Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(6 prodotti)
- BCL(11 prodotti)
- Caspasi(125 prodotti)
- FOXO1(3 prodotti)
- IAP(66 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(125 prodotti)
- PDK(9 prodotti)
- PERK(25 prodotti)
- Chinasi di serina/treonina(15 prodotti)
- Survivin(13 prodotti)
- TNF(92 prodotti)
- c-RET(51 prodotti)
- p53(62 prodotti)
Mostrare 6 più sottocategorie
Trovati 5598 prodotti di "Apoptosi"
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Topoisomerase II inhibitor 17
<p>TopoisomeraseII inhibitor 17 (compound 4c) is a thiazolopyrimidine-based inhibitor of Topoisomerase II with an IC50 of 0.23 μM. This compound significantly disrupts the cell cycle and induces apoptosis.</p>Formula:C25H22Cl3N3O5SPeso molecolare:581.03458RIPK1-IN-22
<p>RIPK1-IN-13 (compound 28) is a selective inhibitor of receptor-interacting serine/threonine-protein kinase 1 (RIPK1), showing a pKi of 7.66 as measured by the ADP-Glo kinase assay. It exhibits inhibitory effects in human leukemia U937 cells with a pIC50 of 7.2.</p>Formula:C22H22N4O3SPeso molecolare:422.14126Tripchlorolide
<p>Tripchlorolide is a useful organic compound for research related to life sciences and the catalog number is T126047.</p>Formula:C20H25ClO6Colore e forma:SolidPeso molecolare:396.86PRMT5-IN-33
<p>PRMT5-IN-33 (compound A8) is a selective inhibitor of PRMT5 that competes with SAM, exhibiting an IC50 of 10.9 nM. It induces apoptosis and inhibits the proliferation of Z-138 and MOLM-13 cells, demonstrating antitumor activity.</p>Formula:C25H24BrN5O3SPeso molecolare:553.07832MKC-1
CAS:<p>MKC-1 (Ro-31-7453) is an oral bisindolylmaleimide inhibitor that disrupts tubulin polymerization, potentially halting cancer cell division.</p>Formula:C22H16N4O4Purezza:99.63% - 99.85%Colore e forma:SolidPeso molecolare:400.39Vinepidine sulfate
CAS:<p>Vinepidine (LY-119863) sulfate, a derivative of vincristine, exhibits antitumor activity .</p>Formula:C46H58N4O13SColore e forma:SolidPeso molecolare:907.04BWA-522
<p>BWA-522 is a small molecule, orally available protein-targeting chimera (PROTAC) that potentates the degradation of both full-length androgen receptor (AR-FL)</p>Formula:C43H51ClN4O7Purezza:98%Colore e forma:SolidPeso molecolare:771.34PBE-AMF
<p>PBE-AMF is a prodrug that activates H2O2 and exhibits anticancer activity. It impedes tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing cell death (apoptosis), and blocking the cell cycle. PBE-AMF effectively and selectively inhibits the proliferation of MDA-MB-231 cells (IC50=6.4 μM) while sparing non-cancerous MCF-10A cells.</p>Colore e forma:Odour SolidTNF-α Antagonist
CAS:<p>TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with</p>Formula:C58H71N11O15S2Colore e forma:SolidPeso molecolare:1226.39FAK-IN-25
<p>FAK-IN-25 (4c) is an inhibitor of FAK with an IC50 value of 50.98 nM. It induces apoptosis and causes cell cycle arrest in the G1 phase, making it relevant for cancer research.</p>Formula:C22H13ClN4OS2Colore e forma:SolidPeso molecolare:448.95Fludarabine triphosphate
CAS:<p>Fludarabine triphosphate inhibits key enzymes, causing cell death.</p>Formula:C10H15FN5O13P3Colore e forma:SolidPeso molecolare:525.17Estradiol (cypionate)
CAS:<p>Estradiol cypionate (Depofemin), the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.</p>Formula:C26H36O3Purezza:99.53% - >99.99%Colore e forma:White Or Off-White Crystalline PowderPeso molecolare:396.56MY-943
<p>MY-943, a potent inhibitor of tubulin polymerization and LSD1, exhibits anticancer properties by inducing G2/M phase arrest, promoting apoptosis, and</p>Formula:C30H36N4O6S2Colore e forma:SolidPeso molecolare:612.76MMRi62
CAS:<p>MMRi62, a MDM2-MDM4 inhibitor, induces ferroptosis and autophagy in PDAC, degrades FTH1 and mutant p53, and inhibits KRAS/TP53 mutant PDAC in mice.</p>Formula:C21H15Cl2N3OPurezza:99.87%Colore e forma:SoildPeso molecolare:396.273-Hydroxyterphenyllin
CAS:<p>3-Hydroxyterphenyllin from A. candidus is a fungal compound with antioxidant, anticancer, antibacterial, and antiviral effects.</p>Formula:C20H18O6Colore e forma:SolidPeso molecolare:354.35LL-K9-3
CAS:<p>LL-K9-3, a selective hydrophobic tagging technology (HyT)-based degrader, specifically targets the CDK9-cyclin T1 complex, displaying DC50 values of 589 nM for</p>Formula:C31H49N5O6S3Colore e forma:SolidPeso molecolare:683.94BODIPY FL thalidomide
CAS:<p>BODIPY FL thalidomide is a fluorescent probe that binds human cereblon protein with high affinity, exhibiting a dissociation constant (Kd) of 3.6 nM [1].</p>Formula:C37H43BF2N6O7Colore e forma:SolidPeso molecolare:732.58fac-[Re(CO)3(L3)(H2O)][NO3]
<p>Fac-[Re(CO)3(L3)(H2O)][NO3] (Compound 3), a rhenium(I) tricarbonyl aqua complex, acts as an anticancer agent through the induction of mitochondrial dysfunction.</p>Formula:C25H17N6O8ReColore e forma:SolidPeso molecolare:715.64Thalidomide-Piperazine 5-fluoride hydrochloride
CAS:<p>Thalidomide-Piperazine 5-fluoride hydrochloride, a derivative of the cereblon (CRBN) inhibitor Thalidomide, serves as a ligand for E3 ubiquitin ligase (Ligands for E3 Ligase), facilitating the synthesis of PROTACs [1].</p>Formula:C17H18ClFN4O4Colore e forma:SolidPeso molecolare:396.8eIF4E-IN-5
<p>eIF4E-IN-5 (Compound 6n) is a cell-permeable eIF4E inhibitor that binds to capped mRNA, thereby inhibiting cap-dependent translation [1].</p>Formula:C30H39Cl2N6O8PColore e forma:SolidPeso molecolare:713.55Antitumor agent-145
CAS:Compound Ir5 (Antitumor agent-145) serves as a tumor inhibitor characterized by significant fluorescence and mitochondrial targeting. It promotes anti-cancer activity by inducing necroptosis and stimulating the necroptosis-related immune response [1].Formula:C44H34IrN5OSColore e forma:SolidPeso molecolare:873.06BIO8898
<p>BIO8898: potent CD40-CD154 inhibitor, IC50 of 25 µM, prevents CD40L-induced apoptosis.</p>Formula:C53H64N8O6Colore e forma:SolidPeso molecolare:909.13PDE4B-IN-4
<p>PDE4B-IN-4 is an inhibitor of PDE4B (IC50: 2.82 nM) and TNF-α (IC50: 7.20 nM). It demonstrates anti-inflammatory properties by reducing neutrophilia in a mouse model of lipopolysaccharide (LPS)-induced sepsis.</p>Formula:C26H27N5O5Colore e forma:SolidPeso molecolare:489.52Zamzetoclax
CAS:<p>Zamzetoclax (compound 1) acts as a potential inhibitor of Mcl-1.</p>Formula:C38H46ClN5O6SColore e forma:SolidPeso molecolare:736.32Mcl-1 inhibitor 15
<p>Mcl-1 Inhibitor 15 (Compound (Ra)-15), with a K i of 0.02 nM, is utilized in cancer research [1].</p>Formula:C40H42ClFN6O4SColore e forma:SolidPeso molecolare:757.32CDC20-IN-2
<p>CDC20-IN-2 (14c) is an inhibitor of Cdc20 with a KD of 7.65 μM, inducing G2/M phase arrest, promoting DNA damage accumulation, and stabilizing key substrates such as Cyclin B1 and Bim. This leads to enhanced apoptosis, as well as inhibition of tumor cell proliferation and migration.</p>Colore e forma:Odour SolidBMSpep-57
CAS:<p>BMSpep-57: Macrocyclic peptide, inhibits PD-1/PD-L1, IC50=7.68 nM, binds PD-L1 (Kd=19 nM/MST, 19.88 nM/SPR), boosts T cell IL-2 in PBMCs.</p>Formula:C89H126N24O19SColore e forma:SolidPeso molecolare:1868.2PD-1/PD-L1-IN-48
<p>PD-1/PD-L1-IN-48 (compound HD10) is an effective inhibitor of the PD-1/PD-L1 interaction, exhibiting an IC50 of 3.1 nM. It plays a vital role in cancer research.</p>Colore e forma:Odour Solidcpm-1285
CAS:<p>CPM-1285 induces apoptosis by effectively inhibiting the function of intracellular Bcl-2 and associated death antagonists.</p>Formula:C153H240N44O42SPurezza:98%Colore e forma:SolidPeso molecolare:3399.88Antitumor agent-112
<p>Antitumor agent-112 (compound 3a) is a potent antitumor agent that induces apoptosis and exhibits cytotoxic activity on A549 cells, with an IC50 value of 91.35</p>Formula:C18H17ClN4O2SPurezza:98%Colore e forma:SolidPeso molecolare:388.87Pyridinium bisretinoid A2E TFA
CAS:<p>Pyridinium bisretinoid A2E (A2E) TFA, a fluorophore derived from retinal pigment epithelium (RPE) lipofuscin, initiates blue-light-induced apoptosis, mediates</p>Formula:C44H58F3NO3Purezza:98%Colore e forma:SolidPeso molecolare:705.93DRI-C21041 (DIEA)
<p>DRI-C21041 DIEA serves as an inhibitor of CD40/CD40L interaction, exhibiting an inhibitory concentration (IC50) of 0.31 μM.</p>Formula:C38H40N4O7SColore e forma:SolidPeso molecolare:696.81DHFR-IN-23
<p>DHFR-IN-23 (compound 5) is a dual inhibitor of DNA binders/DHFR, exhibiting an IC50 value of 0.08 μM against hDHFR. It serves as an apoptosis inducer and is applicable in research on ER+ breast cancer.</p>Colore e forma:Odour SolidFerroptosis-IN-3
<p>Ferroptosis-IN-3 (Compound 25), a ferroptosis inhibitor, demonstrates potent activity by inhibiting RSL3-induced ferroptosis in HT-1080 cells (EC50: 8.6 nM).</p>Purezza:98%Colore e forma:Odour SolidCaerin 1.1 TFA
<p>Caerin 1.1 TFA, a host defense peptide derived from the Australian tree frog Litoria's glandular secretions, exhibits anti-proliferative effects on HeLa cells</p>Purezza:98%Colore e forma:Odour SolidNrf2 activator-9
<p>Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-density</p>Formula:C26H27N5O4Colore e forma:SolidPeso molecolare:473.52Δ8-Tetrahydrocannabinoquinone
CAS:<p>Δ8-Tetrahydrocannabinoquinone (HU-336) is a potent anti-angiogenic agent that inhibits angiogenesis by directly inducing apoptosis in vascular endothelial cells. It achieves this without altering the expression of pro-angiogenic and anti-angiogenic cytokines and receptors. Δ8-Tetrahydrocannabinoquinone also shows significant effectiveness against tumor xenografts in nude mice.</p>Formula:C21H28O3Colore e forma:SolidPeso molecolare:328.45BM-962
CAS:<p>BM-962 (Compound 31) is a potent small-molecule inhibitor with an IC50 value of 4 nM (Ki=0.8 nM) for Bcl-2 and an IC50 of 3.9 nM (Ki<1 nM) for Bcl-xL. It inhibits H1417 and H146 cell lines with IC50 values of 9 and 13 nM, respectively, and shows potential for use in cancer research.</p>Formula:C53H58ClF3N6O7S3Colore e forma:SolidPeso molecolare:1079.7184-B10
CAS:<p>84-B10 provides protection in cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors.</p>Formula:C25H22F3NO5Purezza:99.76%Colore e forma:SolidPeso molecolare:473.44β-Glucuronide-dPBD-PEG5-NH2
CAS:<p>β-Glucuronide-dPBD-PEG5-NH2 is a β-glucuronide-linked pyrrolobenzodiazepine dimer that functions as a proagent for the synthesis of the antibody-drug conjugate</p>Formula:C78H101N7O35Colore e forma:SolidPeso molecolare:1696.66PI3Kδ-IN-16
CAS:<p>PI3Kδ-IN-16 is a selective and potent PI3Kδ inhibitor with anticancer and antiproliferative activity, induces cell cycle arrest and apoptosis.</p>Formula:C22H26N6O2Purezza:99.68%Colore e forma:SoildPeso molecolare:406.48BM-1244
CAS:<p>BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively.</p>Formula:C54H59ClF4N6O8S4Colore e forma:SolidPeso molecolare:1159.78Anticancer agent 157
<p>Anticancer Agent 157 (compound 15) is a nitric oxide (NO) inhibitor with IC50 values of 0.62 μg/mL, exhibiting both anti-inflammatory and anticancer effects.</p>Formula:C14H20O2Purezza:98%Colore e forma:SolidPeso molecolare:220.31dMCL1-2
CAS:<p>dMCL1-2 is a PROTAC-based MCL1 degrader, binding at 30 nM, and induces apoptosis in leukemia.</p>Formula:C61H66N10O12SPurezza:98%Colore e forma:SolidPeso molecolare:1163.3Aphidicolin
CAS:<p>Aphidicolin blocks DNA synthesis, hinders herpes virus growth, and stimulates apoptosis in leukemia cells; it's a mold-derived DNA polymerase inhibitor.</p>Formula:C20H34O4Purezza:>99.99%Colore e forma:SolidPeso molecolare:338.48PROTAC-O4I2
CAS:PROTAC-O4I2, a PROTAC ligand targeting splicing factor 3B1 (SF3B1), induced FLAG-SF3B1 degradation in K562 cells with an IC50 value of 0.244 μM.Formula:C29H29ClN6O5SPurezza:97.45%Colore e forma:SolidPeso molecolare:609.1DJ4
CAS:<p>DJ4 induces a dose-dependent pro-apoptotic effect in the micromolar range.</p>Formula:C19H16N4OSPurezza:≥98%Colore e forma:SoildPeso molecolare:348.426-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
CAS:6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is a PDK1 inhibitor with anticancer and antiproliferative activity that can be used to studyFormula:C9H6BrN3OPurezza:99.81%Colore e forma:SolidPeso molecolare:252.07ILS-920
CAS:<p>ILS-920, a Rapamycin analog, has reduced immunosuppression, enhanced neuroprotection, and preferentially binds FKBP52 and L-type VGCC β1.</p>Formula:C57H86N2O14Purezza:98%Colore e forma:SolidPeso molecolare:1023.3Glutathione arsenoxide hydrochloride
<p>Glutathione arsenoxide hydrochloride: anti-cancer, inhibits tumour metabolism, targets ANT, promotes apoptosis, marks cell proteins.</p>Formula:C18H26AsClN4O9SPurezza:99.74%Colore e forma:SoildPeso molecolare:584.86Apoptosis inducer 37
<p>Apoptosis inducer37 (Derivative 10) is an agent that induces apoptosis and exhibits anticancer properties by causing cell cycle arrest at the S-G2/M phase and promoting cell apoptosis. It significantly inhibits HCT116, SKOV3, and HepG2 cancer cells with IC50 values of 24.98 μM, 26.15 μM, and 23.09 μM, respectively. Apoptosis inducer37 demonstrates antitumor activity and can be utilized in ovarian cancer research.</p>Formula:C27H37BrN2O4SColore e forma:SolidPeso molecolare:564.16574RWJ-56110 dihydrochloride
CAS:<p>RWJ-56110 dihydrochloride is a potent PAR-1 inhibitor (IC50=0.44μM), blocking platelet aggregation, angiogenesis, and induces apoptosis. No PAR-2/3/4 effect.</p>Formula:C41H44Cl3F2N7O3Colore e forma:SolidPeso molecolare:827.2PCC0208017
CAS:<p>PCC0208017 is an inhibitor of MARK3 and MARK4 with IC50s of 1.8 and 2.01 nM. PCC0208017 disrupts microtubule dynamics and displays potent antitumor activity.</p>Formula:C19H20F3N7Purezza:99.48%Colore e forma:SolidPeso molecolare:403.4EGFR/BRAFV600E-IN-3
<p>EGFR/BRAFV600E-IN-3 is an inhibitor targeting EGFR, BRAFV600E, and EGFRT790M with IC50 values of 57 nM, 68 nM, and 9.70 nM, respectively.</p>Formula:C25H18N4O3Purezza:98%Colore e forma:SolidPeso molecolare:422.44P53R3
CAS:<p>P53R3 is a potent reactivator of p53, effectively restoring sequence-specific DNA binding to several p53 hot spot mutants, namely p53 R175H, p53 R248W, and p53</p>Formula:C32H35Cl2N5O2Purezza:98.8%Colore e forma:SolidPeso molecolare:592.56PH14
<p>PH14, a dual PI3K/HDAC inhibitor, demonstrates potent inhibition with IC50 values of 20.3 nM for PI3Kα and 24.5 nM for HDAC3.</p>Purezza:98%Colore e forma:Odour SolidAntitumor agent-116
<p>Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis.</p>Formula:C31H23BrN4O4SPurezza:98%Colore e forma:SolidPeso molecolare:627.51SCR7
CAS:<p>SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).</p>Formula:C18H14N4OSPurezza:98%Colore e forma:SolidPeso molecolare:334.412-HETE
CAS:<p>12-HETE ((±)12-HETE) is a regulator of PGE2, having both antithrombotic and prothrombotic effects.</p>Formula:C20H32O3Colore e forma:SolidPeso molecolare:320.47PD1-PDL1-IN 1 TFA
<p>PD1-PDL1-IN 1 TFA (compound 16) is a potent inhibitor of programmed cell death 1 (PD-1), functioning as an immune modulator [1].</p>Formula:C16H24F3N7O8Colore e forma:SolidPeso molecolare:499.4A947
CAS:<p>A947 is a potent and selective SMARCA2 PROTAC that induces the degradation of SMARCA2, with significant antitumor activity in SMARCA4-mutant NSCLC cells.</p>Formula:C61H76N12O7SPurezza:98.84%Colore e forma:SolidPeso molecolare:1121.4VEGFR/PARP-IN-1
<p>VEGFR/PARP-IN-1 (Compound 14b) is a dual inhibitor of VEGFR and PARP with IC50 values of 191 nM and 60.9 nM, respectively.</p>Formula:C29H27N9OPurezza:98%Colore e forma:SolidPeso molecolare:517.58Cannflavin A
CAS:<p>Cannflavin A, isolated from Cannabis sativa L., exhibits anti-cancer, neuroprotective, and anti-inflammatory activities by inhibiting Aβ1-42 aggregation and</p>Formula:C26H28O6Colore e forma:SolidPeso molecolare:436.5Hexapeptide-11
CAS:<p>Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.</p>Formula:C36H48N6O7Purezza:98%Colore e forma:SolidPeso molecolare:676.8Monensin
CAS:<p>Monensin, from Streptomyces cinnamonensis, inhibits Wnt/β-catenin. Potential anticancer agent.</p>Formula:C36H62O11Purezza:98%Colore e forma:Crystals White Or Off-White CrystalsPeso molecolare:670.87Thalidomide-5,6-Cl
CAS:<p>Thalidomide-5,6-Cl is a cereblon ligand derivative that recruits CRBN protein and forms PROTACs with a linker.</p>Formula:C13H8Cl2N2O4Colore e forma:SolidPeso molecolare:327.12Halenaquinone
CAS:<p>Halenaquinone: PI3K inhibitor, stops RAD51 DNA binding & osteoclastogenesis, induces PC12 cell apoptosis.</p>Formula:C20H12O5Purezza:98%Colore e forma:SolidPeso molecolare:332.31Bleomycin A5
CAS:<p>Bleomycin A5, or Pingyangmycin, is an oral glycopeptide antibiotic and acts as an antineoplastic and apoptosis inducer.</p>Formula:C57H89N19O21S2Colore e forma:SolidPeso molecolare:1440.56JGB1741
CAS:<p>JGB1741, a SIRT1 inhibitor (IC50=15µM), modulates apoptosis markers and p53 acetylation in breast cancer research.</p>Formula:C27H24N2O2SPurezza:99.86%Colore e forma:SolidPeso molecolare:440.56Prodigiosin
CAS:<p>Prodigiosin is a secondary metabolite of Symbiotic bacteria. It also has anti-fungal and anti-cancer activity.</p>Formula:C20H25N3OPurezza:98%Colore e forma:SolidPeso molecolare:323.44VTP50469 fumarate
CAS:<p>VTP50469 fumarate is a highly selective and orally active inhibitor of Menin-MLL interaction (Ki: 104 pM), and has potently anti-leukemia activity.</p>Formula:C76H106F2N12O20S2Purezza:98%Colore e forma:SolidPeso molecolare:1609.86Thalidomide-O-amido-PEG4-propargyl
<p>Thalidomide-O-amido-PEG4-propargyl is a polyethylene glycol (PEG)-based linker employed for the synthesis of proteolysis targeting chimeras (PROTACs)[1].</p>Formula:C26H31N3O10Purezza:98%Colore e forma:SolidPeso molecolare:545.54TNF-α-IN-6
CAS:<p>TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM).</p>Formula:C26H25N9O2Colore e forma:SolidPeso molecolare:495.547C-Reactive Protein (CRP) (174-185)
CAS:<p>CRP protein and its fragment (174-185, RS-83277) boost human monocyte and macrophage cancer-killing effects in vitro.</p>Formula:C62H93N13O16Purezza:98%Colore e forma:SolidPeso molecolare:1276.48Kdo2-Lipid A ammonium
CAS:<p>Kdo2-Lipid A ammonium (KLA) is a selective and potent TLR4 agonist, a lipopolysaccharide.Kdo2-Lipid A ammonium induces the release of TNF and PGE2.</p>Formula:C110H214N6O39P2Purezza:98%Colore e forma:SolidPeso molecolare:2306.84CSF1R-IN-26
<p>CSF1R-IN-26 (Compound III-1) is an inhibitor of CSF-1R with an IC50 of 20.07 nM. It promotes the polarization of M2 macrophages to M1 macrophages, inducing apoptosis in MC-38 cancer cells. CSF1R-IN-26 inhibits the activation of the AKT/ERK/STAT3 signaling pathways, remodels the tumor immune microenvironment, and exhibits antitumor activity in mouse models. In SD rats, CSF1R-IN-26 demonstrates favorable pharmacokinetic properties, with a half-life of 1.86 hours and an oral bioavailability of 79.22%.</p>Colore e forma:Odour SolidNauclefine
CAS:<p>Nauclefine, a plant alkaloid, triggers cancer cell death through PDE3A-SLFN12, binding but not inhibiting PDE3A.</p>Formula:C18H13N3OPurezza:99.92%Colore e forma:SolidPeso molecolare:287.32BRD4 Inhibitor-38
<p>BRD4 Inhibitor-38 (Compound 25) is an orally active BRD4 inhibitor, exhibiting IC50 values of 3.64 μM for BRD4 BD1 and 0.12 μM for BRD4 BD2. It also demonstrates anti-inflammatory properties, with an IC50 value of 1.98 μM for nitric oxide (NO) production.</p>Formula:C19H18N2O4Colore e forma:SolidPeso molecolare:338.357HDSI-18
<p>HDSI-18 is an orally active selective inhibitor of HDAC6 with an IC50 of 1.6 nM. It exhibits cytotoxic effects against K562, MV4-11, MOLM-13, THP-1, and Jurkat cells with IC50 values of 0.48, 0.58, 0.91, 1.79, and 4.31 μM, respectively. HDSI-18 can activate Caspase-3, induce mitochondrial depolarization, and trigger apoptosis (Apoptosis), demonstrating antitumor activity.</p>Formula:C28H28N4O5Colore e forma:SolidPeso molecolare:500.20597DL-Sulforaphane N-acetyl-L-cysteine
CAS:<p>DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC), induces apoptosis through α-microtubulin and phosphorylation of ERK1/2-mediated Stathmin-1, and Hsp70 (NSCLC).</p>Formula:C11H20N2O4S3Colore e forma:SolidPeso molecolare:340.48Tubulin polymerization-IN-45
<p>Tubulin polymerization-IN-45, a tubulin-targeting agent, acts as a tubulin polymerization inhibitor by binding to the tubulin's colchicine site.</p>Formula:C20H18N4O3Colore e forma:SolidPeso molecolare:362.38Xerophilusin B
CAS:<p>Xerophilusin B from Isodon xerophilus halts ESCC cell growth, causes G2/M arrest, and induces apoptosis.</p>Formula:C20H26O5Colore e forma:SolidPeso molecolare:346.42Dynorphin A
CAS:<p>Dynorphin A is a endogenous opioid peptide and a κ-opioid receptor (KOR) agonist,a neurotransmitter and regulator in the central and peripheral nervous systems</p>Formula:C99H155N31O23Purezza:95.93%Colore e forma:SolidPeso molecolare:2147.48Stem bromelain
CAS:<p>Stem bromelain: cysteine protease from pineapple stem with fibrinolytic, anti-inflammatory, antitumoral properties.</p>Colore e forma:SolidFlavopiridol
CAS:<p>Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; also inhibits EGFR, PKA. In Phase 1/2 trials.</p>Formula:C21H20ClNO5Purezza:97.74% - 99.86%Colore e forma:SolidPeso molecolare:401.84D-Trimannuronic acid
CAS:<p>D-Trimannuronic acid from seaweed induces TNF-α in mouse macrophages; useful in pain, dementia studies.</p>Formula:C18H26O19Colore e forma:SolidPeso molecolare:546.387AB-3PRGD2
CAS:<p>AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.</p>Formula:C137H215IN30O45SColore e forma:SolidPeso molecolare:3161.32HTH-01-091 TFA
<p>HTH-01-091 TFA: Potent, selective MELK inhibitor (IC50=10.5 nM); also targets PIM1/2/3, RIPK2, DYRK3, smMLCK, CLK2; used in breast cancer research.</p>Formula:C28H29Cl2F3N4O4Colore e forma:SolidPeso molecolare:613.465-LOX-IN-8
<p>5-LOX-IN-8 is a 5-LOX inhibitor with anti-inflammatory properties. It suppresses IL-6, IL-1β, TNF-α, and IFN-γ in macrophages and reduces IL-8 secretion in SW480 cells. Additionally, 5-LOX-IN-8 decreases the disease activity index in DSS colitis models. This compound is applicable for research in inflammatory bowel disease (IBD).</p>Colore e forma:Odour SolidAvotaciclib hydrochloride
<p>Avotaciclib hydrochloride, a CDK1 inhibitor, is the hydrochloride salt of Avotaciclib and exhibits potential therapeutic use in specific malignancies, including</p>Formula:C13H12ClN7OPurezza:98%Colore e forma:SolidPeso molecolare:317.73Annonacin
CAS:<p>Annonacin is a cytotoxic acetogenin in Graviola leaf extract; it blocks mitochondrial complex and inhibits NKA/SERCA ATPase pumps.</p>Formula:C35H64O7Purezza:98%Colore e forma:SolidPeso molecolare:596.88MitoEbselen-2 chloride
CAS:<p>MitoEbselen-2 mitigates radiation, cuts lipid hydroperoxides, blocks cell death, and boosts survival in irradiated mice.</p>Formula:C35H30ClN2O2PSeColore e forma:SolidPeso molecolare:656.01DS-5272
CAS:<p>DS-5272 is a potent and orally active inhibitor of p53-MDM2 interaction.</p>Formula:C34H38Cl2F2N6O2SColore e forma:SolidPeso molecolare:703.67BM-1074
CAS:<p>BM-1074 is a potent and highly efficacious inhibitor of Bcl-2/Bcl-xL with Ki value of < 1nM [1].</p>Formula:C50H57ClN8O7S3Colore e forma:SolidPeso molecolare:1013.69Anticancer agent 153
<p>Anticancer Agent 153 (Compound 3) promotes apoptosis through the generation of Reactive Oxygen Species (ROS) and elevates the loss of Mitochondrial Membrane</p>Formula:C16H11Cl2N3O3Purezza:98%Colore e forma:SolidPeso molecolare:364.18SM-164 Hydrochloride
<p>SM-164 Hydrochloride: Smac mimetic, cell-permeable, binds XIAP BIR2 and BIR3, IC50 of 1.39 nM, potent XIAP antagonist.</p>Formula:C62H85ClN14O6Colore e forma:SolidPeso molecolare:1157.88Apolizumab
CAS:<p>Apolizumab (Hu1D10) is a humanized antibody targeting HLA-DR beta-chain; induces apoptosis in CLL cells in vitro.</p>Colore e forma:LiquidEmavusertib hydrochloride
CAS:<p>Emavusertib (CA-4948) hydrochloride, a selective and potent IRAK4/FLT3 inhibitor, is designed for oral administration. It achieves an IC 50 of 57 nM against IRAK4 in a FRET kinase assay and demonstrates anti-tumor activity [1] [2] [3].</p>Formula:C24H26ClN7O5Colore e forma:SolidPeso molecolare:527.96Leucettamol A
CAS:<p>Leucettamol A, from Leucetta microraphis, blocks LTB4 receptor and prevents Ubc13-Uev1A complex formation.</p>Formula:C30H52N2O2Purezza:98%Colore e forma:SolidPeso molecolare:472.758Antitumor agent-103
<p>Antitumor Agent-103 (compound 24l) induces apoptosis and possesses antiproliferative and anti-colony formation properties.</p>Formula:C36H36N8O9S2Purezza:98%Colore e forma:SolidPeso molecolare:788.85WKYMVM
CAS:<p>WKYMVM is a N-formyl peptide receptor (FPR1) agonist.</p>Formula:C41H61N9O7S2Purezza:98%Colore e forma:SolidPeso molecolare:856.11PROTAC Bcl-xL ligand-1
<p>PROTAC Bcl-xL ligand-1 serves as a ligand targeting Bcl-xL, essential in synthesizing PROTACs [1].</p>Formula:C32H29IN4O4S2Colore e forma:SolidPeso molecolare:724.63Anticancer agent 132
<p>Compound Rh1 (Anticancer agent 132) acts as an inducer of apoptosis and autophagy, exhibiting both antitumor and antimetastatic activities.</p>Formula:C24H16Cl3F3N5ORhPurezza:98%Colore e forma:SolidPeso molecolare:656.68Zapalog
CAS:<p>Zapalog: photocleavable dimerizer controlling instant protein interactions.</p>Formula:C58H73N7O15Purezza:98%Colore e forma:SolidPeso molecolare:1108.24Verdinexor
CAS:<p>Verdinexor (KPT-335) (KPT-335), a specific XPO1/CRM1 inhibitor, are orally bioavailable.</p>Formula:C18H12F6N6OPurezza:98% - 99.68%Colore e forma:SolidPeso molecolare:442.32PROTAC MNK1 degrader-1
<p>ROTACMNK1degrader-1 is a selective MNK1 PROTAC degrader with a DC50 of 11.92 nM and a Dmax greater than 96% in MV4-11 cells. It significantly reduces p-eIF4E levels with an IC50 of 22.07 nM, induces apoptosis, and causes cell cycle arrest at the G1 phase. This compound exhibits potent antitumor activity, demonstrating strong anti-leukemic effects in MV4-11 xenograft mouse models with acceptable drug safety.</p>Formula:C35H38N6O6SColore e forma:SolidPeso molecolare:670.78HTR2A antagonist 1
<p>HTR2A antagonist 1 (Compound 15f) is an HTR2A antagonist with an IC50 of 42.79 nM. It induces sub-G1 cell cycle arrest and apoptosis in colorectal cancer cells by activating the p53/p21/caspase 3 signaling pathway. HTR2A antagonist 1 exhibits good liver microsomal stability and is useful for colorectal cancer research.</p>Formula:C35H43Cl2F2N5O4Colore e forma:SolidPeso molecolare:706.65Verproside
CAS:<p>Verproside is a useful organic compound for research related to life sciences. The catalog number is T124745 and the CAS number is 50932-20-2.</p>Formula:C22H26O13Colore e forma:SolidPeso molecolare:498.437MG-C-30
CAS:<p>MG-C-30 is an orally active CD27 agonist with an EC50 of 0.84 μM. It activates co-stimulatory signaling in NK cells and T cells, thereby enhancing the immune response. In the EG7-OVA mouse model, MG-C-30 demonstrates antitumor activity.</p>Formula:C24H26N4O3SColore e forma:SolidPeso molecolare:450.55Silicon naphthalocyanine dichloride
CAS:<p>Silicon naphthalocyanine dichloride is a photosensitizer with potential anti-tumor activity. This compound is employed in photodynamic therapy to inhibit cancer by effectively absorbing specific wavelengths of light, thereby generating oxygen radicals that aid in the destruction of cancer cells. The biocompatibility of Silicon naphthalocyanine dichloride demonstrates promising prospects for medical applications.</p>Formula:C48H24Cl2N8SiColore e forma:SolidPeso molecolare:811.75Sodium propionate
CAS:<p>Sodium propionate (Propionic acid sodium salt) has potential anti-inflammatory and anti-apoptotic activities, inhibiting certain signaling pathways.</p>Formula:C3H5NaO2Colore e forma:SoildPeso molecolare:96.06(E/Z)-LAQ824
CAS:<p>(E/Z)-LAQ824 is an inhibitor of histone deacetylase.</p>Formula:C22H25N3O3Purezza:98%Colore e forma:SolidPeso molecolare:379.46Amorfrutin A
CAS:<p>Amorfrutin A is a useful organic compound for research related to life sciences. The catalog number is T124190 and the CAS number is 80489-90-3.</p>Formula:C21H24O4Colore e forma:SolidPeso molecolare:340.419FOXJ1 agonist 1
<p>FOXJ1 agonist 1 (compound 16c), an orally effective small molecule, effectively enhances FOXJ1 expression and acts on multiciliated cells (MCC) in the mammalian airway system to prevent chronic obstructive pulmonary disease (COPD). Foxj1-IN-1 induces motile cilia production in the respiratory system of both zebrafish and mammals and inhibits elastase-induced COPD in mouse models. Additionally, Foxj1-IN-1 demonstrates good liver microsomal stability and favorable in vivo pharmacokinetic (PK) curves and area under the curve (AUC). It exhibits negligible inhibition of CYP and hERG and lacks significant cytotoxicity.</p>Formula:C24H27N5O3Colore e forma:SolidPeso molecolare:433.5Opucolimab
CAS:<p>Opucolimab is a human antibody targeting PD-L1, used in advanced solid tumor research and antibody-drug conjugate synthesis.</p>Colore e forma:LiquidHMGB1-IN-1
<p>HMGB1-IN-1 (compound 6) exhibits potent inhibition of NO production in RAW264.7 cells, with an IC50 of 15.9 ± 0.6 μM, and effectively disrupts the HMGB1/NF-κB/</p>Formula:C57H75N3O15Colore e forma:SolidPeso molecolare:1042.22Betifisolimab
CAS:<p>Betifisolimab (MSB-2311) is a humanized antibody targeting PD-L1 for solid tumors and blood cancer research.</p>Colore e forma:LiquidProlgolimab
CAS:<p>Prolgolimab (BCD-100) is an anti-PD-1 antibody used in melanoma research.</p>Purezza:>95%Colore e forma:LiquidMilademetan tosylate hydrate
CAS:<p>Milademetan tosylate hydrate, an oral MDM2 inhibitor targeting AML and solid tumors, induces G1 arrest and apoptosis.</p>Formula:C37H44Cl2FN5O8SColore e forma:SolidPeso molecolare:808.74Chloranthalactone B
CAS:<p>Chloranthalactone B, a sesquiterpenoid from Sarcandra glabra, inhibits inflammation via AP-1 & p38 MAPK.</p>Formula:C15H16O3Colore e forma:SolidPeso molecolare:244.29SB 699551
CAS:<p>SB 699551 is a selective 5-HT5A antagonist (Ki=6.31 nM) that enhances 5-HT neuronal function. It inhibits SERT (Ki=25.12 nM),inhibit breast cancer.</p>Formula:C34H45N3OPurezza:99.83%Peso molecolare:511.74DMUP
CAS:<p>DMUP inhibits CD47-SIRPα, induces apoptosis, boosts macrophage activity in A549 cells, and has antitumor properties.</p>Formula:C24H24Cl2N2O10PtColore e forma:SolidPeso molecolare:766.45RIPK2-IN-4
<p>RIPK2-IN-4 is a potent and specific inhibitor of RIPK2 with an IC50 value of 5 nM.</p>Formula:C16H10N6S2Peso molecolare:350.04084Anticancer agent 178
<p>Anticanceragent 178 (compound C2) is a potent anticancer compound. It effectively inhibits the proliferation and metabolic activity of MDA-MB 231 cells, with IC50 values of 1.1 and 4.2 μM, respectively. Additionally, Anticanceragent 178 induces ferroptosis and necroptosis in cells.</p>Formula:C32H30ClFeN2O6Peso molecolare:629.11418Necrosis inhibitor 2 (hydrocholide)
<p>Necrosis inhibitor 2 hydrochloride (Compound B19) is an agent that inhibits cellular necrosis. It is useful for researching diseases associated with necrotic pathways, including inflammation, cancer, metabolic disorders, and neurodegenerative diseases.</p>Formula:C24H26ClN5O5Peso molecolare:499.16225ERK-IN-6
<p>ERK-IN-6, a potent agent, inhibits ESCC growth and induces apoptosis through the ERK pathway.</p>Formula:C19H18BrN3O3SColore e forma:SolidPeso molecolare:448.33ECDD-S16
<p>ECDD-S16 is a potent inhibitor of pyroptosis. It effectively suppresses pyroptosis in Raw264.7 cells activated by surface and endosomal TLR ligands.</p>Formula:C35H31FO12Peso molecolare:662.17995ATWLPPRAANLLMAAS
CAS:ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent antitumor capabilities. It effectively inhibits the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induces apoptosis (apoptosis).Formula:C76H123N21O20SPeso molecolare:1682.98Chalcones A-N-5
CAS:<p>Chalcones A-N-5, a non-cytotoxic trihydroxy chalcone, aids cell growth & neuroprotection, inhibits ferroptosis, and targets AD research.</p>Formula:C21H20N4O4Colore e forma:SolidPeso molecolare:392.41BOC-D-FMK
CAS:<p>Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).</p>Formula:C11H18FNO5Purezza:97.02%Colore e forma:SolidPeso molecolare:263.26Sanggenon G
CAS:<p>Sanggenon G inhibits XIAP by binding its BIR3 domain; affinity is 34.26 μM, boosting caspase activation.</p>Formula:C40H38O11Colore e forma:SolidPeso molecolare:694.72Sotigalimab
CAS:<p>Sotigalimab (APX 005) is a monoclonal antibody targeting CD40 with anticancer activity for the study of metastatic pancreatic cancer.</p>Purezza:98.50% - 98.50%Colore e forma:LiquidAMG-7209
CAS:<p>AMG-7209 is an effective and selective MDM2-p53 interaction inhibitor.</p>Formula:C37H41Cl2FN2O7SColore e forma:SolidPeso molecolare:747.7Onfekafusp alfa
CAS:<p>Onfekafusp alfa (L19TNF), a trimeric fusion of L19 scFv and human TNF, targets malignant glioma.</p>Colore e forma:LiquidIzuralimab
CAS:<p>Izuralimab is a bispecific IgG1 antibody that targets both the inducible T-cell costimulator (ICOS/CD278) and PD-1 [1].</p>Colore e forma:LiquidPexelizumab
CAS:<p>Pexelizumab is a humanized antibody targeting C5 to inhibit apoptosis and treat cerebral IR injury and myocardial infarction.</p>Colore e forma:LiquidTyroserleutide hydrochloride
CAS:<p>Tyroserleutide HCl, a tripeptide from pig spleen, inhibits tumor growth in vivo/vitro.</p>Formula:C18H28ClN3O6Purezza:98%Colore e forma:SolidPeso molecolare:417.88LSD1-IN-26
<p>LSD1-IN-26 (12u) is a potent LSD1 inhibitor (IC50=25.3 nM), also inhibits MAO-A/B, induces apoptosis in MGC-803, for gastric cancer research.</p>Formula:C27H25Cl2F2N3OColore e forma:SolidPeso molecolare:516.41Pantoprazole Sodium Hydrate
CAS:<p>Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus</p>Formula:C16H14F2N3NaO4SH2OPurezza:98.32%Colore e forma:SolidPeso molecolare:432.37Pamrevlumab
CAS:<p>FG-3019 (Pamrevlumab), a human antibody, targets CTGF, potentially treating idiopathic pulmonary fibrosis.</p>Purezza:100% (SEC-HPLC) - 95%Colore e forma:LiquidGliotoxin
CAS:<p>Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.</p>Formula:C13H14N2O4S2Purezza:98%Colore e forma:SolidPeso molecolare:326.39LY3415244
<p>LY3415244 is a human bispecific antibody (bsAb) that targets B7-H1/PD-L1/CD274 and TIM-3/HAVCR2/CD366. This compound is applicable in the study of advanced solid tumors.</p>Colore e forma:Odour LiquidEtanercept
CAS:<p>Etanercept is a fusion protein consisting of the soluble portion of the p75-tumor necrosis factor receptor (TNFR) and the Fc fragment of human IgG1 and is commonly used to treat patients with rheumatoid arthritis.Cost-effective and quality-assured.</p>Purezza:98%Colore e forma:LiquidAcetyl coenzyme A
CAS:<p>Acetyl coenzyme A (Acetyl-CoA) is a pivotal molecule connecting multiple cellular metabolic pathways in the tricarboxylic acid cycle, fatty acid synthesis</p>Formula:C23H38N7O17P3SColore e forma:SolidPeso molecolare:809.57PROTAC Bcl2 degrader-1
CAS:<p>PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).</p>Formula:C45H45BrN6O10SPurezza:98%Colore e forma:SolidPeso molecolare:941.84MRT-2359
CAS:<p>"MRT-2359: Oral GSPT1 reducer, anti-cancer, targets NSCLC/SCLC, effective on MYC-driven cells."</p>Formula:C22H17F4N3O6Purezza:98.69%Colore e forma:SoildPeso molecolare:495.38MET/PDGFRA-IN-1
<p>MET/PDGFRA-IN-1 (compound 8c) serves as an inhibitor of MET and PDGFRA proteins, displaying an IC50 of 36 μM against MET.</p>Formula:C26H23N7OPurezza:98%Colore e forma:SolidPeso molecolare:449.51SDH-IN-26
<p>SDH-IN-26 (Compound C3) is a succinate dehydrogenase (SDH) inhibitor with significant inhibitory activity against various plant pathogenic fungi, including solanrhizoctonia and Botrytis cinerea. It exhibits an EC50 value of 0.270 μg/mL against solanrhizoctonia. SDH-IN-26 compromises fungal cell membrane integrity, increases membrane permeability, disrupts cell structure, reduces mitochondrial count, and affects normal hyphal growth. It also decreases mitochondrial membrane potential, inducing apoptosis. SDH-IN-26 holds potential for studying plant diseases caused by fungi.</p>Colore e forma:Odour SolidPL120131
<p>PL120131 is a PD-1/PD-L1 inhibitory peptide that disrupts the interaction between PD-1 and PD-L1 by binding to PD-1. This compound can inhibit the apoptosis signaling pathway mediated by PD-1, thereby preventing apoptosis (apoptosis) in Jurkat cells and primary lymphocytes. Additionally, PL120131 supports cytotoxic T lymphocytes (CTL) in exhibiting antitumor activity.</p>Formula:C62H105N19O18Colore e forma:SolidPeso molecolare:1404.61RIPK3-IN-3
<p>RIPK3-IN-3 (compound 20) is a selective RIPK3 inhibitor that demonstrates potent activity with an IC50 value of 10 nM.</p>Formula:C16H11N5SColore e forma:SolidPeso molecolare:305.36RET ligand-3
<p>RETligand-3 is the ligand for PROTAC QZ2135, which targets RET.</p>Formula:C38H42N10O3Colore e forma:SolidPeso molecolare:686.81(±)-Enterodiol
CAS:<p>"(±)-Enterodiol, the racemate of Enterodiol, is metabolized from lignans found in whole-grain cereals, nuts, legumes, flaxseed, and vegetables by human intestinal bacteria. This compound exhibits apoptotic effects in colorectal cancer (CRC) cells and has been identified to possess anti-cancer activities [1] [2]."</p>Formula:C18H22O4Colore e forma:SolidPeso molecolare:302.36GGTI298 Trifluoroacetate
CAS:<p>GGTI298 trifluoroacetate (GGTI298TFA salt) is a geranylgeranyltransferase I inhibitor that causes cell cycle arrest and induces apoptosis.</p>Formula:C27H33N3O3S·C2HF3O2Purezza:98.07% - >99.99%Colore e forma:SolidPeso molecolare:593.66Barakol
CAS:<p>Barakol, a primary compound found in Cassia siamea, inhibits MMP-3 activity and enhances the anti-metastatic effects of doxorubicin. Additionally, Barakol induces apoptosis (Apoptosis), generates reactive oxygen species, increases the Bax/Bcl-2 expression ratio, and activates caspase-9. This compound also exhibits laxative, anti-anxiety, central nervous system depressant, antioxidant, and anticancer properties.</p>Formula:C13H12O4Colore e forma:SolidPeso molecolare:232.23HSP90-IN-33
<p>HSP90-IN-33 (compound 24e) is an effective Hsp90 inhibitor, demonstrating dissociation constants (Kd) of ≥200 µM for Hsp90α and 7.3 µM for Hsp90β. This compound induces cellular apoptosis (apoptosis) and arrests the cell cycle at the G0/G1 phase. Additionally, HSP90-IN-33 reduces the protein expression of ERα, CDK4, and Akt.</p>Formula:C21H25Cl2N5O2Colore e forma:SolidPeso molecolare:450.36TOPOI/PARP-1-IN-2
<p>TOPOI/PARP-1-IN-2 (compound 6c) serves as a dual inhibitor targeting both PARP-1 and topoisomerase 1 (TOPO-1), with IC50 values of 32.2 nM and 46.2 nM, respectively. This compound exhibits greater selectivity for PARP-1 over PARP-2. Additionally, TOPOI/PARP-1-IN-2 disrupts the S phase of the cell cycle and induces apoptosis in the NCI-60 cancer cell lines.</p>Formula:C16H11ClN4O2SColore e forma:SolidPeso molecolare:358.80FGFR1/VEGFR2-IN-3
<p>FGFR1/VEGFR2-IN-3 (Compound 8m) acts as a dual inhibitor of FGFR1 and VEGFR2. This compound exhibits both anti-cancer cell proliferation and anti-migration activities, and it also has the capability to induce cell apoptosis (apoptosis).</p>Formula:C27H18N4O4Colore e forma:SolidPeso molecolare:462.46ROS inducer 5
<p>ROS inducer 5 (compound 6e) induces intracellular ROS accumulation and subsequent nuclear fragmentation. It can provoke apoptosis in MCF-7 cells with an IC50 of 3.85 μM. ROS inducer 5 is useful for cancer research applications.</p>Formula:C20H15ClN4O2S3Colore e forma:SolidPeso molecolare:475.01PIM-1/CK2-IN-2
<p>PIM-1/CK2-IN-2 (compound 3aA) is an inhibitor of the PIM-1/CK2 enzymes. This compound can induce the mitochondrial apoptosis pathway in CCRF-CEM cells and is utilized in cancer research.</p>Formula:C15H8Br4N2OColore e forma:SolidPeso molecolare:551.85BCL-XL-IN-1
<p>BCL-XL-IN-1 (Compound 11) is a selective inhibitor of BCL-XL, exhibiting a Ki of less than 0.01 nM against BCL-XLTR-FERT. It is primarily used in cancer research.</p>Formula:C46H55N7O6SColore e forma:SolidPeso molecolare:834.04LSD1-IN-36
<p>LSD1-IN-36, an effective LSD1 inhibitor with an IC50 value of 0.8 nM, induces cell apoptosis and arrests the cell cycle. This compound also exhibits antitumor activity.</p>Formula:C22H25N3O6SColore e forma:SolidPeso molecolare:459.52PEAQX tetrasodium hydrate
<p>PEAQX tetrasodium hydrate: potent/selective oral NMDA antagonist, IC50 270 nM (1A/2A), 29600 nM (1A/2B).</p>Formula:C17H15BrN3Na4O6PPurezza:99%Colore e forma:SolidPeso molecolare:560.15Antiproliferative agent-59
<p>Antiproliferative agent-59 (Compound 14u) acts as an inhibitor of tubulin polymerization. Demonstrating anticancer activity in Huh7, SGC-7901, and MCF-7 cell lines, this compound achieves IC50 values of 0.03, 0.18, and 0.13 μM, respectively. Additionally, it arrests the cell cycle at the G2/M phase and induces apoptosis in Huh7 cells. In a xenograft mouse model utilizing Huh7 cells, Antiproliferative agent-59 exhibits antitumor effects against hepatocellular carcinoma without significant toxicity.</p>Formula:C26H22N2O3Colore e forma:SolidPeso molecolare:410.46PD-1-IN-20
<p>PD-1-IN-20 is the less active enantiomer of PD-1-IN-1.</p>Formula:C12H20N6O7Purezza:98%Colore e forma:SolidPeso molecolare:360.32UZH1a
CAS:<p>UZH1a: METTL3 inhibitor, IC50 280 nM, used for epitranscriptomic modulation and has antitumor properties.</p>Formula:C32H42N6O3Colore e forma:SoildPeso molecolare:558.71Thiocolchicine
CAS:<p>Thiocolchicine inhibits tubulin polymerization (IC50: 2.5 µM, Ki: 0.7 µM), induces apoptosis, and serves as an ADC cytotoxin.</p>Formula:C22H25NO5SPurezza:98.19%Colore e forma:SolidPeso molecolare:415.5Diethyl phthalate
CAS:<p>Diethyl phthalate disrupts endocrine and induces apoptosis in PC12 cells; common in plastics, personal care items.</p>Formula:C12H14O4Purezza:99.68% - 99.8%Colore e forma:SolidPeso molecolare:222.24MDM2 ligand 4
<p>MDM2ligand 4 is a ligand of MDM2 and can be used in the synthesis of the PROTAC degrader [KT-253].</p>Formula:C31H33Cl2FN2O4Colore e forma:SolidPeso molecolare:587.509EGFR-IN-143
<p>EGFR-IN-143 (Compound 5f) is a potent EGFR inhibitor with an IC50 value of 0.15 μM. It induces apoptosis by arresting the cell cycle at the G2/M phase and exhibits antitumor activity.</p>Formula:C20H21ClN6O3Colore e forma:SolidPeso molecolare:428.872TrxR-IN-7
<p>TrxR-IN-7 (14f) is a potent inhibitor of thioredoxin reductase (TrxR), with an IC50 value of 3.5 µM. It exhibits antiproliferative activity and can induce apoptosis and the production of reactive oxygen species (ROS).</p>Formula:C22H21NO3Colore e forma:SolidPeso molecolare:347.407TS-IN-5
<p>TS-IN-5 (Compound 15) is an inhibitor of thymidylate synthase (TS). It induces apoptosis by modulating the proteins Bax, BCL-2, PI3K, and STAT1. TS-IN-5 exhibits antitumor activity against liver cancer, breast cancer, and colon cancer.</p>Formula:C16H17N5OSColore e forma:SolidPeso molecolare:327.404HDAC-IN-84
<p>HDAC-IN-84 (compound 4a) is a potent HDAC inhibitor with IC50 values of 0.0045, 0.015, 0.013, 0.038, 5.8, and 26 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC11, respectively. It effectively inhibits the proliferation of leukemia cells without causing toxicity.</p>Formula:C17H21N3O5SColore e forma:SolidPeso molecolare:379.431Ropeginterferon alfa-2b
CAS:<p>Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft), a monopegylated interferon-alpha (IFN-α), is utilized in the study of myeloproliferative neoplasms [1].</p>Colore e forma:LiquidEchitamine chloride
CAS:<p>Echitamine chloride, an alkaloid in Alstonia scholaris, has anti-cancer properties and inhibits pancreatic lipase (IC50: 10.92 µM).</p>Formula:C22H29ClN2O4Colore e forma:SolidPeso molecolare:420.93DefNEtTrp
<p>DefNEtTrp is an iron bis-chelating ligand composed of Def and Trp groups. It demonstrates potent broad-spectrum antiproliferative and cytotoxic effects in cancer cell lines. DefNEtTrp induces apoptosis and ferroptosis, exhibiting cytotoxicity with an IC50 value of 0.77 μM.</p>Formula:C30H27N9O3SColore e forma:SolidPeso molecolare:593.659TTQ-SA
<p>TTQ-SA is a near-infrared spiraling aggregation-induced emitter capable of converting near-infrared light (NIR) into thermal energy, resulting in thermal damage and death of tumor cells. In cancer cells MF-7, TTQ-SA shows cell uptake and targeting capabilities. TTQ-SA binds with DNAzyme to inhibit the expression of the survivin gene, enhancing the sensitivity of tumor cells to photothermal therapy.</p>Formula:C78H53N7SColore e forma:SolidPeso molecolare:1120.37Thalidomide-O-amido-C3-COOH
CAS:<p>Thalidomide-O-amido-C3-COOH is a cereblon ligand-linker for PROTACs, melding Thalidomide with a standard linker.</p>Formula:C19H19N3O8Purezza:98%Colore e forma:SolidPeso molecolare:417.37PROTAC XPO1 degrader-1
<p>PROTAC XPO1 degrader-1 (Compound 2c) is an XPO1 degrader. It exhibits anti-proliferative effects, induces apoptosis, inhibits NF-κB activity, and causes cell cycle arrest at the G1 phase. PROTAC XPO1 degrader-1 is applicable to research on hematological malignancies.</p>Formula:C33H35ClF3N7O7Colore e forma:SolidPeso molecolare:734.122Thalidomide-NH-PEG8-Ts
CAS:<p>Thalidomide-NH-PEG8-Ts: a synthesized Thalidomide-PEG8 E3 ligase linker for PROTAC-mediated IDO1 degradation.</p>Formula:C36H49N3O14SColore e forma:SolidPeso molecolare:779.86Ganoderic acid Mf
CAS:<p>Ganoderic acid Mf: antitumor triterpenoid, arrests G1 cell cycle, selective for cancer cells, triggers apoptosis via mitochondria.</p>Formula:C32H48O5Colore e forma:SolidPeso molecolare:512.72Malformin A
CAS:<p>Malformin A, from A. niger, is a plant growth regulator and has anti-TMV and cancer cell cytotoxic properties. Intraperitoneal LD50 in mice is 3.1 mg/kg.</p>Formula:C23H39N5O5S2Colore e forma:SolidPeso molecolare:529.72STEP-IN-1
<p>STEP-IN-1 (Compound 14b) is a potent and selective inhibitor of STEP, with an IC50 of 5.27 μM. It offers neuroprotective effects by safeguarding neuronal cells from glutamate-induced toxicity, reducing intracellular reactive oxygen species (ROS) accumulation, and inhibiting apoptosis. STEP-IN-1 is applicable in research related to neurodegenerative diseases.</p>Formula:C21H10ClNO7Colore e forma:SolidPeso molecolare:423.76JAK-IN-40
<p>JAK-IN-40 (Compound 46) is an inhibitor of JAK, effectively targeting JAK1, JAK2, and JAK3 with IC50 values of 0.022, 0.759, and 1.601 μM, respectively. It reduces the phosphorylation of STAT3 and inhibits the proliferation of cancer cells Ba/F3 and JAK1-TEL Ba/F3 with GI50 values of 0.614 μM and 0.193 μM. JAK-IN-40 arrests cell cycle progression at the G2/M phase in H1975 and H2087 cells, leading to apoptosis. Additionally, JAK-IN-40 exhibits a synergistic anti-tumor effect when used in combination with Osimertinib.</p>Formula:C26H32N8O3SColore e forma:SolidPeso molecolare:536.65Aviculin
CAS:<p>Aviculin, a lignan glycoside, exhibits anticancer properties by inducing apoptosis in breast cancer cells with an IC50 of 75.47 μM.</p>Formula:C26H34O10Colore e forma:SolidPeso molecolare:506.54TrxR1-IN-2
<p>TrxR1-IN-2 (Compound 6a) acts as a TrxR1 inhibitor that covalently bonds with the Cys475 and Sec498 sites of TrxR1. This interaction hampers TrxR1 activity, resulting in a redox homeostasis disruption and inducing apoptosis and ferroptosis.</p>Formula:C19H23NO6Colore e forma:SolidPeso molecolare:361.389F1324 TFA
<p>F1324 TFA is a potent, high affinity peptidic inhibitor of B cell lymphoma 6 (BCL6), with an IC50 of 1 nM.</p>Formula:C85H122N21F3O22SPurezza:98%Colore e forma:SolidPeso molecolare:1879.06Finotonlimab
<p>Finotonlimab (SCT-I10A), a humanized IgG PD-1 monoclonal antibody, shows potential in the research of solid tumors or lymphomas [1].</p>Colore e forma:Odour LiquidDual Galectin-3/EGFR-IN-1
<p>Dual Galectin-3/EGFR-IN-1 (Compound 29) is a dual inhibitor targeting Galectin-3 and EGFR, with dissociation constants (KD) of 52.29 μM and 3.31 μM, respectively. It inhibits TGF-β-induced hepatic stellate cell (HSC) activation, induces apoptosis in LX-2 cells, and shows antifibrotic activity in the liver.</p>Formula:C32H41N7O10Colore e forma:SolidPeso molecolare:683.709WR-S-462
<p>WR-S-462 is a STAT3 inhibitor. It effectively blocks the phosphorylation and biological functions of STAT3 in vitro. The IC50 of WR-S-462 for inhibiting MDA-MB-231 cells is 0.03 μM, and it exhibits a strong binding affinity for STAT3 protein with a Kd of 58 nM. WR-S-462 prevents the nuclear translocation of p-STAT3 and selectively inhibits the expression of p-STAT3Tyr705 in MDA-MB-231 cells, as well as the expression of downstream target genes regulated by STAT3, such as Cyclin D1, Bcl-2, and Bcl-xl. This compound inhibits the growth and metastasis of triple-negative breast cancer (TNBC).</p>Formula:C24H22N4O4SColore e forma:SolidPeso molecolare:462.52YTHDF2-IN-1
<p>YTHDF2-IN-1 (Compound CK-75) is an inhibitor of YT521-B homology domain family 2 (YTHDF2) with a dissociation constant (Kd) of 26.2 μM, and it effectively blocks the interaction between YTHDF2 and m6A RNA. It suppresses colony formation in JAR cells and exhibits antiproliferative activity in various cancer cell lines, with an IC50 in the micromolar range. Additionally, YTHDF2-IN-1 induces apoptosis in K562 cells and causes cell cycle arrest at the G0/G1 phase.</p>Formula:C21H14N2O4Colore e forma:SolidPeso molecolare:358.35Human membrane-bound PD-L1 polypeptide
CAS:<p>Human membrane-bound PD-L1 polypeptide serves as an antigen for inducing the production of PD-L1 antibodies [1].</p>Formula:C85H140N26O36SPurezza:98%Colore e forma:SolidPeso molecolare:2134.24BK50164
CAS:<p>BK50164: CD73 inhibitor, IC50=13.089µM; binds CD99, KD=1.5µM; anticancer, induces apoptosis, arrests sub-G1.</p>Formula:C13H13ClFN5O7Colore e forma:SolidPeso molecolare:405.72FLT3-IN-21
<p>FLT3-IN-21 (compound LC-3), a potent FLT3 inhibitor with an IC50 value of 8.4 nM, induces apoptosis and arrests the cell cycle in the G1 phase.</p>Formula:C20H22FN5O2Colore e forma:SolidPeso molecolare:383.42BM-1197
CAS:<p>BM-1197, a highly potent and specific dual inhibitor of Bcl-2 and Bcl-xL, effectively targets these proteins with IC50 values of 3.5 nM and 5.2 nM for Bcl-2 and</p>Formula:C53H59ClF4N6O7S4Colore e forma:SolidPeso molecolare:1131.77ReACp53
<p>ReACp53 inhibits amyloid formation, restores p53 in cancer cells and HGSOC-derived organoids.</p>Formula:C108H206N52O24Purezza:98%Colore e forma:SolidPeso molecolare:2617.13PROTAC Bcl-xL degrader-1
<p>PROTAC Bcl-xL degrader-1 targets Bcl-xL & IAP E3 ligases, degrades Bcl-xL, toxic to human platelets & MyLa 1929 (IC50: 62 nM, 8.5 μM).</p>Formula:C76H96ClF3N10O11S3Colore e forma:SolidPeso molecolare:1514.28VB-85247
<p>VB-85247 is a STING agonist that, by activating the STING pathway, induces the upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as the maturation and activation of dendritic cells. It can lead to the regression of tumors within the bladder and is applicable in bladder cancer research.</p>Colore e forma:Odour Solid(D)-PPA 1 TFA
<p>(D)-PPA 1 TFA is a hydrolysis-resistant D-peptide antagonist and a potent PD-1/PD-L1 inhibitor, exhibiting an affinity for PD-1 of 0.51 μM and demonstrating</p>Formula:C72H99F3N20O23Purezza:98%Colore e forma:SolidPeso molecolare:1669.67Ecdysone
CAS:<p>Ecdysone is a major steroid hormone in insects and herbs.</p>Formula:C27H44O6Purezza:99.22%Colore e forma:PowderPeso molecolare:464.63Apoptosis inducer 3
CAS:<p>Apoptosis Inducer 3 (Compound 3), a selective apoptosis triggering agent, induces both apoptosis and late-apoptosis phases, demonstrating cytotoxic effects</p>Formula:C49H55ClN2O7Colore e forma:SolidPeso molecolare:819.42
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