhydrase) IX/XII and CDK6. It exhibits Ki values of 19.7 nM for hCA IX and 26.1 nM for hCA XII. Additionally, Carbonic anhydrase inhibitor33 (11D) can induce G1 phase cell cycle arrest and apoptosis, making it relevant for research in non-small cell lung cancer (NSCLC).Formula:C19H15FN6O2SColore e forma:SolidPeso molecolare:410.09612SM-164 Hydrochloride (957135-43-2 free base)
SM-164 Hydrochloride: cell-permeable, binds to XIAP (BIR2/3 domains), IC50 of 1.39 nM, potent XIAP antagonist.Formula:C62H85ClN14O6Purezza:98%Colore e forma:SolidPeso molecolare:1157.88cis,trans-Germacrone
CAS:cis,trans-Germacrone is an antitumor, antioxidant isomer that inhibits lung cancer and affects Akt/MDM2/p53.Formula:C15H22OColore e forma:SolidPeso molecolare:218.33EGFR-IN-83
EGFR-IN-83 (Compound 9), an EGFR inhibitor with an IC50 of 2.53 nM, exhibits antiproliferative effects on MCF-7 and MDA-MB-231 cell lines, with respective IC50Formula:C22H17F3N4OPurezza:98%Colore e forma:SolidPeso molecolare:410.39W1131 TFA
W1131 TFA is a STAT3 inhibitor and ferroptosis inducer that regulates the IL6-JAK-STAT3 and ferroptosis pathways,gastric cancer.Formula:C25H20F3N5O6Purezza:98.1%Colore e forma:SolidPeso molecolare:543.45Ref: TM-T80847
1mL*10mM (DMSO)Prezzo su richiesta1mg92,00€5mg188,00€10mg311,00€25mg628,00€50mg1.008,00€100mg1.596,00€WKYMVM
CAS:WKYMVM is a N-formyl peptide receptor (FPR1) agonist.Formula:C41H61N9O7S2Purezza:98%Colore e forma:SolidPeso molecolare:856.11TG101209 analog 1
TG101209 analog 1 (Compound 8h) serves as an inhibitor of BUB1B, exhibiting an IC50 of 10.36 μM. It also possesses cytotoxic properties, demonstrated by an IC50 of 1.347 μM against Caki-1 cells, and can induce necrosis and apoptosis.Formula:C24H31N5O5SColore e forma:SolidPeso molecolare:501.598Narasin
CAS:Narasin inhibits dengue virus, treats coccidiosis without harm to cells, and induces cancer cell apoptosis.Formula:C43H72O11Colore e forma:SolidPeso molecolare:765.03Thalidomide-O-C5-acid
CAS:Thalidomide-O-C5-acid, a synthesized E3 ligase linker, merges cereblon and PROTAC tech.Formula:C19H20N2O7Colore e forma:SolidPeso molecolare:388.376Thalidomide-PEG2-C2-NH2
CAS:Thalidomide-O-amido-PEG3-C2-NH2 is a cereblon ligand-linked E3 ligase used in PROTAC with a 2-unit PEG.Formula:C19H24N4O6Purezza:98%Colore e forma:SolidPeso molecolare:404.42XZ338
XZ338 is a highly selective degrader targeting BCL-XL without degrading BCL-2. It exhibits an IC50 value of 3.7 nM against MOLT-4 cells and possesses antiproliferative properties, making it useful for cancer research.Colore e forma:Odour SolidDidocosahexaenoin
CAS:Didocosahexaenoin, omega-3 diglyceride, disrupts mitochondria, induces ROS, apoptosis, and is cytotoxic to prostate cancer cells.Formula:C25H40O5Colore e forma:SolidPeso molecolare:420.58Etoposide phosphate disodium
CAS:Etoposide phosphate disodium, a prodrug of etoposide, is a powerful anticancer drug inhibiting DNA topoisomerase II.
Formula:C29H31Na2O16PColore e forma:SolidPeso molecolare:712.5(-)-Mcl-1 inhibitor 21
CAS:(-)-Mcl-1 inhibitor 21 (Example 1-38) is an Mcl-1 inhibitor with an IC50 of 7.51 μM. It exhibits pro-apoptotic and anti-proliferative activity against SUDHL5 and SUDHL10 cell lines, making it useful for cancer research.
Formula:C32H33N3O4Colore e forma:SolidPeso molecolare:523.622PROTAC FLT3/CDK9 degrader-1
Potent PROTAC degrader for FLT3/CDK9, induces apoptosis, and shows promise for FLT3-ITD mutated AML research.Formula:C48H62N12O7Colore e forma:SolidPeso molecolare:919.08Ro 48-8071
CAS:Oxidosqualene cyclase inhibitorFormula:C23H27BrFNO2Purezza:98%Colore e forma:SolidPeso molecolare:448.37SA-VA
SA-VA, an intracellular self-assembled PROTAC featuring azide and alkyne groups, selectively degrades VEGFR-2 and EphB4 proteins within U87 cells.Formula:C50H53ClF3N11O7SPurezza:98%Colore e forma:SolidPeso molecolare:1044.54Quercetin-d3 hydrate
Quercetin-d3 hydrate is a deuterated form of quercetin hydrate, known as a flavonoid that stimulates recombinant SIRT1 and acts as a PI3K inhibitor. It has IC50 values of 2.4 μM, 3.0 μM, and 5.4 μM for PI3Kγ, PI3K δ, and PI3Kβ, respectively.Colore e forma:Odour SolidA011
A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycleFormula:C27H28N6OPurezza:98%Colore e forma:SolidPeso molecolare:452.55Dapirolizumab
Dapirolizumab is an anti-CD40 monoclonal antibody used in research on systemic lupus erythematosus (SLE) and other autoimmune diseases.Purezza:>95%Colore e forma:LiquidPeso molecolare:150 kDaLiensinine Perchlorate
CAS:Liensinine is the active constituent of plumula nelambinis with anti-hypertension.
Formula:C37H43ClN2O10Purezza:99.80%Colore e forma:SolidPeso molecolare:711.2EGFR-IN-153
EGFR-IN-153 (Compound 5l) is an EGFR inhibitor that suppresses the proliferation of MDA-MB-231 cells with an IC50 of 0.73 μM and induces apoptosis. It is applicable for research in breast cancer.Colore e forma:Odour SolidClaturafenib
CAS:Claturafenib is a brain-permeable, selective, all-mutant BRAF inhibitor.PF-07799933 has shown antitumor activity, used in combination with MEK inhibitors.Formula:C18H15Cl2F2N5O3SPurezza:98.68% - 99.85%Colore e forma:SolidPeso molecolare:490.31Ref: TM-T201081
50mgPrezzo su richiesta1mg66,00€5mg145,00€1mL*10mM (DMSO)172,00€10mg224,00€25mg354,00€U7D-1
U7D-1: First-class USP7 PROTAC degrader, DC50 33 nM, anticancer, induces apoptosis in Jeko-1.Formula:C53H65N9O7Colore e forma:SolidPeso molecolare:940.14PROTAC GPX4 degrader-4
CAS:PROTACGPX4 degrader-4 is a GPX4 PROTAC degrader with a DC50 of 5.32 nM. It inhibits the activity of cancer cell lines RT4, T24, and J82 with IC50 values of 0.09, 2.97, and 7.58 μM, respectively. This compound elevates lipid ROS levels and induces ferroptosis in T24 and RT4 cells. In T24 tumor-bearing BALB/c nude mouse models, PROTACGPX4 degrader-4 demonstrates antitumor activity. It is applicable to bladder cancer research.Formula:C43H58N2O13Colore e forma:SolidPeso molecolare:810.93Gemcitabine-13C,15N2 hydrochloride
CAS:Gemcitabine-13C,15N2(hydrochloride) is the 13C and 15N labeled version of Gemcitabine hydrochloride. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) functions as a nucleoside antimetabolite analog and antineoplastic agent. It interrupts DNA synthesis and repair, which leads to autophagy and apoptosis in cells.Formula:C9H12ClF2N3O4Colore e forma:SolidPeso molecolare:302.64Adenosine-13C10
CAS:Adenosine-13C10 (Adenine riboside-13C10; D-Adenosine-13C10) is the 13C-labeled form of adenosine. Adenosine (Adenine riboside) is a widely occurring endogenous secretion that operates through four G protein-coupled receptors (A1, A2A, A2B, and A3). It affects nearly every aspect of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.Formula:C10H13N5O4Colore e forma:SolidPeso molecolare:277.17Vincristine-d3 sulfate
CAS:Vincristine-d3 (sulfate) is the deuterated form of Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid that inhibits the formation of microtubules in the mitotic spindle, resulting in the arrest of dividing cells at metaphase. It binds to microtubules with a Ki of 85 nM.Formula:C46H58N4O14SColore e forma:SolidPeso molecolare:926.06(R,R)-S63845
(R,R)-S63845 is the isomer of S63845 and serves as a control compound in experiments. S63845 is a potent and selective inhibitor of myeloid cell leukemia 1 (MCL1), binding to human MCL1 with a dissociation constant (Kd) of 0.19 nM.Colore e forma:Odour SolidTop1-IN-2
Top1-IN-2 (Compound 1a) is an inhibitor of topoisomerase 1 (Top1). It suppresses the growth of P-gp drug-resistant tumor cells and induces apoptosis.Colore e forma:Odour SolidVEGFR-2-IN-64
VEGFR-2-IN-64 (Compound 28) is an inhibitor of VEGFR2 with an IC50 of 27.8 nM. It suppresses the proliferation of cancer cells A549, T-47D, and Caco-2, exhibits anti-migration and anti-colony formation activities in T-47D cells, and induces apoptosis in T-47D cells.Formula:C72H123N9O6Colore e forma:SolidPeso molecolare:1210.8NC-R17
NC-R17, an RSL3-based noncovalent GPX4 degrader implicated in ferroptosis, demonstrates anti-tumor activity and is utilized in the design of noncovalent GPX4-Formula:C53H67N7O7Purezza:98%Colore e forma:SolidPeso molecolare:914.14Ono 3403
CAS:Ono 3403, a synthetic serine protease inhibitor, blocks TNF-alpha, NO production, and has antitumor properties.Formula:C26H31N3O8SPurezza:98%Colore e forma:SolidPeso molecolare:545.6Rapamycin-13C,d3
Rapamycin is a potent and specific mTOR inhibitor that suppresses mTOR in HEK293 cells with an IC50 of 0.1 nM. It binds to FKBP12, thereby inhibiting mTORC1. Additionally, Rapamycin serves as an autophagy (autophagy) activator and functions as an immunosuppressant.Colore e forma:Odour SolidSimvastatin-d3
CAS:Simvastatin-d3 is the deuterated form of Simvastatin. Simvastatin (MK 77333) acts as a competitive inhibitor of HMG-CoA reductase (HMGCR) with a Ki of 0.2 nM and is orally active. It reduces cholesterol synthesis and lowers blood cholesterol levels. Additionally, Simvastatin demonstrates antiproliferative effects on cancer cells and can induce apoptosis (apoptosis).Formula:C25H38O5Colore e forma:SolidPeso molecolare:421.59Resveratrol-13C6
Resveratrol-13C6 is a carbon-13 labeled form of Resveratrol. Resveratrol (trans-Resveratrol; SRT501) is a natural polyphenol known for its antioxidant, anti-inflammatory, cardioprotective, and anticancer properties. It targets a variety of proteins, including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, and DNA polymerase, and acts as a specific activator of SIRT1. Additionally, Resveratrol is an effective Pregnane X Receptor (PXR) inhibitor and serves as an Nrf2 activator, capable of mitigating aging-related progressive renal injury in mouse models. It also enhances nitric oxide (NO) production in endothelial cells.Colore e forma:Odour SolidAspidin BB
CAS:Aspidin BB, a phloroglucinol from Dryopteris, inhibits cancer by causing cell cycle arrest and apoptosis in HO-8910 cells.Formula:C25H32O8Colore e forma:SolidPeso molecolare:460.52MNK8
CAS:MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.Formula:C15H12N2O2Purezza:99.74%Colore e forma:SolidPeso molecolare:252.272-Deoxy-D-glucose-d
CAS:2-Deoxy-D-glucose-d is the deuterated form of 2-Deoxy-D-glucose. This compound is a glucose analogue that acts as a glucose metabolism inhibitor by targeting hexokinase to hinder glycolysis.Formula:C6H12O5Colore e forma:SolidPeso molecolare:165.16(E/Z)-LAQ824
CAS:(E/Z)-LAQ824 is an inhibitor of histone deacetylase.Formula:C22H25N3O3Purezza:98%Colore e forma:SolidPeso molecolare:379.46Garivulimab
CAS:Garivulimab (BGB-A333), a humanized IgG1 monoclonal antibody, binds to PD-L1, blocking PD-1 interaction and exhibiting antitumor activity.Colore e forma:LiquidEPZ020411 hydrochloride
CAS:EPZ020411 hydrochloride is a selective and potent small molecule PRMT6 inhibitor with an IC50 value of 10 nM.Formula:C25H39ClN4O3Purezza:99.88%Colore e forma:SolidPeso molecolare:479.05Ref: TM-T22325
1mg57,00€5mg124,00€1mL*10mM (DMSO)138,00€10mg203,00€25mg350,00€50mg533,00€100mg763,00€CWI1-2
CAS:CWI1-2 is a potent IGF2BP2 inhibitor that inhibits its interaction with M6A-modified target transcripts by binding IGF2BP2.Formula:C22H17Cl3N6O3Purezza:98.27%Colore e forma:SoildPeso molecolare:519.77Thiamine-d4 hydrochloride
Thiamine-d4 (hydrochloride) is the deuterated form of Thiamine (hydrochloride). Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient, serving as a cofactor for numerous central metabolic enzymes.Colore e forma:Odour SolidApoptosis inducer 29
Apoptosis Inducer 29 (compound Y9) demonstrates anticancer efficacy in non-small cell lung cancer by inducing lysosomal dysfunction and apoptosis, and exhibits superior performance to Gboixn both in vitro and in vivo.Formula:C33H46ClN3O3Colore e forma:SolidPeso molecolare:568.19Pitavastatin-d5 sodium
Pitavastatin-d5 (sodium) is the deuterated form of Pitavastatin sodium. Pitavastatin (NK-104) sodium acts as a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase. In HepG2 cells, it inhibits cholesterol synthesis from acetate with an IC50 of 5.8 nM. Pitavastatin sodium is a highly effective inducer of hepatic low-density lipoprotein cholesterol (LDL-C) receptors.Colore e forma:Odour SolidBDK-IN-1
BDK-IN-1 (compound (-)-43) is a BDK inhibitor with an IC50 of 0.23 μM and a maximum inhibition rate of 90%. It reduces phosphorylated-E1 levels and is useful in the study of cardiac metabolic diseases.Formula:C18H14F2N2O3SColore e forma:SolidPeso molecolare:376.38EAD1
CAS:EAD1 is a useful organic compound for research related to life sciences. The catalog number is T35329 and the CAS number is 1644388-26-0.
Formula:C24H27Cl2N7Purezza:98%Colore e forma:SolidPeso molecolare:484.42
