Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(8 prodotti)
- Caspasi(144 prodotti)
- FOXO1(3 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(139 prodotti)
- PDK(9 prodotti)
- PERK(26 prodotti)
- Chinasi di serina/treonina(18 prodotti)
- Survivin(14 prodotti)
- TNF(93 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6084 prodotti di "Apoptosi"
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eIF4A-IN-3
CAS:eIF4A-IN-3 (Compound 71E) is an inhibitor of the eukaryotic translation initiation factor 4A (eIF4A). This compound can be utilized as a cytotoxic payload for antibody-drug conjugates (ADCs).Formula:C34H37N3O7Colore e forma:SolidPeso molecolare:599.67GQN-B37-E
CAS:GQN-B37-E is an effective selective binder and inhibitor of MCL-1. It binds to the BH3-binding domain of MCL-1. GQN-B37-E demonstrates binding affinity for MCL-1 within the sub-micromolar range (Ki= 0.6 μM), yet shows negligible binding to BCL-2 or BCL-XL.Formula:C29H23ClN4O4Colore e forma:SolidPeso molecolare:526.97Multi-kinase-IN-1
CAS:Multi-kinase-IN-1, a powerful kinase inhibitor, exhibits antitumor properties by inducing cell apoptosis.Formula:C35H36F2N6O6SColore e forma:SolidPeso molecolare:706.76MA242 free base
CAS:MA242 free base is a dual MDM2/NFAT1 inhibitor that triggers apoptosis in pancreatic cancer cells.Formula:C24H20ClN3O3SColore e forma:SolidPeso molecolare:465.95Necrosis inhibitor 3
CAS:Necrosis Inhibitor 3 (compound B3) effectively inhibits necrosis, demonstrating an IC50 of 0.29 nM in HT29 cells [1].Formula:C25H26N4O4SColore e forma:SolidPeso molecolare:478.56FLT3-ITD-IN-3
CAS:FLT3-ITD-IN-3 (13v) is an orally active inhibitor of FLT3-ITD (internal tandem duplication of FLT3), which works by blocking FLT3 signaling. This inhibition leads to cell cycle arrest in the G0/G1 phase and induces apoptosis. The compound is currently employed in studies related to acute myeloid leukemia (AML).Formula:C27H21ClF2N6O5Colore e forma:SolidPeso molecolare:582.943MA242
CAS:MA242 is a nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy and dual inhibitor of murine double minute 2 (MDM2).Formula:C26H21ClF3N3O5SPurezza:98%Colore e forma:SolidPeso molecolare:579.98KDM1/CDK1-IN-1
KDM1/CDK1-IN-1 inhibits KDM1 (IC50: 0.096 μM) & CDK1 (IC50: 0.078 μM), blocks HOP-92 G2/M phase, induces apoptosis, toxic to cancer cells.Formula:C22H17N5O3SColore e forma:SolidPeso molecolare:431.47FKBP51-Hsp90-IN-2
CAS:FKBP51-Hsp90-IN-2 (Compound E08) functions as a selective inhibitor for the FKBP51 - Hsp90 protein-protein interaction, exhibiting IC 50 values of 0.4 µM for FKBP51 and 5 µM for FKBP52. Beyond its inhibitory actions, FKBP51-Hsp90-IN-2 enhances cellular energy metabolism and promotes neurite growth. This compound is utilized in the study of neurodegenerative diseases and cancer [1].Formula:C25H27N3O2SPeso molecolare:433.57SM-433 hydrochloride
SM-433 hydrochloride, a Smac mimetic & IAP inhibitor, binds XIAP BIR3; potent IC50 <1 μM. (Patent WO2008128171A2)Formula:C32H44ClN5O4Colore e forma:SolidPeso molecolare:598.18Citric acid-13C2
CAS:Citric acid-13C2 is a 13C-labeled form of citric acid. Citric acid serves as a preservative and food additive. It induces apoptosis in HaCaT cells and causes cell cycle arrest at the G2/M and S phases. Additionally, citric acid contributes to liver oxidative damage by reducing antioxidant enzyme activity. It also functions as an acidulant, emulsifier, chelating agent, and buffer, with extensive applications across multiple industries.Formula:C6H8O7Colore e forma:SolidPeso molecolare:194.11eIF4A3-IN-6
CAS:eIF4A3-IN-6 is a potent eIF4A inhibitor, potentially used for treating eIF4A-related diseases like cancer. (US20170145026A1)Formula:C26H25N3O5Colore e forma:SolidPeso molecolare:459.49XIAP degrader-1
XIAP degrader-1 is a small primary amine molecule that promotes the degradation of X-linked apoptosis inhibitory protein (XIAP).Formula:C34H45N5O4Colore e forma:SolidPeso molecolare:587.75GGTI-2154 hydrochloride
CAS:GGTI-2154 hydrochloride: selective GGTase I inhibitor, IC50 21 nM, used in cancer research.Formula:C24H29ClN4O3Colore e forma:SolidPeso molecolare:456.97VEGFR-IN-3
CAS:VEGFR-IN-3 inhibits cancer cell growth (OVCAR-4, MDA-MB-468) with IC50s: 0.29, 0.35μM. Used in cancer research.Formula:C27H28N2O6Colore e forma:SolidPeso molecolare:476.52Tubulin polymerization-IN-6
Compound 5f, a potent tubulin polymerization inhibitor (IC50 = 1.09 μM), blocks cell migration, tube formation, and has anti-angiogenic effects.Formula:C19H21NO7Colore e forma:SolidPeso molecolare:375.37GRP78-IN-1
GRP78-IN-1 binds to GRP78 protein, inhibits cell growth, and triggers apoptosis in breast cancer; has -8.07 kcal/mol binding energy.Formula:C21H23FO3Colore e forma:SolidPeso molecolare:342.4EGFR-IN-47
EGFR-IN-47: strong oral EGFRL858R/T790M/C797S blocker, induces cell death; promising for NSCLC research. IC50: 0.01 μM.Formula:C29H35N7Colore e forma:SolidPeso molecolare:481.64PD-1/PD-L1-IN-23
CAS:PD-1/PD-L1-IN-23: potent, oral PD-1/PD-L1 inhibitor; L7's ester prodrug; exhibits strong antitumor effects.Formula:C32H30BrCl2N3O6Colore e forma:SolidPeso molecolare:703.41GlcNAc-MurNAc
CAS:GlcNAc-MurNAc is a disaccharide and mild TLR4 agonist with a Kd of 383 μM for mouse TLR4. It directly binds to TLR4, activating the downstream NF-κB and IRF pathways. Additionally, GlcNAc-MurNAc ameliorates dextran sulfate sodium salt (DSS)-induced colitis in mice through a TLR4-dependent mechanism, making it useful for inflammatory bowel disease research.Formula:C19H32N2O13Colore e forma:SolidPeso molecolare:496.46Z-VAD-AMC
CAS:Z-VAD-AMC acts as a substrate specifically for caspase-9.Formula:C30H34N4O9Peso molecolare:594.61ABL-L
CAS:ABL-L is able to induce apoptosis in human laryngeal cancer cells using a p53-dependent pathway.Formula:C29H46O6Colore e forma:SolidPeso molecolare:490.67Antitumor agent-184
CAS:Antitumor Agent-184 (compound 12aa) triggers apoptosis in various cell lines, exhibiting IC50 values of 2.35 μM in B16-F10 cells, 7.32 μM in 4T1 cells, and 10.31 μM in CT26 cells.Formula:C22H16N4O2SColore e forma:SolidPeso molecolare:400.45RET-IN-10
CAS:RET-IN-10: Potent RET inhibitor, may treat congenital megacolon and tumors (Patent WO2021135938A1, compound 18).Formula:C29H28N8OSColore e forma:SolidPeso molecolare:536.65Lometrexol disodium
CAS:Lometrexol disodium: Inhibits hSHMT1/2 and GARFT, anticancer by blocking purine synthesis, induces apoptosis and cell cycle arrest.Formula:C21H23N5Na2O6Colore e forma:SolidPeso molecolare:487.424TNF-α-IN-2
CAS:TNF-α-IN-2 is orally active TNFα inhibitor that distorts the TNFα trimer, causing abnormal signal transduction when it binds to TNFR1, rheumatoid arthritis.Formula:C25H21ClF2N6OPurezza:99.92%Colore e forma:SolidPeso molecolare:494.92Nalmefene
CAS:Nalmefene (ORF 11676) is a μ-opioid antagonist and partial κ agonist used in the study of opioid overdose and alcohol dependence.Formula:C21H25NO3Purezza:99.86%Colore e forma:SolidPeso molecolare:339.43Zotatifin
CAS:Zotatifin (eFT226) is a selective eIF4A inhibitor with antiviral and antitumor properties, inhibiting Sox4 translation and inducing apoptosis.Formula:C28H29N3O5Purezza:98.85%Colore e forma:SolidPeso molecolare:487.55Tuvusertib
CAS:Tuvusertib (M1774), an oral ATR inhibitor (Ki<1µM), selectively blocks CHK1 phosphorylation, disrupts DNA repair, and induces tumor cell apoptosis.Formula:C16H12F2N8OPurezza:98.44% - 99.66%Colore e forma:SolidPeso molecolare:370.32Ref: TM-T10406
1mg62,00€5mg131,00€10mg197,00€25mg383,00€50mg533,00€100mg757,00€1mL*10mM (DMSO)150,00€Milademetan
CAS:Milademetan (DS-3032), an MDM2 inhibitor, exhibits antitumor activity, induces G1 cell cycle arrest and apoptosis, and can be used to study solid tumors.Formula:C30H34Cl2FN5O4Purezza:>99.99%Colore e forma:SolidPeso molecolare:618.53Ref: TM-T12040
1mg87,00€5mg170,00€10mg274,00€25mg518,00€50mg847,00€100mg1.454,00€1mL*10mM (DMSO)234,00€HC-5404
CAS:HC-5404 is a potent and selective PERK inhibitor, blocking the activation of the PERK pathway, anti-tumor effects, advanced solid tumors and renal cell Cancer.Formula:C24H24F2N4O3Purezza:99.33%Colore e forma:SolidPeso molecolare:454.47PF-07328948
CAS:PF-07328948 is a branched-chain keto-acid dehydrogenase kinase (BDK) inhibitor, useful for studying CVD metabolic disorders.Formula:C16H8F4O3SPurezza:98.42%Colore e forma:SolidPeso molecolare:356.29Vatalanib hydrochloride
CAS:Vatalanib hydrochloride (PTK787 hydrochloride) is an orally available and highly potent tyrosine kinase (VEGF) inhibitor that reduces the number and size of Aβ plaques in the cortex of 5xFAD mice, which may be useful in the study of Alzheimer's disease and cancer.Formula:C20H16Cl2N4Purezza:99.7%Colore e forma:SolidPeso molecolare:383.27SY-5609
CAS:SY-5609 (CDK7-IN-3) is a selective non-covalent CDK7 inhibitor, with weak inhibitory activity against CDK2, CDK9 and CDK12.Cost-effective and quality-assured.Formula:C23H26F3N6OPPurezza:99.34% - >99.99%Colore e forma:SolidPeso molecolare:490.46Ref: TM-T36038
1mg139,00€2mg200,00€5mg343,00€10mg553,00€25mgPrezzo su richiesta50mgPrezzo su richiesta1mL*10mM (DMSO)373,00€Lometrexol
CAS:<p>Lometrexol (LY 264618) is an antifolate that inhibits GARFT, blocks purine synthesis, induces apoptosis, and has anticancer properties.</p>Formula:C21H25N5O6Purezza:97.76% - 99.56%Colore e forma:SolidPeso molecolare:443.45Zharp1-211
CAS:Zharp1-211 is a RIPK3 inhibitor，reduces JAK/ stat1-mediated chemokines and MHC class II molecules in IECs, (GVHD) for gastrointestinal inflammation.Formula:C24H25N5O4Purezza:99.71%Colore e forma:SolidPeso molecolare:447.49Ref: TM-T87664
1mg87,00€5mg183,00€10mg283,00€25mg562,00€50mg873,00€100mg1.311,00€200mg1.768,00€1mL*10mM (DMSO)202,00€UH15-38
CAS:UH15-38 is a potent and selective RIPK3 inhibitor that blocks necroptosis in alveolar epithelial cells triggered by IAV, useful for studying lung inflammation.Formula:C26H27N5O2Purezza:99.85%Colore e forma:SolidPeso molecolare:441.53Darizmetinib
CAS:Darizmetinib (HRX215) is an MKK4 inhibitor.Formula:C21H17F2N5O3SPurezza:98.03% - 99.57%Colore e forma:SolidPeso molecolare:457.45Ref: TM-T72956
1mg72,00€2mgPrezzo su richiesta5mg156,00€10mg235,00€25mg343,00€50mg423,00€100mg620,00€1mL*10mM (DMSO)157,00€BCL6-IN-3
CAS:BCL6-IN-3: potent BCL6 inhibitor, 70 nM GI50 in SU-DHL4, affects cell functions, antitumor.Formula:C24H31ClF2N6O2Purezza:98.17%Colore e forma:SolidPeso molecolare:508.99Ref: TM-T10487
1mg115,00€5mg255,00€10mg375,00€25mg562,00€50mg787,00€100mg1.074,00€500mgPrezzo su richiesta1mL*10mM (DMSO)391,00€JAK2-IN-7
CAS:JAK2-IN-7 selectively inhibits JAK2 (IC50: 3 nM), shows 14-fold selectivity over JAK1/3, FLT3, induces G0/G1 arrest, apoptosis, and has antitumor effects.Formula:C26H33N7OPurezza:99.54%Colore e forma:SolidPeso molecolare:459.59Ref: TM-T35900
1mg145,00€5mg354,00€10mg630,00€25mg1.301,00€50mg1.738,00€100mg2.357,00€1mL*10mM (DMSO)358,00€Gemcitabine elaidate hydrochloride
CAS:<p>CP-4126, a lipophilic pro-drug of Gemcitabine, converts to active form by esterases, allowing oral administration with dose-dependent effects.</p>Formula:C27H44ClF2N3O5Purezza:98.50% - 99.6%Colore e forma:SolidPeso molecolare:564.11FX-11
CAS:<p>FX-11: potent LDHA inhibitor (Ki 8 μM), activates PKM2, reduces ATP, induces oxidative stress/ROS, cell death, shows antitumor effects.</p>Formula:C22H22O4Purezza:98.95%Colore e forma:SolidPeso molecolare:350.41AP1867-3-(aminoethoxy)
CAS:AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.Formula:C38H50N2O9Colore e forma:SolidPeso molecolare:678.81(R)-Verapamil hydrochloride
CAS:(R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is an inhibitor of P-Glycoprotein.Formula:C27H39ClN2O4Colore e forma:SolidPeso molecolare:491.06β-Zearalanol
CAS:Beta-Zearalenol, a derivative of zearalenone (ZEA) capable of conjugating with glucuronic acid[2], is a mycotoxin produced by Fusarium spp. It induces apoptosis and oxidative stress in mammalian reproductive cells[1].Formula:C18H26O5Colore e forma:SolidPeso molecolare:322.4PIM-447 dihydrochloride
CAS:PIM-447 dihydrochloride is an orally available and selective inhibitor of pan-PIM kinase(Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively).Formula:C24H25Cl2F3N4OPurezza:98%Colore e forma:SolidPeso molecolare:513.38OBAA
CAS:OBAA is a potent inhibitor of phospholipase A2 (PLA2) with an IC 50 of 70 nM. OBAA blocks Melittin-induced Ca 2+ influx in Trypanosoma brucei with an IC 50 of 0.4 μM [1] [2] [3].Formula:C28H44O3Purezza:98%Colore e forma:SolidPeso molecolare:428.65WEHI-539 hydrochloride
CAS:WEHI-539 hydrochloride is a selective Bcl-XL inhibitor with an IC50 of 1.1 nM.Formula:C31H30ClN5O3S2Purezza:98%Colore e forma:SolidPeso molecolare:620.18PRGL493
CAS:PRGL493 blocks ACSL4, halts PC3/MDA-MB-231 cancer cell spread, and inhibits MA-10 tumor progesterone. Effective in mouse PC3 tumor model at 0.25 mg/kg.Formula:C25H21N7O2Purezza:98.80% - 99.11%Colore e forma:SolidPeso molecolare:451.48Platinum, diammine[1,1-cyclobutanedi(carboxylato-kO)(2-)]-, (SP-4-2)-
CAS:Formula:C6H10N2O4PtPurezza:98%Colore e forma:SolidPeso molecolare:369.2326Ref: IN-DA00I84B
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