Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(8 prodotti)
- Caspasi(144 prodotti)
- FOXO1(3 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(139 prodotti)
- PDK(9 prodotti)
- PERK(26 prodotti)
- Chinasi di serina/treonina(18 prodotti)
- Survivin(14 prodotti)
- TNF(93 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6084 prodotti di "Apoptosi"
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Sampangine
CAS:Sampangine, an alkaloid, induces apoptosis by causing cell cycle arrest at the G0/G1 phase and inhibits the biosynthesis of heme.Formula:C15H8N2OColore e forma:SolidPeso molecolare:232.24Topoisomerase inhibitor 4
CAS:Topoisomerase inhibitor4 (compound 45) acts as an effective inhibitor of Topoisomerase1/2, arresting the cell cycle at the G2/M phase and inducing Apoptosis. This compound exhibits potent antitumor activity.Formula:C30H28F3IN4O3Colore e forma:SolidPeso molecolare:676.47Utibaprilat
CAS:Utibaprilat is the primary degradation product of Utibapril and functions as an ACE inhibitor.Formula:C20H27N3O5SColore e forma:SolidPeso molecolare:421.51PARP10/15-IN-2
CAS:PARP10/15-IN-2 (Compound 8h) blocks PARP10/15, has IC50s: 0.15μM/0.37μM, cell-permeable, prevents apoptosis.Formula:C15H11FN2O3Colore e forma:SolidPeso molecolare:286.26NLRP3-IN-28
CAS:NLRP3-IN-28 (compound N77) serves as a potent inhibitor of NLRP3, effectively blocking Nigericin-induced pyroptosis with an EC50 of 0.07μM. Additionally, it mitigates inflammatory reactions in vivo [1].Formula:C12H9F3N2O3SColore e forma:SolidPeso molecolare:318.27p53 Activator 12
CAS:Compound 510B, also known as p53 Activator 12, is a powerful activator of p53. This compound specifically interacts with mutant p53 to restore its DNA-binding function.Formula:C28H35F3N8O2Peso molecolare:572.63NLRP3-IN-26
CAS:NLRP3-IN-26 (compound 15Z), with an IC50 of 0.13 μM, functions as an inhibitor of NLRP3. It is applicable in studies involving the DSS-induced colitis model [1].Formula:C31H33ClN2O6SColore e forma:SolidPeso molecolare:597.12Anticancer agent 16
Anticancer agent 16 showed good cytotoxic effects on HCT-116 cell line (IC50: 8.55 μM), NCI-H460 cell line (IC50: 5.41 μM) and SKOV3 cell line (IC50: 6.4 μM).Formula:C27H33N5O6Colore e forma:SolidPeso molecolare:523.58NPB-1575
CAS:NPB-1575 is a potent, orally active anti-inflammatory agent capable of crossing the blood-brain barrier. It mitigates neuroinflammation and resists ferroptosis by activating IRS2/Nrf2/NF-κB. NPB-1575 protects against cerebral ischemic injury and improves neurological function outcomes, making it suitable for research in focal ischemic stroke.Formula:C19H22O4Colore e forma:SolidPeso molecolare:314.38TNF-α-IN-12
CAS:TNF-α-IN-12, a TNF-α inhibitor with an IC50 of 0.1 μM, can reduce TNF-α blood levels [1].Formula:C21H22O6Colore e forma:SolidPeso molecolare:370.4Tubulin/NRP1-IN-1
CAS:Tubulin/NRP1-IN-1 (compound TN-2) serves as a dual inhibitor targeting both Tubulin and NRP1, exhibiting IC50 values of 0.71 μM and 0.85 μM, respectively. This compound notably reduces the viability of prostate tumor cell lines and triggers apoptosis [1].Formula:C28H37N5O8Colore e forma:SolidPeso molecolare:571.62PLK1-IN-13
CAS:PLK1-IN-13 is a selective, orally active PLK1 inhibitor with an IC50 of 0.27 nM. It also inhibits PLK2 (IC50: 12.72 nM) and PLK3 (IC50: 4.12 nM). PLK1-IN-13 induces cell cycle arrest at the G2 phase, promotes apoptosis, and downregulates the transcription of the cancer-associated oncogene c-MYC. This compound inhibits tumor growth and is applicable for research in acute myeloid leukemia (AML).Formula:C29H39N9O2SColore e forma:SolidPeso molecolare:577.744Vitamin K5 hydrochloride
CAS:Vitamin K5 (hydrochloride), a naphthoquinone compound, exhibits trichomonacidal activity in vitro and can be utilized for anti-infection research [1].Formula:C11H12ClNOPeso molecolare:209.67SILA-123
CAS:SILA-123, an inhibitor of FLT3 (FLT3-WT: IC50=2.1 nM; FLT3-ITD: IC50=1.0 nM), induces cell apoptosis by hindering the cell cycle progression at the G0/G1 phase through the suppression of FLT3 phosphorylation and its downstream signaling pathways. This compound is utilized in the study of acute myeloid leukemia.Formula:C24H25N5O2Colore e forma:SolidPeso molecolare:415.49RIPK1-IN-28
CAS:<p>RIPK1-IN-28 (compound 13) is an orally active inhibitor of RIPK1. It exhibits inhibitory effects on human I2.1 and Hepa1-6 cells, with IC50 values of 0.4 and 1.2 nM, respectively.</p>Formula:C27H24N4O4Colore e forma:SolidPeso molecolare:468.504PBX-7011
CAS:PBX-7011, an active camptothecin derivative, binds to the DDX5 protein in cells and induces cell death through DDX5 protein degradation [1].Formula:C24H21N3O6Peso molecolare:447.44PAK4-IN-5
PAK4-IN-5 (Compound 12i) is a potent inhibitor of PAK4 (IC50: PAK4 at 7.68 nM, PAK1 at 1872.01 nM) that forms stable interactions with the PAK4 enzyme. This compound effectively inhibits the proliferation and migration potential of MDA-MB-231 cells by hindering the phosphorylation of PAK4 and LIMK1. Additionally, PAK4-IN-5 arrests the cell cycle in the G0/G1 phase, induces apoptosis, and prompts the production of reactive oxygen species. The LD50 in mice is greater than 500 mg/kg (oral).Formula:C31H28ClN5OColore e forma:SolidPeso molecolare:522.04VDR agonist 1
CAS:Compound 28 is a nonsteroidal VDR agonist with 690 nM potency, inducing cell cycle arrest and apoptosis in MCF-7 cells.Formula:C32H51N3O2Purezza:98%Colore e forma:SolidPeso molecolare:509.77Ph-Ph+
Ph-Ph+ is a dimerized phenanthroline derivative with antitumor, antibacterial, and antifungal effects.Formula:C24H17N4Colore e forma:SolidPeso molecolare:361.42LA-CB1
CAS:LA-CB1 is a derivative of Abemaciclib that targets CDK4/6 and promotes their degradation via the ubiquitin-proteasome pathway, thereby blocking the CDK4/6-Cyclin D1-Rb-E2F axis and inducing G0/G1 cell cycle arrest and apoptosis (Apoptosis). It demonstrates antiproliferative activity against MDA-MB-231 cells with an IC50 of 0.27 µM and effectively inhibits epithelial-mesenchymal transition, cell migration, invasion, and angiogenesis. In highly invasive models like triple-negative breast cancer (TNBC), LA-CB1 significantly suppresses tumor growth, showing robust dose-dependent antitumor activity. This compound can be utilized in breast cancer research.Formula:C28H23ClFN7OColore e forma:SolidPeso molecolare:527.98
