Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(1 prodotti)
- Caspasi(154 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(127 prodotti)
- PDK(9 prodotti)
- PERK(23 prodotti)
- Chinasi di serina/treonina(17 prodotti)
- Survivin(14 prodotti)
- TNF(90 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6170 prodotti di "Apoptosi"
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Immunosuppressant-1
CAS:Immunosuppressant-1 (Compound 31) suppresses T-cell proliferation triggered by anti-CD3/anti-CD28 co-stimulation and demonstrates immunosuppressive effects,Formula:C14H12BrNO3Purezza:98%Colore e forma:SolidPeso molecolare:322.15YM458
CAS:YM458 inhibits EZH2 (490 nM) and BRD4 (34 nM), curbing tumor cell growth and inducing apoptosis.Formula:C53H61ClN8O5SPurezza:98%Colore e forma:SolidPeso molecolare:957.62AM-8735
CAS:AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).Formula:C27H31Cl2NO6SPurezza:98%Colore e forma:SolidPeso molecolare:568.51D359-0396
CAS:D359-0396 is an orally active NLRP3 inflammasome inhibitor that mitigates pyroptosis and reduces IL-1β release in macrophages by inhibiting the oligomerizationFormula:C24H24N4O2Purezza:98%Colore e forma:SolidPeso molecolare:400.47Anticancer agent 168
CAS:Compound D16 (Anticancer agent 168) is an inhibitor of DNA2 that induces apoptosis and cell-cycle arrest predominantly in the S-phase.Formula:C16H11ClN2O6Colore e forma:SolidPeso molecolare:362.72BMS-561392
CAS:BMS-561392 (DPC333) is a tumor necrosis factor-α ( TNF-α) Invertase inhibitor.Formula:C27H32N4O4Purezza:99.16%Colore e forma:SolidPeso molecolare:476.57HM90822
CAS:HM90822 is an IAP antagonist that inhibits XIAP and cIAP1/2 protein expression, induces IAP ubiquitination and promotes proteasome-dependent IAP degradation.Formula:C30H36ClF2N7O4Purezza:99.66%Colore e forma:SolidPeso molecolare:632.1Siremadlin (R Enantiomer)
CAS:Siremadlin R Enantiomer is the R enantiomer of Siremadlin. Siremadlin is a potent and highly specific inhibitor of MDM-2/p53.Formula:C26H24Cl2N6O4Purezza:98%Colore e forma:SolidPeso molecolare:555.41c-Met/MEK1/Flt-3-IN-1
Antiproliferative Against-3 (comp 33) demonstrates significant activity against Hela (IC 50 = 0.21 µM), A549 (IC 50 = 0.39 µM), and MCF-7 (IC 50 = 0.33 µM) cellFormula:C39H37FN6O5Colore e forma:SolidPeso molecolare:688.75Colletofragarone A2
CAS:Colletofragarone A2 from Colletotrichum sp. blocks mutant p53 and HSP90, aiding cancer treatment.Formula:C22H26O6Colore e forma:SolidPeso molecolare:386.44HDAC-IN-60
CAS:HDAC-IN-60 (compound 21a), a potent histone deacetylase (HDAC) inhibitor, promotes intracellular reactive oxygen species (ROS) production, induces DNA damage,Formula:C20H26N2O6Purezza:98%Colore e forma:SolidPeso molecolare:390.43CPT-Se3
CAS:CPT-Se3, a camptothecin derivative, boosts anticancer activity, triggers apoptosis in Hep G2, and is cytotoxic to various cells with IC50 of 2.19-4.7 μM.Formula:C24H20N2O6Se2Purezza:98%Colore e forma:SolidPeso molecolare:590.35ERα antagonist 1
CAS:ERα antagonist 1 is a selective, potent, covalent estrogen receptor alpha (ERα) antagonist that blocks the cell cycle of MCF-7 cells in G0/G1 phase and inducesFormula:C33H32N2O5SColore e forma:SolidPeso molecolare:568.68SD 1008
CAS:SD 1008 is a JAK2/STAT3 signaling pathway inhibitor. SD 1008 inhibits activation of STAT3, JAK2, and Src.Formula:C18H19NO5Purezza:98%Colore e forma:SolidPeso molecolare:329.35Atiprimod dimaleate
CAS:Atiprimod Dimaleate is a JAK2 inhibitor.Formula:C30H52N2O8Colore e forma:SolidPeso molecolare:568.74USP7-IN-3
CAS:USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).Formula:C29H31F3N6O3Purezza:98%Colore e forma:SolidPeso molecolare:568.59CR-6086
CAS:CR6086: potent EP4 antagonist with DMARD effects, low Ki (16.6 nM), and specific anti-inflammatory action.Formula:C26H27F3N2O3Colore e forma:SolidPeso molecolare:472.5NWP-0476
CAS:NWP-0476 is a modified BCL-2/BCL-xL inhibitor with enhanced specificity for BCL-xL, suitable for research on relapsed T-acute lymphoblastic leukemia (T-ALL) [1Formula:C47H53ClN8O8SColore e forma:SolidPeso molecolare:925.49C6 Phytoceramide (t18:0/6:0)
CAS:C6 Phytoceramide (t18:0/6:0) is a lipid molecule that can be used in life science related research. The CAS number of C6 Phytoceramide (t18:0/6:0) is 249728-94-7.Formula:C24H49NO4Colore e forma:SolidPeso molecolare:415.659PBI-1393
CAS:PBI-1393 can be used as an enhancer for Th1 type cytokine production and primary T cell activation.Formula:C19H31N9O4Colore e forma:SolidPeso molecolare:449.51Methyl 12-methyltridecanoate
CAS:Methyl 12-methyltridecanoate ((R)-betaxolol hydrochloride), a biosurfactant derived from Brevibacterium casei LS14, enhances the biocompatibility ofFormula:C15H30O2Purezza:98%Colore e forma:SolidPeso molecolare:242.4erythro-Austrobailignan-6
CAS:Erythro-Austrobailignan-6: orally active, anti-cancer, inhibits DNA topoisomerases, induces apoptosis, boosts p38/JNK phosphorylation.Formula:C20H24O4Colore e forma:SolidPeso molecolare:328.4Atiprimod dihydrochloride
CAS:JAK2 inhibitor; IC50=397 nM; hampers STAT3/5 phosphorylation; curbs growth and triggers apoptosis in JAK2V617F+ cells.Formula:C22H46Cl2N2Colore e forma:SolidPeso molecolare:409.52Cu(II)-Elesclomol
CAS:Cu(II)-Elesclomol is a complex formed by the anticancer agent Elesclomol and Cu(II), which has anticancer activity and can be used in the study of leukemia.Formula:C19H18CuN4O2S2Purezza:99.99%Colore e forma:SolidPeso molecolare:462.05PD-1/PD-L1-IN-22
CAS:PD-1/PD-L1-IN-22 is a small molecule inhibitor of PD-1/PD-L1 protein-protein interactions that blocks PD-1/PD-L1 interactions (IC50: 0.732 μM).Formula:C25H26BrClN2O3Colore e forma:SolidPeso molecolare:517.84RIP2 kinase inhibitor 2
CAS:RIP2 kinase inhibitor 2 is a receptor-interacting protein-2 kinase inhibitor.Formula:C21H28N4O4SPurezza:98%Colore e forma:SolidPeso molecolare:432.54Nirogacestat dihydrobromide
CAS:Potent γ-secretase inhibitor; IC50: 1.2 nM (cell), 6.2 nM (cell-free); lowers Aβ in mice/guinea pigs' brain, CSF, plasma.Formula:C27H43Br2F2N5OColore e forma:SolidPeso molecolare:651.48RIP2 kinase inhibitor 1
CAS:Potent RIP2 kinase inhibitor with 0.03 μM IC50, selective for autoimmune disease treatment.Formula:C17H17N5O2SPurezza:98%Colore e forma:SolidPeso molecolare:355.41M867
CAS:M867 is a selective, reversible caspase-3 inhibitor, possessing an IC50 of 1.4 nM and a Ki value of 0.7 nM, demonstrating anti-apoptotic activity [1].Formula:C27H43N7O6Purezza:98%Colore e forma:SolidPeso molecolare:561.67WEHI-345 analog
CAS:WEHI-345 analog is an Src inhibitor.Formula:C23H25N7OPurezza:98%Colore e forma:SolidPeso molecolare:415.49(+)-Apogossypol
CAS:(+)-Apogossypol is an antagonist of pan-BCL-2. (+)-Apogossypol binds to Mcl-1(Bcl-2 and Bcl-xL with EC50s of 2.6, 2.8 and 3.69 μM, respectively).Formula:C28H30O6Purezza:98%Colore e forma:SolidPeso molecolare:462.53MI-888 free base
CAS:MI-888 is the most potent MDM2 inhibitor (Ki = 0.44 nM), with high oral efficacy in human cancer models and optimal pharmacokinetics.Formula:C28H32Cl2FN3O3Colore e forma:SolidPeso molecolare:548.48SM-1295
CAS:SM-1295: IAP antagonist, Kd 3077 nM XIAP-BIR3, 3.2 nM c-IAP1-BIR3, 9.5 nM c-IAP2-BIR3.Formula:C29H36BrN5O4Colore e forma:SolidPeso molecolare:598.53Myrothecine A
CAS:Myrothecine A, a trichothecene mycotoxin discovered in M. roridum, exhibits anticancer properties. It effectively inhibits the proliferation of various cancer cell lines, specifically A549, MCF-7, HepG2, and SMMC-7721, with IC50 values of 95, 70, 60, and 25 µM, respectively. At a concentration of 50 µM, Myrothecine A induces G1 cell cycle arrest in HepG2 cells and promotes apoptosis in SMMC-7721 cells by elevating levels of Bax and cleaved caspase-3, -5, and -8.Formula:C29H38O10Colore e forma:SolidPeso molecolare:546.61Mcl-1 inhibitor 17
CAS:Mcl-1 Inhibitor 17 is a compound that functions as an inhibitor of the Mcl-1 protein, specifically designed for use in cancer and other disease research [1].Formula:C27H25FN4O2Colore e forma:SolidPeso molecolare:456.51JAB-2485
CAS:JAB-2485 is a highly potent and selective inhibitor of Aurora kinase A (AURKA), boasting an IC 50 of 0.33 nM, and demonstrates approximately 1700-fold selectivity for AURKA over AURKB. It induces cell cycle arrest and apoptosis, making it a valuable compound for cancer research [1].Formula:C25H28ClF2N5O2Peso molecolare:503.97INU-152
CAS:INU-152: pan-RAF inhibitor with potent anti-tumor effects on BRAFV600E cancers, inhibits MAPK in mutant cells, minimal side effects on RAS-mutant melanoma.Formula:C20H13F2N7O3SPurezza:98%Colore e forma:SolidPeso molecolare:469.42RET-IN-13
CAS:RET-IN-13: potent quinoline RET inhibitor; IC50 = 0.5 nM (WT), 0.9 nM (V804M); potential for RET-related tumor/intestinal disease research.Formula:C32H33F4N5O3Colore e forma:SolidPeso molecolare:611.63Ginsenoside Rk1
CAS:Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Formula:C42H70O12Purezza:98.46% - 99.13%Colore e forma:SolidPeso molecolare:767.00RIP1 kinase inhibitor 8
CAS:RIP1 Kinase Inhibitor 8 (Compound 77), a potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitor, exhibits an IC50 of 20 nM and effectivelyFormula:C18H19F2N5O2Purezza:98%Colore e forma:SolidPeso molecolare:375.37BPR1J-340
CAS:BPR1J-340, a novel potent FLT3 inhibitor, shows anticancer promise, with IC50 ~25 nM and GC50 ~5 nM, causing apoptosis in AML cells.Formula:C29H34N8O3Colore e forma:SolidPeso molecolare:542.63Riboxin
CAS:Riboxin (IDP), an orally administered purine derivative known as hypoxanthine riboside, exhibits antihypoxic and antihyperthermic effects.Formula:C10H14N4O11P2Colore e forma:SolidPeso molecolare:428.19EGFR kinase inhibitor 1
CAS:Potent EGFR blocker; acts on WT, L858R/T790M (IC50: 1.7 nM), less on T790M/C797S; stalls cell cycle, induces apoptosis, deters metastasis.Formula:C30H31N7O2Colore e forma:SolidPeso molecolare:521.61ASC-69
CAS:ASC-69 (APY69) is a promising potent inhibitor of the PD-1/PD-L1 signaling pathway, classified as a small-molecule compound [1].Formula:C19H19N7Purezza:98%Colore e forma:SolidPeso molecolare:345.4Thaspine acetate
CAS:Thaspine: inhibits topoisomerase IB, reduces VEGF, stops endothelial cell growth via PI3K/MAPK pathways.Formula:C22H23NO8Colore e forma:SolidPeso molecolare:429.425MP7
CAS:MP7 (PDK1 inhibitor) is a inhibitor of phosphoinositide-dependent kinase-1 (PDK1).Formula:C28H22F2N4O4Purezza:99.89%Colore e forma:SolidPeso molecolare:516.5Ref: TM-T12398
1mg49,00€5mg108,00€10mgPrezzo su richiesta50mgPrezzo su richiesta1mL*10mM (DMSO)123,00€HAPSBC
CAS:HAPSBC, an S-benzyl iron chelator, modulates the intracellular distribution of ^59Fe [1].Formula:C15H15N3S2Colore e forma:SolidPeso molecolare:301.43HDAC/JAK/BRD4-IN-1
CAS:HDAC/JAK/BRD4-IN-1 (compound 25ap) is a potent triple inhibitor targeting HDAC, JAK, and BRD4.Formula:C24H28N6O3Purezza:98%Colore e forma:SolidPeso molecolare:448.52FHND5071
CAS:FHND5071, a potent and selective RET kinase inhibitor, exerts antitumor effects through the inhibition of RET autophosphorylation and may be utilized for tumorFormula:C30H30D3N9OColore e forma:SolidPeso molecolare:538.66Atiprimod (free base)
CAS:Atiprimod: an oral azaspirane inhibiting STAT3, blocking IL-6/VEGF pathways, and promoting apoptosis by downregulating Bcl-2 and Mcl-1.Formula:C22H44N2Colore e forma:SolidPeso molecolare:336.6Ro 41-5253
CAS:Ro 41-5253 is a RARα antagonist with antitumor activity that inhibits the proliferation of ZR-75.1 estrogen receptor-positive breast cancer cells.Formula:C28H36O5SPurezza:98%Colore e forma:SolidPeso molecolare:484.65CDC801
CAS:CDC801 is an inhibitor of PDE4 and TNF-α with IC50s of 1.1 μM and 2.5 μM, respectively.
Formula:C23H24N2O5Purezza:99.61%Colore e forma:SolidPeso molecolare:408.45Nanatinostat
CAS:Nanatinostat (CHR-3996) is an HDAC inhibitor with selectivity and oral bioavailability, for HDAC1/2/3 .anti-proliferation apoptosis.Formula:C20H19FN6O2Purezza:99.03%Colore e forma:SolidPeso molecolare:394.4Ref: TM-T16270
1mg123,00€5mg295,00€10mg477,00€25mg893,00€50mg1.414,00€100mg2.125,00€1mL*10mM (DMSO)326,00€PARP1/2/TNKS1/2-IN-1
CAS:PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1 and TNKS2.PARP1/2/TNKS1/2-IN-1 has anti-tumor activity and induces apoptosis.Formula:C35H31FN6O5Purezza:99.63%Colore e forma:SolidPeso molecolare:634.66GP 1a
CAS:GP 1a: potent CB2 receptor agonist (EC50=7.1), 30x CB2 over CB1 preference, boosts P-ERK1/2, aids skin healing, anti-inflammatory.
Formula:C23H22Cl2N4OPurezza:99.79%Colore e forma:SolidPeso molecolare:441.35CDDO-3P-Im
CAS:CDDO-3P-Im is an orally active inhibitor of necroptosis with chemopreventive effects. CDDO-3P-Im can be used in studies about ischemia/reperfusion.Formula:C39H46N4O3Purezza:97.72%Colore e forma:SolidPeso molecolare:618.81Ref: TM-T13603
1mg92,00€5mg178,00€10mg295,00€25mg502,00€50mg710,00€100mg1.009,00€200mg1.333,00€1mL*10mM (DMSO)250,00€VU0661013
CAS:VU0661013 is an effective and selective inhibitor of MCL-1.Formula:C39H39Cl2N5O4Purezza:99.04%Colore e forma:SolidPeso molecolare:712.66Oditrasertib
CAS:Oditrasertib, a RIPK1 inhibitor characterized by an IC50 value below 100 nM, is employed in inflammation research.Formula:C14H15F2N3O2Purezza:98.65% - 99.65%Colore e forma:SolidPeso molecolare:295.28Ref: TM-T69726
1mg70,00€5mg150,00€10mg215,00€25mg358,00€50mg517,00€100mg707,00€500mg1.431,00€1mL*10mM (DMSO)138,00€Alrizomadlin
CAS:Alrizomadlin is an orally active MDM2 inhibitor. APG-115 shows significant dose-dependent inhibitory effects on TP53wt AML cell lines.Cost-effective and quality-assured.Formula:C34H38Cl2FN3O4Purezza:98.41% - 99.47%Colore e forma:SolidPeso molecolare:642.59Ref: TM-T14303
1mg52,00€5mg111,00€10mg180,00€25mg359,00€50mg472,00€100mg755,00€1mL*10mM (DMSO)159,00€Ac-YVAD-AOM
CAS:Ac-YVAD-AOM is a selective and potent caspase-1 inhibitor showing antitumor activity and potential analgesic activity.Formula:C33H42N4O10Purezza:98%Colore e forma:SolidPeso molecolare:654.71GCN2-IN-7
CAS:GCN2-IN-7 is an inhibitor of the environmental sensing protein GCN2 with antitumor activity for the study of melanoma.Formula:C22H23BrN8OSPurezza:99.12%Colore e forma:SolidPeso molecolare:527.44Ac-DEVD-CHO
CAS:Ac-DEVD-CHO is a specific Caspase-3 inhibitor (Ki: 230 pM).Ac-DEVD-CHO has an inhibitory effect in SLNT-induced apoptosis.Formula:C20H30N4O11Purezza:95.96% - 98.69%Colore e forma:SolidPeso molecolare:502.47Elobixibat
CAS:Elobixibat (A 3309) blocks IBAT in mice/humans/dogs (IC50: 0.13/0.53/5.8 nM); used for constipation research.Formula:C36H45N3O7S2Purezza:97.43% - 98.03%Colore e forma:SolidPeso molecolare:695.89SAFit2
CAS:SAFit2 is a highly potent and selective inhibitor of fk506 binding protein 51 (FKBP51).Cost-effective and quality-assuredFormula:C46H62N2O10Purezza:98.16% - >99.99%Colore e forma:SolidPeso molecolare:802.99Ref: TM-T16836
1mg66,00€2mg96,00€5mg145,00€10mg222,00€25mg364,00€50mg513,00€100mg722,00€1mL*10mM (DMSO)197,00€Tefinostat
CAS:Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor.Formula:C28H37N3O5Purezza:99.83%Colore e forma:SolidPeso molecolare:495.61Ref: TM-T17028
1mg90,00€5mg215,00€10mg319,00€25mg484,00€50mg640,00€100mg1.009,00€1mL*10mM (DMSO)233,00€CDDO-2P-Im
CAS:CDDO-2P-Im shows chemopreventive effect and reduces the size and severity of the lung tumors in the mouse lung cancer model.Formula:C39H46N4O3Purezza:99.54%Colore e forma:SolidPeso molecolare:618.81Ref: TM-T13602
1mg92,00€5mg205,00€10mg334,00€25mg553,00€50mg782,00€100mg1.054,00€200mg1.414,00€1mL*10mM (DMSO)281,00€NSC697923
CAS:NSC-697923 inhibits UBE2N, triggers p53-dependent and JNK-mediated apoptosis, blocks DNA damage and NF-κB signaling in neuroblastoma cells.Formula:C11H9NO5SPurezza:97% - 99.84%Colore e forma:SolidPeso molecolare:267.26MC4033
CAS:MC4033 exhibits inhibitory concentration 50 (IC50) values of 39.4 µM in HCT116, 52.1 µM in H1299, 41 µM in A549, and 30.1 µM in U937 [1].Formula:C16H13N3O3Purezza:98.16%Colore e forma:SolidPeso molecolare:295.29RH01386
CAS:RH01386, a small molecule, prevents ER stress in β cells, inhibits proapoptotic genes, and may treat type 2 diabetes by restoring insulin secretion.Formula:C18H15F3N4O3SPurezza:99.16% - 99.67%Colore e forma:SolidPeso molecolare:424.4Ref: TM-T13867
1mg70,00€2mg89,00€5mg145,00€10mg207,00€25mg338,00€50mg452,00€100mg620,00€200mg838,00€1mL*10mM (DMSO)135,00€DuP-697
CAS:DuP-697 is an irreversible, specific COX-2 inhibitor with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1.Cost-effective and quality-assured.Formula:C17H12BrFO2S2Purezza:99.92%Colore e forma:SolidPeso molecolare:411.31Ref: TM-T15181
1mg50,00€5mg99,00€10mg145,00€25mg235,00€50mg350,00€100mg515,00€200mg732,00€1mL*10mM (DMSO)117,00€PD-L1-IN-3
CAS:PD-L1-IN-3 is a PD-1/PD-L1 inhibitor for the study of tumors and immune diseases.Formula:C19H15ClFN2OSPurezza:99.47%Colore e forma:SoildPeso molecolare:373.85M3541
CAS:M3541: an oral ATM inhibitor with antitumor effects, hinders DNA repair and promotes cancer cell death.Formula:C23H17FN6O2Purezza:99.47%Colore e forma:SolidPeso molecolare:428.42LB42708
CAS:LB42708 is an orally active farnesyltransferase (FTase) inhibitor (IC50: 0.8/1.2/2.0 nM toward H/N/K-ras).Formula:C30H27BrN4O2Purezza:99.36%Colore e forma:SolidPeso molecolare:555.47Ref: TM-T2678
1mg40,00€5mg79,00€10mg110,00€25mg215,00€50mg324,00€100mg472,00€200mg718,00€1mL*10mM (DMSO)96,00€KSQ-4279
CAS:KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP.KSQ-4279 has anticancer activity and is used in the study of non-small cell lung cancer, osteosarcoma,Formula:C27H25F3N8OPurezza:99.76% - 99.79%Colore e forma:SoildPeso molecolare:534.54ZNL 02-096
CAS:ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolarFormula:C42H45N11O6Purezza:98.2% - 99.84%Colore e forma:SolidPeso molecolare:799.88PP5-IN-1
CAS:PP5-IN-1 is a serine/threonine protein phosphatase-5 (PP5) inhibitor with potential anticancer activity that induces apoptosis in cancer cells.Formula:C18H18N2O3SPurezza:99.13%Colore e forma:SolidPeso molecolare:342.41AZA197
CAS:AZA197 (AZA-197) is a selective Cdc42 inhibitor.Formula:C24H36N6Purezza:99.08%Colore e forma:SolidPeso molecolare:408.58Lartesertib
CAS:Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancerFormula:C23H21FN6O3Purezza:99.9%Colore e forma:SolidPeso molecolare:448.45Ref: TM-T62684
1mg123,00€2mg177,00€5mg295,00€10mg505,00€25mg982,00€50mg1.639,00€100mg2.538,00€1mL*10mM (DMSO)326,00€CPI-360
CAS:CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.Formula:C25H31N3O4Purezza:99.89%Colore e forma:SolidPeso molecolare:437.53JHU395
CAS:JHU395, an oral prodrug of glutamine antagonist DON, shows stable antitumor effects on MPNST in vitro and vivo.Formula:C22H29N3O7Purezza:99.26% - 99.57%Colore e forma:SolidPeso molecolare:447.48HM43239
CAS:HM43239: oral FLT3 inhibitor; IC50: FLT3 WT 1.1nM, ITD 1.8nM, D835Y 1.0nM; blocks p-STAT5/p-ERK; affects SYK, JAK1/2, TAK1; halts leukemia cell growth.Formula:C29H33ClN6Purezza:99.7%Colore e forma:SolidPeso molecolare:501.07Ref: TM-T9428
1mg50,00€5mg99,00€10mg158,00€25mg309,00€50mg464,00€100mg647,00€200mg855,00€1mL*10mM (DMSO)109,00€BMS 310705
CAS:BMS 310705, an Epothilone B analog, targets ovarian/renal/bladder/lung cancer, inducing apoptosis via mitochondria.Formula:C27H42N2O6SColore e forma:SolidPeso molecolare:522.70EMT inhibitor-3
CAS:EMT inhibitor-3 (compound 11i) is an epithelial-mesenchymal transition (EMT) inhibitor that effectively suppresses the proliferation, migration, and invasion of SK-N-SH neuroblastoma cells, with an IC50 value of 2.5 μM. It induces mitochondrial-mediated intrinsic apoptosis in tumor cells by enhancing the Bax/Bcl-2 protein expression ratio, promoting the release of cytochrome C from mitochondria, and activating caspase 9 and caspase 3. EMT inhibitor-3 is applicable for cancer research.Formula:C29H21F2N3O4SeColore e forma:SolidPeso molecolare:592.45JAK-2/3-IN-3
JAK-2-/3-IN-3 (ST4j) is a potent JAK2/3 inhibitor for leukemia research, with IC50s: JAK2, 13 nM; JAK3, 14.86 nM; induces apoptosis.Formula:C13H10Cl2N4O2Colore e forma:SolidPeso molecolare:325.15TZEP7
CAS:TZEP7 functions as an EGFR kinase inhibitor in cancer cells. It exhibits cytotoxicity and induces apoptosis within these cells. TZEP7 downregulates the anti-apoptotic protein Bcl-2, upregulates the pro-apoptotic protein Bax, and increases caspase levels. This compound holds potential for research in anticancer drug development.Formula:C27H19ClFNSColore e forma:SolidPeso molecolare:443.963TrxR/EGFR-IN-1
CAS:TrxR/EGFR-IN-1 (Compound L1Au2) is a TrxR/EGFR inhibitor with activity against both gefitinib-sensitive and -resistant lung cancer, effectively suppressing tumor proliferation and promoting apoptosis. It enhances GPX4 degradation through autophagosome-lysosome and proteasome pathways, leading to ferroptosis. Additionally, it induces endoplasmic reticulum stress and triggers immunogenic cell death, making it applicable for studies on gefitinib-resistant lung cancer.Formula:C24H24AuClFN6O2PColore e forma:SolidPeso molecolare:710.878FKBP51-Hsp90-IN-1
CAS:FKBP51-Hsp90-IN-1 (Compound D10) serves as a selective inhibitor targeting the FKBP51-Hsp90 protein-protein interaction, demonstrating an IC 50 value of 0.1 μM against FKBP51. It holds potential for research applications in stress-related diseases, Alzheimer's disease, and metabolic disorders [1].Formula:C19H24N4O4S2Colore e forma:SolidPeso molecolare:436.55MDM2-IN-26
CAS:MDM2-IN-26 (compound A3) is an inhibitor of MDM2 that facilitates the activation of p53's tumor suppressor functions by inhibiting the MDM2-p53 interaction, with MDM2 being the primary negative regulator of p53. This compound is utilized in cancer research [1].Formula:C32H32Cl2F3N3O4Colore e forma:SolidPeso molecolare:650.52HDAC-IN-37
HDAC-IN-37 inhibits HDACs 1, 3, 8, & 6, induces histone acetylation, halts G1 to S phase, and triggers early apoptosis.Formula:C23H24ClN7OColore e forma:SolidPeso molecolare:449.94RWJ-56110
CAS:protease-activated receptor-1 (PAR1) antagonistFormula:C41H43Cl2F2N7O3Purezza:98%Colore e forma:SolidPeso molecolare:790.73GPX4-IN-13
CAS:GPX4-IN-13 (compound 16), a GPX4 inhibitor, exhibits anticancer properties by diminishing the expression of GPX4, thereby reducing thyroid cell proliferation and inducing ferroptosis. Additionally, this compound effectively inhibits the growth of three distinct thyroid cancer cell lines: N-thy-ori-3-1 (IC 50 =8.39 μM), MDA-T32 (IC 50 =10.28 μM), and MDA-T41 (IC 50 =8.18 μM).Formula:C23H15NO3Colore e forma:SolidPeso molecolare:353.37Decarbamoylmitomycin C
CAS:Decarbamoylmitomycin C, an analog of Mitomycin C (MC), functions as a DNA alkylating agent. It is capable of activating chromatin relaxation by the ataxia-telangiectasia and Rad3-related protein (ATR) in a p53-independent manner.Formula:C14H17N3O4Colore e forma:SolidPeso molecolare:291.302MLKL-IN-6
MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein.
Formula:C20H18N4O5Purezza:98%Colore e forma:SolidPeso molecolare:394.38Spliceostatin A
CAS:Spliceostatin A is an anticancer agent and splicing inhibitor that induces apoptosis by inducing cell cycle arrest in the G1 and G2/M phases.Formula:C28H43NO8Purezza:94.66%Colore e forma:SolidPeso molecolare:521.643ERK-MYD88 interaction inhibitor 1
CAS:ERK-MYD88 Interaction Inhibitor 1, an agent that disrupts the interaction between ERK and MYD88, has demonstrated the ability to trigger an HRI-mediated integrated stress response (ISR) that specifically promotes immunogenic cell apoptosis (apoptosis) in cancer cells. Additionally, in models using Lewis lung cancer mice, this compound has been shown to stimulate anti-tumor T cell responses, thereby exhibiting significant anti-tumor activity.Formula:C22H21N5O2Colore e forma:SolidPeso molecolare:387.43RIP1 kinase inhibitor 1
CAS:RIP1 kinase inhibitor 1 is an orally available and brain-penetrating inhibitor of RIP1 kinase with pKi of 9.04.Formula:C24H20ClN5O3Purezza:98%Colore e forma:SolidPeso molecolare:461.9DeFer-2
CAS:DeFer-2 is a ferritin PROTAC degrader (Kd= 17.1 μM). It triggers the degradation of ferritin leading to the accumulation of free iron ions and an increase in ROS, which subsequently initiates caspase 3-GSDME mediated pyroptosis in cancer cells. DeFer-2 significantly inhibits tumor growth and extends the survival of mice with subcutaneous B16F10 tumors, and it is useful for melanoma research.Formula:C44H69N5O5SColore e forma:SolidPeso molecolare:780.11Tubulin polymerization-IN-9
CAS:Tubulin-IN-9 inhibits tubulin (IC50: 1.82 μM), halts K562 cells in G2/M, induces apoptosis, and has anti-cancer effects.Formula:C19H19NO5SeColore e forma:SolidPeso molecolare:420.32AKN-028 acetate
AKN-028 acetate: an oral TK inhibitor for AML research, targets FLT3 with IC50 of 6 nM, inhibits autophosphorylation, and induces apoptosis.Formula:C19H18N6O2Colore e forma:SolidPeso molecolare:362.39PARP1/BRD4-IN-2
PARP1/BRD4-IN-2, a potent inhibitor of PARP1 and BRD4, halts cell cycle, triggers apoptosis, and has antitumor effects on TNBC.Formula:C25H20N4O4Colore e forma:SolidPeso molecolare:440.45
