Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(1 prodotti)
- Caspasi(154 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(134 prodotti)
- PDK(9 prodotti)
- PERK(23 prodotti)
- Chinasi di serina/treonina(17 prodotti)
- Survivin(14 prodotti)
- TNF(93 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6223 prodotti di "Apoptosi"
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Z-VDVA-(DL-Asp)-FMK
CAS:Z-VDVA-(DL-Asp)-FMK is a derivative compound of Z-VDVAD-FMK specifically designed as an inhibitor targeting caspase-2.Formula:C32H46FN5O11Colore e forma:SolidPeso molecolare:695.742FLT3-IN-21
FLT3-IN-21 (compound LC-3), a potent FLT3 inhibitor with an IC50 value of 8.4 nM, induces apoptosis and arrests the cell cycle in the G1 phase.Formula:C20H22FN5O2Colore e forma:SolidPeso molecolare:383.42Bim BH3, Peptide IV
CAS:This Bim peptide belongs to the pro-apoptotic group of the Bcl-2 family of proteins.Formula:C145H222N44O41SPurezza:98%Colore e forma:SolidPeso molecolare:3269.65Antimycobacterial agent-5
Antimycobacterial agent-5 (compound 27) is an imidazopyridine amide compound that targets the Mycobacterium electron transport chain (ETC) respiratory CIII2CIV2 supercomplex. It acts on Mycobacterium smegmatis CIII2CIV2 with an IC50 of 441 nM.Formula:C25H34ClN3OPeso molecolare:427.23904Apoptolidin
CAS:Apoptolidin, from Nocardiopsis, induces apoptosis, targets mitochondrial ATPase (Ki 4-5 μM), kills glial cells, and has antibiotic and antifungal properties.Formula:C58H96O21Colore e forma:SolidPeso molecolare:1129.385ARB-272572 hydrochloride
CAS:ARB-272572 hydrochloride is a PD-L1 inhibitor that inhibits PD-1/PD-L1 cell signaling by inducing PD-L1 protein homology interactions.Formula:C32H36N6O4·xClHPurezza:99.38%Colore e forma:SoildPeso molecolare:568.68(Free base）R1-ICR-5
CAS:R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.Formula:C54H70N8O7S2Colore e forma:SolidPeso molecolare:1007.31HDAC3-IN-6
HDAC3-IN-6 (Compound SC26) is a selective HDAC3 inhibitor with an IC50 of 53 nM. It induces PD-L1 expression in a dose-dependent manner and leads to significant apoptosis and reactive oxygen species (ROS) production. HDAC3-IN-6 exhibits strong antitumor efficacy against colorectal cancer.Formula:C23H23N5O3Colore e forma:SolidPeso molecolare:417.46Thiamine-d4 hydrochloride
Thiamine-d4 (hydrochloride) is the deuterated form of Thiamine (hydrochloride). Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient, serving as a cofactor for numerous central metabolic enzymes.Colore e forma:Odour SolidSimvastatin-d3
CAS:Simvastatin-d3 is the deuterated form of Simvastatin. Simvastatin (MK 77333) acts as a competitive inhibitor of HMG-CoA reductase (HMGCR) with a Ki of 0.2 nM and is orally active. It reduces cholesterol synthesis and lowers blood cholesterol levels. Additionally, Simvastatin demonstrates antiproliferative effects on cancer cells and can induce apoptosis (apoptosis).Formula:C25H38O5Colore e forma:SolidPeso molecolare:421.59Baceridin
CAS:Baceridin, a cyclic hexapeptide and proteasome inhibitor, can be isolated from the culture medium of Epiphytic Bacillus.Formula:C37H57N7O6Purezza:98%Colore e forma:SolidPeso molecolare:695.89HJC0416 hydrochloride
CAS:HJC0416 hydrochloride: potent oral STAT3 inhibitor, better anticancer effects than Stattic, promising for breast cancer research.Formula:C18H18Cl2N2O4SColore e forma:SolidPeso molecolare:429.31Anticancer agent 102
CAS:Anticancer Agent 102, a tetracaine derivative, exhibits anti-cancer activity by inducing apoptosis [1].Formula:C20H19F6N3OColore e forma:SolidPeso molecolare:431.37BCMA72-80
CAS:BCMA72-80: HLA-A2-specific peptide with high affinity; used in multiple myeloma and other BCMA+ tumor research.Formula:C59H97N13O11SPurezza:98%Colore e forma:SolidPeso molecolare:1196.55QN523
CAS:QN523 has drug-like traits, kills cancer cells in vitro, effective in vivo against pancreatic cancer, works via autophagy.Formula:C14H10N4OPurezza:99.83%Colore e forma:SolidPeso molecolare:250.26PIYLGGVFQ
PIYLGGVFQ is a TNF-α peptide inhibitor. It can suppress TNF-α-mediated apoptosis, nuclear translocation, and activation of NF-κB. In a CIA mouse model, PIYLGGVFQ has demonstrated anti-arthritic activity.Formula:C49H72N10O12Colore e forma:SolidPeso molecolare:993.16PROTAC EGFR degrader 5
CAS:PROTAC EGFR degrader 5 effectively breaks down EGFR Del19 in HCC827 cells at 34.8 nM, inducing apoptosis and G1 arrest.Formula:C57H72FN13O5SColore e forma:SolidPeso molecolare:1070.33XmAb-2513
XmAb-2513 is a humanized monoclonal antibody inhibitor targeting CD30. It demonstrates significant anti-proliferative activity along with excellent antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). XmAb-2513 is applicable in research on hematological malignancies such as Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL).Colore e forma:Odour LiquidTasisulam sodium
CAS:Tasisulam triggers apoptosis, halts mitosis, and normalizes blood vessels to combat cancer.Formula:C11H5BrCl2NNaO3S2Colore e forma:SolidPeso molecolare:437.09TQB2916
TQB2916 is a humanized IgG2 monoclonal antibody agonist that targets CD40. It exhibits significant antitumor activity by occupying CD40 and activating immune function. TQB2916 is applicable for research in advanced solid tumors and lymphomas.Colore e forma:Odour LiquidBC011
BC011 is a human monoclonal antibody (mAb) targeting TNFRSF1B. It enhances the proliferation of CD8+ T cells and depletes Treg cells, resulting in an increased proportion of effector T cells within the tumor microenvironment. BC011 is applicable in the study of tumor immunology.Colore e forma:Odour LiquidIBI356
IBI356 is a humanized monoclonal antibody inhibitor that targets OX40L/CD134L/CD252. It can be utilized in the study of chronic inflammatory skin diseases, such as atopic dermatitis.Colore e forma:Odour LiquidSilicon naphthalocyanine dichloride
CAS:Silicon naphthalocyanine dichloride is a photosensitizer with potential anti-tumor activity. This compound is employed in photodynamic therapy to inhibit cancer by effectively absorbing specific wavelengths of light, thereby generating oxygen radicals that aid in the destruction of cancer cells. The biocompatibility of Silicon naphthalocyanine dichloride demonstrates promising prospects for medical applications.Formula:C48H24Cl2N8SiColore e forma:SolidPeso molecolare:811.75MK-1248
MK-1248 is a human IgG4 monoclonal antibody (mAb) targeting TNFSF18. It enhances the proliferative response of tumor-infiltrating lymphocytes to anti-CD3 stimulation and promotes the production of anti-tumor associated regulatory cytokines. MK-1248 is utilized in research on solid tumors.Colore e forma:Odour LiquidCAY10678
CAS:CAY10678 is an mPGES-1 inhibitor that inhibits PD-1.CAY10678 reduces collagen deposition and T-cell depletion, and may be used to study melanoma.CASHIPSFormula:C23H34N4OPurezza:99.66%Colore e forma:SolidPeso molecolare:382.54Antitumor agent-116
Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis.Formula:C31H23BrN4O4SPurezza:98%Colore e forma:SolidPeso molecolare:627.51EGFR-IN-86
EGFR-IN-86 (compound 4i), an EGFR inhibitor (IC50: 1.5 nM), demonstrates potent activity against glioblastoma by inducing apoptosis and causing G2/M phase cellFormula:C20H21N7O2SPurezza:98%Colore e forma:SolidPeso molecolare:423.49AEG 3482
CAS:AEG 3482 blocks JNK, induces HSP70, binds HSP90, and boosts HSP25 expression, preventing cell death.
Formula:C10H8N4O2S2Purezza:99.76%Colore e forma:SolidPeso molecolare:280.33GSK2800528
GSK2800528 is a human monoclonal antibody (mAb) targeting TNFSF2/TNFa, utilized for research related to inflammation and psoriasis.Colore e forma:Odour LiquidPlaculumab
CAS:Placulumab (ART621), an anti-TNF α monoclonal antibody, targets inflammation, potentially aiding arthritis treatment.Colore e forma:LiquidSH-5
CAS:SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene productsFormula:C29H59O10PColore e forma:SolidPeso molecolare:598.75Barasertib
CAS:AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Formula:C26H31FN7O6PPurezza:99.92% - 99.97%Colore e forma:SolidPeso molecolare:587.54Bfl-1-IN-6
Bfl-1-IN-6 (Compound 20) is an orally active inhibitor of Bcl-2-related protein A1 (BFL1) with an IC50 of 19 nM. This compound can stabilize BFL1 protein, activate cleaved caspase 3, and demonstrates antitumor activity in mouse models.Formula:C22H24ClFN2O2Colore e forma:SolidPeso molecolare:402.89GB-223
GB-223 is a human monoclonal antibody (mAb) that targets TNFSF11/RANKL/CD254. It is applicable in the study of giant cell tumors of bone and postmenopausal osteoporosis.Colore e forma:Odour LiquidNecroptosis-IN-3
CAS:Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis.Formula:C12H17NOSPurezza:99.85%Colore e forma:SoildPeso molecolare:223.33GPLGIAGQ
CAS:GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting.Formula:C31H53N9O10Purezza:98%Colore e forma:SolidPeso molecolare:711.81HG-7-85-01
CAS:HG-7-85-01 is a novel ATP-competitive and type II tyrosine kinase inhibitor targeting both wild-type and watchman mutant BCR-ABL, PDGFRα, Kit, and Src kinases.Formula:C31H31F3N6O2SPurezza:98.08%Colore e forma:SolidPeso molecolare:608.68PROTAC EGFR degrader 9
CAS:PROTACEGFRdegrader 9 (Compound C6) is an orally active, CRBN-based PROTAC EGFR degrader. It has a DC50 of 10.2 nM and a Kd of 240.2 nM against EGFRL858R/T790M/C797S. PROTACEGFRdegrader 9 demonstrates effective degradation activity against various EGFR mutants while not affecting EGFRWT.
Formula:C45H48F3N9O6SPeso molecolare:899.98Sanggenon G
CAS:Sanggenon G inhibits XIAP by binding its BIR3 domain; affinity is 34.26 μM, boosting caspase activation.Formula:C40H38O11Colore e forma:SolidPeso molecolare:694.72Tubulin/MMP-IN-3
Tubulin/MMP-IN-3 (Compound 15j) is a dual inhibitor of tubulin polymerization and MMP, effectively inhibiting MMP-2 and MMP-9 with IC50 values of 21.13 μM and 19.24 μM, respectively. It disrupts the NF-κB signaling pathway, leading to mitochondrial dysfunction and mitochondrial-dependent apoptosis. Tubulin/MMP-IN-3 shows antiproliferative activity in various cancer cells by causing cell cycle arrest at the G2/M phase and demonstrates antitumor effects in mouse models.Formula:C38H41N2O12PColore e forma:SolidPeso molecolare:748.712FAK-IN-24
CAS:FAK-IN-24 (Compound 9f) is a potent FAK inhibitor with an IC50 of 0.815 nM. It induces DNA damage and apoptosis, and exhibits activity against glioblastoma. FAK-IN-24 effectively inhibits proliferation of glioblastoma cell lines U87-MG (IC50= 15 nM) and U251 (IC50= 20 nM), and suppresses tumor growth in U87-MG xenograft models.Formula:C39H45Cl2F3N8O3Colore e forma:SolidPeso molecolare:801.728TPP-1 TFA
TPP-1 TFA is a high-affinity PD-L1 inhibitor (KD=95nM) that boosts T-cell function to curb tumor growth.Formula:C109H151F3N34O34S2Colore e forma:SolidPeso molecolare:2602.69GD3 Ganglioside sodium
GD3 Ganglioside sodium is a crucial ganglioside in human melanoma and functions as an inducer of mitochondrial permeability. It targets mitochondria directly in a manner controlled by bcl-2. Following the aggregation of death-inducing receptors, ceramide accumulates rapidly, synthesizes GD3 ganglioside, and triggers apoptosis.Colore e forma:SolidLenalidomide-d5
CAS:Lenalidomide-d5 is a deuterated form of Lenalidomide. Lenalidomide (CC-5013) is a derivative of Thalidomide and acts as an orally active immunomodulator in a molecular glue manner. It serves as a ligand for the ubiquitin E3 ligase cereblon (CRBN). Through the CRBN-CRL4 ubiquitin ligase complex, Lenalidomide selectively ubiquitinates and degrades the lymphocyte transcription factors IKZF1 and IKZF3. It effectively inhibits the growth of mature B-cell lymphomas, including multiple myeloma, and induces T cells to release interleukin-2 (IL-2).Formula:C13H13N3O3Colore e forma:SolidPeso molecolare:264.29Calphostin C
CAS:Calphostin C is a protein kinase C inhibitor.Formula:C44H38O14Purezza:98%Colore e forma:Red To Brown PowderPeso molecolare:790.76Glutathione arsenoxide hydrochloride
Glutathione arsenoxide hydrochloride: anti-cancer, inhibits tumour metabolism, targets ANT, promotes apoptosis, marks cell proteins.Formula:C18H26AsClN4O9SPurezza:99.74%Colore e forma:SoildPeso molecolare:584.86FKBP12 Ligand-Linker Conjugate 1
CAS:FKBP12 Ligand-Linker Conjugate 1 is a complex comprising a target protein ligand for FKBP12 and a linker, which is utilized in the synthesis of the PROTAC degrader MC-25B.Formula:C42H63N3O11Colore e forma:SolidPeso molecolare:785.963U7D-1
U7D-1: First-class USP7 PROTAC degrader, DC50 33 nM, anticancer, induces apoptosis in Jeko-1.Formula:C53H65N9O7Colore e forma:SolidPeso molecolare:940.14Zalypsis
CAS:Zalypsis, a transcription factor inhibitor, is used potentially for the treatment of lymphoma, and cervical carcinoma.Formula:C37H38F3N3O8Colore e forma:SolidPeso molecolare:709.71IPH10
IPH10 is an anticancer agent with strong antitumor effects in vivo and exhibits no liver or kidney toxicity. It significantly increases the reactive oxygen species (ROS) levels in tumor cells, decreases mitochondrial membrane potential, and induces apoptosis (apoptosis) in these cells.Formula:C32H33NO4Colore e forma:SolidPeso molecolare:495.61Betamethasone
CAS:Betamethasone (NSC-39470), a glucocorticoid steroid, has immunosuppressive and anti-inflammatory properties.Formula:C22H29FO5Purezza:98% - 99.71%Colore e forma:White Or Almost White Powder Solid CrystallinePeso molecolare:392.46Giloralimab
CAS:Giloralimab (ABBV-927) is a antibody targeting CD40 with anticancer activity for the study of triple-negative breast cancer and non-small cell lung cancer.Purezza:95.6% (SDS-PAGE); 95.1% (SEC-HPLC) - 95.6% (SDS-PAGE); 95.1% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:146.34 kDaDimethachlor
CAS:Dimethachlor is a pesticide and herbicide used in wetland areas.Formula:C13H18ClNO2Colore e forma:SolidPeso molecolare:255.74BMS-986156
BMS-986156 is a fully humanized IgG1 agonist monoclonal antibody that targets the glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR). It binds to GITR and enhances the activation of T effector cells while deactivating T regulatory cells. BMS-986156 is applicable for research in advanced solid tumors.AChE-IN-81
AChE-IN-81 (compound 22) is a reversible, selective inhibitor of AChE with an 80.0% inhibition rate and an IC50 of 3.7 μM. It binds to AChE with an affinity (Kd) of 5.37 μM. AChE-IN-81 effectively reduces apoptosis in zebrafish brain cells and shows potential neuroprotective activity in an H2O2-induced SH-SY5Y cell damage model.Formula:C37H54ClNO5Colore e forma:SolidPeso molecolare:628.28PROTAC LZK-IN-1
CAS:PROTAC LZK-IN-1 (Compound 21A) is a PROTAC molecule that targets the degradation of LZK (leucine zipper kinase, encoded by MAP3K13). At a concentration of 10 μM, PROTAC LZK-IN-1 facilitates the degradation of LZK and inhibits the expression of p53 and c-MYC, leading to reduced viability of global head and neck squamous cell carcinoma (HNSCC) cell lines. This compound is applicable in anticancer research.
Formula:C51H64F2N10O5SColore e forma:SolidPeso molecolare:967.18PKM2 modulator 1
PKM2 modulator 1 (compound C998) is an effective PKM2 inhibitor with antiproliferative activity. It induces apoptosis and holds potential for research in glioblastoma studies.Formula:C26H25N3O3Colore e forma:SolidPeso molecolare:427.5BAG3/HSP70-IN-1
USP1-IN-11 (compound 38-P2) is a selective, reversible, and non-competitive inhibitor of USP1 (Ubiquitin-specific protease 1). It activates the DDR (DNA damage repair) pathway, leading to cell cycle arrest and apoptosis, thereby inhibiting cell survival. USP1-IN-11 increases sensitivity to Olaparib in drug-resistant cells and works synergistically with Andrographolide in cancer cells with functional BRCA. In the MDA-MB-436 xenograft model, USP1-IN-11 demonstrates significant dose-dependent antitumor activity.Formula:C28H39N7O4Colore e forma:SolidPeso molecolare:537.65Thalidomide-PEG3-NH2
CAS:Thalidomide-PEG3-NH2: a cereblon-based E3 ligase ligand-linker for PROTAC tech.Formula:C19H23N3O7Colore e forma:SolidPeso molecolare:405.407Lipustobart
CAS:Lipustobart is an IgG4-kappa humanized monoclonal antibody targeting PDCD1 (programmed cell death 1, PD1, PD-1, CD279), with immunostimulant and antineoplasticPurezza:98%Colore e forma:LiquidTulinercept
CAS:Tulinercept (OPRX-106), a monoclonal antibody, may be utilized in a range of biochemical research applications [1].Colore e forma:LiquidCLEFMA
CAS:CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.Formula:C23H17Cl2NO4Purezza:99.00%Colore e forma:SolidPeso molecolare:442.29Ref: TM-T9582
1mg64,00€5mg131,00€1mL*10mM (DMSO)149,00€10mg188,00€25mg299,00€50mg427,00€100mg575,00€200mg750,00€MDM2/4-p53-IN-3
MDM2/4-p53-IN-3 inhibits MDM2/4-p53 PPIs (IC50: 18.5nM MDM2, 14.8nM MDM4), used in cancer research.Formula:C25H24Cl2FN3O3Colore e forma:SolidPeso molecolare:504.38Dazodalibep
CAS:Dazodalibep (MEDI 4920; VIB 4920) is a monoclonal antibody that specifically targets CD40LG/TNFSF5 and is fused to human serum albumin (ALB/HSA) [1].Colore e forma:LiquidAnti-PD-L1/B7-H1 Antibody (29E.2A3)
Anti-PD-L1/B7-H1 Antibody (29E.2A3) represents a chimeric antibody of mouse IgG2b, κ type, specifically targeting human PD-L1/B7-H1. The recommended isotype control for this antibody is Mouse IgG2b kappa, Isotype Control.TAPI 0
CAS:ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 to inhibit Chlamydia trachomatis growth.Formula:C24H32N4O5Purezza:98%Colore e forma:SolidPeso molecolare:456.54Bcl-2-IN-4
CAS:Bcl-2-IN-4: potent, selective, oral Bcl-2 inhibitor with 1.5 nM IC50, >200x selectivity over Bcl-xL.Formula:C46H50ClN9O7SColore e forma:SolidPeso molecolare:908.46Thalidomide-O-PEG4-Boc
CAS:Thalidomide-O-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].Formula:C28H38N2O11Purezza:98%Colore e forma:SolidPeso molecolare:578.61p-MPPF
CAS:p-MPPF is a 5-HT antagonist that can be used to study neurological diseases.Formula:C25H27FN4O2Purezza:99.92%Colore e forma:SolidPeso molecolare:434.51Zigakibart
CAS:Zigakibart (BION-1301) is a humanized monoclonal antibody targeting TNFSF13 with anti-inflammatory activity for the study of immunoglobulin A nephropathy (IgAN)Purezza:95.8% (SDS-PAGE); 99.8% (SEC-HPLC) - 95.8% (SDS-PAGE); 99.8% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:145.03 kDaAnticancer agent 268
Anticanceragent 268 (Compound 4k) is a potential antitumor agent. It exhibits antiproliferative effects on HepG2 cells, with an IC50 value of 6.08 μM. Additionally, Anticanceragent 268 induces apoptosis and inhibits colony formation and migration of HepG2 cells.Colore e forma:Odour SolidAntiangiogenic agent 6
Antiangiogenic agent 6 (Pt-1) effectively inhibits angiogenesis and induces necroptosis in tumor cells.Formula:C37H24F6N3PPtColore e forma:SolidPeso molecolare:850.66Anti-Mouse PD-1 (LALA-PG) Antibody (RMP1-14)
Anti-MousePD-1(LALA-PG) Antibody (RMP1-14) is an IgG2a, κ antibody inhibitor derived from mice that targets and inhibits mouse PD-1.Colore e forma:Odour LiquiddTAGV-1-NEG
CAS:Negative control for dTAGV-1.Formula:C68H90N6O14SColore e forma:SolidPeso molecolare:1247.56MYC-RIBOTAC
MYC-RIBOTAC, a ribonuclease-targeting chimera (RIBOTAC) specific to the MYC internal ribosome entry site (IRES), comprises an MYC mRNA-binding element tetheredFormula:C55H58N10O11SPurezza:98%Colore e forma:SolidPeso molecolare:1067.17Mcl-1 inhibitor 16
Mcl-1 Inhibitor 16 (Compound 9), a platinum-based mitochondrial-targeting agent, inhibits Mcl-1 and induces Bax/Bak-dependent apoptosis in cancer cells.Formula:C25H29Cl2N3PtColore e forma:SolidPeso molecolare:637.51Fludioxonil
CAS:Fludioxonil (CGA 173506), a phenylpyrrole fungicide, inhibits the growth of B. cinerea from strawberry and blackberry crops.Formula:C12H6F2N2O2Purezza:99.971%Colore e forma:SolidPeso molecolare:248.18Thalidomide-O-amide-C5-NH2
CAS:Thalidomide-O-amide-C5-NH2 is a synthetic E3 ligase linker combining cereblon ligand and PROTAC linker.Formula:C20H24N4O6Colore e forma:SolidPeso molecolare:416.43Anti-ETBR Antibody (DEDN6526A Naked Antibody)
DEDN6526A (RG-7636) is a humanized ADC compound targeting endothelin B receptor (ETBR), which can be used to study melanoma.Colore e forma:LiquidPeso molecolare:145.54 kDaAntitumor agent-150
Antitumor agent-150 (V10) is a breast cancer treatment that functions as a PROTAC degrader of MDM2.Formula:C70H106N8O14SPeso molecolare:1314.75492YX-02-030
CAS:YX-02-030M is a PROTACMDM2 degrader. It inhibits the binding of MDM2 to p53 and VHL to HIF1α, with IC50 values of 63 nM and 1.35 μM, respectively. YX-02-030M binds to MDM2 and recruits the VHL E3 ubiquitin ligase to initiate MDM2 degradation, effectively killing p53 mutant or deficient triple-negative breast cancer (TNBC) cells.
Formula:C66H85Cl2N9O10SPeso molecolare:1267.41Anti-Mouse PD-L1/B7-H1 (LALA-PG) Antibody (10F.9G2)
Anti-Mouse PD-L1/B7-H1 (LALA-PG) Antibody (10F.9G2) is an IgG2a, κ antibody inhibitor derived from mice, specifically targeting and inhibiting mouse PD-L1/B7-H1.Colore e forma:Odour LiquidKRN 5500
CAS:KRN 5500, a derivative of the nucleoside antibiotic spicamycin, has a wide range of antitumor activity against human cancer cell lines.Formula:C28H43N7O7Purezza:98%Colore e forma:SolidPeso molecolare:589.68PD-1/PD-L1-IN-39
PD-1/PD-L1-IN-39 (X 14) is an orally active PD-1/PD-L1 inhibitor with an IC50 value of 15.73 nM. It exhibits strong binding affinity to human and mouse PD-L1, with KD values of 14.62 and 392 nM, respectively. PD-1/PD-L1-IN-39 also demonstrates antitumor activity.Formula:C23H20ClFN2O3Peso molecolare:426.11465Zamzetoclax
CAS:Zamzetoclax (compound 1) acts as a potential inhibitor of Mcl-1.Formula:C38H46ClN5O6SColore e forma:SolidPeso molecolare:736.32PROTAC 20S proteasome subunit β5 degrader 1
PROTAC 20S proteasome subunit β5 degrader 1 (compound 12f) serves as a targeted degrader of the 20S proteasome subunit β5, exhibiting a DC50 value of 0.11 μM in FaDu cells. This compound disrupts the cell cycle and promotes apoptosis (apoptosis), while inhibiting cell proliferation and migration in both FaDu and KM3/BTZ cells. It is applicable for research into resistance to Bortezomib in pharyngeal carcinoma and multiple myeloma.Colore e forma:Odour SolidAMG-7209
CAS:AMG-7209 is an effective and selective MDM2-p53 interaction inhibitor.Formula:C37H41Cl2FN2O7SColore e forma:SolidPeso molecolare:747.7Retifanlimab
CAS:Retifanlimab (MGA-012) is a monoclonal antibody targeting programmed cell death protein 1 (PD-1). Retifanlimab is used in studies of Merkel cell carcinoma.Purezza:98.56% (SEC-HPLC) - >95.0% (SDS-PAGE); 100% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:148.28 kDaCytostatin (sodium salt)
CAS:Cytostatin: natural antitumor, inhibits cell adhesion, blocks melanoma, induces apoptosis, targets PP2A selectively, IC50s: 1.3-3.1 µg/ml & 29 nM.Formula:C21H33NaO7PColore e forma:SolidPeso molecolare:451.452Tanfanercept
CAS:Tanfanercept (HL036337) is an anti-TNF-α antibody, improving corneal erosions in dry eye mice.Colore e forma:Liquid1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
CAS:Phospholipid with stearic acid and 15(S)-HpETE boosts ferroptosis in MEFs upon GPX4 inhibition.
Formula:C43H78NO10PColore e forma:SolidPeso molecolare:800.068NMC-001
NMC-001 is a human IgG1 monoclonal antibody (mAb) that targets MDM2. It is useful for pancreatic cancer research. The recommended isotype control is HumanIgG1kappa, Isotype Control.Colore e forma:Odour LiquidOpnurasib
CAS:Opnurasib (JDQ-443) is an orally available and selective and potent covalent KRAS G12C inhibitor with antitumor activity for the study of advanced non-smallFormula:C29H28ClN7OPurezza:98.88%Colore e forma:SolidPeso molecolare:526.03Ref: TM-T40292
50mgPrezzo su richiesta1mg100,00€5mg334,00€1mL*10mM (DMSO)385,00€10mg500,00€25mg803,00€Baminercept
CAS:Baminercept (BG 9924) is a lymphotoxin-β receptor-immunoglobulin fusion protein that blocks the lymphotoxin-letter/LIGHT axis.Purezza:95% (SDS-PAGE); 98.3% (SEC-HPLC) - 95% (SDS-PAGE); 98.3% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:46.88 kDaRaptinal
CAS:Raptinal activates caspase-3 directly and initiates intrinsic caspase-dependent apoptosis pathway in multiple cell lines.
Formula:C28H18O2Purezza:≥98%Colore e forma:SolidPeso molecolare:386.44Bcl-2-IN-15
Bcl-2-IN-15 (Compound 13d) is a Bcl-2 inhibitor with an IC50 of 363 nM, which impedes the proliferation of the NCI leukemia cancer cell line [1].Colore e forma:Odour SolidRMC-4998 formic
RMC-4998 formic is an orally active inhibitor targeting the GTP-bound state of the KRASG12C mutant. It forms a trimeric complex with intracellular CYPA and the activated KRASG12C mutant, displaying an IC50 value of 28 nM. This compound inhibits ERK signaling and induces apoptosis in KRASG12C mutant cancer cells and is utilized in tumor research.Colore e forma:Odour SolidElteN378
CAS:ElteN378: potently inhibits FKBP12 (Ki=0.5 nM), low weight, similar affinity to Rapamycin.Formula:C23H26N2O3Purezza:99.06%Colore e forma:SolidPeso molecolare:378.46Ref: TM-T9950
1mg167,00€1mL*10mM (DMSO)295,00€5mg356,00€10mg528,00€25mg848,00€50mg1.153,00€100mg1.603,00€200mg2.142,00€PRLX-93936 HCL
CAS:PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.Formula:C21H26Cl2N4O2Purezza:98.4% - 99.94%Colore e forma:SolidPeso molecolare:437.37Citatuzumab bogatox
CAS:Citatuzumab bogatox is a recombinant immunotoxin targeting EpCAM with the toxin bouganin, inducing apoptosis in EpCAM-positive tumors.Colore e forma:Liquid
