Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(1 prodotti)
- Caspasi(154 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(137 prodotti)
- PDK(9 prodotti)
- PERK(23 prodotti)
- Chinasi di serina/treonina(18 prodotti)
- Survivin(14 prodotti)
- TNF(94 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6231 prodotti di "Apoptosi"
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INF200
INF200 (compound 5), a sulfonylurea-based inhibitor of NLRP3 and associated pyroptosis, exhibits cardiometabolic benefits in a rat model of high-fat diet (HFD)-Formula:C13H13ClN2O4Purezza:98%Colore e forma:SolidPeso molecolare:296.71Ascochlorin
CAS:Ascochlorin, an isoprenoid antibiotic, inhibits STAT3 to combat tumors, induces apoptosis, and reduces inflammation.Formula:C23H29ClO4Purezza:98%Colore e forma:SolidPeso molecolare:404.93Psalmotoxin 1
CAS:Psalmotoxin 1 is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker.Formula:C200H312N62O57S6Purezza:98%Colore e forma:SolidPeso molecolare:4689.41SP3N hydrochloride
SP3N hydrochloride is a specific degrader of the prolyl isomerase (FKBP12). Its alkylamine moiety is metabolized into an active aldehyde (SP3CHO), which recruits the SCFFBXO22 ligase for the degradation of FKBP12. SP3N hydrochloride is applicable in cancer research.Colore e forma:Odour SolidSuramin
CAS:Suramin is an RdRp and PTPase inhibitor with anti-parasitic, anti-tumor, and anti-angiogenic activities, inhibiting sirtuins and DNA topoisomerase II.Formula:C51H40N6O23S6Purezza:99.80%Colore e forma:SolidPeso molecolare:1297.28AlbA-DCA
AlbA-DCA, a compound of Albiziabioside A and dichloroacetate, boosts ROS and reduces lactic acid in tumors, killing cancer cells and triggering apoptosis.Formula:C43H67Cl2NO12Purezza:98%Colore e forma:SolidPeso molecolare:860.9PZ703b hydrochloride
PZ703b hydrochloride, a Bcl-xl PROTAC, triggers apoptosis and halts cancer growth; used in bladder cancer studies.Formula:C80H103Cl2F3N10O11S4Colore e forma:SolidPeso molecolare:1636.9Thalidomide-O-amido-C8-NH2 hydrochloride
Thalidomide-O-amido-C8-NH2 hydrochloride, a synthetic cereblon ligand-linker for PROTAC synthesis.Formula:C23H31ClN4O6Purezza:98%Colore e forma:SolidPeso molecolare:494.97PD1-PDL1-IN 1 TFA
PD1-PDL1-IN 1 TFA (compound 16) is a potent inhibitor of programmed cell death 1 (PD-1), functioning as an immune modulator [1].Formula:C16H24F3N7O8Colore e forma:SolidPeso molecolare:499.4PI3Kα-IN-14
PI3Kα-IN-14 (compound F8), a potent PI3Kα inhibitor, exhibits an IC50 value of 0.14 nM and markedly diminishes mitochondrial membrane potential, resulting inPurezza:98%Colore e forma:Odour SolidCannflavin A
CAS:Cannflavin A, isolated from Cannabis sativa L., exhibits anti-cancer, neuroprotective, and anti-inflammatory activities by inhibiting Aβ1-42 aggregation andFormula:C26H28O6Colore e forma:SolidPeso molecolare:436.5Ac-VDVAD-CHO TFA
Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor with IC50 values of 46 nM and 15 nM, respectively.Colore e forma:Odour SolidShepherdin (79-87)
CAS:Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.Formula:C41H64N12O12SPurezza:98%Colore e forma:SolidPeso molecolare:949.09PTD-p65-P1 Peptide
PTD-p65-P1: a NF-kappaB inhibitor blocking activation from multiple inflammatory stimuli.Formula:C168H275N57O44SPurezza:98%Colore e forma:SolidPeso molecolare:3829.5XZ739
CAS:XZ739: Cereblon-based PROTAC, degrades BCL-XL (DC50 2.5 nM in MOLT-4, 16hr), induces caspase apoptosis.Formula:C65H76ClF3N8O12S3Colore e forma:SolidPeso molecolare:1349.99MSU-42011
CAS:MSU-42011: oral RXR-like agonist, inhibits iNOS & p-ERK, antitumor in lung cancer model, effective preclinical treatment.Formula:C24H34N2O2Purezza:99.6%Colore e forma:SoildPeso molecolare:382.54Ankaflavin
CAS:Ankaflavin, from red rice fermentation, is a PPARγ agonist with anti-inflammatory properties and selectively kills cancer cells.Formula:C23H30O5Purezza:98%Colore e forma:SolidPeso molecolare:386.48p38-α MAPK-IN-8
p38-α MAPK-IN-8 (Compound 13) is a lipophilic cationic derivative. It exhibits cytotoxicity toward various tumor cells, inducing cell cycle arrest and apoptosis, as well as increasing reactive oxygen species (ROS) production and causing mitochondrial membrane potential depolarization. Its antitumor activity may be related to the p38α MAPK pathway, making it a potential candidate for cancer research.Formula:C49H62BrO4PColore e forma:SolidPeso molecolare:825.892β-Apopicropodophyllin
CAS:β-Apopicropodophyllin, a natural product isolated from Hyptis wticillata, promotes apoptosis through mechanisms including microtubule disruption, DNA damage,Formula:C22H20O7Colore e forma:SolidPeso molecolare:396.39Platycoside G3
CAS:Platycoside G3 is a useful organic compound for research related to life sciences. The catalog number is T124100 and the CAS number is 849758-44-7.Formula:C63H102O32Colore e forma:SolidPeso molecolare:1371.48ChoKα inhibitor-5
ChoKα Inhibitor-5, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoKα1 with an IC50 value of 0.64 μM and induces apoptosis.Formula:C54H68Br2N4S4Colore e forma:SolidPeso molecolare:1061.21PEAQX tetrasodium hydrate
PEAQX tetrasodium hydrate: potent/selective oral NMDA antagonist, IC50 270 nM (1A/2A), 29600 nM (1A/2B).Formula:C17H15BrN3Na4O6PPurezza:99%Colore e forma:SolidPeso molecolare:560.15PD-1-IN-20
PD-1-IN-20 is the less active enantiomer of PD-1-IN-1.Formula:C12H20N6O7Purezza:98%Colore e forma:SolidPeso molecolare:360.32Mechercharmycin A
CAS:Mechercharmycin A, a cytotoxic compound, was isolated from Thermoactinomyces sp. YM3-251, a marine source. It demonstrates potent antitumor activity.Formula:C35H32N8O7SColore e forma:SolidPeso molecolare:708.75AS-99 free base
CAS:AS-99 is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 μM, Kd= 0.89 μM) with anti-leukemic activity.Formula:C27H30F3N5O3S2Colore e forma:SolidPeso molecolare:593.68EGFR T790M/L858R-IN-2
EGFRT790M/L858R-IN-2: selective inhibitor, IC50: 3.5 nM (mutant), 1290 nM (WT); reduces p-EGFR/AKT/ERK1/2, triggers apoptosis, G1 arrest, anti-cancer.Formula:C28H28FN7OColore e forma:SolidPeso molecolare:497.57TD1092
TD1092, a pan-IAP degrader, activates caspase 3/7, induces apoptosis in cancer cells, inhibits NF-κB, and is used in cancer research.Formula:C55H70N8O9Colore e forma:SolidPeso molecolare:987.19HEMTAC CDK4/6 degrader 1
CAS:HEMTAC CDK4/6 degrader 1, a PROTAC targeting HSP90/CDK4/6, Kd of 35.7 μM, disrupts B16F10 melanoma cell cycle, and induces apoptosis.Formula:C48H53ClN16O4Colore e forma:SolidPeso molecolare:953.49PCC0208017
CAS:PCC0208017 is an inhibitor of MARK3 and MARK4 with IC50s of 1.8 and 2.01 nM. PCC0208017 disrupts microtubule dynamics and displays potent antitumor activity.
Formula:C19H20F3N7Purezza:99.48%Colore e forma:SolidPeso molecolare:403.4AKN-028
CAS:AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.
Formula:C17H14N6Purezza:99.88%Colore e forma:SolidPeso molecolare:302.33Delmitide
CAS:Delmitide, a TNF-alpha production inhibitor, is used potentially for the treatment of Crohn's disease and ulcerative colitis.Formula:C59H105N17O11Purezza:98%Colore e forma:SolidPeso molecolare:1228.57P53R3
CAS:P53R3 is a potent reactivator of p53, effectively restoring sequence-specific DNA binding to several p53 hot spot mutants, namely p53 R175H, p53 R248W, and p53Formula:C32H35Cl2N5O2Purezza:98.8%Colore e forma:SolidPeso molecolare:592.56TRAP-1
TRAP-1 (XJZ-06-462) is a p53 transcription activator that effectively activates mutant p53 and triggers the transcription of p53 target genes. In the p53Y220C pancreatic cell line, TRAP-1 rapidly upregulates p21 and other p53 target genes. TRAP-1 also inhibits cell proliferation, exhibiting IC50 values of 3.94 μM and 0.531 μM in BxPC-3 and A549 cell lines, respectively. Additionally, TRAP-1 modulates autophagy in lung cancer cells and provides protection against oxidative stress and apoptosis.Formula:C57H66ClF3N11O3PSColore e forma:SolidPeso molecolare:1108.69MG-277
MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.Formula:C41H42Cl2FN5O5Purezza:98%Colore e forma:SolidPeso molecolare:774.71Ac-YVAD-CHO acetate
Ac-YVAD-CHO acetate, potent reversible ICE and caspase-1 inhibitor; K_i: 3.0 nM (mouse), 0.76 nM (human); blocks IL-lβ production.Formula:C25H36N4O10Colore e forma:SolidPeso molecolare:552.57Daporinad hydrochloride
CAS:Daporinad hydrochloride (FK 866 hydrochloride) is a NAMPT inhibitor with antitumor and antiangiogenic activity that induces apoptosis in tumor cells.Formula:C24H30ClN3O2Purezza:98.99%Colore e forma:SolidPeso molecolare:427.97Pantoprazole Sodium Hydrate
CAS:Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagusFormula:C16H14F2N3NaO4SH2OPurezza:98.32%Colore e forma:SolidPeso molecolare:432.37MDM2/4-p53-IN-2
MDM2/4-p53-IN-2 (2q) is a dual MDM2/MDM4 inhibitor, p53 activator; IC50: 70.7 nM(MDM2), 81.4 nM(MDM4); tumor suppressor.Formula:C25H17Cl3FN3O3Colore e forma:SolidPeso molecolare:532.78Calcimycin hemimagnesium
CAS:Calcimycin hemimagnesium is an antibiotic, ionophore, and ATPase inhibitor that boosts intracellular Ca2+, causing cell death and apoptosis.Formula:C58H72MgN6O12Colore e forma:SolidPeso molecolare:1069.53Thalidomide-NH-PEG4-COOH
CAS:Thalidomide-NH-PEG4-COOH is a E3 ligase ligand-linker for synthesizing the selective degrader dCBP-1 targeting p300/CBP.Formula:C24H31N3O10Colore e forma:SolidPeso molecolare:521.523HJC0416 hydrochloride
CAS:HJC0416 hydrochloride: potent oral STAT3 inhibitor, better anticancer effects than Stattic, promising for breast cancer research.Formula:C18H18Cl2N2O4SColore e forma:SolidPeso molecolare:429.31FLT3-IN-21
FLT3-IN-21 (compound LC-3), a potent FLT3 inhibitor with an IC50 value of 8.4 nM, induces apoptosis and arrests the cell cycle in the G1 phase.Formula:C20H22FN5O2Colore e forma:SolidPeso molecolare:383.42Flavopiridol
CAS:Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; also inhibits EGFR, PKA. In Phase 1/2 trials.Formula:C21H20ClNO5Purezza:97.74% - 99.99%Colore e forma:SolidPeso molecolare:401.84PROTAC Bcl2 degrader-1
CAS:PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).Formula:C45H45BrN6O10SPurezza:98%Colore e forma:SolidPeso molecolare:941.84Ref: TM-T10485
10mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiesta1mg1.080,00€5mg2.340,00€PROTAC Bcl-xL degrader-1
PROTAC Bcl-xL degrader-1 targets Bcl-xL & IAP E3 ligases, degrades Bcl-xL, toxic to human platelets & MyLa 1929 (IC50: 62 nM, 8.5 μM).Formula:C76H96ClF3N10O11S3Colore e forma:SolidPeso molecolare:1514.28VB-85247
VB-85247 is a STING agonist that, by activating the STING pathway, induces the upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as the maturation and activation of dendritic cells. It can lead to the regression of tumors within the bladder and is applicable in bladder cancer research.Colore e forma:Odour SolidW1131 TFA
W1131 TFA is a STAT3 inhibitor and ferroptosis inducer that regulates the IL6-JAK-STAT3 and ferroptosis pathways,gastric cancer.Formula:C25H20F3N5O6Purezza:98.1%Colore e forma:SolidPeso molecolare:543.45Ref: TM-T80847
1mL*10mM (DMSO)Prezzo su richiesta1mg92,00€5mg188,00€10mg311,00€25mg628,00€50mg1.008,00€100mg1.596,00€Dapirolizumab
Dapirolizumab is an anti-CD40 monoclonal antibody used in research on systemic lupus erythematosus (SLE) and other autoimmune diseases.Purezza:>95%Colore e forma:LiquidPeso molecolare:150 kDa(-)-Mcl-1 inhibitor 21
CAS:(-)-Mcl-1 inhibitor 21 (Example 1-38) is an Mcl-1 inhibitor with an IC50 of 7.51 μM. It exhibits pro-apoptotic and anti-proliferative activity against SUDHL5 and SUDHL10 cell lines, making it useful for cancer research.
Formula:C32H33N3O4Colore e forma:SolidPeso molecolare:523.622Cyanoacetamide
CAS:Cyanoacetamide has inhibitory activity against the myeloid leukaemia cell differentiation protein Mcl-1Formula:C3H4N2OPurezza:97.04%Colore e forma:Needles From Alcohol White To Light Cream Crystalline PowderPeso molecolare:84.08
