Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(6 prodotti)
- BCL(11 prodotti)
- Caspasi(127 prodotti)
- FOXO1(3 prodotti)
- IAP(65 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(126 prodotti)
- PDK(9 prodotti)
- PERK(24 prodotti)
- Chinasi di serina/treonina(15 prodotti)
- Survivin(13 prodotti)
- TNF(91 prodotti)
- c-RET(51 prodotti)
- p53(62 prodotti)
Mostrare 6 più sottocategorie
Trovati 5622 prodotti di "Apoptosi"
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3-AP-Me
CAS:<p>3-AP-Me is the dimethyl derivative of the ribonucleotide reductase inhibitor 3-AP (SML0568). It activates the endoplasmic reticulum (ER) stress pathway by promoting eIF2α phosphorylation and upregulating gene expression of transcription factors ATF4 and ATF6, thereby inducing apoptosis. Additionally, 3-AP-Me activates cellular stress kinases c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase, leading to the upregulation of spliced mRNA variant XBP1. It is applicable in cancer research.</p>Formula:C9H13N5SColore e forma:SolidPeso molecolare:223.298NLRP3-IN-78
CAS:<p>NLRP3-IN-78 (compound 21) is an NLRP3 inhibitor with a 46.72% inhibition rate of GSDMD-induced pyroptosis at 5 μM. It binds to the NLRP3 protein and prevents GSDMD-NT oligomerization. Additionally, NLRP3-IN-78 inhibits GSDMD cleavage and upstream NF-κB signaling, demonstrating anti-inflammatory activity.</p>Formula:C12H5Cl2N3O4S2Colore e forma:SolidPeso molecolare:390.222HDAC-IN-27 dihydrochloride
CAS:<p>HDAC-IN-27 dihydrochloride (Compound 11h) is a potent, orally active, HDACI class-selective inhibitor, with IC50 values ranging from 0.43 to 3.01 nM for HDAC1-3. This compound exhibits both in vivo and in vitro anticancer activity. HDAC-IN-27 shows significant antiproliferative effects against acute myeloid leukemia (AML) cell lines by inducing apoptosis and histone acetylation (AcHH3 and AcHH4). It is useful for research on acute myeloid leukemia (AML).</p>Formula:C20H24Cl2N4O2Colore e forma:SolidPeso molecolare:423.336Anticancer agent 69
<p>Anticancer agent 69 targets PC3 cells (IC50=26 nM), raises ROS, lowers EGFR, and induces apoptosis.</p>Formula:C19H26N8SColore e forma:SolidPeso molecolare:398.53FLT3-ITD-IN-3
CAS:<p>FLT3-ITD-IN-3 (13v) is an orally active inhibitor of FLT3-ITD (internal tandem duplication of FLT3), which works by blocking FLT3 signaling. This inhibition leads to cell cycle arrest in the G0/G1 phase and induces apoptosis. The compound is currently employed in studies related to acute myeloid leukemia (AML).</p>Formula:C27H21ClF2N6O5Colore e forma:SolidPeso molecolare:582.943Antitumor agent-76
CAS:<p>Antitumor agent-76 is a water-soluble, orally active, rapid-release prodrug of Triptolide that exhibits anticancer effects.</p>Formula:C28H36ClNO10Colore e forma:SolidPeso molecolare:582.04PD-1/PD-L1-IN-15
<p>PD-1/PD-L1-IN-15 is a potent inhibitor of PD-1/PD-L1 (IC50: 60.1 nM) and has shown investigational potential for tumor immunotherapy.</p>Formula:C32H30N4O3Colore e forma:SolidPeso molecolare:518.61TH-6
TH-6, a potent HDAC inhibitor (IC50: HDAC1-0.115, 2-0.135, 3-0.242, 6-0.138, 8-2.120 μM), blocks cell migration, invasion, and has anti-tumor properties.Formula:C22H24FN3O5Colore e forma:SolidPeso molecolare:429.44NVP-CGM097 sulfate
CAS:<p>NVP-CGM097 sulfate is a potent and selective inhibitor of MDM2 (hMDM2, IC50 of 1.7±0.1 nM).</p>Formula:C38H49ClN4O8SPurezza:98%Colore e forma:SolidPeso molecolare:757.34MA242 free base
CAS:<p>MA242 free base is a dual MDM2/NFAT1 inhibitor that triggers apoptosis in pancreatic cancer cells.</p>Formula:C24H20ClN3O3SColore e forma:SolidPeso molecolare:465.95AK-295
CAS:<p>AK 295, also known as CX 295, is a dipeptide inhibitor of alpha-ketoamide calpain.</p>Formula:C26H40N4O6Colore e forma:SolidPeso molecolare:504.62Anticancer agent 14
<p>Anticancer agent 14: a potent breast cancer inhibitor; induces cell death, disrupts mito. membrane potential (IC50: 0.20-0.65 μM).</p>Formula:C29H34N2O3Colore e forma:SolidPeso molecolare:458.59Multi-kinase-IN-1
CAS:<p>Multi-kinase-IN-1, a powerful kinase inhibitor, exhibits antitumor properties by inducing cell apoptosis.</p>Formula:C35H36F2N6O6SColore e forma:SolidPeso molecolare:706.76Ferroptosis-IN-18
CAS:<p>Ferroptosis-IN-18 (51) is a phenothiazine derivative known for its potent anti-ferroptotic and antioxidant properties. It is useful for research related to intracerebral hemorrhage (ICH).</p>Formula:C25H27N3SColore e forma:SolidPeso molecolare:401.567Scytonemin
CAS:<p>Scytonemin, a cyanobacterial pigment, inhibits cancer cell growth by decreasing Plk1 activity, especially effective on U266 myeloma cells.</p>Formula:C36H20N2O4Colore e forma:SolidPeso molecolare:544.55RIPK1-IN-14
CAS:<p>RIPK1-IN-14 inhibits RIPK1 with 92 nM IC50 and reduces necrotic apoptosis in U937 cells.</p>Colore e forma:SoildhCAIX/XII-IN-5
<p>Coumarin 9a: Selective inhibitor of hCA IX/XII (Ki 93.3/85.7 nM), blocks cancer cell growth, and induces apoptosis.</p>Formula:C18H13NO3Colore e forma:SolidPeso molecolare:291.3HDAC-IN-9
<p>HDAC-IN-9, a dual tubulin/HDAC inhibitor, impedes A549 cell invasion/migration and shows strong anti-tumor/angiogenic effects.</p>Formula:C33H38N2O4Colore e forma:SolidPeso molecolare:526.67ZLHQ-5f
<p>ZLHQ-5f inhibits CDK2/Topo I, with IC50 of 0.145μM for CDK2/CycA2, and promotes apoptosis by arresting HCT116 cells in S phase.</p>Formula:C28H25N5O2Colore e forma:SolidPeso molecolare:463.53D-Cl-amidine hydrochloride
<p>D-Cl-amidine hydrochloride is a potent and highly selective inhibitor of PAD1. It exhibits excellent tolerance and does not induce significant toxicity [1].</p>Formula:C14H20Cl2N4O2Colore e forma:SolidPeso molecolare:347.24
