Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(6 prodotti)
- BCL(11 prodotti)
- Caspasi(125 prodotti)
- FOXO1(3 prodotti)
- IAP(66 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(125 prodotti)
- PDK(9 prodotti)
- PERK(25 prodotti)
- Chinasi di serina/treonina(15 prodotti)
- Survivin(13 prodotti)
- TNF(92 prodotti)
- c-RET(51 prodotti)
- p53(62 prodotti)
Mostrare 6 più sottocategorie
Trovati 5598 prodotti di "Apoptosi"
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Prodigiosin hydrochloride
CAS:<p>Prodigiosin hydrochloride is a bioactive red pigment from bacteria with antibacterial, antifungal, anticancer properties, and inhibits Wnt/β-catenin.</p>Formula:C20H26ClN3OColore e forma:SolidPeso molecolare:359.9CDK9-Cyclin T1 PPI-IN-1
<p>CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective inhibitor of the CDK9-Cyclin T1 protein-protein interaction (PPI), suppressing cell proliferation in TNBC</p>Purezza:98%Colore e forma:Odour SolidPH14
<p>PH14, a dual PI3K/HDAC inhibitor, demonstrates potent inhibition with IC50 values of 20.3 nM for PI3Kα and 24.5 nM for HDAC3.</p>Purezza:98%Colore e forma:Odour SolidGemcitabine monophosphate sodium salt hydrate
CAS:<p>Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine.</p>Formula:C9H12F2N3Na2O8PPurezza:98%Colore e forma:SolidPeso molecolare:405.16Thalidomide-NH-C10-COOH
<p>Compound 6b is a synthetic Thalidomide-VHL E3 ligase-linker for PROTACs.</p>Formula:C24H31N3O6Purezza:98%Colore e forma:SolidPeso molecolare:457.52c-JUN peptide
CAS:<p>Peptide from c-Jun (33-57) blocks JNK binding, inhibits phosphorylation, upregulates p21, and induces HeLa cell apoptosis.</p>Formula:C121H210N36O34SPurezza:98%Colore e forma:SolidPeso molecolare:2743.55PPIA-IN-1
<p>PPIA-IN-1 (Compound 20b) is an inhibitor of peptidyl-prolyl isomerase A (PPIA) with a KD of 0.52 μM. It demonstrates antiproliferative activity across various cancer cell lines, including an IC50 of 0.69 μM in HCT116 cells, induces cell cycle arrest at the G0/G1 phase, and exhibits antimetastatic effects in HCT116 cells. PPIA-IN-1 elevates ROS levels, causing DNA damage, ER stress, and mitochondrial dysfunction, and induces apoptosis in HCT116 cells via the MAPK pathway. Additionally, PPIA-IN-1 shows antitumor activity in a CT26 xenograft mouse model.</p>Formula:C23H21Cl2FN4O7Colore e forma:SolidPeso molecolare:555.34PARP1-IN-27
<p>PARP1-IN-27 (Compound 9B) serves as an inhibitor of both PARP1 and PARP2, exhibiting IC 50 values of 2.53 nM and 6.45 nM, respectively, in SUM149PT cells. This compound effectively suppresses the proliferation of BRCA-mutated cancer cell lines such as SUM149PT, HCC1937, and Capan-1, with respective IC 50 values of 0.62, 1.91, and 4.26 μM. Additionally, PARP1-IN-27 exacerbates DNA double-strand breaks, enhances ROS production, causes G2/M phase cell cycle arrest, and triggers apoptosis in SUM149PT cells.</p>Formula:C17H12FNO4Colore e forma:SolidPeso molecolare:313.28WEHI-3773
<p>WEHI-3773 is an inhibitor of the interaction between VDAC2 and either BAK or BAX. It prevents BAX-mediated apoptosis (Apoptosis) by blocking the recruitment of BAX to the mitochondria through VDAC2. Conversely, WEHI-3773 promotes BAK-mediated apoptosis (Apoptosis) by limiting VDAC2's inhibitory sequestration of BAK. This compound shows promise for research in the field of cancer therapy.</p>Colore e forma:Odour SolidAnticancer agent 137
<p>Anticancer agent 137 (8q), a potent PI3k inhibitor, exhibits broad-spectrum anticancer activity by inducing G2/M cell cycle arrest and apoptosis.</p>Formula:C26H27NO6Purezza:98%Colore e forma:SolidPeso molecolare:449.5ZC0109
<p>ZC0109 inhibits IDO1 (50 nM) & TrxR1 (3.0 μM), induces ROS, arrests G1/S phase, causing cancer cell apoptosis.</p>Formula:C22H20BrFN8O4SColore e forma:SolidPeso molecolare:591.41Isoharringtonine
CAS:<p>Isoharringtonine, an alkaloid from Cephalotaxus koreana, inhibits and induces apoptosis in cancer cells.</p>Formula:C28H37NO9Colore e forma:SolidPeso molecolare:531.59Aspidin BB
CAS:<p>Aspidin BB, a phloroglucinol from Dryopteris, inhibits cancer by causing cell cycle arrest and apoptosis in HO-8910 cells.</p>Formula:C25H32O8Colore e forma:SolidPeso molecolare:460.52Bax inhibitor peptide, negative control
CAS:<p>The compound is a negative control peptide for the Bax inhibitor peptides V5 and P5.</p>Formula:C28H52N6O6SPurezza:98%Colore e forma:SolidPeso molecolare:600.81Pipernonaline
CAS:<p>Pipernonaline is a useful organic compound for research related to life sciences. The catalog number is T124000 and the CAS number is 88660-10-0.</p>Formula:C21H27NO3Colore e forma:SolidPeso molecolare:341.451AKT-IN-18
<p>AKT-IN-18, an Akt inhibitor, demonstrates an IC50 value of 69.45 μM in A549 cells, effectively impeding Akt activity.</p>Formula:C19H14ClN5O2SPurezza:98%Colore e forma:SolidPeso molecolare:411.86Conglobatin
CAS:<p>Conglobatin is a natural product for research related to life sciences. The catalog number is T36494 and the CAS number is 72263-05-9.</p>Formula:C28H38N2O6Colore e forma:SolidPeso molecolare:498.62Eciskafusp alfa
CAS:<p>Eciskafusp alfa, a cis-targeted IL2v immunocytokine, acts on programmed cell death 1 (PDCD1, commonly known as PD-1), preferentially targeting antigen-specific</p>Purezza:98%Colore e forma:SolidThalidomide-PEG2-C2-NH2 hydrochloride
CAS:<p>Thalidomide-based cereblon ligand with 2-unit PEG linker for PROTAC, in hydrochloride form.</p>Formula:C19H25ClN4O6Purezza:98%Colore e forma:SolidPeso molecolare:440.88Apoptosis inducer 37
<p>Apoptosis inducer37 (Derivative 10) is an agent that induces apoptosis and exhibits anticancer properties by causing cell cycle arrest at the S-G2/M phase and promoting cell apoptosis. It significantly inhibits HCT116, SKOV3, and HepG2 cancer cells with IC50 values of 24.98 μM, 26.15 μM, and 23.09 μM, respectively. Apoptosis inducer37 demonstrates antitumor activity and can be utilized in ovarian cancer research.</p>Formula:C27H37BrN2O4SColore e forma:SolidPeso molecolare:564.16574PD1-PDL1-IN 1 TFA
<p>PD1-PDL1-IN 1 TFA (compound 16) is a potent inhibitor of programmed cell death 1 (PD-1), functioning as an immune modulator [1].</p>Formula:C16H24F3N7O8Colore e forma:SolidPeso molecolare:499.4VEGFR2/HDAC1-IN-1
<p>VEGFR2/HDAC1-IN-1 (compound 13) is a potent dual inhibitor of VEGFR-2 and HDAC, with IC50 values of 57.83 nM for VEGFR-2 and 9.82 nM for HDAC.</p>Purezza:98%Colore e forma:Odour Solid2,5-Dimethylcyclohexa-2,5-diene-1,4-dione
CAS:<p>2,5-Dimethylcyclohexa-2,5-diene-1,4-dione inhibits the viability of HL60 and K562 cells and exhibits antibacterial and anticancer properties.</p>Formula:C8H8O2Purezza:99.80%Colore e forma:SolidPeso molecolare:136.15JPS014 TFA
<p>JPS014 TFA, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC</p>Formula:C48H60F3N7O9SPurezza:98%Colore e forma:SolidPeso molecolare:968.09Besufetamig
CAS:<p>Besufetamig is a bispecific antibody targeting programmed cell death protein 1 (PD-1) and the CD3ε chain. It modulates immune cell activity, exerting both immunosuppressive and antitumor effects. Besufetamig holds promise for cancer research.</p>Colore e forma:LiquidApoptosis inducer 13
<p>Apoptosis Inducer 13 (Compound Ru4) promotes apoptosis in cancer cells while also suppressing their migration and invasion.</p>Formula:C59H54ClF6N8O4PRuPurezza:98%Colore e forma:SolidPeso molecolare:1220.6PUMA BH3
<p>PUMA BH3 activates Bak, binds Bcl-2; triggers apoptosis via cytochrome C release; Kd 26 nM.</p>Formula:C128H202N42O43SPurezza:98%Colore e forma:SolidPeso molecolare:3049.3RWJ-56110 dihydrochloride
CAS:<p>RWJ-56110 dihydrochloride is a potent PAR-1 inhibitor (IC50=0.44μM), blocking platelet aggregation, angiogenesis, and induces apoptosis. No PAR-2/3/4 effect.</p>Formula:C41H44Cl3F2N7O3Colore e forma:SolidPeso molecolare:827.2Mangafodipir trisodium
CAS:<p>Mangafodipir trisodium can enhance contrast in magnetic resonance imaging (MRI) of the liver, is a contrast agent delivered intravenously.</p>Formula:C22H27MnN4Na3O14P2Purezza:98%Colore e forma:SolidPeso molecolare:757.32eIF4E-IN-2
CAS:<p>eIF4E-IN-2 effectively inhibits eIF4e, crucial for research on diseases like cancer.</p>Formula:C37H33ClF2N8O4S2Colore e forma:SolidPeso molecolare:791.29Bcl-2-IN-5
CAS:<p>Bcl-2-IN-5: BCL-2 inhibitor, IC50: 0.12 nM (wt), 0.14 nM (D103Y), 0.22 nM (G101V); Cell growth IC50: 0.2 nM, 0.44 nM (RS4;11).</p>Formula:C55H63FN8O8SColore e forma:SolidPeso molecolare:1015.2JNK-1-IN-3
CAS:<p>JNK-1-IN-3 (Compound 9e) downregulates JNK1 and phosphorylated JNK1, reduces c-Jun and c-Fos expression in tumours, and restores p53 activity.</p>Formula:C19H17FN4O3Purezza:97.551%Colore e forma:SolidPeso molecolare:368.36Thalidomide-O-C8-COOH
CAS:<p>Thalidomide-O-C8-COOH, also known as Cereblon ligand 3, is a Thalidomide-derived compound that serves as a Cereblon (CRBN) ligand for the targeted recruitment</p>Formula:C22H26N2O7Colore e forma:SolidPeso molecolare:430.45AP1867-2-(carboxymethoxy)
CAS:<p>AP1867-2-(carboxymethoxy), a moiety based on the synthetic FKBP12F36V-directed ligand AP1867, connects to the CRBN ligand through a linker to generate dTAG</p>Formula:C38H47NO11Colore e forma:SolidPeso molecolare:693.78Anticancer agent 273
<p>Anticanceragent 273 (Compound 9q) is an effective anticancer compound identified from matrine. It inhibits cancer cell proliferation, with an IC50 of 4.48 μM against HeLa cells. Anticanceragent 273 exerts its anticancer effects by modulating PI3K/AKT expression and activating activating transcription factor 4 (ATF4), which induces endoplasmic reticulum stress and triggers apoptosis. It holds potential for cancer research, including cervical cancer.</p>Colore e forma:Odour SolidDJ4
CAS:<p>DJ4 induces a dose-dependent pro-apoptotic effect in the micromolar range.</p>Formula:C19H16N4OSPurezza:≥98%Colore e forma:SoildPeso molecolare:348.42Platycoside G3
CAS:<p>Platycoside G3 is a useful organic compound for research related to life sciences. The catalog number is T124100 and the CAS number is 849758-44-7.</p>Formula:C63H102O32Colore e forma:SolidPeso molecolare:1371.48Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine
CAS:<p>Cereblon ligand for PROTAC R&D; has E3 ligase, alkylC1-PEG3-alkylC3 linker, terminal amine. Part of Arvinas-licensed tool molecules.</p>Formula:C25H35ClN4O9Colore e forma:SolidPeso molecolare:571.02Polyinosinic-polycytidylic acid potassium
CAS:<p>Poly(I:C) potassium is a synthetic RNA analog, activates TLR3/RIG-I, used as a vaccine adjuvant, and induces apoptosis in cancer cells.</p>Formula:(C10H13N4O8P)x·(C9H14N3O8P)x·xKColore e forma:SolidThalidomide-O-PEG4-amine
CAS:<p>Thalidomide-O-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].</p>Formula:C23H31N3O9Purezza:98%Colore e forma:SolidPeso molecolare:493.51Aphidicolin
CAS:<p>Aphidicolin blocks DNA synthesis, hinders herpes virus growth, and stimulates apoptosis in leukemia cells; it's a mold-derived DNA polymerase inhibitor.</p>Formula:C20H34O4Purezza:>99.99%Colore e forma:SolidPeso molecolare:338.48CST626
CAS:<p>CST626 is a PROTAC degrader that targets XIAP, cIAP1, and cIAP2.</p>Formula:C61H82N8O9SPurezza:95.87%Colore e forma:SolidPeso molecolare:1103.42Topoisomerase II inhibitor 14
CAS:<p>Topoisomerase II inhibitor 14: powerful anticancer agent that induces apoptosis, halts S phase, and lowers GSH, MDA, and NO levels.</p>Formula:C15H11Cl2N5Purezza:99.62%Colore e forma:SoildPeso molecolare:332.19HQY1428
<p>HQY1428 is an orally active CDK12 inhibitor. It impedes DNA replication, causing cell cycle arrest at the G2/M phase in SKOV3 cells, and induces DNA double-strand breaks as well as apoptosis. In the SKOV3 xenograft mouse model, HQY1428 demonstrates antitumor activity. Additionally, when combined with the HER2 inhibitor Lapatinib in the NCI-N87 xenograft mouse model, HQY1428 produces a synergistic therapeutic effect.</p>Formula:C25H28ClFN6O3SColore e forma:SolidPeso molecolare:546.16162RET ligand-1
CAS:<p>RETligand-1 is a target protein ligand that specifically interacts with RET and can be utilized in the synthesis of the PROTAC LDD39.</p>Formula:C28H24F2N6O3Colore e forma:SolidPeso molecolare:530.525Os30
<p>Os30 is a potent fourth-generation EGFR inhibitor, specifically targeting the EGFRC797S-TK mutation with IC50 values of 18 nM for EGFRDel19/T790M/C797S TK and</p>Purezza:98%Colore e forma:Odour SolidEriosematin
CAS:<p>Eriosematin has anti-proliferative and apoptosis-inducing properties and is a compound extracted from the root of Flemingia philippinensis in the Philippines.</p>Formula:C19H20O4Purezza:98%Colore e forma:SolidPeso molecolare:312.36p38α inhibitor 6
<p>p38α inhibitor6 (compound 19) is a p38α inhibitor with an IC50 value of 0.68 μM. It induces apoptosis, arrests the cell cycle in the G0 and G2/M phases, reduces TNF-α concentration, upregulates the expression of the tumor suppressor gene p53, increases the Bax/BCL-2 ratio, and activates caspase3/7.</p>Colore e forma:Odour Solid(±)-Indoxacarb
CAS:<p>(±)-Indoxacarb is a pyrazoline insecticide with insecticidal activity and cytotoxicity, blocks sodium channels in insect neurons, and can induce apoptosis.</p>Formula:C22H17ClF3N3O7Colore e forma:SolidPeso molecolare:527.83Ferroptosis-IN-16
<p>Ferroptosis-IN-16 (Compound 13l) acts as a specific inhibitor of ferroptosis, demonstrating EC50 values of 0.7 nM in ES-2 cells and 0.9 nM in LX-2 cells. It effectively alleviates acute liver injury induced by Acetaminophen in mouse models and shows excellent metabolic stability in mouse liver microsomes.</p>Formula:C26H23N5OColore e forma:SolidPeso molecolare:421.49
