Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(11 prodotti)
- Caspasi(144 prodotti)
- FOXO1(3 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(139 prodotti)
- PDK(9 prodotti)
- PERK(26 prodotti)
- Chinasi di serina/treonina(18 prodotti)
- Survivin(14 prodotti)
- TNF(93 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6071 prodotti di "Apoptosi"
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GSK-3β inhibitor 15
GSK-3β inhibitor 15 (Compound 54), with an IC50 of 3.4 nM, effectively suppresses Aβ 1-42-induced phosphorylation of GSK-3β and tau protein, as well as LPS-Formula:C17H16N6OSColore e forma:SolidPeso molecolare:352.41Cholicamideβ
Cholicamideβ (compound 6), a self-assembling small molecule cancer vaccine adjuvant, forms low cytotoxicity virus-like particles and upon binding to peptideFormula:C55H94N2O6Purezza:98%Colore e forma:SolidPeso molecolare:879.34SF1126
CAS:SF1126 is a first-in-class PI3K/BRD4 inhibitor and RGDS-conjugated LY294002 prodrug, enhancing solubility and targeting tumor integrins.Formula:C39H48N8O14Purezza:98%Colore e forma:SolidPeso molecolare:852.841-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
CAS:<p>Phospholipid with stearic acid and 15(S)-HpETE boosts ferroptosis in MEFs upon GPX4 inhibition.</p>Formula:C43H78NO10PColore e forma:SolidPeso molecolare:800.068PK095
CAS:<p>PK095 is a proprietary compound in the guanidine - based F1F0-ATPase inhibitor family.</p>Formula:C20H18N4O2SPurezza:96.84%Colore e forma:SoildPeso molecolare:378.45CTP-347
CAS:CTP-347, a deuterated version of paroxetine, is potentially the best non-hormonal drug in its class for the treatment of hot flashes.Formula:C19H20FNO3Peso molecolare:331.38DRI-C21041 (DIEA)
DRI-C21041 DIEA serves as an inhibitor of CD40/CD40L interaction, exhibiting an inhibitory concentration (IC50) of 0.31 μM.Formula:C38H40N4O7SColore e forma:SolidPeso molecolare:696.81DHFR-IN-23
DHFR-IN-23 (compound 5) is a dual inhibitor of DNA binders/DHFR, exhibiting an IC50 value of 0.08 μM against hDHFR. It serves as an apoptosis inducer and is applicable in research on ER+ breast cancer.Colore e forma:Odour SolidHLDA-212
CAS:HLDA-212 (Compound 43) is a bifunctional small molecule designed to target HaloTag-tagged protein (target protein, TP) and Aurora kinase A/B (AURKA/B, effector protein, EP). By binding TP and EP, it forms a stable ternary complex (TP:RIPTAC:EP) that inhibits the cell survival functions of EP, inducing apoptosis in cancer cells expressing TP. In 293_HFL cells, HLDA-212 demonstrates antiproliferative activity with a GI50 of 0.011 μM. This compound holds promise for treating cancers with high TP expression, such as prostate cancer and hematological malignancies.Formula:C70H90BrFN8O19SPeso molecolare:1478.47p53-Mdm2 inhibitor 4
CAS:p53-Mdm2 inhibitor 4 inhibits the p53-MDM2 protein-protein interaction.Formula:C23H20FN3O3Purezza:98.66%Colore e forma:SoildPeso molecolare:405.42Valproic acid sodium salt
CAS:Sodium valproate is an anti-epileptic, boosting brain GABA levels and possibly affecting potassium channels for membrane stability.Formula:C8H15NaO2Purezza:98% - 99.78%Colore e forma:White PowderPeso molecolare:166.2HDAC-IN-57
CAS:HDAC-IN-57 is an orally active pan-inhibitor of histone deacetylase (HDAC), inhibiting HDAC1, HDAC2, HDAC6, and HDAC8 with IC50 values of 2.07 nM, 4.71 nM, 2.4Formula:C21H19N3O4Purezza:98.62%Colore e forma:SoildPeso molecolare:377.39Mcl-1 inhibitor 14
Compound (Ra)-10, also known as Mcl-1 inhibitor 14, is a potent inhibitor of myeloid cell leukemia-1 (MCL-1), exhibiting a K_i of 0.018 nM, and holds potentialFormula:C39H41ClFN5O5SColore e forma:SolidPeso molecolare:746.29Ferroptosis inducer-4
Ferroptosisinducer-4 (Compound 5) is a phospholipid-based ferroptosis inducer featuring a terminal double bond at the sn-2 position. It exhibits significant cytotoxicity towards HT-1080 cells with an IC50 value of 18 μM. The toxicity mechanism involves the generation of lipid peroxides and oxidative damage to the cell membrane induced by the terminal double bond. Ferroptosisinducer-4 can be utilized in studies pertaining to the regulation of ferroptosis.Formula:C33H64NO7PColore e forma:SolidPeso molecolare:617.84Nrf2 activator-9
Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-densityFormula:C26H27N5O4Colore e forma:SolidPeso molecolare:473.52ReACp53 acetate
ReACp53 acetate could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines.Formula:C110H210N52O26Purezza:99.55%Colore e forma:SolidPeso molecolare:2677.18Anti-inflammatory agent 61
Compound 5b (Anti-inflammatory agent 61) is a potent anti-inflammatory agent that diminishes TNF-α expression in LPS-induced inflammation within RAW 264.7 cellsColore e forma:Odour SolidMcl1-IN-26
CAS:Mcl1-IN-26 is an effective and selective myeloid cell leukemia 1 inhibitor.Formula:C45H52ClN5O6SColore e forma:SolidPeso molecolare:826.44SB-1295
SB-1295, an orally active CDK9/T1 inhibitor with an IC50 of 0.17 μM, exhibits antiproliferative effects on HCT 116 and MIA PaCa-2 cells.Formula:C23H22ClNO6Purezza:98%Colore e forma:SolidPeso molecolare:443.88HC Toxin
CAS:HC Toxin: cyclic tetrapeptide, reversible HDAC inhibitor (IC50=30 nM), upregulates 15-lipoxygenase-1, induces fetal hemoglobin, from C. carbonum.Formula:C21H32N4O6Colore e forma:SolidPeso molecolare:436.509
