Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(8 prodotti)
- Caspasi(147 prodotti)
- FOXO1(3 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(140 prodotti)
- PDK(9 prodotti)
- PERK(26 prodotti)
- Chinasi di serina/treonina(19 prodotti)
- Survivin(14 prodotti)
- TNF(91 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6114 prodotti di "Apoptosi"
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Tubulin inhibitor 17
Compound 3b inhibits tubulin polymerization, IC50 12.38 µM, with anticancer properties and promotes cell apoptosis.Formula:C17H16N2OColore e forma:SolidPeso molecolare:264.32Bafilomycin C1
CAS:vacuolar H+-ATPases (V-ATPases) inhibitorFormula:C39H60O12Purezza:98%Colore e forma:Light Tan SolidPeso molecolare:720.89Belotecan
CAS:Belotecan (CKD-602) inhibits DNA topoisomerase I, blocks cell cycle, induces apoptosis, and is a camptothecin-derived anticancer agent.Formula:C25H27N3O4Colore e forma:SolidPeso molecolare:433.5AB8939
CAS:AB8939 is a potent small-molecule inhibitor of microtubule/tubulin polymerization, exhibiting antitumor activity (with tumor cell proliferation inhibition IC50≤10 nM). It effectively circumvents resistance mechanisms mediated by P-glycoprotein and myeloperoxidase. AB8939 can induce G2/M phase cell cycle arrest and apoptosis.
Formula:C22H24N4O3Colore e forma:SolidPeso molecolare:392.451FLT3/TrKA-IN-1
FLT3/TrKA-IN-1: Potent dual kinase inhibitor for FLT3 & TrKA, promising for AML research.Formula:C28H30N4O2Colore e forma:SolidPeso molecolare:454.56PD-1/PD-L1-IN-55
CAS:PD-1/PD-L1-IN-55 (compound D6) is a potent PD-1/PD-L1 inhibitor with an IC50 of 4.8 nM. It enhances IFN-γ secretion and decreases the proportion of late apoptosis due to PD-L1.Formula:C25H23ClN2O3Colore e forma:SolidPeso molecolare:434.92MLKL-IN-6
MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein.
Formula:C20H18N4O5Purezza:98%Colore e forma:SolidPeso molecolare:394.38Ketorolac hydrochloride
CAS:Ketorolac (RS37619) hydrochloride is a nonsteroidal anti-inflammatory drug and a non-selective COX inhibitor, exhibiting IC50 values of 20 nM for COX-1 and 120 nM for COX-2. This compound is utilized in a 0.5% ophthalmic solution format for the investigation of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and post-operative ocular inflammation pain. Additionally, Ketorolac hydrochloride serves as a DDX3 inhibitor, making it pertinent for research in cancer therapies.Formula:C15H14ClNO3Colore e forma:SolidPeso molecolare:291.73Fosizensertib
CAS:Fosizensertib is an inhibitor of RIP-1 kinase and is used in research related to ulcerative colitis.Formula:C22H21F2N4O5PColore e forma:SolidPeso molecolare:490.397PROTAC FKBP Degrader-3
CAS:PROTAC FKBP Degrader-3, with FKBP and VHL binding groups linked, is a potent FKBP degrader.Formula:C68H90N6O17SPurezza:98%Colore e forma:SolidPeso molecolare:1295.54ABL-L
CAS:ABL-L is able to induce apoptosis in human laryngeal cancer cells using a p53-dependent pathway.Formula:C29H46O6Colore e forma:SolidPeso molecolare:490.67Cetzole
CAS:Cetzole (Compound 1) acts as an inducer of ferroptosis (iron-dependent cell death) through the accumulation of ROS, leading to cell death. The compound exhibits varying half-maximal cytotoxic concentrations (CC50) against several cell lines: 2.56 μM in NCI-H522, 10.31 μM in NCI-H522 GFP-SCL7A11 #8, 2.71 μM in NCI-H522 RV-GFP, 3.07 μM in HT-1080, 14.9 μM in NARF2, and 6.28 μM in MDA-MB-231. This highlights Cetzole's potential for research in cancer therapeutics.Formula:C11H11NOSColore e forma:SolidPeso molecolare:205.28L-threo-Sphingosine C-18
CAS:L-threo-Sphingosine C-18 is a protein kinase C inhibitor.Formula:C18H37NO2Purezza:98%Colore e forma:SolidPeso molecolare:299.49WF-47-JS03
WF-47-JS03: RET kinase inhibitor, crosses blood-brain barrier, 500x more selective for KDR, IC50: 1.7 nM in Ba/F3 cells, 5.3 nM in LC-2/ad lung cancer cells.
Formula:C30H38N6O2Colore e forma:SolidPeso molecolare:514.66RWJ-56110
CAS:protease-activated receptor-1 (PAR1) antagonistFormula:C41H43Cl2F2N7O3Purezza:98%Colore e forma:SolidPeso molecolare:790.73Kahweol Acetate
CAS:Kahweol Acetate, a semi-synthetic coffee bean derivative, inhibits osteoclasts, cancer cells, DNA damage, and oxidative stress.Formula:C22H28O4Colore e forma:SolidPeso molecolare:356.46MAPK-IN-5
CAS:MAPK-IN-5 is a potent inhibitor of MAPK, with an IC50 value of 1.35 μM in HeLa cells. It induces ROS-mediated DNA damage and mitochondrial apoptosis (apoptosis) via the MAPK pathway. MAPK-IN-5 significantly inhibits colony formation in HeLa cells, reduces viable cell numbers, suppresses cell migration, and arrests the cell cycle at the G2/M phase. It is applicable in cervical cancer research.Formula:C30H29F3N6O4Colore e forma:SolidPeso molecolare:594.58HAC-Y6
CAS:HAC-Y6 exerts its anticancer effects by inducing cell cycle arrest. It prompts apoptosis in COLO 205 cells with an IC50 of 0.52 µM.Formula:C23H22N2O4Colore e forma:SolidPeso molecolare:390.43FLT3-ITD-IN-3
CAS:FLT3-ITD-IN-3 (13v) is an orally active inhibitor of FLT3-ITD (internal tandem duplication of FLT3), which works by blocking FLT3 signaling. This inhibition leads to cell cycle arrest in the G0/G1 phase and induces apoptosis. The compound is currently employed in studies related to acute myeloid leukemia (AML).Formula:C27H21ClF2N6O5Colore e forma:SolidPeso molecolare:582.943HI042
CAS:HI042 is an FMS-like tyrosine kinase 3 (FLT3) inhibitor, showing an IC50 value of 0.62 μM for MOLM-13 cells, 0.33 μM for MV4-11 cells, and 0.89 μM for OCI-AML3 cells. It selectively reduces the survival rate of FLT3-internal tandem duplication (FLT3-ITD) positive cell lines, induces apoptosis, disrupts cell cycle progression, and diminishes colony-forming ability. HI042 is applicable for acute myeloid leukemia (AML) research.Formula:C14H11N3O3SColore e forma:SolidPeso molecolare:301.32
