Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(1 prodotti)
- Caspasi(154 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(127 prodotti)
- PDK(9 prodotti)
- PERK(23 prodotti)
- Chinasi di serina/treonina(17 prodotti)
- Survivin(14 prodotti)
- TNF(90 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6170 prodotti di "Apoptosi"
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HDAC-IN-53
CAS:HDAC-IN-53 inhibits HDAC1-3 with IC50s: 47, 125, 450 nM. Inactive on class II HDACs; triggers apoptosis; reduces tumor growth in mice.Formula:C23H20ClN7O2Purezza:98%Colore e forma:SolidPeso molecolare:461.9Mcl-1 inhibitor 17
CAS:Mcl-1 Inhibitor 17 is a compound that functions as an inhibitor of the Mcl-1 protein, specifically designed for use in cancer and other disease research [1].Formula:C27H25FN4O2Colore e forma:SolidPeso molecolare:456.51NSC 689534
CAS:NSC 689534 forms a chelate with copper (Cu 2+), resulting in the NSC 689534/Cu 2+ complex, which is a potent inducer of oxidative stress and exhibits antitumor activity [1].Formula:C19H18N6SColore e forma:SolidPeso molecolare:362.45Anticancer agent 128
CAS:Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently binds to the BIR3 domains of XIAP, cIAP1, and cIAP2, exhibiting IC50 values of 24.9 nM, 19Formula:C26H38N4O4Purezza:98%Colore e forma:SolidPeso molecolare:470.6MK-2206 free base
CAS:MK-2206 free base is an allosteric Akt inhibitor that is both potent and selective, administered orally, exhibiting IC50 values of 8, 12, and 65 nM for Akt1,Formula:C25H21N5OPurezza:98%Colore e forma:SolidPeso molecolare:407.47Anticancer agent 105
CAS:Anticancer agent 105, a thienopyrimidine scaffold-based compound, exhibits selective toxicity towards melanoma and induces apoptosis.Formula:C25H24KN3O6SPurezza:98%Colore e forma:SolidPeso molecolare:533.64HM90822
CAS:HM90822 is an IAP antagonist that inhibits XIAP and cIAP1/2 protein expression, induces IAP ubiquitination and promotes proteasome-dependent IAP degradation.Formula:C30H36ClF2N7O4Purezza:99.66%Colore e forma:SolidPeso molecolare:632.1GNE-900
CAS:GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectivelyFormula:C23H21N5Purezza:99.20%Colore e forma:SolidPeso molecolare:367.451,2-Di-13(Z)-Docosenoyl-3-Oleoyl-rac-glycerol
CAS:1,2-Di-13(Z)-docosenoyl-3-oleoyl-rac-glycerol is a triacylglycerol composed of 13(Z)-docosenoic acid at both the sn-1 and sn-2 positions and oleic acid at the sn-3 position.Formula:C65H120O6Colore e forma:SolidPeso molecolare:997.64EP1013
CAS:EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.Formula:C18H23FN2O6Purezza:98%Colore e forma:SolidPeso molecolare:382.38S-Adenosyl-L-methionine (1,4-butanedisulfonate)
CAS:S-Adenosyl-L-methionine (SAMe) 1,4-butanedisulfonate functions as an orally active methyl group donor and serves as a dietary supplement known for itsFormula:C19H32N6O11S3Purezza:98%Colore e forma:SolidPeso molecolare:616.69Anticancer agent 127
CAS:Anticancer agent 127 (142D6), an IAP inhibitor, covalently binds to the BIR3 domains of XIAP, cIAP1, and cIAP2, with IC50 values of 12 nM, 14 nM, and 9 nM,Formula:C26H37FN4O6SPurezza:98%Colore e forma:SolidPeso molecolare:552.66SAFit1
CAS:SAFit1 is an inhibitor of FK506 binding protein 51 (FKBP51)-specific (Ki: 4±0.3 nM).Formula:C42H53NO11Purezza:98%Colore e forma:SolidPeso molecolare:747.87Ref: TM-T16835
1mgPrezzo su richiesta5mg167,00€10mgPrezzo su richiesta25mg595,00€50mg982,00€100mg1.693,00€1mL*10mM (DMSO)Prezzo su richiestaAAPK-25
CAS:AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.Formula:C21H13Cl2N3O2SPurezza:97.05%Colore e forma:SolidPeso molecolare:442.32Ref: TM-T10215
1mg54,00€5mg118,00€10mg172,00€25mg313,00€50mg469,00€100mg680,00€1mL*10mM (DMSO)131,00€BHD
CAS:BHD, a reversible male contraceptive agent, effectively induces spermatogenic cell apoptosis and causes abnormalities in seminiferous tubules in vivo at dosesFormula:C21H16Cl2N4OColore e forma:SolidPeso molecolare:411.28CR-1-31-B
CAS:CR-1-31-B, a synthetic rocaglate, inhibits eIF4A, hinders protein synthesis initiation, and induces apoptosis in cancer cells.Formula:C28H29NO8Colore e forma:SolidPeso molecolare:507.5391-Stearoyl-2-Adrenoyl-sn-glycero-3-PC
CAS:1-Stearoyl-2-Adrenoyl-sn-glycero-3-PC (PC(18:0/22:4)) acts as a cyclin-dependent kinase (CDK) inhibitor, promoting apoptosis and restricting the proliferation of various cancer cell lines [1].Formula:C48H88NO8PColore e forma:SolidPeso molecolare:838.19Cu(II)-Elesclomol
CAS:Cu(II)-Elesclomol is a complex formed by the anticancer agent Elesclomol and Cu(II), which has anticancer activity and can be used in the study of leukemia.Formula:C19H18CuN4O2S2Purezza:99.99%Colore e forma:SolidPeso molecolare:462.05Ethylene glycol dimethacrylate
CAS:Ethylene glycol dimethacrylate, a methacrylate monomer, demonstrates cytotoxic and genotoxic impacts on human gingival fibroblasts (HGFs), elevatingFormula:C10H14O4Purezza:98%Colore e forma:SolidPeso molecolare:198.22iMAC2 hydrochloride
CAS:iMAC2 hydrochloride, a potent inhibitor of the mitochondrial apoptosis-induced channel (MAC), demonstrates an IC50 of 28 nM and an LD50 of 15000 nM. It exhibits an anti-apoptotic effect by blocking the release of cytochrome c [1].Formula:C19H22Br2Cl2FN3Colore e forma:SolidPeso molecolare:542.11Ac-VAD-CHO
CAS:Ac-Val-Ala-Asp-CHO (Ac-VAD-CHO) serves as a pan-caspase inhibitor and preserves mitochondrial membrane potential (MMP) while preventing the release ofFormula:C14H23N3O6Purezza:98%Colore e forma:SolidPeso molecolare:329.35Delmitide acetate
CAS:Delmitide acetate (RDP58) is an orally active d-isomer decapeptide that exhibits potent anti-inflammatory properties.Formula:C61H109N17O13Purezza:98%Colore e forma:SolidPeso molecolare:1288.62Sirt1/2-IN-3
CAS:Sirt1/2-IN-3 (compound PS9) serves as a dual inhibitor of SIRT1/2, exhibiting IC50 values of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respectively.Formula:C17H14ClNO4SPurezza:98%Colore e forma:SolidPeso molecolare:363.82MOTS-c
CAS:MOTS-c is a mitochondria-derived polypeptide (MDP) that has anti-damage and anti-inflammatory effects by activating the AMPK pathway and inhibiting the MAPFormula:C101H152N28O22S2Colore e forma:SolidPeso molecolare:2174.6CDKI-83
CAS:CDKI-83, a potent CDK9 inhibitor, inhibits tumor growth with GI50 <1μM and triggers apoptosis in A2780 cells, showing promise as an anti-cancer agent.Formula:C21H23N7O3S2Colore e forma:SolidPeso molecolare:485.58Bcl-2-IN-13
CAS:Bcl-2-IN-13 is a potent inhibitor of Bcl-2, exhibiting an IC50 of 17 nM, and holds potential for use in cancer research [1].Formula:C42H44ClN7O6S3Colore e forma:SolidPeso molecolare:874.49WNY1613
CAS:WNY1613: Potent PI3Kδ inhibitor with anti-NHL properties, induces apoptosis in cells, affects phosphorylation in vitro/in vivo.Formula:C29H35N9O3Colore e forma:SolidPeso molecolare:557.65PARP-1-IN-3
CAS:PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.PARP-1-IN-3 has potential anti-Formula:C21H17BrN2O3Purezza:99.86%Colore e forma:SolidPeso molecolare:425.28KRIBB3
CAS:KRIBB3: novel anticancer microtubule inhibitor; halts MDA-MB-231 cell migration/invasion by targeting Hsp27 phosphorylation.Formula:C19H19NO4Colore e forma:SolidPeso molecolare:325.36FGFR-IN-8
CAS:FGFR-IN-8, potent oral FGFR inhibitor for wild-type/mutant types, induces apoptosis with anti-cancer properties.Formula:C27H31Cl2N9O2Colore e forma:SolidPeso molecolare:584.5Antitumor agent-92
CAS:Antitumor Agent-92, a derivative of Icaritin, halts cell cycle, triggers cell death, and is promising for liver cancer study.Formula:C33H41NO10Purezza:98%Colore e forma:SolidPeso molecolare:611.68(Rac)-Lisaftoclax
CAS:(Rac)-Lisaftoclax ((Rac)-APG-2575), a Bcl-2 inhibitor, is utilized in hematologic malignancy research (CN112898295A) [1].Formula:C45H48ClN7O8SColore e forma:SolidPeso molecolare:882.42RIPK1-IN-8
CAS:RIPK1-IN-8 is an aminoimidazolopyridine and is a selective and potent inhibitor of RIPK1 (IC50: 4 nM).RIPK1-IN-8 has research potential in inflammatory diseasesFormula:C26H24F2N6O3Colore e forma:SolidPeso molecolare:506.5AM-8735
CAS:AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).Formula:C27H31Cl2NO6SPurezza:98%Colore e forma:SolidPeso molecolare:568.51INU-152
CAS:INU-152: pan-RAF inhibitor with potent anti-tumor effects on BRAFV600E cancers, inhibits MAPK in mutant cells, minimal side effects on RAS-mutant melanoma.Formula:C20H13F2N7O3SPurezza:98%Colore e forma:SolidPeso molecolare:469.42UNC3474
CAS:UNC3474, a small molecule ligand, selectively interacts with the aromatic methyl-lysine binding cage of the tumor protein 53BP1 Tudor domain (TT), exhibiting aFormula:C17H28N2OColore e forma:SolidPeso molecolare:276.42Antitumor agent-110
CAS:Antitumor Agent-110 (Compound 13), an imidazotetrazine anticancer agent, exhibits excellent permeability.Formula:C10H6N6OSPurezza:98%Colore e forma:SolidPeso molecolare:258.26CPT-Se3
CAS:CPT-Se3, a camptothecin derivative, boosts anticancer activity, triggers apoptosis in Hep G2, and is cytotoxic to various cells with IC50 of 2.19-4.7 μM.Formula:C24H20N2O6Se2Purezza:98%Colore e forma:SolidPeso molecolare:590.35TC ASK 10
CAS:TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1,IC50 = 14 nM). The IC50 value for ASK2 is 0.51 μM.Formula:C21H23Cl2N5OPurezza:99.86%Colore e forma:SolidPeso molecolare:432.35Ref: TM-T13099
1mg33,00€5mg86,00€10mg124,00€25mg236,00€50mg371,00€100mg532,00€200mg705,00€1mL*10mM (DMSO)95,00€SF5
CAS:SF5 is an inhibitor of the apoptosis pathway through JNK-p53-caspase apoptotic cascade.Formula:C15H13NSPurezza:99.59%Colore e forma:SolidPeso molecolare:239.34LY303511 hydrochloride
CAS:LY303511, a structural analog of LY294002, selectively inhibits mTOR-dependent phosphorylation of S6K, unlike its counterpart, which acts as a phosphatidylinositol 3-kinase (PI3K) inhibitor. It effectively reduces cell proliferation in human lung epithelial adenocarcinoma cells by hindering G2/M phase progression and suppressing casein kinase 2 activity. Additionally, LY303511 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity in HeLa cells resistant to TRAIL-induced apoptosis and blocks voltage-gated potassium (Kv) channels.Formula:C19H20Cl2N2O2Colore e forma:SolidPeso molecolare:379.28Bcl-2-IN-11
CAS:Bcl-2-IN-11 (compound 6) is a potent and selective inhibitor of Bcl-2 activity, exhibiting an IC50 of 0.9 nM, and demonstrates minimal inhibition against Bcl-xlFormula:C45H49ClFN7O8SColore e forma:SolidPeso molecolare:902.43NSC 48160
CAS:NSC 48160 is an anti-pancreatic cancersmall molecule that inhibits growth and enhance apoptosis of pancreatic cancer cells through the mitochondrial pathway.Formula:C18H29NOPurezza:98.10%Colore e forma:SolidPeso molecolare:275.43Ref: TM-T79783
1mg83,00€5mg175,00€10mg282,00€25mg556,00€50mg914,00€100mg1.468,00€1mL*10mM (DMSO)193,00€RET-IN-24
CAS:RET-IN-24 (Compound 26) is a selective inhibitor of RET tyrosine kinase, demonstrating antitumor activity [1].Formula:C27H26F2N8OColore e forma:SolidPeso molecolare:516.55GW405833 hydrochloride
CAS:GW405833 hydrochloride, a potent and selective agonist of the cannabinoid-2 (CB2) receptor (EC 50 = 0.65 nM; maximum inhibition = 44.6%), exhibits significant antihyperalgesic effects in various rodent pain models [1] [2] [3].Formula:C23H25Cl3N2O3Colore e forma:SolidPeso molecolare:483.82K145 hydrochloride
CAS:K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM.Formula:C18H25ClN2O3SPurezza:99.8%Colore e forma:SolidPeso molecolare:384.92Tylvalosin
CAS:Tylvalosin (Acetylisovaleryltylosin) is a broad-spectrum macrolide antibiotic with antibacterial and antiviral properties, effective against PRRSV infection.Formula:C53H87NO19Purezza:98%Colore e forma:SolidPeso molecolare:1042.25BI-0252
CAS:BI-0252 is an inhibitor of MDM2-p53 (IC50:4 nM).Formula:C30H26Cl2FN3O3Purezza:98%Colore e forma:SolidPeso molecolare:566.45Z-LLY-FMK
CAS:Z-LLY-FMK (Calpain Inhibitor IV) serves as an inhibitor of calpain, a family of proteases implicated in the apoptosis of various cell systems.Formula:C30H40FN3O6Purezza:98%Colore e forma:SolidPeso molecolare:557.65Topoisomerase II inhibitor 15
CAS:Topoisomerase II inhibitor 15 (compound 2g) serves as a potent apoptotic inducer, exhibiting heightened selectivity for head and neck tumors [1].Formula:C15H11Cl2N5Purezza:98%Colore e forma:SolidPeso molecolare:332.19A-1293102
CAS:A-1293102 is a potent, selective inhibitor of BCL-XL, effective in inducing apoptosis in tumor cells reliant on BCL-XL [1].Formula:C42H40F3N7O7S5Colore e forma:SolidPeso molecolare:972.13CIL62
CAS:CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].Formula:C23H26O5Purezza:97.07%Colore e forma:SolidPeso molecolare:382.45Ref: TM-T8468
1mg38,00€5mg86,00€10mg116,00€25mg222,00€50mg371,00€100mg504,00€200mg675,00€1mL*10mM (DMSO)94,00€Ferroptocide
CAS:Ferroptocide is a thioredoxin inhibitor that induces iron death in cancer cells and can be used in breast cancer research.Formula:C30H36ClN3O7Colore e forma:SolidPeso molecolare:586.08SM-433
CAS:SM-433: Smac mimetic, blocks IAPs, strong XIAP BIR3 affinity (IC50 <1 μM). See patent WO2008128171A2.Formula:C32H43N5O4Colore e forma:SolidPeso molecolare:561.71E235
CAS:E235, an activator of the transcription factor 4 (ATF4), enhances the integrated stress response (ISR) and DNA damage response, thereby reducing cell viabilityFormula:C28H25FN4OSPurezza:98.85%Colore e forma:SolidPeso molecolare:484.59BET-IN-20
CAS:BET-IN-20 (compound 10), a BRD4 BD1 inhibitor (IC 50 =1.9 nM), exhibits significant anticancer properties. It promotes apoptosis in acute myeloid leukemia (AML) cells and arrests the cell cycle in the G0/G1 phase. Additionally, BET-IN-20 inhibits both c-Myc and CDK6, and enhances PARP cleavage [1].Formula:C25H24N4O2Colore e forma:SolidPeso molecolare:412.48(S)-Verapamil hydrochloride
CAS:(S)-Verapamil hydrochloride is an inhibitor of leukotriene C4 (LTC4) and calcein transport by MRP1,and leads to the death of potentially resistant tumor cells.Formula:C27H39ClN2O4Colore e forma:SolidPeso molecolare:491.06ER proteostasis regulator-1
CAS:ER Proteostasis Regulator-1 (Compound 481) is a potent modulator of endoplasmic reticulum proteostasis with research applications in Alzheimer's disease andFormula:C18H22N2O3Colore e forma:SolidPeso molecolare:314.38MY-673
CAS:MY-673, a colchicine binding site inhibitor (CBSI), impedes tubulin polymerization and disrupts the ERK signaling pathway, consequently modulating SMAD4 proteinFormula:C18H14N2O4Colore e forma:SolidPeso molecolare:322.31TL02-59
CAS:TL02-59: Fgr inhibitor (IC50=0.03nM), also targets Lyn (0.1nM), Hck (160nM), halts acute myelogenous leukemia growth.Formula:C32H34F3N5O4Purezza:98.77%Colore e forma:SolidPeso molecolare:609.64Ref: TM-T13186
1mg49,00€2mg62,00€5mg93,00€10mg133,00€25mg260,00€50mg401,00€100mg557,00€200mg790,00€1mL*10mM (DMSO)111,00€AT-9283 L-lactate
CAS:AT-9283 L-lactate is an inhibitor of aurora kinase.Formula:C22H29N7O5Purezza:98%Colore e forma:SolidPeso molecolare:471.52MAO-B-IN-26
CAS:MAO-B-IN-26 (Compound IC9) serves as both a MAO-B and acetylcholinesterase inhibitor.Formula:C17H12BrNOPurezza:98%Colore e forma:SolidPeso molecolare:326.19NSC194598
CAS:NSC194598 is a p53 DNA-binding inhibitor, demonstrating an in vitro IC50 of 180 nM and an in vivo range of 2-40 μM.Formula:C20H19N3OColore e forma:SolidPeso molecolare:317.38ST1074
CAS:ST1074, a dual inhibitor of CerS2 and CerS4, promotes apoptosis and is applicable in cancer research [1].Formula:C20H36ClNO3Purezza:98%Colore e forma:SolidPeso molecolare:373.96Biguanidinium-porphyrin
CAS:Imidodicarbonimidic diamide hydrochloride, a phototoxic compound with anti-proliferative properties.Formula:C46H36ClN9Purezza:92.48% - 93.91%Colore e forma:SoildPeso molecolare:750.29WEHI-345 analog
CAS:WEHI-345 analog is an Src inhibitor.Formula:C23H25N7OPurezza:98%Colore e forma:SolidPeso molecolare:415.49GSK840
CAS:GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinaseFormula:C21H23N3O3Purezza:99.7%Colore e forma:SolidPeso molecolare:365.43HDAC-IN-63
CAS:HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor with IC50 values of 0.844 nM for FLT3 and 30.0 nM for HDAC1.Formula:C25H26Cl2N6O3Colore e forma:SolidPeso molecolare:529.42NBI-961
CAS:NBI-961, a potent NEK2 inhibitor, suppresses proteasomal degradation and effectively induces G2/mitosis arrest and apoptosis within diffuse large B cellFormula:C28H27F3N6O2SColore e forma:SolidPeso molecolare:568.61PD-L1-IN-2
CAS:PD-L1-IN-2, a Naamidine J derivative, serves as a promising antineoplastic immunomodulator by hindering PD-L1 activity.Formula:C33H38N4O6Purezza:98%Colore e forma:SolidPeso molecolare:586.68BAX-IN-1
CAS:BAX-IN-1 is a potential selective inhibitor of Bcl-2-associated X protein (BAX).Formula:C16H14N6OColore e forma:SolidPeso molecolare:306.32RIPK2-IN-3
CAS:RIPK2-IN-3 (FCG806791773) is a RIPK2 inhibitor with anti-inflammatory and anticancer activities, useful for research on immune diseases and cancer.Formula:C25H22N4O2Purezza:99.57%Colore e forma:SolidPeso molecolare:410.47PLK1/BRD4-IN-1
CAS:PLK1/BRD4-IN-1 (9b) is an orally active dual inhibitor of PLK1 (IC50: 22 nM) and BRD4 (IC50: 109 nM).Formula:C31H43N9O2Colore e forma:SolidPeso molecolare:573.73WEHI-345
CAS:WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.Formula:C22H23N7OPurezza:>99.99%Colore e forma:SolidPeso molecolare:401.46JNJ-1013
CAS:JNJ-1013 is a selective IRAK1 PROTAC degrader with an IC50 of 72 nM ,antiproliferative and proapoptotic, increases cleaved-PARP expression.Formula:C46H55N9O7SPurezza:99.596%Colore e forma:SolidPeso molecolare:878.05N-Oleoyl serinol
CAS:N-Oleoyl serinol, a ceramide analog, plays a crucial role in stem cell therapy by inhibiting the development of teratomas in stem cells. It triggers apoptosis in remaining pluripotent embryoid body-derived cells (EBCs), thwarts teratoma formation, and promotes the enrichment of EBC cells that proceed to neural differentiation post-transplantation [1].Formula:C21H41NO3Colore e forma:SolidPeso molecolare:355.563PRMT6-IN-3
CAS:PRMT6-IN-3 is a selective PRMT6 inhibitor with an IC50 value of 192 nM.PRMT6-IN-3 has anticancer activity and induces apoptosis in cancer cells.Formula:C19H26N4O2SPurezza:98.12%Colore e forma:SolidPeso molecolare:374.5HDAC-IN-59
CAS:HDAC-IN-59 (compound 13a), a potent histone deacetylase (HDAC) inhibitor, enhances intracellular reactive oxygen species (ROS) production, induces DNA damage,Formula:C20H25NO7Purezza:98%Colore e forma:SolidPeso molecolare:391.42CP-24879 hydrochloride
CAS:CP-24879 HCl, a Δ5D/Δ6D dual-inhibitor, reduces liver lipid buildup and inflammation.
Formula:C11H18ClNOPurezza:98.08%Colore e forma:SolidPeso molecolare:215.72WYE-132
CAS:WYE-125132: potent mTOR inhibitor, IC50 0.19 nM, selective over PI3Ks/hSMG1/ATR.Formula:C27H33N7O4Purezza:99.16%Colore e forma:SolidPeso molecolare:519.6CRT0066101 hydrochloride
CAS:Protein kinase D (PKD), a serine/threonine protein kinase activated by diacylglycerol downstream of PKC signaling, has three human isoforms that modulate cell proliferation, survival, invasion, and protein transport. CRT0066101 acts as an inhibitor of these three PKD isoforms, with IC50 values of 1, 2.5, and 2 nM for PKD1, PKD2, and PKD3, respectively. It demonstrates selectivity for PKD over a range of more than 90 protein kinases, including PKCα, PKBα, MEK, ERK, c-Raf, c-Src, and c-Abl. This specificity allows CRT0066101 to inhibit cell proliferation, induce apoptosis, and notably reduce the viability of pancreatic cancer cells both in vitro and in vivo.Formula:C18H23ClN6OColore e forma:SolidPeso molecolare:374.87MS-177
CAS:MS-177 is a PROTAC EZH2 degrader that promotes cholangiocarcinoma growth through the EZH2-mediated WNT7B/β-catenin pathway.Formula:C48H55N11O8Colore e forma:SolidPeso molecolare:914.02Ref: TM-T69771
1mg84,00€5mg177,00€10mg281,00€25mg557,00€50mg893,00€100mg1.341,00€1mL*10mM (DMSO)358,00€Ogremorphin
CAS:Ogremorphin (GPR68-IN-1) is a potent inhibitor of GPR68, exhibiting an EC50 of 170 nM.it is utilized in the study of autoimmune chronic inflammatory diseases [1Formula:C21H17N3OSPurezza:99.65% - 99.65%Colore e forma:SolidPeso molecolare:359.44BTM-3528
CAS:BTM-3528 is a mitochondrial protease OMA1 activator that induces an overactivation of the mitochondrial integrated stress response (ISR).Formula:C24H19F4N3O2S2Purezza:99.37% - 99.37%Colore e forma:SolidPeso molecolare:521.55BTM-3566
CAS:BTM-3566 triggers ISR via OMA1, induces apoptosis in cancer cells, and is used to research DLBCL.Formula:C24H23F4N3O2S2Purezza:99.95%Colore e forma:SolidPeso molecolare:525.58RET-IN-25
CAS:RET-IN-25 (compound 6b) is an anticancer RET kinase inhibitor that demonstrates efficacy against medullary thyroid carcinoma (MTC), exhibiting half-maximalFormula:C22H17N3O5SColore e forma:SolidPeso molecolare:435.45HJC0152 free base
CAS:HJC0152 (free base) is an orally active, potent STAT3 inhibitor that impedes cell cycle progression, induces apoptosis, and notably reduces MDA-MB-231 xenograftFormula:C15H13Cl2N3O4Purezza:98%Colore e forma:SolidPeso molecolare:370.19Atiprimod dihydrochloride
CAS:JAK2 inhibitor; IC50=397 nM; hampers STAT3/5 phosphorylation; curbs growth and triggers apoptosis in JAK2V617F+ cells.Formula:C22H46Cl2N2Colore e forma:SolidPeso molecolare:409.52Docebenone
CAS:Docebenone is a selective and orally active inhibitor of 5-LO.Formula:C21H26O3Colore e forma:SolidPeso molecolare:326.43Met-F-AEA
CAS:Met-F-AEA is a metabolically stable analogue of anandamine that exhibits antitumor activity by inhibiting cell growth through the activation of apoptosis [1].Formula:C23H38FNOColore e forma:SolidPeso molecolare:363.561RIPK-IN-4
CAS:RIPK-IN-4 is a potent, selective RIPK2 inhibitor with nanomolar activity and oral bioavailability for studying innate immune pathways.Formula:C18H21FN4O3SPurezza:98%Colore e forma:SolidPeso molecolare:392.45Nedometinib
CAS:Nedometinib (NFX-179) is a MEK1 inhibitor with anticancer and antitumor activities, which can be used to study malignant tumors.Formula:C17H16FIN4O3Purezza:99.18%Colore e forma:SolidPeso molecolare:470.24Ref: TM-T78209
1mg66,00€5mg145,00€10mg215,00€25mg353,00€50mg537,00€100mg708,00€1mL*10mM (DMSO)150,00€TMX-2164
CAS:TMX-2164: strong, irreversible BCL6 inhibitor, IC50=152 nM, long-lasting action, inhibits cell proliferation.Formula:C25H24ClFN6O6SColore e forma:SolidPeso molecolare:591.01Lactoferrin (17-41) acetate
CAS:Lactoferrin 17-41 (Lactoferricin B) acetate, a peptide derived from bovine lactoferrin spanning residues 17-41, exhibits broad-spectrum antimicrobial properties against Gram-positive and Gram-negative bacteria, viruses, protozoa, and fungi. Additionally, this compound demonstrates antitumor activities [1] [2].Formula:C143H226N46O33S3Colore e forma:SolidPeso molecolare:3183.82Deoxynybomycin
CAS:Deoxynybomycin, a selective anti-tumor agent, inhibits topoisomerase I and induces apoptosis.Formula:C16H14N2O3Purezza:98%Colore e forma:SolidPeso molecolare:282.29Riboxin
CAS:Riboxin (IDP), an orally administered purine derivative known as hypoxanthine riboside, exhibits antihypoxic and antihyperthermic effects.Formula:C10H14N4O11P2Colore e forma:SolidPeso molecolare:428.19Cerivastatin
CAS:Cerivastatin is an HMG-CoA reductase inhibitor with anticancer and lipid-lowering effects and can be used to study primary hyperlipidemia.Formula:C26H34FNO5Purezza:97.80% - 99.56%Colore e forma:SolidPeso molecolare:459.55GSK2245035
CAS:GSK2245035: selective nasal TLR7 agonist, boosts Type-1 IFN (pEC50: 9.3 IFNα, 6.5 TFNα), curbs Th2 cytokines in blood cultures.Formula:C20H34N6O2Colore e forma:SolidPeso molecolare:390.52USP7-IN-3
CAS:USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).Formula:C29H31F3N6O3Purezza:98%Colore e forma:SolidPeso molecolare:568.59Myrothecine A
CAS:Myrothecine A, a trichothecene mycotoxin discovered in M. roridum, exhibits anticancer properties. It effectively inhibits the proliferation of various cancer cell lines, specifically A549, MCF-7, HepG2, and SMMC-7721, with IC50 values of 95, 70, 60, and 25 µM, respectively. At a concentration of 50 µM, Myrothecine A induces G1 cell cycle arrest in HepG2 cells and promotes apoptosis in SMMC-7721 cells by elevating levels of Bax and cleaved caspase-3, -5, and -8.Formula:C29H38O10Colore e forma:SolidPeso molecolare:546.61
